Phorbol ester mediated activation of inducible nitric oxide synthase results in platelet profilin nitration

Ischiropoulos, 1998, Biological tyrosine nitration: a pathophysiological function of nitric oxide and reactive oxygen species, Arch. Biochem. Biophys., 356, 1, 10.1006/abbi.1998.0755 Radomski, 1987, The anti-aggregating properties of vascular endothelium: interactions between prostacyclin and nitric oxide, Br. J. Pharmacol., 92, 639, 10.1111/j.1476-5381.1987.tb11367.x Beckman, 1990, Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide, Proc. Natl. Acad. Sci. USA, 87, 1620, 10.1073/pnas.87.4.1620 Beckman, 1996, Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly, Am. J. Physiol., 271, C1424, 10.1152/ajpcell.1996.271.5.C1424 Lassing, 1985, Specific interaction between phosphatidylinositol 4,5-bisphosphate and profilactin, Nature, 314, 472, 10.1038/314472a0 Lu, 2001, Profilin binding to poly-l-proline and actin monomers along with ability to catalyse actin nucleotide exchange is required for viability of fission yeast, Mol. Biol. Cell, 12, 1161, 10.1091/mbc.12.4.1161 Kinosian, 2002, Actin filament barbed end elongation with nonmuscle MgATP-actin and MgADP-actin in the presence of profilin, Biochemistry, 41, 6734, 10.1021/bi016083t Reinhard, 1995, The proline-rich adhesion and microfilament protein VASP is a ligand for profilins, EMBO J., 14, 1583, 10.1002/j.1460-2075.1995.tb07146.x Gertler, 1996, Mena, a relative of VASP and Drosophila Enabled, is implicated in the control of microfilament dynamics, Cell, 87, 227, 10.1016/S0092-8674(00)81341-0 Savi, 1992, The NK1 receptor is involved in the neurokinin-induced shape change of rabbit platelets, FEBS Lett., 312, 200, 10.1016/0014-5793(92)80935-A Nieuwland, 1994, α2-Adrenergic receptors activate protein kinase C in human platelets via pertussis toxin- sensitive G-protein, FEBS Lett., 101, 161 Matsushima, 1993, Alteration of human platelet protein kinase C with normal ageing, Mechanisms of ageing and Development, 69, 129, 10.1016/0047-6374(93)90077-5 Laemmli, 1970, Cleavage of structural proteins during the assembly of the head of bacteriophage T4, Nature, 227, 680, 10.1038/227680a0 Green, 1982, Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids, Anal. Biochem., 126, 31, 10.1016/0003-2697(82)90118-X Lee, 1999, Advantages of calcium green-1 over other fluorescent dyes in measuring cytosolic calcium in platelets, Anal. Biochem., 273, 186, 10.1006/abio.1999.4212 Radomski, 1993, Platelet adhesion to human vascular endothelium is modulated by constitutive and cytokine induced nitric oxide, Cardiovasc. Res., 27, 1380, 10.1093/cvr/27.7.1380 Leoncini, 1991, Oxidative metabolism of human platelets, Biochem. Int., 25, 647 Singh, 1996, Profilin and gelsolin stimulate phosphatidylinositol 3-kinase activity, Biochemistry, 35, 16544, 10.1021/bi9609634 Sabetkar, 2002, The nitration of proteins in platelets: significance in platelet function, Free Radic. Biol. Med., 33, 728, 10.1016/S0891-5849(02)00890-0 Naseem, 2000, The nitration of platelet cytosolic proteins during agonist-induced activation of platelets, FEBS Lett., 473, 119, 10.1016/S0014-5793(00)01490-3 Chen, 1996, Further evidence of the presence of constitutive and inducible nitric oxide synthase isoforms in human platelets, J. Cardiovasc. Pharmacol., 27, 154, 10.1097/00005344-199601000-00024 Hortelano, 1992, Phorbol esters induce nitric oxide synthase activity in rat hepatocytes Antagonism with the induction elicited by lipopolysaccharide, J. Biol. Chem., 267, 24937, 10.1016/S0021-9258(19)73987-8 Kane, 1999, Induction of NF-κB by the Akt/PKB kinase, Curr. Biol., 9, 601, 10.1016/S0960-9822(99)80265-6 Nywana, 1999, Activation of phosphatidylinositol 3-kinase in response to interleukin-1leads to phosphorylation and activation of the NF-kB p65/RelA subunit, Mol. Cell Biol., 19, 4798, 10.1128/MCB.19.7.4798 Christian, 2000, The Iκ -B/NF-kB system: a key determinant of mucosal inflammation and protection, Am. J. Physiol. Cell Physiol., 278, C451, 10.1152/ajpcell.2000.278.3.C451 Bart, 2000, The PI3K–PDK1 connection: more than just a road to PKB, Biochem. J., 346, 561, 10.1042/0264-6021:3460561 Possel, 1997, 2,7-Dihydrodichloro fluorescein diacetate as a fluorescent marker for peroxynitrite formation, FEBS Lett., 416, 175, 10.1016/S0014-5793(97)01197-6 Warnholtz, 1999, Increased NADH-oxidase-mediated superoxide production in the early stages of atherosclerosis: evidence for involvement of the renin-angiotensin system, Circulation, 99, 2027, 10.1161/01.CIR.99.15.2027 Behr-Roussel, 2000, Effect of chronic treatment with the inducible nitric oxide synthase inhibitor N-iminoethyl-l-lysine or with l-arginine on progression of coronary and aortic atherosclerosis in hypercholesterolemic rabbits, Circulation, 102, 1033, 10.1161/01.CIR.102.9.1033 Tannous, 1999, Evidence for iNOS-dependent peroxynitrite production in diabetic platelets, Diabetologia, 42, 539, 10.1007/s001250051192