Pharmacokinetics of ethanol after oral administration in the fasting state

Journal of Pharmacokinetics and Biopharmaceutics - Tập 5 Số 3 - Trang 207-224 - 1977
Paul K. Wilkinson1,2, Allen J. Sedman2, Ermelinda Sakmar2, Donald R. Kay2, John G. Wagner2
1Auburn University
2The University of Michigan

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D. R. Laurence,Clinical Pharmacology, 3rd ed., J. Churchill and A. Churchill, London, 1966, p. 283.

J. E. Finch, M. J. Kendall, and M. Mitchard. An assessment of gastric emptying by breathanalyser.Br. J. Clin. Pharmacol. 1:233–236 (1974).

W. W. Westerfeld and M. P. Schulman. Metabolism and caloric value of alcohol.J. Am. Med. Assoc. 170:197–203 (1959).

T. Chang and A. J. Glazko. Effects of ethanol on intestinal amino acid transport. In M. A. Rothschild, M. Oratz, and S. S. Schreiber (eds.),Alcohol and Abnormal Protein Bile Synthesis, Biochemical and Clincal, Pergamon Press, New York, 1975, pp. 95–110.

E. Mellanby. Alcohol and alcoholic intoxication.Br. J. Inebriety 17:157–178 (1920).

J. N. Hunt and I. Macdonald. The influence of volume on gastric emptying.J. Physiol. 126:459–474 (1954).

E. Mellanby. Alcohol; Its Absorption into and Disappearance from the Blood Under Different Conditions, Medical Research Council, Special Report Service, No. 31, HMSO, London, 1919.

H. H. Mitchell and E. G. Curzon. The food value of ethyl alcohol.J. Stud. Alcohol 1:227–245 (1940).

J. N. Hunt and J. D. Pathak. The osmotic effects of some simple molecules and ions on gastric emptying.J. Physiol. 154:254–269 (1960).

W. W. Jetter,-Studies on alcohol. II. Experimental feeding of alcohol to non alcoholic individuals.Am. J. Med. Sci. 196:487–493 (1938).

C. F. Cori, E. L. Villiaume, and G. T. Cori. Studies on intestinal absorption. II. The absorption of ethyl alcohol.J. Biol. Chem. 87:19–25 (1930).

F. R. Sidell and J. E. Pless. Ethyl alcohol: Blood levels and performance decrements after oral administration to man.Psychopharmacologia 19:246–261 (1971).

H. W. Southgate. CXIII. The effect of alcohol, under varying conditions of diet, on man and animals, with some observations on the fate of alcohol in the body.Biochem. J. 19:737–745 (1925).

L. Goldberg. Behavioral and physiological effects of alcohol on man.Psychosom. Med. 28:570–595 (1966).

E. M. Sellers, M. Lang, J. Koch-Weser, E. LeBlanc, and H. Kalant. Interaction of chloral hydrate and ethanol in man. I. Metabolism,Clin. Pharmacol. Ther. 13:37–49 (1973).

G. P. Mould, S. H. Curry, and T. B. Binns. Interaction of glutethimide and phenobarbitone with ethanol in man.J. Pharm. Pharmacol. 24:894–899 (1972).

R. N. Harger, R. B. Forney, and R. S. Baker. Estimation of the level of blood alcohol from analysis of breath. II. Use of rebreathed air.J. Stud. Alcohol 17:1–18 (1956).

M. A. Evans, R. Martz, B. E. Rodda, G. F. Kiplinger, and R. B. Forney. Quantitative relationship between blood alcohol concentration and psychomotor performance.Clin. Pharmacol. Ther. 15:253–260 (1974).

R. B. Forney, F. W. Hughes, R. N. Harger, and A. B. Richards. Alcohol distribution in the vascular system: Concentration of orally administered alcohol in blood from various points in the vascular system, and in rebreathed air, during absorption.J. Stud. Alcohol 25:205–217 (1964).

D. O. Gibbons and A. F. Lant Effects of intravenous and oral propantheline and metoclopramide on ethanol absorption.Clin. Pharmacol. Ther. 17:578–583 (1975).

H. W. Haggard, L. O. Greenberg, and L. H. Cohen. Quantitative differences in the effects of alcoholic beverages.New Engl. J. Med. 219:466–470 (1938).

J. G. Wagner and J. A. Patel. Variations in absorption and elimination rates of ethyl alcohol in a single subject.Res. Commun. Chem. Pathol. Pharmacol. 4:61–76 (1972).

A. J. Sedman. Blood levels of ethanol and a decision-making pharmacokinetic digital computer program. Ph.D. dissertation, The University of Michigan, Ann Arbor, Michigan, 1974, University Microfilms No. 7510290.

A. J. Sedman, P. K. Wilkinson, E. Sakmar, D. J. Weidler, and J. G. Wagner. Food effects on the absorption and metabolism of ethyl alcohol.J. Stud, Alcohol. 37:1197–1214 (1976).

J. G. Wagner, P. K. Wilkinson, A. J. Sedman, D. R. Kay, and D. J. Weidler. Elimination of alcohol from human blood.J. Pharm. Sci. 65:152–154 (1976).

M. G. Eggleton. Some factors affecting the metabolic rate of alcohol.J. Physiol. 98:239–254 (1940).

H. W. Newman, A. J. Lehman, and W. C. Cutting. Effect of dosage on rate of disappearance of alcohol from the blood stream.J. Pharmacol. Exp. Ther. 61:58–61 (1937).

F. Lundquist and H. Wolthers. The kinetics of alcohol elimination in man.Acte Pharmacol. Toxicol. 14:265–289 (1958).

R. D. Hawkins and H. Kalant. The metabolism of ethanol and its metabolic effects.Pharmacol. Rev. 24:67–157 (1972).

N. H. Raskin. Alcoholism or acetaldehydism.New Engl. J. Med. 292:422–423 (1975).

P. K. Wilkinson, J. G. Wagner, and A. J. Sedman. A sensitive headspace gas Chromatographic method for the determination of ethanol utilizing capillary blood samples.Anal. Chem. 47:1506–1510 (1975).

C. M. Metzler. Biostatistical Technical Report 7292/69/7292/005, Upjohn Co., Kalamazoo, Mich., November 25, 1969.

J. G. Wagner. Properties of the Michaelis-Menten equation and its integrated form which are useful in pharmacokinetics.J. Pharmacokin. Biopharm. 1:103–121 (1973).

L. Michaelis and M. L. Menten. Die Kinetik der Invertinwirkung.Biochem. Z. 49:333–369 (1913).

J. G. Wagner and E. Nelson. Percent absorbed plots derived from blood level and/or urinary excretion data.J Pharm. Sci. 52:610–611 (1963).

J. G. Wagner.Fundamentals of Clinical Pharmacokinetics, Drug Intelligence Publications, Hamilton, Ill., 1975, p. 200.

J. N. Hunt. The site of receptors slowing gastric emptying in response to starch in test meals.J. Physiol. 154:270–276 (1960).

E. Elias, G. J. Gibson, L. F. Greenwood, J. N. Hunt, and J. H. Tripp. The slowing of gastric emptying by monosaccharides and disaccharides in test meals.J. Physiol. 194:317–326 (1968).

P. K. Wilkinson, A. J. Sedman, E. Sakmar, R. H. Earhart, D. J. Weidler, and J. G. Wagner. Blood ethanol concentrations during and following constant rate intravenous infusion of alcohol in man.Clin. Pharmacol Ther. 19:213–223 (1976).

P. L. Altmen and D. S. Dittmer (eds.).Blood and Other Body Fluids, Federation of American Societies for Experimental Biology, Bethesda, Md., 1971, pp. 496–497.

A. R. Cooke and A. Birchall. Absorption of ethanol from the stomach.Gastroenterology 57:269–272 (1969).

A. J. Sedman, P. K. Wilkinson, and J. G. Wagner. Concentrations of ethanol in two segments of the vascular system.J. Forensic Sci. 21:315–322 (1976).