Pharmacological profiling an abundantly expressed schistosome serotonergic GPCR identifies nuciferine as a potent antagonist
Tài liệu tham khảo
Abdulla, 2009, Drug discovery for schistosomiasis: hit and lead compounds identified in a library of known drugs by medium-throughput phenotypic screening, PLoS Negl. Trop. Dis., 3, e478, 10.1371/journal.pntd.0000478
Ayers, 2007, Anthelmintic activity of aporphine alkaloids from Cissampelos capensis, Planta Med., 73, 296, 10.1055/s-2007-967124
Chan, 2014, ’Death and axes’; unexpected Ca2+ entry phenologs predict new anti-schistosomal agents, PLoS Pathog., 10, e1003942, 10.1371/journal.ppat.1003942
Chan, 2015, Ergot alkaloids (Re)generate new leads as antiparasitics, PLoS Negl. Trop. Dis., 9, e0004063, 10.1371/journal.pntd.0004063
Chan, 2016, Kinetic profiling an abundantly expressed planarian serotonergic GPCR identifies bromocriptine as a perdurant antagonist, Int. J. Parasitol. Drugs Drug Resist., 6, 356, 10.1016/j.ijpddr.2016.06.002
Chan, 2016, A miniaturized screen of a schistosoma mansoni serotonergic G protein-coupled receptor identifies novel classes of parasite-selective inhibitors, PLoS Pathog., 12, e1005651, 10.1371/journal.ppat.1005651
El-Shehabi, 2012, A novel G protein-coupled receptor of Schistosoma mansoni (SmGPR-3) is activated by dopamine and is widely expressed in the nervous system, PLoS Negl. Trop. Dis., 6, e1523, 10.1371/journal.pntd.0001523
Farrell, 2016, In vitro and in vivo characterization of the alkaloid nuciferine, PLoS ONE, 11, e0150602, 10.1371/journal.pone.0150602
Hobson, 2006, SER-7, a Caenorhabditis elegans 5-HT7-like receptor, is essential for the 5-HT stimulation of pharyngeal pumping and egg laying, Genetics, 172, 159, 10.1534/genetics.105.044495
Lin, 2014, Anthelmintic activities of aporphine from Nelumbo nucifera Gaertn. cv. Rosa-plena against Hymenolepis nana, Int. J. Mol. Sci., 15, 3624, 10.3390/ijms15033624
MacDonald, 2015, A constitutively active G protein-coupled acetylcholine receptor regulates motility of larval Schistosoma mansoni, Mol. Biochem. Parasitol., 202, 29, 10.1016/j.molbiopara.2015.09.001
Mansour, 2016, High throughput screening identifies novel lead compounds with activity against larval, Juvenile and adult schistosoma mansoni, PLoS Negl. Trop. Dis., 10, e0004659, 10.1371/journal.pntd.0004659
Mukherjee, 2009, The sacred lotus (Nelumbo nucifera) – phytochemical and therapeutic profile, J. Pharm. Pharmacol., 61, 407, 10.1211/jpp.61.04.0001
Munusamy, 2013, Structure-based identification of aporphines with selective 5-HT(2A) receptor-binding activity, Chem. Biol. Drug Des., 81, 250, 10.1111/cbdd.12069
Neves, 2015, Natural products as leads in schistosome drug discovery, Molecules, 20, 1872, 10.3390/molecules20021872
Patocka, 2014, Serotonin signaling in Schistosoma mansoni: a serotonin-activated G protein-coupled receptor controls parasite movement, PLoS Pathog., 10, e1003878, 10.1371/journal.ppat.1003878
Paveley, 2012, Whole organism high-content screening by label-free, image-based Bayesian classification for parasitic diseases, PLoS Negl. Trop. Dis., 6, e1762, 10.1371/journal.pntd.0001762
Pax, 1996, Neuromuscular physiology and pharmacology of parasitic flatworms, Parasitology, 113, S83, 10.1017/S003118200007791X
Ponnala, 2014, Evaluation of structural effects on 5-HT(2A) receptor antagonism by aporphines: identification of a new aporphine with 5-HT(2A) antagonist activity, Bioorg. Med. Chem. Lett., 24, 1664, 10.1016/j.bmcl.2014.02.066
Ponnala, 2015, Synthesis and evaluation of aporphine analogs containing C1 allyl isosteres at the h5-HT(2A) receptor, Bioorg. Med. Chem. Lett., 25, 5102, 10.1016/j.bmcl.2015.10.012
Protasio, 2012, A systematically improved high quality genome and transcriptome of the human blood fluke Schistosoma mansoni, PLoS Negl. Trop. Dis., 6, e1455, 10.1371/journal.pntd.0001455
Ribeiro, 2005, Classical transmitters and their receptors in flatworms, Parasitology, 131, S19, 10.1017/S0031182005008565
Shen, 2015, A new golden age of natural products drug discovery, Cell, 163, 1297, 10.1016/j.cell.2015.11.031
Singh, 2016