Pharmacogenomics of drug resistance in Breast Cancer Resistance Protein (BCRP) and its mutated variants

Aronica, 2005, Localization of breast cancer resistance protein (BCRP) in microvessel endothelium of human control and epileptic brain, Epilepsia, 46, 849, 10.1111/j.1528-1167.2005.66604.x Rosenberg, 2010, The human breast cancer resistance protein (BCRP/ABCG2) shows conformational changes with mitoxantrone, Structure, 18, 482, 10.1016/j.str.2010.01.017 Nakanishi, 2003, Functional characterization of human breast cancer resistance protein (BCRP, ABCG2) expressed in the oocytes of Xenopus laevis, Mol Pharmacol, 64, 1452, 10.1124/mol.64.6.1452 Ni, 2010, Structure and function of the human breast cancer resistance protein (BCRP/ABCG2), Curr Drug Metab, 11, 603, 10.2174/138920010792927325 Boeckmann, 2003, The SWISS-PROT protein knowledgebase and its supplement TrEMBL in 2003, Nucleic Acids Res, 31, 365, 10.1093/nar/gkg095 Nayarisseri, 2013, In silico investigations on HSP90 and its inhibition for the therapeutic prevention of breast cancer, J Pharm Res, 7, 150, 10.1016/j.jopr.2013.02.020 Rose, 2011, The RCSB Protein Data Bank: redesigned web site and web services, Nucleic Acids Res, 39, D392, 10.1093/nar/gkq1021 Chen, 2003, A tweezers-like motion of the ATP-binding cassette dimer in an ABC transport cycle, Mol Cell, 12, 651, 10.1016/j.molcel.2003.08.004 Dawson, 2006, Structure of a bacterial multidrug ABC transporter, Nature, 443, 180, 10.1038/nature05155 Eswar, 2006, Comparative protein structure modeling with MODELLER, Curr Protoc Bioinformatics, 15, 1, 10.1002/0471250953.bi0506s15 Marti-Renom, 2000, Comparative protein structure modeling of genes and genomes, Annu Rev Biophys Biomol Struct, 29, 291, 10.1146/annurev.biophys.29.1.291 Sali, 1993, Comparative protein modelling by satisfaction of spatial restraints, J Mol Biol, 234, 779, 10.1006/jmbi.1993.1626 Fiser, 2000, Modeling of loops in protein structures, Protein Sci, 9, 1753, 10.1110/ps.9.9.1753 Carter, 2003, DSSPcont: continuous secondary structure assignments for proteins, Nucleic Acids Res, 31, 3293, 10.1093/nar/gkg626 McGuffin, 2000, The PSIPRED protein structure prediction server, Bioinformatics, 16, 404, 10.1093/bioinformatics/16.4.404 Ramachandran, 1963, Stereochemistry of polypeptide chain configurations, J Mol Biol, 7, 95, 10.1016/S0022-2836(63)80023-6 Laskowski, 1996, AQUA and PROCHECK-NMR: programs for checking the quality of protein structures solved by NMR, J Biomol NMR, 8, 477, 10.1007/BF00228148 Tamura, 2006, Functional validation of the genetic polymorphisms of human ATP-binding cassette (ABC) transporter ABCG2: identification of alleles that are defective in porphyrin transport, Mol Pharmacol, 70, 287, 10.1124/mol.106.023556 Austin Doyle, 2003, Multidrug resistance mediated by the breast cancer resistance protein BCRP (ABCG2), Oncogene, 22, 7340, 10.1038/sj.onc.1206938 Adzhubei, 2010, A method and server for predicting damaging missense mutations, Nat Methods, 7, 248, 10.1038/nmeth0410-248 Adzhubei, 2013, Predicting functional effect of human missense mutations using PolyPhen-2, Curr Protoc Hum Genet, 10.1002/0471142905.hg0720s76 Prokop, 2008, TRITON: a graphical tool for ligand-binding protein engineering, Bioinformatics, 24, 1955, 10.1093/bioinformatics/btn344