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Nấm Vân Chi phát triển trên gạo lứt nảy mầm ức chế sản xuất IgE thông qua sự điều hòa cân bằng Th1/Th2 trong tế bào lympho hạch treo chuột
Tóm tắt
Chúng tôi đã so sánh các hiệu ứng điều hòa miễn dịch của nấm Vân Chi (Phellinus linteus - PL), gạo lứt nảy mầm (BR) và nấm P. linteus phát triển trên gạo lứt nảy mầm (PB) đối với sản xuất IgE trong tế bào lympho hạch treo mạc treo chuột (MLN). Tất cả các chiết xuất đều làm giảm nồng độ IgE từ 43% đến 65% so với nhóm chuột kiểm soát trong cả huyết thanh và tế bào lympho MLN. Ngoài ra, PL và PB đã tăng tỷ lệ tế bào T CD4+ lên 9% và 12% trong tế bào lympho MLN. Nồng độ IFN-γ, cytokine Th1, tăng đáng kể từ 44% đến 67%, trong khi nồng độ IL-4 và IL-10, cytokine Th2, giảm đáng kể từ 30% đến 60% ở cả ba nhóm được điều trị so với nhóm kiểm soát. Những kết quả này cho thấy PB ức chế sản xuất IgE thông qua sự điều hòa cân bằng Th1/Th2 để giảm đáp ứng Th2 trong tế bào lympho MLN, mặc dù không tìm thấy hiệu ứng hiệp đồng của PB.
Từ khóa
#Phellinus linteus #gạo lứt nảy mầm #tế bào lympho hạch treo mạc treo #IgE #Th1/Th2 cytokine #tế bào T CD4+ #IFN-γ #IL-4 #IL-10 #cytokine điều hòa miễn dịchTài liệu tham khảo
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