Pharmaceutical properties of 'sucupira' (Pterodon spp.)

Brazilian Journal of Pharmaceutical Sciences - Tập 46 Số 4 - Trang 607-616 - 2010
Daiane Hansen1, Mitsue Haraguchi2, Antônio Alonso3
1University Federal of Goiás; Biological Institute of São Paulo
2Biological Institute of São Paulo
3University Federal of Goiás

Tóm tắt

The plant of the genus Pterodon (Fabaceae, Leguminosae), commonly known as 'sucupira' or 'faveira', are disseminated throughout the central region of Brazil and has frequently been used in popular medicine for its anti-rheumatic, analgesic, and anti-inflammatory properties. In recent years, interest in these plants has increased considerably. The biological effects of different phytoextracts and pure metabolites have been investigated in several experimental models in vivo and in vitro. The literature describes flavonoids, triterpene and steroids, while one paper presented studies with proteins isolated from the genus. This review provides an overview of phytochemical and pharmacological research in Pterodon, showing the main chemical compounds studied to date, and focusing on the relationship between these molecules and their biological activity. Furthermore, this study paves the way for more in-depth investigation, isolation and characterization of the molecules of this plant genus.

Từ khóa


Tài liệu tham khảo

ALMEIDA M.E.L, 1975, Further isoflavones, Pterodon apparicioi. Phytochemistry, 14, 2716, 10.1016/0031-9422(75)85263-0

ARAÚJO A.P.U, 2005, Kunitz type Bauhinia bauhinioides inhibitors devoid of disulfide bridges: isolation of the cDNAs, heterologous expression and structural studies, Biol. Chem, 386, 561

ARRIAGA A.M.C, 2000, Further diterpenoids isolated from Pterodon polygalaeflorus, J. Braz. Chem. Soc.,, 11, 187, 10.1590/S0103-50532000000200015

BASSO L.A, 2005, The use of biodiversity as source of new chemical entities against defined molecular targets for treatment of malaria, tuberculosis, and T-cell mediated diseases- a review, Mem. Inst. Oswaldo Cruz, 100, 575, 10.1590/S0074-02762005000600001

BRAZ FILHO R, Chemistry of Brazilian Leguminosae, XXXIV Isoflavones of Pterodon pubescens. Phytochemistry, 10, 2835

CALIXTO N.O, 2007, Antiplatelet activity of geranylgeraniol isolated from Pterodon pubescens fruit oil is mediated by inhibition of cyclooxigenase-1, Planta Med, 73, 480, 10.1055/s-2007-967177

CAMPOS A.M, 1994, Diterpenoids from Pterodon polygalaeflorus, Phytochemistry, 36, 403, 10.1016/S0031-9422(00)97084-5

CARDOSO C.C, 2008, Suppression of T and B cell responses by Pterodon pubescens seeds ethanolic extract, Pak. J. Biol. Sci, 11, 2308, 10.3923/pjbs.2008.2308.2313

CARVALHO J.C.T, 1999, Anti-inflammatory activity of the crude extract from the fruits of Pterodon emarginatus Vog, J. Ethnopharmacol, 64, 127, 10.1016/S0378-8741(98)00116-0

CARVALHO J.C.T., 2004, Sucupira, Pterodon emarginatus Vog, 383

COELHO M.G.P, 2001, Subacute toxicity evaluation of a hydroalcoholic extract of Pterodon pubescens seeds in mice with collagen-induced arthritis, J. Ethnopharmacol, 77, 159, 10.1016/S0378-8741(01)00288-4

COELHO M.G, 2004, Immunomodulatory effects of sucupira (Pterodon pubescens) seed infusion on collagen-induced arthritis, Clin. Exp. Rheumatol, 22, 213

COELHO L.P, 2005, Anti-nociceptive properties of ethanolic extract and fractions of Pterodon pubescens Benth. seeds, J. Ethnopharmacol, 98, 109, 10.1016/j.jep.2005.01.014

DE OMENA M.C, 2006, Larvicidal diterpenes from Pterodon polygalaeflorus, Vector Borne Zoonotic Dis, 6, 216, 10.1089/vbz.2006.6.216

DEMUNER A.J, 1996, Structure and plant growth regulatory activity of new diterpenes from Pterodon polygalaeflorus, J.Nat.Prod, 59, 770, 10.1021/np960140f

DIAS F. D, 1995, Genotoxicity of the natural cercaricides "sucupira" oil and eremanthine in mammalian cells in vitro and in vivo, Environ. Mol. Mutagen, 26, 338, 10.1002/em.2850260410

DOS SANTOS FILHO D, 1987, Chemoprophylactic activity of soaps containing essential oil from the fruits of Pterodon pubescens in Schistosomiasis mansoni, Mem. Inst. Oswaldo Cruz, 82, 343

DOS SANTOS FILHO D, 1972, Prophylaxis of Schistosomiaris: Diterpenes from Pterodon pubescens, An. Acad. Bras. Ciênc, 44, 45

DUARTE I.D.G, Possible participation of endogenous opioid peptides on the mechanism involved in analgesia induced by vouacapan, Life Sci, 50, 1992

DUARTE I.D, 1996, Evidence of the involvement of biogenic amines in the anti-nociceptive effect of a vouacapan extracted from Pterodon polygalaeflorus Benth, J. Ethnopharmacol, 55, 13, 10.1016/S0378-8741(96)01465-1

DUTRA R.C, 2008, Anti-nociceptive activity of the essential oil and fractions of Pterodon emarginatus Vogel seeds, Lat. Am. J. Pharm, 27, 865

DUTRA R.C, 2008, Quantification of Phenolic Constituents and Antioxidant Activity of Pterodon emarginatus Vogel seeds, Int. J. Mol. Sci., 9, 606, 10.3390/ijms9040606

DUTRA R.C, 2009, Antimicrobial and leishmanicidal activities of seeds of Pterodon emarginatus, Braz. J. Pharmacogn, 19, 429, 10.1590/S0102-695X2009000300016

DUTRA R.C, 2009, Antiulcerogenic and anti-inflammatory activities of the essential oil from Pterodon emarginatus seeds, J. Pharm. Pharmacol, 61, 243, 10.1211/jpp.61.02.0015

DUTRA R.C, 2009, Healing effect of Pterodon emarginatus seeds in experimental models of cutaneous ulcers in rabbits, Lat. Am. J. Pharm, 28, 375

EUZEBIO F.P.G, 2009, Effect of6α, 7β-dihydroxyvouacapan-17β-oic acid and its lactone derivatives on the growth of human cancer cells., Bioorg. Chem, 37, 96, 10.1016/j.bioorg.2009.03.004

EVANGELISTA G.L, 2007, Essential oil of Pterodon polygalaeflorus inhibits electromechanical coupling on rat isolated trachea, J. Ethnopharmacol, 109, 515, 10.1016/j.jep.2006.08.028

FASCIO M, 1970, Two new diterpenes from Pterodon pubescens, An. Acad. Bras. Ciênc, 97

FASCIO M, 1975, Diterpenoid furans from Pterodon species, Phytochemistry, 15, 201, 10.1016/S0031-9422(00)89084-6

GALINA E, 1974, Chemistry of Brazilian Leguminosae: XLVI Isoflavones from Pterodon appariciori, Phytochemistry, 13, 2593, 10.1016/S0031-9422(00)86942-3

HANSEN D, 2007, Crystal structure of a novel cysteinless plant Kunitz-type protease inhibitor, Biochem. Biophys. Res. Commun, 360, 735, 10.1016/j.bbrc.2007.06.144

KATZ N, 1993, Chemoprophylactic activity on Schistosomiasis mansoni of soaps containing essential oil from the fruits of Pterodon pubescens, Rev. Inst. Med. Trop, 35, 183

LEAL L.K, 2000, Anti-nociceptive, anti-inflammatory and bronchodilator activities of Brazilian medicinal plants containing coumarin: a comparative study, J. Ethnopharmacol, 70, 151, 10.1016/S0378-8741(99)00165-8

LEONHARDT V, 2010, 749

MAHAJAN J.R, 1970, New diterpenoids from Pterodon emarginatus, An. Acad. Bras. Ciênc, 42, 103

MAHAJAN J.R, 1972, New diterpenoids from Pterodon emarginatus, An. Acad. Bras. Ciênc, 44, 51

MAHAJAN J.R, 1973, New diterpenoids from Pterodon emarginatus, J. Chem. Soc. Perkin Trans.I, 520, 10.1039/p19730000520

MARQUES D.D, 1998, Isoflavonoids and triterpenoids isolated from Pterodon polygalaeflorus, J. Braz. Chem. Soc, 9, 295, 10.1590/S0103-50531998000300014

MENNA-BARRETO R.F.S, 2008, Anti-Trypanosoma cruzi activity of Pterodon pubescens seed oil: geranylgeraniol as the major bioactive component, Parasitol. Res., 103, 111, 10.1007/s00436-008-0937-0

MORAES W.F, 2009, Anti-inflammatory and anti-nociceptive effects of Pterodon emarginatus stem bark alcohol extract, Pharm. Biol, 47, 146, 10.1080/13880200802436117

MORS W.B, 1966, Ação profilática do óleo dos frutos de Sucupira-Branca, Pterodon pubescens Benth, contra a infecção pelo Schistosoma mansoni., An. Acad. Bras. Ciênc, 325

MORS W.B, 1967, Chemoprophyloactic agent in schistosomiasis: 14,15-epoxygeranylgeraniol., Science, 157, 950, 10.1126/science.157.3791.950

NETO J.J, 1976, Contribuição ao Estudo Farmacognóstico dos frutos de Pterodon pubescens Bentham: Parte III- Identificação cromatográfica em fase gasosa, química e ação microbiológica do óleo do fruto, Rev. Fac. Farm. Odontol., Araraquara, 10, 317

NUNAN E.A, 1982, Furane diterpenes with anti- and pro-inflammatory activity, Rev. Bras. Pesq. Med. Biol, 15, 450

OLIVEIRA D.M.T, 2005, Anatomy and Ontogeny of Pterodon emarginatus (FABACEAE: FABOIDEAE) Seed, Braz. J. Biol., 65, 483, 10.1590/S1519-69842005000300014

PIMENTA A.T.A, 2006, Estudo fitoquímico e avaliação da atividade larvicida de Pterodon polygalaeflorus Benth (Leguminosae) sobre Aedes aegypti, Rev. Bras. Farm, 16, 501, 10.1590/S0102-695X2006000400011

SABINO K.C, 1999, vitro and in vivo toxicological study of the Pterodon pubescens seed oil, Toxicol. Lett, 108, 27, 10.1016/S0378-4274(99)00110-1

SABINO K.C, 1999, Successful treatment of collagen-induced arthritis in mice with a hydroalcohol extract of seeds of Pterodon pubescens, Phytother. Res, 13, 613, 10.1002/(SICI)1099-1573(199911)13:7<613::AID-PTR503>3.0.CO;2-D

SANTOS FILHO D, 1969, Prophylaxis of Schistosoma by the fruit oil of Pterodon pubescens Benth. [Profilaxia de esquistossomose pelo óleo de Pterodon pubescens Benth: Dois novos diterpenos]., Bol. Fac. Farm. Odontol. Ribeirão Preto, 6, 142

SILVA M.C, 2004, Acute and topic anti-edematogenic fractions isolated from the seeds of Pterodon pubescens, J. Pharm. Pharmacol, 56, 135, 10.1211/0022357022485

SILVA D.P, 2007, . Identification of an α-Amylase Inhibitor from Pterodon pubescens with Ability To Inhibit Cowpea Weevil Digestive Enzymes., J. Agric. Food Chem., 55, 4382, 10.1021/jf0637628

SPINDOLA H.M, 2009, Furanoditerpenes from Pterodon pubescens Benth with selective in vitro anticancer activity for prostate cell line, J.Braz.Chem. Soc., 20, 569, 10.1590/S0103-50532009000300024

SUÁREZ G.R, 1980, Depósito de taninos en la testa de Amaranthus hypochondriacus L. (alegria), Agrociencia, 42, 35

TORRENEGRA R, 1989, Homoormosanine-Type Alkaloids from Bowdichia Virgiloides, Phytochemistry, 28, 2219, 10.1016/S0031-9422(00)97953-6

VIEIRA C.R, 2008, Antiproliferative activity of Pterodon pubescens Benth. seed oil and its active principle on human melanoma cells, Phytomedicine, 15, 528, 10.1016/j.phymed.2007.08.003