Pharmacokinetics of N-acetylcysteine in man

Sheffner AL (1983) The reduction in vitro in viscosity of mucoprotein solutions by a new mucolytic agent N-acetyl-L-cysteine. Ann NY Acad Sci 106: 298?310

Prescott LF, Illingworth RN, Critchley JAJH, Stewart MJ, Adam RD, Proudfoot AT (1979) Intravenous N-acetylcysteine: The treatment of choice for paracetamol poisoning. Br Med J 2: 1097?1100

Myers C, Bonow R, Palmeri S, Jenkins J, Corden B, Locker G, Doroshow J, Epstein S (1983) A randomized controlled trial assessing the prevention of doxorubicin cardiomyopathy by N-Acetylcysteine. Semin Oncol 10 [Suppl 1]: 53?55

Holoye PY, Duelge J, Hansen RM, Anderson T (1983) Prophylaxis, of ifosfamide toxicity with oral acetylcysteine. Semin Oncol 10 [Suppl 1]: 66?71

Botta JA, Nelson LW, Wieker JH Jr (1973) Acetylcysteine in the prevention of cyclophosphamide-induced cystitis in rats. J Natl Cancer Inst 51: 1051?1058

Grassi C, Morandi GC (1976) A controlled trial of intermittent oral acetylcysteine in the long-term treatment of chronic bronchitis. Eur J Clin Pharmacol 9: 393?396

Lemy-Debois N, Frigerio G, Lualdi P (1978) Oral acetylcysteine in bronchopulmonary disease. Comparative clinical trial with bromhexine. Acta Therapeut 4: 125?132

Multicenter Study Group (1980) Long-term oral acetylcysteine in chronic bronchitis. A double-blind controlled study. Eur J Respir Dis 61 [Suppl 111]: 93?108

Boman G, Bäcker U, Larsson S, Melander B, Wåhlinder L (1983) Oral acetylcysteine reduces exacerbation rates in chronic bronchitis: Report of a trial organized by the Swedish Society for Pulmonary Diseases. Eur J Respir Dis 64: 405?415

Rodenstein D, De Coster A, Gazzaniga A (1978) Pharmacokinetics of oral acetylcysteine: Absorption, binding and metabolism in patients with respiratory disorders. Clin Pharmacokinet 3: 247?254

Maddock J (1980) Biological properties of acetylcysteine: Assay development and pharmacokinetic studies. Eur J Respir Dis 61 [Suppl 111]: 52?58

Morgan LR, Holdiness MR, Gillen LE (1983) N-Acetylcysteine: Its bioavailability and interaction with ifosfamide metabolites. Semin Oncol 10 [Suppl 1]: 56?61

Frank H, Thiel D, Langer K (1984) Determination of N-acetyl-L-cysteine in biological fluids. J Chromatogr 309: 261?267

Kågedal B, Källberg M, Mårtensson J (1984) Determination of non-protein-bound N-acetylcysteine in plasma by high-performance liquid chromatography. J Chromatogr 311: 170?175

Lewis PA, Woodward AJ, Maddock J (1984) High-performance liquid chromatographic assay for N-acetylcysteine in plasma and urine. J Pharm Sci 73 [7]: 996?998

Borgström L, Johansson C-G, Larsson H, Lenander R (1981) Pharmacokinetics of bendroflumethiazide after low oral doses. J Pharmacokinet Biopharmaceut 9 [4]: 431?441

Kågedal B, Källberg M (1982) Reversed-phase ion-pair high-performance liquid chromatography of mercaptoacetate and N-acetylcysteine after derivatization with N-(1-pyrene)maleimide and N-(7-methylamino-4-methyl-3-coumarinyl)-maleimide. J Chromatogr 229: 409?415

Krenzelok EP, North DS, Peterson RG (1980) The effect of activated charcoal administration on N-acetylcysteine serum levels in human subjects. Vet Hum Toxicol 22 [Suppl 2]: 56?58

Rowland M, Tozer TN (1980) Clinical pharmacokinetics concepts and applications. Lea & Febiger, Philadelphia, p 50

Rowland M, Tozer TN (1980) Clinical pharmacokinetics concepts and applications. Lea & Febiger, Philadelphia, p 149

Bonanomi L, Gazzaniga A (1980) Toxicological, pharmacokinetic and metabolic studies on acetylcysteine. Eur J Respir Dis 61 [Suppl 111]: 45?51

Sheffner AL, Medler EM, Baily KR, Gallo DG, Mueller AJ, Sarett HP (1966) Metabolic studies with acetylcysteine. Biochem Pharmacol 15: 1523?1535

Lauterburg BH, Corcoran GB, Mitchell JR (1983) Mechanism of action of N-acetylcysteine in the protection against the hepatotoxicity of acetaminophen in rats in vivo. J Clin Invest 71: 980?991

Grassi C, Morandini GC, Frigerio G (1973) Clinical evaluation of systemic acetylcysteine by different routes of administration. Curr Ther Res 15: 165?179