Phthalates in cosmetic and personal care products: Concentrations and possible dermal exposure

Environmental Research - Tập 111 Số 3 - Trang 329-336 - 2011
Diane Koniecki1, Rong Wang2, Richard P. Moody2, Jiping Zhu2
1Cosmetics Division, Health Canada, Ottawa, Canada
2Exposure and Biomonitoring Division, Health Canada, Ottawa, Canada

Tóm tắt

Từ khóa


Tài liệu tham khảo

Adibi, 2008, Characterization of phthalate exposure among pregnant women assessed by repeat air and urine samples, Environ. Health Perspect., 116, 467, 10.1289/ehp.10749

Azzi, 1995, Topical dermatological vehicles: engineering the delivery system, 801

Barber, 1992, A comparative study of the rates of in vitro percutaneous absorption of eight chemicals using rat and human skin, Fund. Appl. Toxicol., 19, 493, 10.1016/0272-0590(92)90086-W

Benson, 2009, Hazard to the developing male reproductive system from cumulative exposure to phthalate esters—dibutyl phthalate, diisobutyl phthalate, butylbenzyl phthalate, diethylhexyl phthalate, diphenyl phthalate, and diisononyl phthalate, Regul. Toxicol. Pharmacol., 53, 90, 10.1016/j.yrtph.2008.11.005

Blount, 2000, Levels of seven urinary phthalate metabolites in a human reference population, Environ. Health Perspect., 108, 979, 10.1289/ehp.00108979

Borch, 2006, Diisobutyl phthalate has comparable anti-androgenic effects to di-n-butyl phthalate in fetal rat testis, Toxicol. Lett., 163, 183, 10.1016/j.toxlet.2005.10.020

Bronaugh, 1982, Methods for in vitro percutaneous absorption studies. II. animal models for human skin, Toxicol. Appl. Pharmacol., 62, 481, 10.1016/0041-008X(82)90149-1

Bornehag, 2004, The association between asthma and allergic symptoms in children and phthalates in house dust: a nested case-control study, Environ. Health Perspect., 112, 1393, 10.1289/ehp.7187

Bornehag, 2005, Phthalates in indoor dust and their association with building characteristics, Environ. Health Perspect., 113, 1399, 10.1289/ehp.7809

B+S Chemie, 2000. Diisobutyl Phthalate. Material Safety Data Sheet. B+S Chemie. GmbH. 6pp.

Calafat, 2006, Integrating biomonitoring exposure data into the risk assessment process: phthalates [diethyl phthalate and di(2-ethylhexyl) phthalate] as a case study, Environ. Health Perspect., 114, 1783, 10.1289/ehp.9059

Chan, 1994, Di-n-butyl phthalate: evaluation of risks to health from environmental exposure in Canada, J. Environ. Sci. Health, Part C, Environ. Carcinog. Ecotoxicol. Rev., 12, 257, 10.1080/10590509409373444

Christiansen, 2008, Combined exposure to anti-androgens causes markedly increased frequency of hypospadias in the rat, J. Androl., 31, 241

CDC [Centers for Disease Control and Prevention], 2005. Third National Report on Human Exposure to Environmental Chemicals, Centers for Disease Control and Prevention, Atlanta, GA. Available at 〈http://www.cdc.gov/exposurerepon/〉

Duty, 2005, Personal care product use predicts urinary concentrations of some phthalate monoesters, Environ. Health Perspect., 113, 1530, 10.1289/ehp.8083

Deutschle, 2008, A controlled challenge study on di(2-ethylhexyl) phthalate (DEHP) in house dust and the immune response in human nasal mucosa of allergic subjects, Environ. Health Perspect., 116, 1487, 10.1289/ehp.11474

Destaillats, 2008, Indoor pollutants emitted by office equipment: a review of reported data and information needs, Int. J. Hyg. Environ. Health, 210, 345

ECB [European Chemicals Bureau], 2008. European Union Risk Assessment Report bis (2-ethylhexyl) phthalate (DEHP) (CAS No: 117-81-7). 2nd Priority List vol: 80 European Commission/Joint Research Centre. Available at 〈http://ecb.jrc.it〉

EFSA [European Food Safety Authority], 2005, Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) related to Bis(2-ethylhexyl)phthalate (DEHP) for use in food contact materials, EFSA J., 243, 1

EFSA [European Food Safety Authority], 2005, Opinion of the scientific panel on food additives, flavourings, processing aids and materials in contact with food (AFC) on a request from the commission related to di-butylphthalate (DBP) for use in food contact materials. Question No. EFSA-Q-2003-192, EFSA J., 242, 1

Elsisi, 1989, Dermal absorption of phthalate diesters in rats, Fund. Appl. Toxicol., 12, 7077, 10.1016/0272-0590(89)90063-8

Foster, 2000, Effects of di-n-butyl phthalate (DBP) on male reproductive development in the rat: implications for human risk assessment, Food Chem. Toxicol., 38, S97, 10.1016/S0278-6915(99)00128-3

Foster, 2006, Distruption of reproductive development in male rat offspring following in utero exposure to phthalate esters, Int. J. Androl., 29, 140, 10.1111/j.1365-2605.2005.00563.x

Geiss, 2009, Investigation of volatile organic compounds and phthalates present in the cabin air of used private cars, Environ. Int., 35, 1188, 10.1016/j.envint.2009.07.016

Grandjean, 2006, Possible effects of phthalate exposure in doses relevant for humans, Int. J. Androl., 29, 181, 10.1111/j.1365-2605.2005.00679.x

Greenpeace, 2005. Perfume—An investigation of chemicals in 36 eauz de toilette and eauz de parfum. Greenpeace International. Available at 〈http://www.greenpeace.org/international/en/publications/reports/perfume-an-investigation-of/〉

Gwinn, 2007, Gene expression profiling of di-n-butyl phthalate in normal human mammary epithelial cells, J. Environ. Pathol. Toxicol. Oncol., 26, 51, 10.1615/JEnvironPatholToxicolOncol.v26.i1.60

Gray, 2000, Perinatal exposure to phthalates DEHP, BBP, and DINP, but not DEP, DMP or DOTP, althers sexual differentiation of the male rat, Toxicol. Sci., 58, 350, 10.1093/toxsci/58.2.350

Hauser, 2005, Phthalate and human health, Occup. Environ. Med., 62, 806, 10.1136/oem.2004.017590

EC [Health Canada], 2009a. Cosmetics and Personal Care. Health Canada (EC), Consumer Product Safety. Available at 〈www.hc-sc.gc.ca/cps-spc/person/cosmet/index-eng.php〉

EC [Health Canada],2009b Proposed Phthalates Regulations for Soft Vinyl Children's Toys and Child Care Articles. Available at 〈http://hc-sc.gc.ca/cps-spc/legislation/consultation/phthalates-phthalates-eng.php〉

EC [Health Canada],1998. Exposure factors for assessing total daily intake of Priority Substances by the general population of Canada. Unpublished report, December 1998. Ottawa (ON): Priority Substances Section, Environmental Health Directorate.

EC/EC [Health Canada/Environment Canada], 1994a. Dibutyl phthalate. Canadian Environmental Protection Act, Priority Substances List Assessment. Ottawa (ON): Minister of Supply and Services of Canada, 34 pp.

1994

Heudorf, 2007, Phthalates: toxicology and exposure, Int. J. Hyg. Environ. Health, 210, 623, 10.1016/j.ijheh.2007.07.011

Hines, 2009, Concentrations of phthalate metabolites in milk, urine, saliva, and serum of lactating North Carolina women, Environ. Health Perspect., 117, 86, 10.1289/ehp.11610

Högberg, 2008, Phthalate diesters and their metabolites in human breast milk, blood or serum, and urine as biomarkers of exposure in vulnerable populations, Environ. Health Perspect., 116, 334, 10.1289/ehp.10788

Houlihan, J., Brody, C., Schwan, B., 2002. “Not Too Pretty” Phthalates, beauty products and the FDA. Available at 〈www.ewg.org/reports/nottoopretty〉.

Howdeshell, 2008, A mixture of five phthalate esters inhibit fetal testicular testosterone production in the Sprague-Dawley rat in a cumulative, dose additive manner, Toxicol. Sci., 105, 153, 10.1093/toxsci/kfn077

Hubinger, 2006, Analysis of consumer cosmetic products for phthalate esters, J. Cosmetic Sci., 57, 127

IARC [International Agency for Research on Cancer], 2000, Some industrial chemicals, IARC Monographs, 77, 41

Jackson, 2008, Subungual penetration of dibutyl phthalate in human fingernails, Skin Pharmacol. Physiol., 21, 10, 10.1159/000109083

Janjua, 2007, Systemic uptake of diethyl phthalate, dibutyl phthalate, and butyl paraben following whole body topical application and reproductive and thyroid hormone levels in humans, Environ. Sci. Technol., 41, 5564, 10.1021/es0628755

Jakkola, 2008, The role of exposure to phthalates from polyvinyl chloride products in the development of asthma and allergies: a systematic review and metaanalysis, Environ. Health Perspect., 116, 845, 10.1289/ehp.10846

Kamrin, 2009, Phthalates risk, phthalates regulation, and public health: a review, J. Toxicol. Environ. Health, Part B, 12, 157, 10.1080/10937400902729226

Koch, 2005, New metabolites of di (2-ethylhexyl) phthalate DEHP in human urine and serum after single oral doses of deuterium-labelled DEHP, Archives Toxicol., 79, 367, 10.1007/s00204-004-0642-4

Koo, 2004, Estimated exposure to phthalates in cosmetics and risk assessment, J. Toxicol. Environ. Health, 67, 1901, 10.1080/15287390490513300

Koralik, 2008, The association between phthalates in dust and allergic diseases among Bulgarian children, Environ. Health Perspect., 116, 98, 10.1289/ehp.10498

Lee, 2004, Diverse developmental toxicity of di-n-butyl phthalate in both sexes of rat offspring after maternal exposure during the period from late gestation through lactation, Toxicology, 203, 221, 10.1016/j.tox.2004.06.013

Latini, 2009, Lactational exposure to phthalates in Southern Italy, Environ. Int., 35, 236, 10.1016/j.envint.2008.06.002

Latini, 2004, Plasticizers, infant and reproductive health, Reprod. Toxicol., 19, 27, 10.1016/j.reprotox.2004.05.011

Lehmann, 2004, Dose-dependent alterations in gene expression and testosterone synthesis in the fetal testes of male rats exposed to di (n-butyl) phthalate, Toxicol. Sci., 81, 60, 10.1093/toxsci/kfh169

Lyche, 2009, Reproductive and developmental toxicity of phthalates, J. Toxicol. Environ. Health, Part B, 12, 225, 10.1080/10937400903094091

Main, 2006, Human breast milk contamination with phthalates and alterations of endogenous reproductive hormones in infants three months of age, Environ. Health Perspect., 114, 270, 10.1289/ehp.8075

Meek, 1994, Bis (2-ethylhexhyl) phthalate: evaluation of risks to health from environmental exposure in Canada. J. Environ. Sci. and Health. Part C, Environ. Carcinog. and Ecotoxicol. Rev., 12, 179, 10.1080/10590509409373439

Mint, 1993, Percutaneous absorption of dimethyl phthalate and di-n-butylphthalate through rat and human skin in vitro, Vol 3B, 646

Mint, 1994, Percutaneous absorption of diethyl phthalate through rat and human skin in vitro, Toxicol. in Vitro, 2, 251, 10.1016/0887-2333(94)90190-2

Mylchreest, 1998, Male reproductive tract malformations in rats following gestational and lactational exposure to di(n-butyl) phthalate: an antiandrogenic mechanism?, Toxicol. Sci., 43, 47, 10.1093/toxsci/43.1.47

NRC [National Research Council], 2008. Phthalates and cumulative risk assessment: The tasks ahead. Committee on the Health Risks of Phthalates. Prepublication Copy. The National Academies Press. Washington, D.C. 175 pp. Available at 〈www.nationalacademies.org〉.

NIOSH [National Institute for Occupational Safety and Health], 2009. Skin Permeation Calculator. Available at 〈www.cdc.gov/niosh/topics/skin/skinPermCalc.htm1〉.

Payan, 2001, In vivo and in vitro percutaneous absorption of [14C] Di-n-butylphthalate in rat, Am. Soc. Pharacol. Exp. Therap., 29, 843

Potts, 1992, Predicting skin permeability, Pharm. Res., 9, 663, 10.1023/A:1015810312465

RIVM, 2006

Rank, 2005, Classification and risk assessment of chemicals: the case of DEHP in the light of REACH, J. Trans.disciplinary Environ. Studies, 4, 1602

Sathyanarayana, 2008, Baby care products: possible sources of infant phthalates exposure, Pediatrics, 121, 260, 10.1542/peds.2006-3766

SCCNFP [Scientific Committee on Cosmetic Products and Non-Food Products Intended for Consumers], 2002. Opinion on diethyl phthalate in cosmetic products adopted during the 20th Plenary meeting of 4 June 2002, Brussels, SCCNFP/0411/01, 36 pp.

SCCP [Scientific Committee on Consumer Products], 2007. Opinion on phthalates in cosmetic products opinion adopted at the 11th plenary meeting of 21 March 2007, Brussels, SCCP/1016/06, 19 pp.

Schettler, 2006, Human exposure to phthalates via consumer products, Int. J. Androl., 29, 134, 10.1111/j.1365-2605.2005.00567.x

Schripp, 2010, Chamber studies on mass-transfer of di(2-ethylhexyl)phthalate (DEHP) and di- n-butylphthalate (DnBP) from emission sources into house dust, Atmos. Environ., 44, 2840, 10.1016/j.atmosenv.2010.04.054

Scott, 1987, In vitro absorption of some o-phthalate diesters through human and rat skin, Environ. Health Perspect., 74, 223, 10.1289/ehp.8774223

Swan, 2005, Anogenital distance – a marker of fetal androgen action – is decreased in male infants following phthalate exposure during pregnancy, Environ. Health Perspect., 113, 1056, 10.1289/ehp.8100

Takatori, 2007, Determination of phthalate monoester levels in human breast milk by high pressure liquid chromatography/tandem mass spectrometry, Bunseki Kagaku, 56, 225, 10.2116/bunsekikagaku.56.1025

U.S. EPA [United States Environmental Protection Agency], 1993. Diethyl phthalate (DEP) (CASRN 84-66-2). Integrated Risk Information System. Available at 〈www.epa.gov/NCEA/iris/subst/0226.htm〉

U.S. EPA [United States Environmental Protection Agency], 1991. Di(2-ethylhexyl) phthalate (DEHP) (CASRN 117-81-7). ). Integrated Risk Information System. Available at 〈www.epa.gov/iris/subst/0038.htm〉

U.S EPA [United States Environmental Protection Agency], 2006. Toxicological review of dibutyl phthalate (external peer review draft). Available at 〈www.epa.gov/ncea/iris/recent_2006.html〉 date of entry 2006-06-27

U.S. EPA [United States Environmental Protection Agency], 2008. Child-specific exposure factors handbook. National Center for Environmental Assessment, Office of Research and Development. EPA/600/R-06/096F. Available at 〈http://cfpub.epa.gov/ncea/CFM/〉

Wang, 2009, Low molecular weight cyclic volatile methylsiloxanes in cosmetic products sold in Canada: implication for dermal exposure, Environ. Int., 35, 900, 10.1016/j.envint.2009.03.009

Wittassek, 2008, Phthalates: metabolism and exposure, Int. J. Androl., 31, 131, 10.1111/j.1365-2605.2007.00837.x

Wittassek, 2009, Fetal exposure to phthalates—a pilot study, Int. J. Hyg. Environ. Health, 212, 492, 10.1016/j.ijheh.2009.04.001

Wolfe, 2003

Wormuth, 2006, What are the sources of exposure to eight frequently used phthalic acid esters in Europeans?, Risk Anal., 26, 803, 10.1111/j.1539-6924.2006.00770.x

Xu, 2010, Predicting residential exposure to phthalate plasticizer emitted from vinyl flooring: sensitivity, uncertainty, and implications for biomonitoring, Environ. Health Perspect., 118, 253, 10.1289/ehp.0900559

Zhu, 2006, Phthalate esters in human milk: concentration variations over a six-month postpartum time, Environ. Sci. Technol., 40, 5276, 10.1021/es060356w