Phenotypic and functional heterogeneity of cancer-associated fibroblast within the tumor microenvironment
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Paget, 1889, The distribution of secondary growths in cancer of the breast, Lancet, 1571
Bhowmick, 2004, TGF-β signaling in fibroblasts modulates the oncogenic potential of adjacent epithelia, Science, 303, 847, 10.1126/science.1090922
Ronnov-Jessen, 1995, The origin of the myofibroblasts in breast cancer. Recapitulation of tumor environment in culture unravels diversity and implicates converted fibroblasts and recruited smooth muscle cells, J. Clin. Invest., 95, 859, 10.1172/JCI117736
Orimo, 2007, Heterogeneity of stromal fibroblasts in tumors, Cancer Biol. Ther., 6, 618, 10.4161/cbt.6.4.4255
Ishii, 2003, Bone-marrow-derived myofibroblasts contribute to the cancer-induced stromal reaction, Biochem. Biophys. Res. Commun., 309, 232, 10.1016/S0006-291X(03)01544-4
Ishii, 2007, Presence of human circulating progenitor cells for cancer stromal fibroblasts in the blood of lung cancer patients, Stem Cells, 25, 1469, 10.1634/stemcells.2006-0449
Sugimoto, 2006, Identification of fibroblast heterogeneity in the tumor microenvironment, Cancer Biol. Ther., 5, 1640, 10.4161/cbt.5.12.3354
Polanska, 2013, Carcinoma-associated fibroblasts: non-neoplastic tumour-promoting mesenchymal cells, J. Cell. Physiol., 228, 1651, 10.1002/jcp.24347
Augsten, 2014, Cancer-associated fibroblasts as another polarized cell type of the tumor microenvironment, Front. Oncol., 4, 62, 10.3389/fonc.2014.00062
Kawase, 2008, Podoplanin expression by cancer associated fibroblasts predicts poor prognosis of lung adenocarcinoma, Int. J. Cancer, 123, 1053, 10.1002/ijc.23611
Pula, 2011, Podoplanin expression by cancer-associated fibroblasts predicts poor outcome in invasive ductal breast carcinoma, Histopathology, 59, 1249, 10.1111/j.1365-2559.2011.04060.x
Hoshino, 2011, Podoplanin-positive fibroblasts enhance lung adenocarcinoma tumor formation: podoplanin in fibroblast functions for tumor progression, Cancer Res., 71, 4769, 10.1158/0008-5472.CAN-10-3228
Wikberg, 2013, High intratumoral expression of fibroblast activation protein (FAP) in colon cancer is associated with poorer patient prognosis, Tumour Biol., 34, 1013, 10.1007/s13277-012-0638-2
Zhao, 2009, Tumor-promoting phenotype of CD90hi prostate cancer-associated fibroblasts, Prostate, 69, 991, 10.1002/pros.20946
Chen, 2014, Cancer-associated fibroblasts regulate the plasticity of lung cancer stemness via paracrine signalling, Nat. Commun., 5, 3472, 10.1038/ncomms4472
Lee, 2015, Twist1 is a key regulator of cancer-associated fibroblasts, Cancer Res., 75, 73, 10.1158/0008-5472.CAN-14-0350
Jung, 2013, Recruitment of mesenchymal stem cells into prostate tumours promotes metastasis, Nat. Commun., 4, 1795, 10.1038/ncomms2766
Maxwell, 2014, Tumor-derived CXCL8 signaling augments stroma-derived CCL2-promoted proliferation and CXCL12-mediated invasion of PTEN-deficient prostate cancer cells, Oncotarget, 5, 4895, 10.18632/oncotarget.2052
Kojima, 2010, Autocrine TGF-beta and stromal cell-derived factor-1 (SDF-1) signaling drives the evolution of tumor-promoting mammary stromal myofibroblasts, Proc. Natl. Acad. Sci. U. S. A., 107, 20009, 10.1073/pnas.1013805107
Orimo, 2005, Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion, Cell, 121, 335, 10.1016/j.cell.2005.02.034
Yu, 2014, Cancer-associated fibroblasts induce epithelial–mesenchymal transition of breast cancer cells through paracrine TGF-β signalling, Br. J. Cancer, 110, 724, 10.1038/bjc.2013.768
Calon, 2015, Stromal gene expression defines poor-prognosis subtypes in colorectal cancer, Nat. Genet., 47, 320, 10.1038/ng.3225
Calon, 2012, Dependency of colorectal cancer on a TGF-β-driven program in stromal cells for metastasis initiation, Cancer Cell, 22, 571, 10.1016/j.ccr.2012.08.013
Tyan, 2011, Breast cancer cells induce cancer-associated fibroblasts to secrete hepatocyte growth factor to enhance breast tumorigenesis, PLoS One, 6, e15313, 10.1371/journal.pone.0015313
Jia, 2013, Cancer-associated fibroblasts from hepatocellular carcinoma promote malignant cell proliferation by HGF secretion, PLoS One, 8, e63243, 10.1371/journal.pone.0063243
Wu, 2013, Hepatocyte growth factor activates tumor stromal fibroblasts to promote tumorigenesis in gastric cancer, Cancer Lett., 335, 128, 10.1016/j.canlet.2013.02.002
Saito, 2015, The role of HGF/MET and FGF/FGFR in fibroblast-derived growth stimulation and lapatinib-resistance of esophageal squamous cell carcinoma, BMC Cancer, 15, 82, 10.1186/s12885-015-1065-8
Luga, 2012, Exosomes mediate stromal mobilization of autocrine Wnt-PCP signaling in breast cancer cell migration, Cell, 151, 1542, 10.1016/j.cell.2012.11.024
Camp, 2011, Interactions with fibroblasts are distinct in Basal-like and luminal breast cancers, Mol. Cancer Res., 9, 3, 10.1158/1541-7786.MCR-10-0372
Otomo, 2014, TSPAN12 is a critical factor for cancer-fibroblast cell contact-mediated cancer invasion, Proc. Natl. Acad. Sci. U. S. A., 111, 18691, 10.1073/pnas.1412062112
Duda, 2010, Malignant cells facilitate lung metastasis by bringing their own soil, Proc. Natl. Acad. Sci. U. S. A., 107, 21677, 10.1073/pnas.1016234107
Arrigoni, 2014, Direct but not indirect co-culture with osteogenically differentiated human bone marrow stromal cells increases RANKL/OPG ratio in human breast cancer cells generating bone metastases, Mol. Cancer, 13, 238, 10.1186/1476-4598-13-238
Kraman, 2010, Suppression of antitumor immunity by stromal cells expressing fibroblast activation protein-alpha, Science, 330, 827, 10.1126/science.1195300
Feig, 2013, Targeting CXCL12 from FAP-expressing carcinoma-associated fibroblasts synergizes with anti-PD-L1 immunotherapy in pancreatic cancer, Proc. Natl. Acad. Sci. U. S. A., 110, 20212, 10.1073/pnas.1320318110
Kinoshita, 2013, Forkhead box P3 regulatory T cells coexisting with cancer associated fibroblasts are correlated with a poor outcome in lung adenocarcinoma, Cancer Sci., 104, 409, 10.1111/cas.12099
Erez, 2010, Cancer-associated fibroblasts are activated in incipient neoplasia to orchestrate tumor-promoting inflammation in an NF-kappaB-dependent manner, Cancer Cell, 17, 135, 10.1016/j.ccr.2009.12.041
Vosseler, 2009, Distinct progression-associated expression of tumor and stromal MMPs in HaCaT skin SCCs correlates with onset of invasion, Int. J. Cancer, 125, 2296, 10.1002/ijc.24589
Boire, 2005, PAR1 is a matrix metalloprotease-1 receptor that promotes invasion and tumorigenesis of breast cancer cells, Cell, 120, 303, 10.1016/j.cell.2004.12.018
Gaggioli, 2007, Fibroblast-led collective invasion of carcinoma cells with differing roles for RhoGTPases in leading and following cells, Nat. Cell Biol., 9, 1392, 10.1038/ncb1658
Neri, 2015, Podoplanin-expressing cancer-associated fibroblasts lead and enhance the local invasion of cancer cells in lung adenocarcinoma, Int. J. Cancer, 10.1002/ijc.29464
Green, 2013, Paracrine Wnt signaling both promotes and inhibits human breast tumor growth, Proc. Natl. Acad. Sci. U. S. A., 110, 6991, 10.1073/pnas.1303671110
Akiri, 2009, Wnt pathway aberrations including autocrine Wnt activation occur at high frequency in human non-small-cell lung carcinoma, Oncogene, 28, 2163, 10.1038/onc.2009.82
Engle, 1999, Transforming growth factor beta1 suppresses nonmetastatic colon cancer at an early stage of tumorigenesis, Cancer Res., 59, 3379
Flaberg, 2011, High-throughput live-cell imaging reveals differential inhibition of tumor cell proliferation by human fibroblasts, Int. J. Cancer, 128, 2793, 10.1002/ijc.25612
Takahashi, 2015, Podoplanin-expressing cancer-associated fibroblasts inhibit small cell lung cancer growth, Oncotarget, 6, 9531, 10.18632/oncotarget.3371
Straussman, 2012, Tumour micro-environment elicits innate resistance to RAF inhibitors through HGF secretion, Nature, 487, 500, 10.1038/nature11183
Wang, 2009, Crosstalk to stromal fibroblasts induces resistance of lung cancer to epidermal growth factor receptor tyrosine kinase inhibitors, Clin. Cancer Res., 15, 6630, 10.1158/1078-0432.CCR-09-1001
Yoshida, 2015, Podoplanin-positive cancer-associated fibroblasts in the tumor microenvironment induce primary resistance to EGFR-TKIs in lung adenocarcinoma with EGFR mutation, Clin. Cancer Res., 21, 642, 10.1158/1078-0432.CCR-14-0846
Yu, 2014, Cancer-associated fibroblasts induce epithelial–mesenchymal transition of breast cancer cells through paracrine TGF-β signaling, Br. J. Cancer, 110, 724, 10.1038/bjc.2013.768
Hu, 2015, Fibroblast-derived exosomes contribute to chemoresistance through priming cancer stem cells in colorectal cancer, PLoS One, 10, e0125625, 10.1371/journal.pone.0125625
Ramon, 2014, Oncolytic adenoviruses in cancer treatment, Biomedicines, 2, 36, 10.3390/biomedicines2010036
Miyamoto, 2004, Tumor-stroma interaction of human pancreatic cancer: acquired resistance to anticancer drugs and proliferation regulation is dependent on extracellular matrix proteins, Pancreas, 28, 38, 10.1097/00006676-200401000-00006
van der Kuip, 2001, Adhesion to fibronectin selectively protects Bcr-Abl+ cells from DNA damage-induced apoptosis, Blood, 98, 1532, 10.1182/blood.V98.5.1532
Dangi-Garimella, 2011, Three-dimensional collagen I promotes gemcitabine resistance in pancreatic cancer through MT1-MMP-mediated expression of HMGA2, Cancer Res., 71, 1019, 10.1158/0008-5472.CAN-10-1855
Dangi-Garimella, 2013, Three-dimensional collagen I promotes gemcitabine resistance in vitro in pancreatic cancer cells through HMGA2-dependent histone acetyltransferase expression, PLoS One, 8, e64566, 10.1371/journal.pone.0064566
Provenzano, 2012, Enzymatic targeting of the stroma ablates physical barriers to treatment of pancreatic ductal adenocarcinoma, Cancer Cell, 21, 418, 10.1016/j.ccr.2012.01.007
Sun, 2012, Treatment-induced damage to the tumor microenvironment promotes prostate cancer therapy resistance through WNT16B, Nat. Med., 18, 1359, 10.1038/nm.2890
Lotti, 2013, Chemotherapy activates cancer-associated fibroblasts to maintain colorectal cancer-initiating cells by IL-17A, J. Exp. Med., 210, 2851, 10.1084/jem.20131195
Shekhar, 2007, Direct involvement of breast tumor fibroblasts in the modulation of tamoxifen sensitivity, Am. J. Pathol., 170, 1546, 10.2353/ajpath.2007.061004
Martinez-Outschoorn, 2011, Anti-estrogen resistance in breast cancer is induced by the tumor microenvironment and can be overcome by inhibiting mitochondrial function in epithelial cancer cells, Cancer Biol. Ther., 12, 924, 10.4161/cbt.12.10.17780
Lafkas, 2008, P53 mutations in stromal fibroblasts sensitize tumors against chemotherapy, Int. J. Cancer, 123, 967, 10.1002/ijc.23546
Dittmer, 2011, Mesenchymal stem cells and carcinoma-associated fibroblasts sensitize breast cancer cells in 3D cultures to kinase inhibitors, Int. J. Oncol., 39, 689
Loeffler, 2006, Targeting tumor-associated fibroblasts improves cancer chemotherapy by increasing intratumoral drug uptake, J. Clin. Invest., 116, 1955, 10.1172/JCI26532
Mertens, 2013, Therapeutic effects of deleting cancer-associated fibroblasts in cholangiocarcinoma, Cancer Res., 73, 897, 10.1158/0008-5472.CAN-12-2130
Olive, 2009, Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer, Science, 324, 1457, 10.1126/science.1171362
Sherman, 2014, Vitamin D receptor-mediated stromal reprogramming suppresses pancreatitis and enhances pancreatic cancer therapy, Cell, 159, 80, 10.1016/j.cell.2014.08.007
Yasunaga, 2011, Cancer-stroma targeting therapy by cytotoxic immunoconjugate bound to the collagen 4 network in the tumor tissue, Bioconjug. Chem., 22, 1776, 10.1021/bc200158j
Yasunaga, 2013, Tailored immunoconjugate therapy depending on a quantity of tumor stroma, Cancer Sci., 104, 231, 10.1111/cas.12062