Pertussis vaccine-induced experimental autoimmune encephalomyelitis in mice
Tóm tắt
A small dose of the Bordetella pertussis vaccine is used as an adjuvant for the induction of experimental autoimmune encephalomyelitis (EAE) in mice. The effects of two doses of the Pertussis vaccine on clinical signs, antibody titers, and the expression of CD4 and MHC molecules in brain tissue sections of mice with EAE were examined. EAE was induced by spinal cord homogenate in Complete Freund adjuvant (CFA) in 30 of 40 C57BL/6 mice divided in groups: EAE mice with a small adjuvant dose of the Pertussis vaccine (EAE-1), EAE mice with a human dose of the Pertussis vaccine (EAE-2), EAE mice (EAE-3). None of the mice from the EAE groups progressed to severe EAE. Five mice from the EAE-2 group were found dead on the 13th day post-immunization. A significant increase of anti-MOG (myelin oligodendrocyte glycoprotein) antibodies was detected in mice with EAE compared to non-treated mice. Myelin loss and brain tissue lesions were observed in EAE-1 and EAE-2 mice compared to EAE-3 and non-treated mice. A high expression of MHC-II and a mild expression of MHC-I was detected in the brains of mice with EAE. No expressions were detected in intact brains. Scattered CD4-positive cells were detected in the brains of EAE-1 and EAE-2 mice compared to EAE-3 and non-treated mice. A small dose of the Bordetella pertussis vaccine could maintain the developed clinical signs and histological changes in mice with EAE, while higher doses led to additional adverse effects. The expression of CD4 and MHC class I and II molecules, as well as an increase in anti-MOG antibodies could be used as markers capable of monitoring the development and progression of EAE.
Tài liệu tham khảo
Toplak N., Avcin T., Influenza and autoimmunity, Ann. NY Acad. Sci., 2009, 1173, 619–629
Shoenfeld Y., Aron-Maor A., Vaccination and autoimmunity — ‘Vaccinosis’ a dangerous liaison?, J. Autoimmun., 2000, 14, 1–10
Weber M.S., Benkhoucha M., Lehmann-Horn K., Hertzenberg D., Sellner J., Santiago-Raber M.L., et al., Repetitive pertussis toxin promotes development of regulatory T cells and prevents central nervous system autoimmune disease, PLoS One, 2010, 5, e16009
Carrizosa A.M., Nicholson L., Farzan M., Southwood S., Sette A., Sobel R.A., et al., Expansion of self antigen is necessary for the induction of experimental autoimmune encephalomyelitis by T cells primed with a cross-reactive enviromental antigen, J. Immunol., 1998, 161, 3307–3314
Sakuma H., Kohyama K., Park I., Miyakoshi A., Tanuma N., Matsumoto Y., Clinicopathological study of a myelin oligodendrocyte glycoprotein-induced demyelinating disease in LEW.1AV1 rats, Brain, 2004, 127, 2201–2213
Brückener K.E., el Bayâ A., Galla H.J., Schmidt M.A., Permeabilization in a cerebral endothelial barrier model by pertussis toxin involves the PKC effector pathway and is abolished by elevated levels of cAMP, J. Cell. Sci., 2003, 116, 1837–1846
Frei K., Eugster H., Bopst M., Constantinescu C.S., Lavi E., Fontana A., Tumor necrosis factor α and lymphotoxin α are not required for induction of acute experimental autoimmune encephalomyelitis, J. Exp. Med., 1997, 185, 2177–2182
Cua D.J., Hutchins B., LaFace D.M., Stohlman S.A., Coffman R.L., Central nervous system expression IL-10 inhibits autoimmune encephalomyelitis, J. Immunol., 2001, 166, 602–608
Donnelly S., Loscher C.E., Lynch M.A., Mills K.H.G., Whole-cell but not acellular pertussis vaccine induce convulsive activity in mice: evidence of a role for toxin-induced interleukin-1b in a new murine model for analysis of neuronal side effects of vaccination, Infect. Immun., 2001, 69, 4217–4223
Hickey W.F., Migration of hematogenous cells through the bloodbrain barrier and the initiation of CNS inflammation, Brain. Pathol., 1991, 1, 97–105
Brabb T., von Dassow P., Ordonez N., Schnabel B., Duke B., Goverman J., In situ tolerance within the central nervous system as a mechanism for preventing autoimmunity, J. Exp. Med., 2000, 192, 871–880
Stampachiacchiere B., Aloe L., Differential modulatory effect of NGF on MHC class I and class II expression in spinal cord cells of EAE rats, J. Neuroimmunol., 2005, 169, 20–30
Bö L., Mörk S., Kong P., Nyland H., Pardo C.A., Trapp B.D., Detection of MHC class II-antigens on macrophages and microglia, but not on astrocytes and endothelia in active multiplesclerosis lessions, J. Neuroimmunol., 1994, 51, 135–46
Greter M., Heppner F.L., Lemos M.P., Odermatt B.M., Goebels N., Laufer T., et al., Dendritic cells permit immune invasion of the CNS in an animal model of multiple sclerosis, Nat. Med., 2005, 11, 328–334
Lalive P.H., Auto antibodies in inflammatory demyelinating diseases of the central nervous system, Swiss Med. Wkly., 2008, 138, 692–707
Lalive P.H., Molnarfi N., Benkhoucha M., Weber M.S., Santiago-Raber M., Antibody response in MOG(35-55) induced EAE, J. Neuroimmunol., 2011, 240–241, 28–33
Lyons J.A., Ramsbottom M.J., Cross A.H., Critical role of antigenspecific antibody in experimental autoimmune encephalomyelitis induced by recombinant myelin oligodendrocyte glycoprotein, Eur. J. Immunol., 2002, 32, 1905–13
Mills K.H.G., Ryan M., Ryan E., Mahon B.P., A murine model in which protection correlates with pertussis vaccine efficacy inchildren reveals complementary roles for humoral and cell-mediated immunity in protection against Bordetella pertussis, Infect. Immun., 1998, 66, 594–602
Voller A., Bidwell D., Bartlett A., Enzyme immunoassays in diagnostic medicine. Theory and practice, Bull. World Health Organ., 1976, 53, 55–65
Stevanovic I., Ninkovic M., Stojanovic I., Ljubisavljevic S., Stojnev S., Bokonjic D., Beneficial effect of agmatine in the acute phase of experimental autoimmune encephalomyelitis in iNOS-/- knockout mice, Chem. Biol. Interact., 2013, 206, 309–318
Amiel S.A., The effects of Bordetella pertussis vaccine on cerebral vascular permeability, Br. J. Exp. Path., 1976, 57, 653–662
Steinman L., Weiss A., Adelman N., Lim M., Oehlert J., Zuniga R., et al., Murine model for pertussis vaccine encephalopathy: role of the major histocompatibility complex; antibody to albumin and to Bordetella pertussis and pertussis toxin, Dev. Biol. Stand., 1985, 61, 439–446
Flexner S., Postvaccinal encephalitis and allied conditions, JAMA, 1930, 94, 305–311
Ziemssen T., Ziemssen F., The role of the humoral immune system in multiple sclerosis (MS) and its animal model experimental autoimmune encephalomyelitis (EAE), Autoimmun. Rev., 2005, 4, 460–467
Quintana F.J., Cohen I.R., Autoantibody patterns in diabetes-prone NOD mice and in standard C57BL/6 mice, J. Autoimmun. 2001, 17, 191–197
Brunner C., Lassmann H., Waehneldt T.V., Matthieu J., Linington C., Differential ultrastructural localization of myelin basic protein, myelin/oligodendroglial glycoprotein, and 2′,3′-cyclic nucleotide 3′-phosphodiesterase in the CNS of adult rats, J. Neurochemistry, 1989, 52, 296–304
Linington C., Bradl M., Lassmann H., Brunner C., Vass K., Augmentation of demyelination in rat acute allergic encephalomyelitis by circulating mouse monoclonal antibodies directed against a myelin/oligodendrocyte glycoprotein, Am. J. Pathol., 1988, 130, 443–454
Schluesener H.J., Sobel R.A., Linington C., Weiner H.L., A monoclonal antibody against a myelin oligodendrocyte glycoprotein induces relapses and demyelination in central nervous system autoimmune disease, J. Immunol. 1987, 139, 4016–4021
Almolda B., Costa M., Montoya M., Gonzalez B., Castellano B., CD4 microglial expression correlates with spontaneous clinical improvement in the acute Lewis rat EAE model, J. Neuroimmunol., 2009, 209, 65–80
Heppner F.L., Greter M., Marino D., Falsig J., Raivich G., Hovelmeyer N., et al., Experimental autoimmune encephalomyelitis repressed by microglial paralysis, Nat. Med., 2005, 11, 146–152
Carson M.J., Bilousova T.V., Puntambekar S.S., Melchior B., Doose J.M., Ethell I.M., A rose by any other name? The potential consequences of microglial heterogeneity during CNS health and disease, Neurotherapeutics, 2007, 4, 571–579
Almolda B., Gonzalez B., Castellano B., Activated microglial cells acquire an immature dendritic cell phenotype and may terminate the immune response in an acute model of EAE, J. Neuroimmunol., 2010, 223, 39–54
Stojkovic A., Kosanovic D., Maslovaric I., Jovanova-Nesic K., Role of inactivated influenza vaccine in regulation of experimental autoimmune encephalomyelitis, Int. J. Neurosci., 2014, 124, 139–147
Höftberger R., Aboul-Enein F., Brueck W., Lucchinetti C., Rodriguez M., Schmidbauer M., et al., Expression of major histocompatibility complex class I molecules on the different cell types in multiple sclerosis lesions, Brain. Pathol., 2004, 14, 43–50
Horwitz M.S., Evans C.F., Klier F.G., Oldstone M.B., Detailed in vivo analysis of interferon-gamma induced major histocompatibility complex expression in the the central nervous system: astrocytes fail to express major histocompatibility complex class I and II molecules, Lab. Invest., 1999, 79, 235–242
Neumann H., Cavalie A., Jenne D.E., Wekerle H., Induction of MHC class I genes in neurons, Science, 1995, 269, 549–552
Neumann H., Medana I.M., Bauer J., Lassmann H., Cytotoxic T lymphocytes in autoimmune and degenerative CNS diseases, Trends Neurosci., 2002, 25, 313–319