Pharmacological modulation of astrocytes and the role of cell type-specific histone modifications for the treatment of mood disorders

Haydon, 2015, How do astrocytes participate in neural plasticity?, Cold Spring Harb Perspect Biol, 7, a020438, 10.1101/cshperspect.a020438 Di Benedetto, 2013, Targeting glia cells: novel perspectives for the treatment of neuropsychiatric diseases, Curr Neuropharmacol, 11, 171, 10.2174/1570159X11311020004 Parpura, 2000, Physiological astrocytic calcium levels stimulate glutamate release to modulate adjacent neurons, Proc Natl Acad Sci U S A, 97, 8629, 10.1073/pnas.97.15.8629 Parpura, 2012, Glial cells in (patho)physiology, J Neurochem, 121, 4, 10.1111/j.1471-4159.2012.07664.x Duman, 2012, Synaptic dysfunction in depression: potential therapeutic targets, Science, 338, 68, 10.1126/science.1222939 Lavialle, 2011, Structural plasticity of perisynaptic astrocyte processes involves ezrin and metabotropic glutamate receptors, Proc Natl Acad Sci U S A, 108, 12915, 10.1073/pnas.1100957108 Bernardinelli, 2014, Activity-dependent structural plasticity of perisynaptic astrocytic domains promotes excitatory synapse stability, Curr Biol, 24, 1679, 10.1016/j.cub.2014.06.025 Panatier, 2015, Astrocytic mGluR5 and the tripartite synapse, Neuroscience Deschwanden, 2011, Reduced metabotropic glutamate receptor 5 density in major depression determined by [(11)C]ABP688 PET and postmortem study, Am J Psychiatry, 168, 727, 10.1176/appi.ajp.2011.09111607 Ledda, 2007, GDNF and GFRalpha1 promote formation of neuronal synapses by ligand-induced cell adhesion, Nat Neurosci, 10, 293, 10.1038/nn1855 Otsuki, 2008, Altered expression of neurotrophic factors in patients with major depression, J Psychiatr Res, 42, 1145, 10.1016/j.jpsychires.2008.01.010 Di Benedetto, 2012, N-desalkylquetiapine activates ERK1/2 to induce GDNF release in C6 glioma cells: a putative cellular mechanism for quetiapine as antidepressant, Neuropharmacology, 62, 209, 10.1016/j.neuropharm.2011.07.001 Chung, 2013, Astrocytes mediate synapse elimination through MEGF10 and MERTK pathways, Nature, 504, 394, 10.1038/nature12776 Zschocke, 2011, Antidepressant drugs diversely affect autophagy pathways in astrocytes and neurons—dissociation from cholesterol homeostasis, Neuropsychopharmacology, 36, 1754, 10.1038/npp.2011.57 Di Benedetto, 2013, Talking to the synapse: how antidepressants can target glial cells to reshape brain circuits, Curr Drug Targets, 14, 1329, 10.2174/1389450111314110011 Cabezas, 2014, Astrocytic modulation of blood brain barrier: perspectives on Parkinson's disease, Front Cell Neurosci, 8, 211, 10.3389/fncel.2014.00211 Allaman, 2011, Fluoxetine regulates the expression of neurotrophic/growth factors and glucose metabolism in astrocytes, Psychopharmacology (Berl), 216, 75, 10.1007/s00213-011-2190-y Uhr, 2008, Polymorphisms in the drug transporter gene ABCB1 predict antidepressant treatment response in depression, Neuron, 57, 203, 10.1016/j.neuron.2007.11.017 Kong, 2009, Requirement of AQP4 for antidepressive efficiency of fluoxetine: implication in adult hippocampal neurogenesis, Neuropsychopharmacology, 34, 1263, 10.1038/npp.2008.185 Skucas, 2011, Impairment of select forms of spatial memory and neurotrophin-dependent synaptic plasticity by deletion of glial aquaporin-4, J Neurosci, 31, 6392, 10.1523/JNEUROSCI.6249-10.2011 Kong, 2014, Aquaporin-4 knockout exacerbates corticosterone-induced depression by inhibiting astrocyte function and hippocampal neurogenesis, CNS Neurosci Ther, 20, 391, 10.1111/cns.12222 Rajkowska, 2013, Coverage of blood vessels by astrocytic endfeet is reduced in major depressive disorder, Biol Psychiatry, 73, 613, 10.1016/j.biopsych.2012.09.024 Lopizzo, 2015, Gene-environment interaction in major depression: focus on experience-dependent biological systems, Front Psychiatry, 6, 68, 10.3389/fpsyt.2015.00068 Sun, 2013, Epigenetics of the depressed brain: role of histone acetylation and methylation, Neuropsychopharmacology, 38, 124, 10.1038/npp.2012.73 Sharma, 2008, Histone deactylase 1 expression is increased in the prefrontal cortex of schizophrenia subjects: analysis of the National Brain Databank microarray collection, Schizophr Res, 98, 111, 10.1016/j.schres.2007.09.020 Hobara, 2010, Altered gene expression of histone deacetylases in mood disorder patients, J Psychiatr Res, 44, 263, 10.1016/j.jpsychires.2009.08.015 Schroeder, 2007, Antidepressant-like effects of the histone deacetylase inhibitor, sodium butyrate, in the mouse, Biol Psychiatry, 62, 55, 10.1016/j.biopsych.2006.06.036 Covington, 2009, Antidepressant actions of histone deacetylase inhibitors, J Neurosci, 29, 11451, 10.1523/JNEUROSCI.1758-09.2009 Uchida, 2011, Epigenetic status of Gdnf in the ventral striatum determines susceptibility and adaptation to daily stressful events, Neuron, 69, 359, 10.1016/j.neuron.2010.12.023 Cruceanu, 2013, H3K4 tri-methylation in synapsin genes leads to different expression patterns in bipolar disorder and major depression, Int J Neuropsychopharmacol, 16, 289, 10.1017/S1461145712000363 Mayhew, 2015, Astrocyte and microglial control of glutamatergic signalling: a primer on understanding the disruptive role of chronic stress, J Neuroendocrinol, 27, 498, 10.1111/jne.12273 Lima, 2014, Astrocyte pathology in the prefrontal cortex impairs the cognitive function of rats, Mol Psychiatry, 19, 834, 10.1038/mp.2013.182 Sanacora, 2013, From pathophysiology to novel antidepressant drugs: glial contributions to the pathology and treatment of mood disorders, Biol Psychiatry, 73, 1172, 10.1016/j.biopsych.2013.03.032 Bessa, 2009, The mood-improving actions of antidepressants do not depend on neurogenesis but are associated with neuronal remodeling, Mol Psychiatry, 14, 764, 10.1038/mp.2008.119 Shulha, 2012, Epigenetic signatures of autism: trimethylated H3K4 landscapes in prefrontal neurons, Arch Gen Psychiatry, 69, 314, 10.1001/archgenpsychiatry.2011.151 MacDonald, 2008, Histone deacetylases 1 and 2 are expressed at distinct stages of neuro-glial development, Dev Dyn, 237, 2256, 10.1002/dvdy.21626 Zhang, 2014, An RNA-sequencing transcriptome and splicing database of glia, neurons, and vascular cells of the cerebral cortex, J Neurosci, 34, 11929, 10.1523/JNEUROSCI.1860-14.2014 Cheung, 2010, Developmental regulation and individual differences of neuronal H3K4me3 epigenomes in the prefrontal cortex, Proc Natl Acad Sci U S A, 107, 8824, 10.1073/pnas.1001702107 Jakovcevski, 2015, Neuronal Kmt2a/Mll1 histone methyltransferase is essential for prefrontal synaptic plasticity and working memory, J Neurosci, 35, 5097, 10.1523/JNEUROSCI.3004-14.2015 Sanz, 2009, Cell-type-specific isolation of ribosome-associated mRNA from complex tissues, Proc Natl Acad Sci U S A, 106, 13939, 10.1073/pnas.0907143106