Phase II evaluation of menogaril in patients with advanced cervical carcinoma
Tóm tắt
Fourteen patients with advanced/recurrent squamous cell carcinoma of the uterine cervix received menogaril, 200 mg/m2 by one hour intravenous infusion at four-week intervals. No objective regressions were observed. Median time to progression was less than two months and median survival was seven months. All patients experienced neutropenia. Platelet toxicity was negligible. Venous irritation and phlebitis occurred at the infusion site in 43% of patients. Menogaril as administered in this protocol is ineffective in treating previously irradiated advanced/recurrent squamous cell carcinoma of the uterine cervix and warrants no further investigation in this disease at the dosage and administration schedule used in this protocol.
Tài liệu tham khảo
Perez CA, Breaux S, Madoc-Jones H, Bedwinck JM, Camel HM, Purdy JA: Radiation therapy alone in the treatment of carcinoma of the uterine cervix. I. Analysis of tumor recurrence. Cancer 51:1393–1402, 1983
Young RC: Gynecologic malignancies. In: Pinedo HM (ed) Cancer chemotherapy. Excerpta Medica, Oxford: 340–375, 1979
Muscato MS, Perry MC, Yarbro JW: Chemotherapy of cervical carcinoma. Semin Oncol 9:373–387, 1982
Wallace HJ, Hreshchyshyn MM, Wilbanks GP, Boronow RC, Fowler WC, Blessing JA: Comparison of the therapeutic effects of adriamycin alone vs adriamycin plus vincristine vs adriamycin plus cyclophosphamide in the treatment of advanced carcinoma of the cervix. Cancer Treat Rep 62:1435–1441, 1978
Neil GL, Fuentzel SL, McGovren JP: Therapy of mouse tumors with 7-con-0-methylnogarol and other analogs of the anthracycline antibiotic, nogalamycin. Cancer Treat Rep 63:1971–1978, 1979
McGovren JP, Neil GL, Denlinger RH, Hall TL, Crampton SL, Swenberg JA: Chronic cardiotoxicity studies in rabbits with 7-con-0-methylnogarol, a new anthracycline antitumor agent. Cancer Res 39:4849–4855, 1979
Bhuyan BK, McGovren JP, Crampton SL: Intracellular uptake of 7-con-0-methylnogarol and Adriamycin by cells in culture and its relationship to cell survival. Cancer Res 41:882–887, 1981
Li LH, Keuntzel SLK, Murch LL, Pschigoda LM, Krueger WC: Comparative biological and biochemical effects of nogalamycin and its analogues on L-1210 leukemia. Cancer Res 39:4816–4822, 1979
Adams EB, Crampton SL, Bhuyan BK: Effect of 7-con-0- methylnogarol on DNA synthesis, survival, and cell cycle progression of Chinese hamster ovary cells. Cancer Res 41:4981–4987, 1981