Phosphorylation of eIF2α mitigates endoplasmic reticulum stress and hepatocyte necroptosis in acute liver injury

Stephenson, 2002, Jaundice in primary school pupils, Postgrad Med J, 78, 9

Alpert, 2016, The pathology of alcoholic liver disease, Clin Liver Dis, 20, 473, 10.1016/j.cld.2016.02.006

Clark, 2018, Clinical and histologic features of adults with alpha-1 antitrypsin deficiency in a non-cirrhotic cohort, J Hepatol, 10.1016/j.jhep.2018.08.005

Kroemer, 2009, Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009, Cell Death Differ, 16, 3, 10.1038/cdd.2008.150

Roychowdhury, 2016, Receptor interacting protein 3 protects mice from high-fat diet-induced liver injury, Hepatology, 64, 1518, 10.1002/hep.28676

Schwabe, 2018, Apoptosis and necroptosis in the liver: a matter of life and death, Nat Rev Gastroenterol Hepatol, 10.1038/s41575-018-0065-y

Iurlaro, 2016, Cell death induced by endoplasmic reticulum stress, FEBS J, 283, 2640, 10.1111/febs.13598

Wang, 2016, A mechanistic review of cell death in alcohol-induced liver injury, Alcohol Clin Exp Res, 40, 1215, 10.1111/acer.13078

Wang, 2016, Increased hepatic receptor interacting protein kinase 3 expression due to impaired proteasomal functions contributes to alcohol-induced steatosis and liver injury, Oncotarget, 7, 17681, 10.18632/oncotarget.6893

Choi, 2015, Melatonin attenuates carbon tetrachloride-induced liver fibrosis via inhibition of necroptosis, Transl Res, 166, 292, 10.1016/j.trsl.2015.04.002

Haga, 2018, Detection of necroptosis in ligand-mediated and hypoxia-induced injury of hepatocytes using a novel optic probe-detecting receptor-interacting protein (RIP)1/RIP3 binding, Oncol Res, 26, 503, 10.3727/096504017X15005102445191

Yang, 2016, The end of RIPK1-RIPK3-MLKL-mediated necroptosis in acetaminophen-induced hepatotoxicity?, Hepatology, 64, 311, 10.1002/hep.28263

Liu, 2018, RIP3 deficiency protects against traumatic brain injury (TBI) through suppressing oxidative stress, inflammation and apoptosis: dependent on AMPK pathway, Biochem Biophys Res Commun, 499, 112, 10.1016/j.bbrc.2018.02.150

Mahdi, 2016, Role of endoplasmic reticulum stress and unfolded protein responses in health and diseases, Indian J Clin Biochem, 31, 127, 10.1007/s12291-015-0502-4

Saveljeva, 2015, Endoplasmic reticulum stress induces ligand-independent TNFR1-mediated necroptosis in L929 cells, Cell Death Dis, 6, e1587, 10.1038/cddis.2014.548

Zhu, 2018, Ripk3 promotes ER stress-induced necroptosis in cardiac IR injury: a mechanism involving calcium overload/XO/ROS/mPTP pathway, Redox Biol, 16, 157, 10.1016/j.redox.2018.02.019

Marycz, 2018, Excessive endoplasmic reticulum stress correlates with impaired mitochondrial dynamics, mitophagy and apoptosis, in liver and adipose tissue, but not in muscles in EMS horses, Int J Mol Sci, 19

Harada, 2017, Endoplasmic reticulum stress in mice increases hepatic expression of genes carrying a premature termination codon via a nutritional status-independent GRP78-dependent mechanism, J Cell Biochem, 118, 3810, 10.1002/jcb.26031

Hughes, 2017, Endoplasmic reticulum stress and unfolded protein response in cartilage pathophysiology; contributing factors to apoptosis and osteoarthritis, Int J Mol Sci, 18

Rajesh, 2016, The eIF2alpha serine 51 phosphorylation-ATF4 arm promotes HIPPO signaling and cell death under oxidative stress, Oncotarget, 7, 51044, 10.18632/oncotarget.10480

Kimball, 1999, Eukaryotic initiation factor eIF2, Int J Biochem Cell Biol, 31, 25, 10.1016/S1357-2725(98)00128-9

Khan, 2018, Origins of robustness in translational control via eukaryotic translation initiation factor (eIF) 2, J Theor Biol, 445, 92, 10.1016/j.jtbi.2018.02.020

Dev, 2009, Archaeal aIF2B interacts with eukaryotic translation initiation factors eIF2alpha and eIF2Balpha: implications for aIF2B function and eIF2B regulation, J Mol Biol, 392, 701, 10.1016/j.jmb.2009.07.030

Meng, 2018, Periostin has a protective role in melatonininduced cell apoptosis by inhibiting the eIF2alphaATF4 pathway in human osteoblasts, Int J Mol Med, 41, 1003

Cnop, 2017, Endoplasmic reticulum stress and eIF2alpha phosphorylation: the Achilles heel of pancreatic beta cells, Mol Metab, 6, 1024, 10.1016/j.molmet.2017.06.001

Eigner, 2017, The unfolded protein response impacts melanoma progression by enhancing FGF expression and can be antagonized by a chemical chaperone, Sci Rep, 7, 17498, 10.1038/s41598-017-17888-9

Malo, 2013, 4-Phenylbutyric acid reduces endoplasmic reticulum stress, trypsin activation, and acinar cell apoptosis while increasing secretion in rat pancreatic acini, Pancreas, 42, 92, 10.1097/MPA.0b013e318259f6ca

Kusama, 2017, Sodium 4-phenylbutyric acid prevents murine acetaminophen hepatotoxicity by minimizing endoplasmic reticulum stress, J Gastroenterol, 52, 611, 10.1007/s00535-016-1256-3

Anuncibay-Soto, 2018, Salubrinal and robenacoxib treatment after global cerebral ischemia. Exploring the interactions between ER stress and inflammation, Biochem Pharmacol, 151, 26, 10.1016/j.bcp.2018.02.029

Gao, 2013, The endoplasmic reticulum stress inhibitor salubrinal inhibits the activation of autophagy and neuroprotection induced by brain ischemic preconditioning, Acta Pharmacol Sin, 34, 657, 10.1038/aps.2013.34

Knupp, 2018, Increased mitochondrial respiration promotes survival from endoplasmic reticulum stress, Cell Death Differ

Feng, 2017, Endoplasmic reticulum stress inducer tunicamycin alters hepatic energy homeostasis in mice, Int J Mol Sci, 18

Dong, 2016, The protective or damaging effect of tumor necrosis factor-alpha in acute liver injury is concentration-dependent, Cell Biosci, 6, 8, 10.1186/s13578-016-0074-x

Kim, 2017, Necrostatin-1 protects against d-galactosamine and lipopolysaccharide-induced hepatic injury by preventing TLR4 and RAGE signaling, Inflammation, 40, 1912, 10.1007/s10753-017-0632-3

Lebeaupin, 2018, Endoplasmic reticulum stress signalling and the pathogenesis of non-alcoholic fatty liver disease, J Hepatol, 69, 927, 10.1016/j.jhep.2018.06.008

Carlisle, 2014, 4-Phenylbutyrate inhibits tunicamycin-induced acute kidney injury via CHOP/GADD153 repression, PLOS ONE, 9, e84663, 10.1371/journal.pone.0084663

Zinszner, 1998, CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulum, Genes Dev, 12, 982, 10.1101/gad.12.7.982

Han, 2016, PHLDA3 overexpression in hepatocytes by endoplasmic reticulum stress via IRE1-Xbp1s pathway expedites liver injury, Gut, 65, 1377, 10.1136/gutjnl-2014-308506

Zhang, 2007, An J. Cytokines, inflammation, and pain, Int Anesthesiol Clin, 45, 27, 10.1097/AIA.0b013e318034194e

Taraborrelli, 2018, LUBAC prevents lethal dermatitis by inhibiting cell death induced by TNF, TRAIL and CD95L, Nat Commun, 9, 3910, 10.1038/s41467-018-06155-8

Malhi, 2010, Hepatocyte death: a clear and present danger, Physiol Rev, 90, 1165, 10.1152/physrev.00061.2009

Fusakio, 2016, Transcription factor ATF4 directs basal and stress-induced gene expression in the unfolded protein response and cholesterol metabolism in the liver, Mol Biol Cell, 27, 1536, 10.1091/mbc.E16-01-0039

Freundt, 2018, The transcription factor ATF4 promotes expression of cell stress genes and cardiomyocyte death in a cellular model of atrial fibrillation, Biomed Res Int, 2018, 3694362, 10.1155/2018/3694362

Guo, 2017, Pyrazinamide-induced hepatotoxicity is alleviated by 4-PBA via inhibition of the PERK-eIF2alpha-ATF4-CHOP pathway, Toxicology, 378, 65, 10.1016/j.tox.2017.01.002

Wang, 2018, Eukaryotic translation initiation factor 2 subunit alpha (eIF2alpha) inhibitor salubrinal attenuates paraquat-induced human lung epithelial-like A549 cell apoptosis by regulating the PERK-eIF2alpha signaling pathway, Toxicol In Vitro, 46, 58, 10.1016/j.tiv.2017.10.006

Dara, 2016, Questions and controversies: the role of necroptosis in liver disease, Cell Death Discov, 2, 16089, 10.1038/cddiscovery.2016.89

Li, 2018, Hydrogen-rich saline protects against small-scale liver ischemia-reperfusion injury by inhibiting endoplasmic reticulum stress, Life Sci, 194, 7, 10.1016/j.lfs.2017.12.022

Kim, 2017, Functional interaction of endoplasmic reticulum stress and hepatitis B virus in the pathogenesis of liver diseases, World J Gastroenterol, 23, 7657, 10.3748/wjg.v23.i43.7657

Hou, 2017, Tauroursodeoxycholic acid attenuates endoplasmic reticulum stress and protects the liver from chronic intermittent hypoxia induced injury, Exp Ther Med, 14, 2461, 10.3892/etm.2017.4804