Pharmacology of myopia and potential role for intrinsic retinal circadian rhythms

Abreu-Villaça, 2011, Developmental aspects of the cholinergic system, Behav. Brain Res., 221, 367, 10.1016/j.bbr.2009.12.049

Anisimov, 2006, Light pollution, reproductive function and cancer risk, Neuro Endocrinol. Lett., 27, 35

Arumugam, 2012, Muscarinic antagonist control of myopia: evidence for M4 and M1 receptor-based pathways in the inhibition of experimentally-induced axial myopia in the tree shrew, Invest. Ophthalmol. Vis. Sci., 53, 5827, 10.1167/iovs.12-9943

Ashby, 2007, A muscarinic cholinergic antagonist and a dopamine agonist rapidly increase ZENK mRNA expression in the form-deprived chicken retina, Exp. Eye Res., 85, 15, 10.1016/j.exer.2007.02.019

Ashby, 2009, The effect of ambient illuminance on the development of deprivation myopia in chicks, Invest. Ophthalmol. Vis. Sci., 50, 5348, 10.1167/iovs.09-3419

Ashby, 2010, Gene expression within the amacrine cell layer of chicks after myopic and hyperopic defocus, Invest. Ophthalmol. Vis. Sci., 51, 3726, 10.1167/iovs.09-4615

Ashby, 2010, The effect of bright light on lens compensation in chicks, Invest. Ophthalmol. Vis. Sci., 51, 5247, 10.1167/iovs.09-4689

Bailes, 2010, Melanopsin and inner retinal photoreception, Cell. Mol. Life Sci., 67, 99, 10.1007/s00018-009-0155-7

Barnard, 2006, Melanopsin regulates visual processing in the mouse retina, Curr. Biol., 16, 389, 10.1016/j.cub.2005.12.045

Bartlett, 2003, A tolerability study of pirenzepine ophthalmic gel in myopic children, J. Ocul. Pharmacol. Ther., 19, 271, 10.1089/108076803321908392

Bartmann, 1994, Constant light affects retinal dopamine levels and blocks deprivation myopia but not lens-induced refractive errors in chickens, Vis. Neurosci., 11, 199, 10.1017/S0952523800001565

Bartness, 2012, Seasonal changes in adiposity: the roles of the photoperiod, melatonin and other hormones, and sympathetic nervous system, Exp. Biol. Med., 227, 363, 10.1177/153537020222700601

Bellingham, 2006, Evolution of melanopsin photoreceptors: discovery and characterization of a new melanopsin in nonmammalian vertebrates, PLoS Biol., 4, 1334

Borchert, 2011, Risk factors for hyperopia and myopia in preschool children: the Multi-Ethnic Pediatric Eye Disease and Baltimore Pediatric Eye Disease Studies, Ophthalmology, 118, 1966, 10.1016/j.ophtha.2011.06.030

Bradley, 1999, Emmetropization in the Rhesus monkey (Macaca mulatta): birth to young adulthood, Invest. Ophthalmol. Vis. Sci., 40, 214

Brodstein, 1984, The treatment of myopia with atropine and bifocals: a long-term prospective study, Ophthalmology, 91, 1373, 10.1016/S0161-6420(84)34138-0

Brown, 1930, Sight saving class work from the standpoint of the American Ophthalmological Society and the National Society for the Prevention of Blindness, Trans. Am. Ophthalmol. Soc., 28, 155

Brown, 2009, In vivo human choroidal thickness measurements: evidence for diurnal fluctuations, Invest. Ophthalmol. Vis. Sci., 50, 5, 10.1167/iovs.08-1779

Cameron, 2008, Electroretinography of wild-type and Cry mutant mice reveals circadian tuning of photopic and mesopic retinal responses, J. Biol. Rhythms, 23, 489, 10.1177/0748730408325874

Campbell, 2012, Diurnal rhythms of spherical refractive error, optical axial length and power in the chick, Invest. Ophthalmol. Vis. Sci., 53, 6245, 10.1167/iovs.11-8844

Caulfield, 1998, International union of pharmacology. XVII. Classification of muscarinic acetylcholine receptors, Pharmacol. Rev., 50, 279

Chapell, 2001, Myopia and night-time lighting during sleep in children and adults, Percept. Mot. Skills, 92, 640, 10.2466/pms.2001.92.3.640

Chebib, 2009, Novel, potent, and selective GABAC antagonists inhibit myopia development and facilitate learning and memory, JPET, 328, 448, 10.1124/jpet.108.146464

Chia, 2012, Atropine for the treatment of childhood myopia: safety and efficacy of 0.5%, 0.1%, and 0.01 doses (Atropine for the Treatment of Myopia 2), Ophthalmology, 119, 347, 10.1016/j.ophtha.2011.07.031

Chua, 2006, Atropine for the treatment of myopia, Ophthalmology, 113, 2285, 10.1016/j.ophtha.2006.05.062

Cinzano, 2001, The first world Atlas of the artificial night sky brightness, Mon. Not. R. Astron. Soc., 328, 689, 10.1046/j.1365-8711.2001.04882.x

Cohen, 2008, Light intensity modulated corneal power and refraction in the chick eye exposed to continuous light, Vision Res., 48, 2329, 10.1016/j.visres.2008.07.010

Cohen, 2011, Dependency between light intensity and refractive development under light–dark cycles, Exp. Eye Res., 92, 40, 10.1016/j.exer.2010.10.012

Cohen, 2012, Ambient illuminance, retinal dopamine release and refractive development in chicks, Exp. Eye Res., 103, 33, 10.1016/j.exer.2012.08.004

Cottriall, 2001, Diisopropylfluorophosphate alters retinal neurotransmitter levels and reduces experimentally-induced myopia, Naunyn-Schmiedeberg's Arch. Pharmacol., 364, 372, 10.1007/s002100100460

Cottriall, 1996, The M1 muscarinic antagonist pirenzepine reduces myopia and eye enlargement in the tree shrew, Invest. Ophthalmol. Vis. Sci., 37, 1368

Cottriall, 2001, Inhibition of myopia development in chicks using himbacine: a role for M4 receptors?, NeuroReport, 12, 2453, 10.1097/00001756-200108080-00033

Cowan, 1942, Myopia, Am. J. Ophthalmol., 25, 844, 10.1016/S0002-9394(42)91032-8

Czepita, 2004, Refractive errors among students occupying rooms lighted with incandescent or fluorescent lamps, Ann. Acad. Med. Stetin., 50, 51

Czepita, 2005, Occurrence of refractive errors among students who before the age of two grew up under the influence of light emitted by incandescent or fluorescent lamps, Ann. Acad. Med. Stetin., 51, 33

Daubs, 1982, Environmental factors in the epidemiology of malignant myopia, Am. J. Optom. Physiol. Opt., 59, 271, 10.1097/00006324-198203000-00012

Daubs, 1984, Some geographic, environmental and nutritive concomitants of malignant myopia, Ophthalmic Physiol. Opt., 4, 143, 10.1111/j.1475-1313.1984.tb00348.x

Dementi, 1994, Ocular effects of organophosphates: a historical perspective of Saku disease, J. Appl. Toxicol., 14, 119, 10.1002/jat.2550140214

Deng, 2011, Birth season, photoperiod, and infancy refraction, Optom. Vis. Sci., 88, 383, 10.1097/OPX.0b013e31820b0517

Deng, 2010, Children's refractions and visual activities in the school year and summer, Optom. Vis. Sci., 87, 406, 10.1097/OPX.0b013e3181da8a85

Dirani, 2009, Outdoor activity and myopia in Singapore teenage children, Br. J. Ophthalmol., 93, 997, 10.1136/bjo.2008.150979

Duffy, 2009, Effect of light on human circadian physiology, Sleep Med. Clin., 4, 165, 10.1016/j.jsmc.2009.01.004

El-Shazly, 2012, Passive smoke exposure might be associated with hypermetropia, Ophthalmic Physiol. Opt., 32, 304, 10.1111/j.1475-1313.2012.00918.x

Farbrother, 2004, Family aggregation of high myopia: estimation of the sibling recurrence risk ratio, Invest. Ophthalmol. Vis. Sci., 45, 2873, 10.1167/iovs.03-1155

Fischer, 1998, Identification and localization of muscarinic acetylcholine receptors in the ocular tissues of the chick, J. Comp. Neurol., 392, 273, 10.1002/(SICI)1096-9861(19980316)392:3<273::AID-CNE1>3.0.CO;2-Z

Fischer, 1998, Cholinergic amacrine cells are not required for the progression and atropine-mediated suppression of form-deprivation myopia, Brain Res., 794, 48, 10.1016/S0006-8993(98)00188-7

Foulds, 2010, Physical factors in myopia and potential therapies

French, 2012, Comparison of refraction and ocular biometry in European Caucasian children living in Northern Ireland and Sydney, Australia, Invest. Ophthalmol. Vis. Sci., 53, 4021, 10.1167/iovs.12-9556

Fulk, 2002, Seasonal variation in myopia progression and ocular elongation, Optom. Vis. Sci., 79, 46, 10.1097/00006324-200201000-00012

Ganesan, 2010, Pharmaceutical intervention for myopia control, Expert Rev. Ophthalmol., 5, 759, 10.1586/eop.10.67

Geller, 1998, The organophosphate pesticide chlorpyrifos affects form deprivation myopia, Invest. Ophthalmol. Vis. Sci., 39, 1290

Gil, 1997, Muscarinic receptor subtypes in human iris-ciliary body measured by immunoprecipitation, Invest. Ophthalmol. Vis. Sci., 38, 1434

Glasser, 1996, A history of studies of visual accommodation in birds, Q. Rev. Biol., 71, 475, 10.1086/419554

Golombek, 2010, Physiology of circadian entrainment, Physiol. Rev., 90, 1063, 10.1152/physrev.00009.2009

Guggenheim, 2003, Myopia, genetics, and ambient lighting at night in a UK sample, Br. J. Ophthalmol., 87, 580, 10.1136/bjo.87.5.580

Guggenheim, 2012, Time outdoors and physical activity as predictors of incident myopia in childhood: a prospective cohort study, Invest. Ophthalmol. Vis. Sci., 53, 2856, 10.1167/iovs.11-9091

Guo, 1995, Retinal dopamine and lens-induced refractive errors in chicks, Curr. Eye Res., 14, 385, 10.3109/02713689508999936

Guo, 1996, Effects of continuous light on experimental refractive errors in chicks, Ophthalmic Physiol. Opt., 16, 486, 10.1016/0275-5408(96)00011-7

Gwiazda, 2000, Myopia and ambient night-time lighting, Nature, 404, 144, 10.1038/35004663

Hornbeak, 2009, Myopia genetics: a review of current research and emerging trends, Curr. Opin. Ophthalmol., 20, 356, 10.1097/ICU.0b013e32832f8040

Hut, 2011, The cholinergic system, circadian rhythmicity, and time memory, Behav. Brain Res., 221, 466, 10.1016/j.bbr.2010.11.039

Ip, 2008, Prevalence of hyperopia and associations with eye findings in 6- and 12-year-olds, Ophthalmology, 115, 678, 10.1016/j.ophtha.2007.04.061

Ishikawa, 1980, Development of myopia following chronic organophosphate pesticide intoxication: an epidemiological and experimental study, 233

Iuvone, 1989, Dopamine synthesis and metabolism in rhesus monkey retina: development, aging and the effects of monocular visual deprivation, Vis. Neurosci., 2, 465, 10.1017/S0952523800012360

Iuvone, 1991, Effects of apomorphine, a dopamine receptor agonist, on ocular refraction and axial elongation in a primate model of myopia, Invest. Ophthalmol. Vis. Sci., 32, 1674

Iuvone, 2005, Circadian clocks, clock networks, arylalkylamine N-acetyltransferase, and melatonin in the retina, Prog. Retin. Eye Res., 24, 433, 10.1016/j.preteyeres.2005.01.003

Jackson, 2011, Dopamine D4 receptor activation controls circadian timing of the adenylyl cyclase 1/cyclic AMP signaling system in mouse retina, Eur. J. Neurosci., 34, 57, 10.1111/j.1460-9568.2011.07734.x

Jackson, 2012, Retinal dopamine mediates multiple dimensions of light-adapted vision, J. Neurosci., 32, 9359, 10.1523/JNEUROSCI.0711-12.2012

Jacobsen, 2008, Does the level of physical activity in university students influence development and progression of myopia? – a 2-year prospective cohort study, Invest. Ophthalmol. Vis. Sci., 49, 1322, 10.1167/iovs.07-1144

Jakubik, 1994, Two populations of muscarinic binding sites in the chick heart distinguished by affinities for ligands and selective inactivation, Br. J. Pharmacol., 113, 1529, 10.1111/j.1476-5381.1994.tb17170.x

Jensen, 1957, Enlargement of avian eye by subjecting chicks to continuous incandescent illumination, Science, 125, 741, 10.1126/science.125.3251.741

Johnson, 2003, Entrainment of circadian programs, Chronobiol. Int., 20, 741, 10.1081/CBI-120024211

Jones-Jordan, 2011, Visual activity before and after the onset of juvenile myopia, Invest. Ophthalmol. Vis. Sci., 52, 1841, 10.1167/iovs.09-4997

Jones-Jordan, 2012, Time outdoors, visual activity, and myopia progression in juvenile-onset myopes, Invest. Ophthalmol. Vis. Sci., 53, 7169, 10.1167/iovs.11-8336

Jones, 2007, Parental history of myopia, sports and outdoor activities, and future myopia, Invest. Ophthalmol. Vis. Sci., 48, 3524, 10.1167/iovs.06-1118

Kee, 2007, Temporal constraints on experimental emmetropization in infant monkeys, Invest. Ophthalmol. Vis. Sci., 48, 957, 10.1167/iovs.06-0743

Kee, 2001, Differences in time course and visual requirements of ocular responses to lenses and diffusers, Invest. Ophthalmol. Vis. Sci., 42, 575

Kennedy, 1995, Progression of myopia, Trans. Am. Ophthalmol. Soc., 93, 755

Klein, 2005, Support for polygenic influences on ocular refractive error, Invest. Ophthalmol. Vis. Sci., 46, 442, 10.1167/iovs.04-0794

Leech, 1995, Pirenzepine prevents form deprivation myopia in a dose dependent manner, Ophthalmic Physiol. Opt., 15, 351, 10.1016/0275-5408(95)00074-N

Li, 2000, Diurnal illumination patterns affect the development of the chick eye, Vision Res., 40, 2387, 10.1016/S0042-6989(00)00098-5

Li, 1995, Constant light produces severe corneal flattening and hyperopia in chickens, Vision Res., 35, 1203, 10.1016/0042-6989(94)00231-A

Lind, 1998, Muscarinic acetylcholine receptor antagonists inhibit chick scleral chondrocytes, Invest. Ophthalmol. Vis. Sci., 39, 2217

Liu, 2009, Nicotinic acetylcholine receptor subunits in rhesus monkey retina, Invest. Ophthalmol. Vis. Sci., 50, 1408, 10.1167/iovs.08-2398

Liu, 2004, Emmetropization under continuous but non-constant light in chicks, Exp. Eye Res., 79, 719, 10.1016/j.exer.2004.08.007

Liu, 1998, Twenty-four-hour change in axial length in the rabbit eye, Invest. Ophthalmol. Vis. Sci., 39, 2796

Loman, 2002, Darkness and near work: myopia and its progression in third-year law students, Ophthalmology, 109, 1032, 10.1016/S0161-6420(02)01012-6

Low, 2010, Family history, near work, outdoor activity, and myopia in Singapore Chinese preschool children, Br. J. Ophthalmol., 94, 1012, 10.1136/bjo.2009.173187

Lu, 2009, Associations between near work, outdoor activity, and myopia among adolescent students in rural China: the Xichang Pediatric Refractive Error Study Report No. 2, Arch. Ophthalmol., 127, 769, 10.1001/archophthalmol.2009.105

Luft, 2003, Variable effects of previously untested muscarinic receptor antagonists on experimental myopia, Invest. Ophthalmol. Vis. Sci., 44, 1330, 10.1167/iovs.02-0796

Lyhne, 2001, The importance of genes and environment for ocular refraction and its determiners: a population based study among 20–45 year old twins, Br. J. Ophthalmol., 85, 1470, 10.1136/bjo.85.12.1470

Mallen, 2006, Transient axial length change during the accommodation response in young adults, Invest. Ophthalmol. Vis. Sci., 47, 1251, 10.1167/iovs.05-1086

Mandel, 2008, Season of birth, natural light, and myopia, Ophthalmology, 115, 686, 10.1016/j.ophtha.2007.05.040

Mapstone, 1985, Diurnal variation in the dimensions of the anterior chamber, Arch. Ophthalmol., 103, 1485, 10.1001/archopht.1985.01050100061019

McBrien, 2011, The M4 muscarinic antagonist MT-3 inhibitors myopia in chick: evidence for site of action, Ophthalmic Physiol. Opt., 31, 529, 10.1111/j.1475-1313.2011.00841.x

McBrien, 2001, Retinal acetylcholine content in normal and myopic eyes: a role in ocular growth control?, Vis. Neurosci., 18, 571, 10.1017/S0952523801184075

McBrien, 1993, Atropine reduces experimental myopia and eye enlargement via a nonaccommodative mechanism, Invest. Ophthalmol. Vis. Sci., 34, 205

McCarthy, 2007, Dopaminergic agents affect the ability of brief periods of normal vision to prevent form-deprivation myopia, Exp. Eye Res., 84, 100, 10.1016/j.exer.2006.09.018

McGlinn, 2007, Form deprivation myopia in chick induces limited changes in retinal gene expression, Invest. Ophthalmol. Vis. Sci., 48, 3430, 10.1167/iovs.06-1538

McKean-Cowdin, 2011, Risk factors for astigmatism in preschool children: the Multi-Ethnic Pediatric Eye Disease and Baltimore Pediatric Eye Disease Studies, Ophthalmology, 118, 1974, 10.1016/j.ophtha.2011.06.031

McKenzie, 1997, Deprivation of form vision suppresses diurnal cycling of retinal levels of leu-enkephalin, Aust. N. Z. J. Ophthalmol., 25, S79, 10.1111/j.1442-9071.1997.tb01765.x

McMahon, 2009, Season of birth, daylight hours at birth, and high myopia, Ophthalmology, 116, 468, 10.1016/j.ophtha.2008.10.004

Megaw, 1996, The effect of form deprivation on retinal leu-enkephalin levels is mediated by a rod-driven pathway, Aust. N. Z. J. Ophthalmol., 24, 58, 10.1111/j.1442-9071.1996.tb00997.x

Meyer, 1999, Experimental animal myopia models are applicable to human juvenile-onset myopia, Surv. Ophthalmol., 44, S93, 10.1016/S0039-6257(99)00091-0

Miwa, 2011, Neural systems governed by nicotinic acetylcholine receptors: emerging hypotheses, Neuron, 70, 20, 10.1016/j.neuron.2011.03.014

Mohawk, 2011, Cell autonomy and synchrony of suprachiasmatic nucleus circadian oscillators, Trends Neurosci., 34, 349, 10.1016/j.tins.2011.05.003

Morgan, 2005, How genetic is school myopia?, Prog. Retin. Eye Res., 24, 1, 10.1016/j.preteyeres.2004.06.004

Morgan, 1996, A retinal dark-light switch: a review of the evidence, Vis. Neurosci., 13, 399, 10.1017/S0952523800008087

Morgan, 2012, Myopia, Lancet, 379, 1739, 10.1016/S0140-6736(12)60272-4

Mutti, 2010, Hereditary and environmental contributions to emmetropization and myopia, Optom. Vis. Sci., 87, 255, 10.1097/OPX.0b013e3181c95a24

Mutti, 2012, Vitamin D receptor (VDR) and group-specific component (GC, vitamin E-binding protein) polymorphisms in myopia, Invest. Ophthalmol. Vis. Sci., 52, 3818, 10.1167/iovs.10-6534

Mutti, 2002, Parental myopia, near work, school achievement, and children's refractive error, Invest. Ophthalmol. Vis. Sci., 43, 3633

Navara, 2007, The dark side of light at night: physiological, epidemiological, and ecological consequences, J. Pineal Res., 43, 215, 10.1111/j.1600-079X.2007.00473.x

Nickla, 2006, The phase relationships between the diurnal rhythms in axial length and choroidal thickness and the association with ocular growth rate in chicks, J. Comp. Physiol. A, 192, 399, 10.1007/s00359-005-0077-2

Nickla, 2010, The multifunctional choroid, Prog. Retin. Eye Res., 29, 144, 10.1016/j.preteyeres.2009.12.002

Nickla, 2002, Diurnal rhythms in intraocular pressure, axial length, and choroidal thickness in a primate model of eye growth, the common marmoset, Invest. Ophthalmol. Vis. Sci., 43, 2519

Nickla, 1998, The circadian rhythm in intraocular pressure and its relation to diurnal ocular growth changes in chicks, Exp. Eye Res., 66, 183, 10.1006/exer.1997.0425

Nickla, 1998, Visual influences on diurnal rhythms in ocular length and choroidal thickness in chick eyes, Exp. Eye Res., 66, 163, 10.1006/exer.1997.0420

Nickla, 2001, Endogenous rhythms in axial length and choroidal thickness in chicks: implications for ocular growth regulation, Invest. Ophthalmol. Vis. Sci., 42, 584

Norton, 1999, Animal models of myopia: learning how vision controls the size of the eye, Inst. Lab. Anim. Res. J., 40, 59, 10.1093/ilar.40.2.59

Norton, 2003, Refractive state of tree shrew eyes measured with cortical visual evoked potentials, Optom. Vis. Sci., 80, 623, 10.1097/00006324-200309000-00006

O'Hara, 1998, Nicotine and nicotinic receptors in the circadian system, Psychoneuroendocrinology, 23, 161, 10.1016/S0306-4530(97)00077-2

Oishi, 1985, Effects of duration and intensity of illumination on several parameters of the chick eye, Comp. Biochem. Physiol., 81A, 319, 10.1016/0300-9629(85)90141-0

Onal, 2007, Refractive errors of medical students in Turkey: one year follow-up of refraction and biometry, Optom. Vis. Sci., 84, 175, 10.1097/OPX.0b013e3180335c52

Padmanabhan, 2007, Constant light rearing disrupts compensation to imposed- but not induced-hyperopia and facilitates compensation to imposed myopia in chicks, Vision Res., 47, 1855, 10.1016/j.visres.2007.04.001

Pan, 2012, Worldwide prevalence and risk factors for myopia, Ophthalmic Physiol. Opt., 32, 3, 10.1111/j.1475-1313.2011.00884.x

Papastergiou, 1998, Ocular axial length and choroidal thickness in newly hatched chicks and one-year-old chickens fluctuate in a diurnal pattern that is influenced by visual experience and intraocular pressure changes, Exp. Eye Res., 66, 195, 10.1006/exer.1997.0421

Pardue, 2008, High susceptibility to experimental myopia in a mouse model with a retinal on pathway defect, Invest. Ophthalmol. Vis. Sci., 49, 706, 10.1167/iovs.07-0643

Pärssinen, 1993, Myopia and myopic progression among schoolchildren: a three-year follow-up study, Invest. Ophthalmol. Vis. Sci., 34, 2794

Paul, 2009, The role of retinal photoreceptors in the regulation of circadian rhythms, Rev. Endocr. Metab. Disord., 10, 271, 10.1007/s11154-009-9120-x

Pauley, 2004, Lighting for the human circadian clock: recent research indicates that lighting has become a public health issue, Med. Hypotheses, 63, 588, 10.1016/j.mehy.2004.03.020

Pearce, 2012, Latitudinal variation in light levels drives human visual system size, Biol. Lett., 8, 90, 10.1098/rsbl.2011.0570

Pendrak, 1995, Ciliary ganglion choline acetyltransferase activity in avian macrophthalmos, Exp. Eye Res., 60, 237, 10.1016/S0014-4835(05)80106-X

Pickett Seltner, 1997, Endogenous opiates in the chick retina and their role in form-deprivation myopia, Vis. Neurosci., 14, 801, 10.1017/S0952523800011548

Pickett Seltner, 1995, The effect of vasoactive intestinal peptide on development of form deprivation myopia in the chick: a pharmacological and immunocytochemical study, Vision Res., 35, 1265, 10.1016/0042-6989(94)00244-G

Poyer, 1994, The effect of muscarinic agonists and selective receptor subtype antagonists on the contractile response of the isolated rhesus monkey ciliary muscle, Exp. Eye Res., 59, 729, 10.1006/exer.1994.1159

Pozdeyev, 2008, Dopamine modulates diurnal and circadian rhythms of protein phosphorylation in photoreceptor cells of mouse retina, Eur. J. Neurosci., 27, 2691, 10.1111/j.1460-9568.2008.06224.x

Quinn, 1999, Myopia and ambient lighting at night, Nature, 399, 113, 10.1038/20094

Rahi, 2011, Myopia over the lifecourse: prevalence and early life influences in the 1958 British birth cohort, Ophthalmology, 118, 797, 10.1016/j.ophtha.2010.09.025

Rau, 1951, The Danish sight-saving school, Sight Sav. Rev., 21, 142

Read, 2008, Diurnal variation of axial length, intraocular pressure, and anterior eye biometrics, Invest. Ophthalmol. Vis. Sci., 49, 2911, 10.1167/iovs.08-1833

Read, 2010, Human optical axial length and defocus, Invest. Ophthalmol. Vis. Sci., 51, 6262, 10.1167/iovs.10-5457

Rickers, 1995, Dose-dependent effects of intravitreal pirenzepine on deprivation myopia and lens-induced refractive errors in chickens [letter], Exp. Eye Res., 61, 509, 10.1016/S0014-4835(05)80147-2

Rohrer, 1995, Stimulation of dopamine amacrine cells by stroboscopic illumination or fibroblast growth factor (bFGF, FGF-2) injections: possible roles in prevention of form-deprivation myopia, Brain Res., 686, 169, 10.1016/0006-8993(95)00370-6

Rohrer, 1993, Apomorphine blocks form-deprivation myopia in chickens by a dopamine D2-receptor mechanism acting in retina or pigmented epithelium, Vis. Neurosci., 10, 447, 10.1017/S0952523800004673

Rose, 2008, Outdoor activity reduces the prevalence of myopia in children, Ophthalmology, 115, 1279, 10.1016/j.ophtha.2007.12.019

Rose, 2008, Myopia, lifestyle, and schooling in students of Chinese ethnicity in Singapore and Sydney, Arch. Ophthalmol., 126, 527, 10.1001/archopht.126.4.527

Rose, 2002, High heritability of myopia does not preclude rapid changes in prevalence, Clin. Exp. Ophthalmol., 30, 168, 10.1046/j.1442-9071.2002.00521.x

Rosenfield, 1998, Myopia and nearwork: causation or merely association?, 193

Ruan, 2008, An autonomous circadian clock in the inner mouse retina regulated by dopamine and GABA, PLoS Biol., 6, e249, 10.1371/journal.pbio.0060249

Ruan, 2006, Circadian organization of the mammalian retina, Proc. Natl. Acad. Sci. U. S. A., 103, 9703, 10.1073/pnas.0601940103

Rymer, 2005, The role of the retinal pigment epithelium in eye growth regulation and myopia: a review, Vis. Neurosci., 22, 251, 10.1017/S0952523805223015

Sakamoto, 2005, Dopamine regulates melanopsin mRNA expression in intrinsically photosensitive retinal ganglion cells, Eur. J. Neurosci., 22, 3129, 10.1111/j.1460-9568.2005.04512.x

Saw, 2004, Childhood myopia and parental smoking, Br. J. Ophthalmol., 88, 934, 10.1136/bjo.2003.033175

Saw, 2000, Factors related to the progression of myopia in Singaporean children, Optom. Vis. Sci., 77, 549, 10.1097/00006324-200010000-00009

Saw, 2001, Myopia and night lighting in children in Singapore, Br. J. Ophthalmol., 85, 527, 10.1136/bjo.85.5.527

Saw, 2002, Near-work activity, night-lights, and myopia in the Singapore-China study, Arch. Ophthalmol., 120, 620, 10.1001/archopht.120.5.620

Schaeffel, 2008, The mouse as a model for myopia, and optics of its eye

Schaeffel, 2010, The mouse model of myopia, 303

Schmid, 2004, Inhibitory effects of apomorphine and atropine and their combination on myopia in chicks, Optom. Vis. Sci., 81, 137, 10.1097/00006324-200402000-00012

Sherwin, 2012, The association between time spent outdoors and myopia using a novel biomarker of outdoor light exposure, Invest. Ophthalmol. Vis. Sci., 53, 4363, 10.1167/iovs.11-8677

Shih, 1999, Effects of different concentrations of atropine on controlling myopia in myopic children, J. Ocul. Pharmacol. Ther., 15, 85, 10.1089/jop.1999.15.85

Siatkowski, 2004, Safety and efficacy of 2% pirenzepine ophthalmic gel in children with myopia, Arch. Ophthalmol., 122, 1667, 10.1001/archopht.122.11.1667

Siatkowski, 2008, Two-year multicenter, randomized double-masked, placebo-controlled, parallel safety and efficacy study of 2% pirenzepine ophthalmic gel in children with myopia, J. AAPOS, 12, 332

Smith, 2001, Continuous ambient lighting and eye growth in primates, Invest. Ophthalmol. Vis. Sci., 42, 1146

Smith, 2012, Protective effects of high ambient lighting on the development of form-deprivation myopia in rhesus monkeys, Invest. Ophthalmol. Vis. Sci., 53, 421, 10.1167/iovs.11-8652

Smith, 2003, Continuous ambient lighting and lens compensation in infant monkeys, Optom. Vis. Sci., 80, 374, 10.1097/00006324-200305000-00012

Smith, 2002, Effects of brief periods of unrestricted vision on the development of form-deprivation myopia in monkeys, Invest. Ophthalmol. Vis. Sci., 43, 291

Song, 2011, Atropine in ameliorating the progression of myopia in children with mild to moderate myopia: a meta-analysis of controlled clinical trials, J. Ocul. Pharmacol. Ther., 27, 361, 10.1089/jop.2011.0017

Steenhard, 2000, Phase shifting the retinal circadian clock: xPer2 mRNA induction by light and dopamine, J. Neurosci., 20, 8572, 10.1523/JNEUROSCI.20-23-08572.2000

Stevens, 2001, Light in the built environment: potential role of circadian disruption in endocrine disruption and breast cancer, Cancer Causes Control, 12, 279, 10.1023/A:1011237000609

Stone, 1997, Neural mechanisms and eye growth control, 241

Stone, 2008, Myopia pharmacology: etiologic clues, therapeutic potential, 167

Stone, 2010, Gene profiling in experimental models of eye growth: clues to myopia pathogenesis, Vision Res., 50, 2322, 10.1016/j.visres.2010.03.021

Stone, 1988, Increase in retinal vasoactive intestinal polypeptide after eyelid fusion in primates, Proc. Natl. Acad. Sci. U. S. A., 85, 257, 10.1073/pnas.85.1.257

Stone, 1995, Photoperiod, early post-natal eye growth, and visual deprivation, Vision Res., 35, 1195, 10.1016/0042-6989(94)00232-B

Stone, 1991, Muscarinic antagonist effects on experimental chick myopia, Exp. Eye Res., 52, 755, 10.1016/0014-4835(91)90027-C

Stone, 1989, Retinal dopamine and form-deprivation myopia, Proc. Natl. Acad. Sci. U. S. A., 86, 704, 10.1073/pnas.86.2.704

Stone, 2003, GABA, experimental myopia and ocular growth in chick, Invest. Ophthalmol. Vis. Sci., 44, 3933, 10.1167/iovs.02-0774

Stone, 2011, Image defocus and altered retinal gene expression in chick: clues to the pathogenesis of ametropia, Invest. Ophthalmol. Vis. Sci., 52, 5765, 10.1167/iovs.10-6727

Stone, 2004, Diurnal axial length fluctuations in human eyes, Invest. Ophthalmol. Vis. Sci., 45, 63, 10.1167/iovs.03-0294

Stone, 2001, Effects of nicotinic antagonists on ocular growth and experimental myopia, Invest. Ophthalmol. Vis. Sci., 42, 557

Stone, 2006, Associations between childhood refraction and parental smoking, Invest. Ophthalmol. Vis. Sci., 47, 4277, 10.1167/iovs.05-1625

Storch, 2007, Intrinsic circadian clock of the mammalian retina: importance for retinal processing of visual information, Cell, 130, 730, 10.1016/j.cell.2007.06.045

Summers Rada, 2009, Ocular expression of avian thymic hormone: changes during the recovery from induced myopia, Mol. Vis., 15, 778

Tan, 2005, One-year multicenter, double-masked, placebo-controlled, parallel safety and efficacy study of 2% pirenzepine ophthalmic gel in children with myopia, Ophthalmology, 112, 84, 10.1016/j.ophtha.2004.06.038

Tietje, 1991, Embryonic chick heart expresses multiple muscarinic acetylcholine receptor subtypes, J. Biol. Chem., 266, 17382, 10.1016/S0021-9258(19)47384-5

Tigges, 1999, Effects of muscarinic cholinergic receptor antagonists on postnatal eye growth of rhesus monkeys, Optom. Vis. Sci., 76, 397, 10.1097/00006324-199906000-00020

Tkatchenko, 2006, Form deprivation modulates retinal neurogenesis in primate experimental myopia, Proc. Natl. Acad. Sci. U. S. A., 103, 4681, 10.1073/pnas.0600589103

Tkatchenko, 2010, Mouse experimental myopia as features of primate myopia, Invest. Ophthalmol. Vis. Sci., 51, 1297, 10.1167/iovs.09-4153

Tomonari, 2005, A non-canonical photopigment, melanopsin, is expressed in the differentiating ganglion, horizontal, and bipolar cells of the chicken retina, Dev. Dyn., 234, 783, 10.1002/dvdy.20600

Tong, 2009, Atropine for the treatment of childhood myopia: effect on myopia progression after cessation of atropine, Ophthalmology, 116, 572, 10.1016/j.ophtha.2008.10.020

Tosini, 2008, The circadian clock system in the mammalian retina, BioEssays, 30, 624, 10.1002/bies.20777

Troilo, 1993, Ocular development and visual deprivation myopia in the common marmoset (Callithrix jacchus), Vision Res., 33, 1311, 10.1016/0042-6989(93)90039-Y

Turner, 2008, Circadian photoreception: ageing and the eye's important role in systemic health, Br. J. Ophthalmol., 92, 1439, 10.1136/bjo.2008.141747

Vannas, 2003, Myopia and natural lighting extremes: risk factors in Finnish army conscripts, Acta Ophthalmol. Scand., 81, 588, 10.1046/j.1395-3907.2003.0151.x

Vessey, 2002, Muscarinic receptor protein expression in the ocular tissues of the chick during normal and myopic eye development, Brain Res. Dev. Brain Res., 135, 79, 10.1016/S0165-3806(02)00309-7

Viney, 2007, Local retinal circuits of melanopsin-containing ganglion cells identified by transsynaptic viral tracing, Curr. Biol., 17, 981, 10.1016/j.cub.2007.04.058

Vitale, 2009, Increased prevalence of myopia in the United States between 1971–1972 and 1999–2004, Arch. Ophthalmol., 127, 1632, 10.1001/archophthalmol.2009.303

Vugler, 2007, Dopamine neurones form a discrete plexus with melanopsin cells in normal and degenerating retina, Exp. Neurol., 205, 26, 10.1016/j.expneurol.2007.01.032

Wallman, 1993, Retinal control of eye growth and refraction, Prog. Retin. Res., 12, 133, 10.1016/0278-4327(93)90007-G

Wallman, 1981, The eyes of young chickens grow toward emmetropia, Invest. Ophthalmol. Vis. Sci., 20, 557

Wallman, 2010, The relevance of studies in chicks for understanding myopia in humans, 239

Wallman, 2004, Homeostasis of eye growth and the question of myopia, Neuron, 43, 447, 10.1016/j.neuron.2004.08.008

Weiss, 1993, Diurnal growth rhythms in the chicken eye: relation to myopia development and retinal dopamine levels, J. Comp. Physiol. A, 172, 263, 10.1007/BF00216608

Wells, 1811, Observations and experiment on vision, Philos. Trans. R Soc., 101, 389, 10.1098/rstl.1811.0021

Welsh, 2010, Suprachiasmatic nucleus: cell autonomy and network properties, Annu. Rev. Physiol., 72, 551, 10.1146/annurev-physiol-021909-135919

Wilson, 2006, The relation of axial length and intraocular pressure fluctuations in human eyes, Invest. Ophthalmol. Vis. Sci., 47, 1778, 10.1167/iovs.05-0869

Witkovsky, 2004, Dopamine and retinal function, Doc. Ophthalmol., 108, 17, 10.1023/B:DOOP.0000019487.88486.0a

Wojciechowski, 2011, Nature and nurture: the complex genetics of myopia and refractive error, Clin. Genet., 301, 10.1111/j.1399-0004.2010.01592.x

Wojciechowski, 2005, Familial aggregation of hyperopia in an elderly population of siblings in Salsbury, Maryland, Ophthalmology, 112, 78, 10.1016/j.ophtha.2004.07.026

Woodman, 2011, Axial elongation following prolonged near work in myopes and emmetropes, Br. J. Ophthalmol., 95, 652, 10.1136/bjo.2010.180323

Wu, 2011, Naturally-expressed nicotinic acetylcholine receptor subtypes, Biochem. Pharmacol., 82, 800, 10.1016/j.bcp.2011.07.067

Wu, 2010, Effects of outdoor activities on myopia among rural school children in Taiwan, Ophthalmic Epidemiol., 17, 338, 10.3109/09286586.2010.508347

Wyse, 2011, Circadian desynchrony and metabolic dysfunction: did light pollution make us fat?, Med. Hypotheses, 77, 1139, 10.1016/j.mehy.2011.09.023

Yujnovsky, 2006, Signaling mediated by the dopamine D2 receptor potentiates circadian regulation by CLOCK: BMAL1, Proc. Natl. Acad. Sci. U. S. A., 103, 6386, 10.1073/pnas.0510691103

Zadnik, 1997, Myopia development in childhood, Optom. Vis. Sci., 74, 603, 10.1097/00006324-199708000-00021

Zadnik, 2000, Myopia and ambient night-time lighting. CLEERE Study Group. Collaborative longitudinal evaluation of ethnicity and refractive error, Nature, 404, 143, 10.1038/35004661

Zhang, 2008, Intraretinal signaling by ganglion cell photoreceptors to dopaminergic amacrine neurons, Proc. Natl. Acad. Sci. U. S. A., 105, 14181, 10.1073/pnas.0803893105

Zhang, 2010, Population density and refractive error among Chinese children, Invest. Ophthalmol. Vis. Sci., 51, 4969, 10.1167/iovs.10-5424

Zhilov, 1977, Light and myopic refraction in children, J. Hyg. Epidemiol. Microbiol. Immunol., 21, 234

Zhou, 2010, Relative axial myopia induced by prolonged light exposure in C57BL/6 mice, Photochem. Photobiol., 86, 131, 10.1111/j.1751-1097.2009.00637.x