Pharmacophore modeling for biological targets with high flexibility: LXRβ case study
Tài liệu tham khảo
Khedkar, 2007, Pharmacophore modeling in drug discovery and development: an overview, Med Chem, 3, 187, 10.2174/157340607780059521
Yang, 2010, Pharmacophore modeling and applications in drug discovery: challenges and recent advances, Drug Discov Today, 15, 444, 10.1016/j.drudis.2010.03.013
Fang, 2021, Recent advances in the medicinal chemistry of farnesoid X receptor, J Med Chem, 64, 17545, 10.1021/acs.jmedchem.1c01017
El-Gendy, 2018, Recent advances in the medicinal chemistry of liver X receptors, J Med Chem, 61, 10935, 10.1021/acs.jmedchem.8b00045
Griffett, 2020, The orphan nuclear receptor TLX Is a receptor for synthetic and natural retinoids, Cell Chem Biol, 10.1016/j.chembiol.2020.07.013
Shahien, 2020, Modulation of estrogen-related receptors subtype selectivity: conversion of an ERRβ/γ selective agonist to ERRα/β/γ pan agonists, Bioorg Chem, 102, 10.1016/j.bioorg.2020.104079
Peet, 1998, The LXRs: A new class of oxysterol receptors, Curr Opin Genet Dev, 8, 571, 10.1016/S0959-437X(98)80013-0
Bernotas, 2010, 4-(3-Aryloxyaryl)Quinoline sulfones are potent liver X receptor agonists, Bioorg Med Chem Lett, 20, 209, 10.1016/j.bmcl.2009.10.132
Gronemeyer, 2004, Principles for modulation of the nuclear receptor superfamily, Nat Rev Drug Discov, 3, 950, 10.1038/nrd1551
Wang, 2018, Liver X receptors in lipid signalling and membrane homeostasis, Nat Rev Endocrinol, 14, 451, 10.1038/s41574-018-0037-x
Jaye, 2005, Discovery of substituted maleimides as liver X receptor agonists and determination of a ligand-bound crystal structure, J Med Chem, 48, 5419, 10.1021/jm050532w
Zuercher, 2010, Discovery of tertiary sulfonamides as potent liver X receptor antagonists, J Med Chem, 53, 3412, 10.1021/jm901797p
Chen, 2020, Discovery of novel liver X receptor inverse agonists as lipogenesis inhibitors, Eur J Med Chem, 206, 10.1016/j.ejmech.2020.112793
Dixon, 2006, PHASE: A new engine for pharmacophore perception, 3D QSAR model development, and 3D database screening: 1. Methodology and preliminary results, J Comput Aided Mol Des, 20, 647, 10.1007/s10822-006-9087-6
Pascual, 2019, A New pharmacophore model for the design of sigma-1 ligands validated on a large experimental dataset, Front Pharmacol, 10, 1
Dixon, 2006, PHASE: A novel approach to pharmacophore modeling and 3D database searching, Chem Biol Drug Des, 67, 370, 10.1111/j.1747-0285.2006.00384.x
