Phenotypic impact of regulatory noise in cellular stress-response pathways

Avery SV (2006) Microbial cell individuality and the underlying sources of heterogeneity. Nat Rev Microbiol 4:577–587

Bar-Even A, Paulsson J, Maheshri N, Carmi M, O’Shea E et al (2006) Noise in protein expression scales with natural protein abundance. Nat Genet 38:636–643

Barkai N, Shilo BZ (2007) Variability and robustness in biomolecular systems. Mol Cell 28:755–760

Batada NN, Hurst LD (2007) Evolution of chromosome organization driven by selection for reduced gene expression noise. Nat Genet 39:945–949

Becskei A, Serrano L (2000) Engineering stability in gene networks by autoregulation. Nature 405:590–593

Becskei A, Kaufmann BB, van Oudenaarden A (2005) Contributions of low molecule number and chromosomal positioning to stochastic gene expression. Nat Genet 37:937–944

Blake WJ, Kærn M, Cantor CR, Collins JJ (2003) Noise in eukaryotic gene expression. Nature 422:633–637

Blake WJ, Balazsi G, Kohanski MA, Isaacs FJ, Murphy KF et al (2006) Phenotypic consequences of promoter-mediated transcriptional noise. Mol Cell 24:853–865

Booth IR (2002) Stress and the single cell: intrapopulation diversity is a mechanism to ensure survival upon exposure to stress. Int J Food Microbiol 78:19–30

Brock A, Chang H, Huang S (2009) Non-genetic heterogeneity—a mutation-independent driving force for the somatic evolution of tumours. Nat Rev Genet 10:336–342

Dublanche Y, Michalodimitrakis K, Kummerer N, Foglierini M, Serrano L (2006) Noise in transcription negative feedback loops: simulation and experimental analysis. Mol Syst Biol 2:41

Fraser D, Kærn M (2009) A chance at survival: gene expression noise and phenotypic diversification strategies. Mol Microbiol 71:1333–1340

Fraser HB, Hirsh AE, Giaever G, Kumm J, Eisen MB (2004) Noise minimization in eukaryotic gene expression. PLoS Biol 2:e137

Gari E, Piedrafita L, Aldea M, Herrero E (1997) A set of vectors with a tetracycline-regulatable promoter system for modulated gene expression in Saccharomyces cerevisiae. Yeast 13:837–848

Guido NJ, Lee P, Wang X, Elston TC, Collins JJ (2007) A pathway and genetic factors contributing to elevated gene expression noise in stationary phase. Biophys J 93:L55–L57

Hooshangi S, Thiberge S, Weiss R (2005) Ultrasensitivity and noise propagation in a synthetic transcriptional cascade. Proc Natl Acad Sci USA 102:3581–3586

Kærn M, Elston TC, Blake WJ, Collins JJ (2005) Stochasticity in gene expression: from theories to phenotypes. Nat Rev Genet 6:451–464

Lehner B (2008) Selection to minimise noise in living systems and its implications for the evolution of gene expression. Mol Syst Biol 4:170

Lopez-Maury L, Marguerat S, Bahler J (2008) Tuning gene expression to changing environments: from rapid responses to evolutionary adaptation. Nat Rev Genet 9:583–593

Losick R, Desplan C (2008) Stochasticity and cell fate. Science 320:65–68

Louis M, Becskei A (2002) Binary and graded responses in gene networks. Sci STKE 2002: PE33

Maamar H, Raj A, Dubnau D (2007) Noise in gene expression determines cell fate in Bacillus subtilis. Science 317:526–529

Martegani E, Brambilla L, Porro D, Ranzi BM, Alberghina L (1993) Alteration of cell-population structure due to cell-lysis in Saccharomyces-cerevisiae cells overexpressing the Gal4 gene. Yeast 9:575–582

Newman JR, Ghaemmaghami S, Ihmels J, Breslow DK, Noble M et al (2006) Single-cell proteomic analysis of S. cerevisiae reveals the architecture of biological noise. Nature 441:840–846

Ozbudak EM, Thattai M, Kurtser I, Grossman AD, van Oudenaarden A (2002) Regulation of noise in the expression of a single gene. Nat Genet 31:69–73

Pedraza JM, van Oudenaarden A (2005) Noise propagation in gene networks. Science 307:1965–1969

Raj A, van Oudenaarden A (2008) Nature, nurture, or chance: stochastic gene expression and its consequences. Cell 135:216–226

Raser JM, O’Shea EK (2004) Control of stochasticity in eukaryotic gene expression. Science 304:1811–1814

Rosenfeld N, Young JW, Alon U, Swain PS, Elowitz MB (2005) Gene regulation at the single-cell level. Science 307:1962–1965

Smits WK, Kuipers OP, Veening JW (2006) Phenotypic variation in bacteria: the role of feedback regulation. Nat Rev Microbiol 4:259–271

Tanase-Nicola S, ten Wolde PR (2008) Regulatory control and the costs and benefits of biochemical noise. PLoS Comput Biol 4:e10125

Urlinger S, Baron U, Thellmann M, Hasan MT, Bujard H et al (2000) Exploring the sequence space for tetracycline-dependent transcriptional activators: novel mutations yield expanded range and sensitivity. Proc Natl Acad Sci USA 97:7963–7968

Zhang Z, Qian W, Zhang J (2009) Positive selection for elevated gene expression noise in yeast. Mol Syst Biol 5:299