Phosphorylation-Dependent Assembly and Coordination of the DNA Damage Checkpoint Apparatus by Rad4TopBP1

Alcasabas, 2001, Mrc1 transduces signals of DNA replication stress to activate Rad53, Nat. Cell Biol., 3, 958, 10.1038/ncb1101-958 Boos, 2011, Regulation of DNA replication through Sld3-Dpb11 interaction is conserved from yeast to humans, Curr. Biol., 21, 1152, 10.1016/j.cub.2011.05.057 Cescutti, 2010, TopBP1 functions with 53BP1 in the G1 DNA damage checkpoint, EMBO J., 29, 3723, 10.1038/emboj.2010.238 Du, 2003, Retention but not recruitment of Crb2 at double-strand breaks requires Rad1 and Rad3 complexes, Mol. Cell. Biol., 23, 6150, 10.1128/MCB.23.17.6150-6158.2003 Du, 2004, Homo-oligomerization is the essential function of the tandem BRCT domains in the checkpoint protein Crb2, J. Biol. Chem., 279, 38409, 10.1074/jbc.M403326200 Du, 2006, Histone modification-dependent and -independent pathways for recruitment of checkpoint protein Crb2 to double-strand breaks, Genes Dev., 20, 1583, 10.1101/gad.1422606 Esashi, 1999, Cdc2 phosphorylation of Crb2 is required for reestablishing cell cycle progression after the damage checkpoint, Mol. Cell, 4, 167, 10.1016/S1097-2765(00)80364-0 Fenech, 1991, Cloning and characterization of the rad4 gene of Schizosaccharomyces pombe; a gene showing short regions of sequence similarity to the human XRCC1 gene, Nucleic Acids Res., 19, 6737, 10.1093/nar/19.24.6737 Fukuura, 2011, CDK promotes interactions of Sld3 and Drc1 with Cut5 for initiation of DNA replication in fission yeast, Mol. Biol. Cell, 22, 2620, 10.1091/mbc.E10-12-0995 Furuya, 2004, Chk1 activation requires Rad9 S/TQ-site phosphorylation to promote association with C-terminal BRCT domains of Rad4TOPBP1, Genes Dev., 18, 1154, 10.1101/gad.291104 Garcia, 2005, Identification and functional analysis of TopBP1 and its homologs, DNA Repair (Amst.), 4, 1227, 10.1016/j.dnarep.2005.04.001 Gong, 2010, BACH1/FANCJ acts with TopBP1 and participates early in DNA replication checkpoint control, Mol. Cell, 37, 438, 10.1016/j.molcel.2010.01.002 Kilkenny, 2008, Structural and functional analysis of the Crb2-BRCT2 domain reveals distinct roles in checkpoint signaling and DNA damage repair, Genes Dev., 22, 2034, 10.1101/gad.472808 Kumagai, 2006, TopBP1 activates the ATR-ATRIP complex, Cell, 124, 943, 10.1016/j.cell.2005.12.041 Kumagai, 2010, Treslin collaborates with TopBP1 in triggering the initiation of DNA replication, Cell, 140, 349, 10.1016/j.cell.2009.12.049 Kumagai, 2011, Direct regulation of Treslin by cyclin-dependent kinase is essential for the onset of DNA replication, J. Cell Biol., 193, 995, 10.1083/jcb.201102003 Lee, 2005, Structure of the BRCT repeat domain of MDC1 and its specificity for the free COOH-terminal end of the gamma-H2AX histone tail, J. Biol. Chem., 280, 32053, 10.1074/jbc.C500273200 Lee, 2007, The Rad9-Hus1-Rad1 checkpoint clamp regulates interaction of TopBP1 with ATR, J. Biol. Chem., 282, 28036, 10.1074/jbc.M704635200 Lin, 2012, The Rad4(TopBP1) ATR-activation domain functions in G1/S phase in a chromatin-dependent manner, PLoS Genet., 8, e1002801, 10.1371/journal.pgen.1002801 Qu, 2012, Phosphorylation-dependent interactions between Crb2 and Chk1 are essential for DNA damage checkpoint, PLoS Genet., 8, e1002817, 10.1371/journal.pgen.1002817 Rappas, 2011, Structure and function of the Rad9-binding region of the DNA-damage checkpoint adaptor TopBP1, Nucleic Acids Res., 39, 313, 10.1093/nar/gkq743 Rothbauer, 2008, A versatile nanotrap for biochemical and functional studies with fluorescent fusion proteins, Mol. Cell. Proteomics, 7, 282, 10.1074/mcp.M700342-MCP200 Saka, 1997, Damage and replication checkpoint control in fission yeast is ensured by interactions of Crb2, a protein with BRCT motif, with Cut5 and Chk1, Genes Dev., 11, 3387, 10.1101/gad.11.24.3387 Shiozaki, 2004, Structure of the BRCT repeats of BRCA1 bound to a BACH1 phosphopeptide: implications for signaling, Mol. Cell, 14, 405, 10.1016/S1097-2765(04)00238-2 Smits, 2010, Mechanisms of ATR-mediated checkpoint signalling, Front. Biosci. (Landmark Ed.), 15, 840, 10.2741/3649 Stucki, 2005, MDC1 directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks, Cell, 123, 1213, 10.1016/j.cell.2005.09.038 Takeishi, 2010, Casein kinase 2-dependent phosphorylation of human Rad9 mediates the interaction between human Rad9-Hus1-Rad1 complex and TopBP1, Genes Cells, 15, 761, 10.1111/j.1365-2443.2010.01418.x Tanaka, 2001, Mrc1 channels the DNA replication arrest signal to checkpoint kinase Cds1, Nat. Cell Biol., 3, 966, 10.1038/ncb1101-966 Taylor, 2011, Mcm10 interacts with Rad4/Cut5(TopBP1) and its association with origins of DNA replication is dependent on Rad4/Cut5(TopBP1), DNA Repair (Amst.), 10, 1154, 10.1016/j.dnarep.2011.09.001 Williams, 2004, Structural basis of phosphopeptide recognition by the BRCT domain of BRCA1, Nat. Struct. Mol. Biol., 11, 519, 10.1038/nsmb776 Willson, 1997, Isolation and characterization of the Schizosaccharomyces pombe rhp9 gene: a gene required for the DNA damage checkpoint but not the replication checkpoint, Nucleic Acids Res., 25, 2138, 10.1093/nar/25.11.2138