Đánh giá Dược động học của Các Phân Bổ Thuốc Điều Trị Động Kinh Dạng Phóng Thích Từ Từ

Springer Science and Business Media LLC - Tập 22 - Trang 11-21 - 2012
Meir Bialer1
1Department of Pharmacy, School of Pharmacy, Hebrew University of Jerusalem, Jerusalem, Israel

Tóm tắt

Động kinh là một bệnh mãn tính yêu cầu điều trị lâu dài, và hầu hết các loại thuốc chống động kinh đã được xác lập (trừ phenobarbital) phải được sử dụng nhiều lần trong ngày. Điều này dẫn đến các vấn đề về tuân thủ và biến động nồng độ trong huyết tương, có thể dẫn đến các mức độ dưới điều trị và tiềm năng độc hại. Việc phát triển các dạng chế phẩm phóng thích kéo dài của các tác nhân chống động kinh hiện có có thể cải thiện liệu pháp chống động kinh. Hiện tại, chỉ có 4 loại thuốc chính sau đây được sử dụng để điều trị động kinh: phenobarbital, phenytoin, carbamazepine và axit valproic. Trong số đó, chỉ có 2 loại cuối là ứng cử viên phù hợp cho các dạng chế phẩm phóng thích kéo dài. Do đó, bài đánh giá này tập trung vào việc đánh giá và các tác động lâm sàng của các dạng chế phẩm phóng thích kéo dài của axit valproic và carbamazepine.

Từ khóa

#Động kinh #thuốc chống động kinh #phóng thích kéo dài #phenobarbital #phenytoin #carbamazepine #axit valproic

Tài liệu tham khảo

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