Phosphatidylcholine Synthesis for Lipid Droplet Expansion Is Mediated by Localized Activation of CTP:Phosphocholine Cytidylyltransferase

Cell Metabolism - Tập 14 - Trang 504-515 - 2011
Natalie Krahmer1,2, Yi Guo3, Florian Wilfling1, Maximiliane Hilger4, Susanne Lingrell5,6, Klaus Heger7, Heather W. Newman3, Marc Schmidt-Supprian7, Dennis E. Vance5, Matthias Mann4, Robert V. Farese3,8,9, Tobias C. Walther1
1Department of Cell Biology, Yale University School of Medicine, New Haven, CT, 06520 USA
2Organelle Architecture and Dynamics, Max Planck Institute of Biochemistry, 82152 Martinsried, Germany
3Gladstone Institute of Cardiovascular Disease, San Francisco, CA 94158, USA
4Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, 82152 Martinsried, Germany
5Group on the Molecular and Cell Biology of Lipids, University of Alberta, Edmonton, Alberta T6G 2H7, Canada
6Department of Biochemistry, University of Alberta, Edmonton, Alberta T6G 2H7, Canada
7Molecular Immunology and Signal Transduction, Max Planck Institute of Biochemistry, 82152 Martinsried, Germany
8Department of Medicine, University of California, San Francisco, San Francisco, CA 94158, USA
9Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94158, USA

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