Phosphorylation of Sphingoid Long-chain Bases in Arabidopsis: Functional Characterization and Expression of the First Sphingoid Long-chain Base Kinase Gene in Plants

Abbas, H.K., Tanaka, T., Duke, S.O., Porter, J.K., Wray, E.M., Hodges, L., Sessions, A.E., Wang, E., Merrill, A.H., Jr and Riley, R.T. (1994) Fumonisin- and AAL-toxin-induced disruption of sphingolipid metabolism with accumulation of free sphingoid bases. Plant Physiol.106: 1085–1093.

Cahoon, E.B. and Lynch, D.V. (1991) Analysis of glucocerebrosides of rye (Secale cereale L. cv Puma) leaf and plasma membrane. Plant Physiol.95: 58–68.

Coursol, S., Fan, L.M., Le Stunff, H., Spiegel, S., Gilroy, S. and Assmann, S.M. (2003) Sphingolipid signalling in Arabidopsis guard cells involves heterotrimeric G proteins. Nature423: 651–654.

Crowther, G.J. and Lynch, D.V. (1997) Characterization of sphinganine kinase activity in corn shoot microsomes. Arch. Biochem. Biophys.337: 284–290.

Dunn, T.M., Lynch, D.V., Michaelson, L.V. and Napier, J.A. (2004) A post-genomic approach to understanding sphingolipid metabolism in Arabidopsis thaliana. Ann. Bot.93: 483–497.

Herr, D.R., Fyrst, H., Creason, M.B., Phan, V.H., Saba, J.D. and Harris, G.L. (2004) Characterization of the Drosophila sphingosine kinases and requirement for Sk2 in normal reproductive function. J. Biol. Chem.279: 12685–12694.

Imai, H., Morimoto, Y. and Tamura, K. (2000) Sphingoid base composition of monoglucosylceramide in Brassicaceae. J. Plant Physiol.157: 453–456.

Imai, H., Ohnishi, M., Hotsubo, K., Kojima, M. and Ito, S. (1997) Sphingoid base composition of cerebrosides from plant leaves. Biosci. Biotechnol. Biochem.61: 351–353.

Kohama, T., Olivera, A., Edsall, L., Nagiec, M.M., Dickson, R. and Spiegel, S. (1998) Molecular cloning and functional characterization of murine sphingosine kinase. J. Biol. Chem.273: 23722–23728.

Lee, M.J., Van Brocklyn, J.R., Thangada, S., Liu, C.H., Hand, A.R., Menzeleev, R., Spiegel, S. and Hla, T. (1998) Sphingosine-1-phosphate as a ligand for the G protein-coupled receptor EDG-1. Science279: 1552–1555.

Liang, H., Yao, N., Song, J.T., Luo, S., Lu, H. and Greenberg, J.T. (2003) Ceramides modulate programmed cell death in plants. Genes Dev.17: 2636–2641.

Liu, H., Sugiura, M., Nava, V.E., Edsall, L.C., Kono, K., Poulton, S., Milstien, S., Kohama, T. and Spiegel, S. (2000) Molecular cloning and functional characterization of a novel mammalian sphingosine kinase type 2 isoform. J. Biol. Chem.275: 19513–19520.

Liu, H., Chakravarty, D., Maceyka, M., Milstien, S. and Spiegel, S. (2002) Sphingosine kinases: a novel family of lipid kinases. Prog. Nucleic Acid Res. Mol. Biol.71: 493–511.

Nagiec, M.M., Skrzypek, M., Nagiec, E.E., Lester, R.L. and Dickson, R.C. (1998) The LCB4 (YOR171c) and LCB5 (YLR260w) genes of Saccharomyces encode sphingoid long chain base kinases. J. Biol. Chem.273: 19437–19442.

Nava, V.E., Lacana, E., Poulton, S., Liu, H., Sugiura, M., Kono, K., Milstien, S., Kohama, T. and Spiegel, S. (2000) Functional characterization of human sphingosine kinase-1. FEBS Lett.473: 81–84.

Ng, C.K., Carr, K., McAinsh, M.R., Powell, B. and Hetherington, A.M. (2001) Drought-induced guard cell signal transduction involves sphingosine-1-phosphate. Nature410: 596–599.

Nishiura, H., Tamura, K. Morimoto, Y. and Imai, H. (2000) Characterization of sphingolipid long-chain base kinase in Arabidopsis thaliana. Biochem. Soc. Trans28: 747–748.

Ohnishi, M., Imai, H., Kojima, M., Yoshida, S., Murata, N., Fujino, Y. and Ito, S. (1988) Separation of cerebroside species in plants by reversed-phase HPLC and their phase transition temperature. In Proceedings of ISF-JOCS World Congress 1988 Vol. II. pp. 930–935. The Japan Oil Chemists’ Society, Tokyo.

Olivera, A., Barlow, K.D. and Spiegel, S. (2000) Assaying sphingosine kinase activity. Methods Enzymol.311: 215–223.

Sperling, P., Zahringer, U. and Heinz, E. (1998) A sphingolipid desaturase from higher plants. Identification of a new cytochrome b5 fusion protein. J. Biol. Chem.273: 28590–28596.

Spiegel, S., Foster, D. and Kolesnick, R. (1996) Signal transduction through lipid second messengers. Curr. Opin. Cell Biol.8: 159–167.

Topham, M.K. and Prescott, S.M. (1999) Mammalian diacylglycerol kinases, a family of lipid kinases with signaling functions. J. Biol. Chem.274: 11447–11450.

Yoshida, R., Hobo, T., Ichimura, K., Mizoguchi, T., Takahashi, F., Aronso, J., Ecker, J.R. and Shinozaki, K. (2002) ABA-activated SnRK2 protein kinase is required for dehydration stress signaling in Arabidopsis. Plant Cell Physiol.43: 1473–1483.