Persulfidation of transcription factor FOXO1 at cysteine 457: A novel mechanism by which H2S inhibits vascular smooth muscle cell proliferation

Gibbons, 1994, The emerging concept of vascular remodeling, N Engl J Med, 330, 1431, 10.1056/NEJM199405193302008 Tang, 2006, Hydrogen sulfide as a new endogenous gaseous transmitter in the cardiovascular system, Curr Vasc Pharmacol, 4, 17, 10.2174/157016106775203144 Jha, 2008, Hydrogen sulfide attenuates hepatic ischemia-reperfusion injury: role of antioxidant and antiapoptotic signaling, Am J Physiol Heart Circ Physiol, 295, H801, 10.1152/ajpheart.00377.2008 Yang, 2010, Cystathionine gamma-lyase deficiency and overproliferation of smooth muscle cells, Cardiovasc Res, 86, 487, 10.1093/cvr/cvp420 Liu, 2018, Hydrogen sulfide attenuates myocardial fibrosis in diabetic rats through the JAK/STAT signaling pathway, Int J Mol Med, 41, 1867 Yang, 2008, H2S as a physiologic vasorelaxant: hypertension in mice with deletion of cystathionine gamma-lyase, Science, 322, 587, 10.1126/science.1162667 Du, 2004, The possible role of hydrogen sulfide as a smooth muscle cell proliferation inhibitor in rat cultured cells, Heart Vessels, 19, 75, 10.1007/s00380-003-0743-7 Li, 2014, H2S inhibition of chemical hypoxia-induced proliferation of HPASMCs is mediated by the upregulation of COX-2/PGI2, Int J Mol Med, 33, 359, 10.3892/ijmm.2013.1579 Tran, 2002, DNA repair pathway stimulated by the forkhead transcription factor FOXO3a through the Gadd45 protein, Science, 296, 530, 10.1126/science.1068712 Seoane, 2004, Integration of Smad and forkhead pathways in the control of neuroepithelial and glioblastoma cell proliferation, Cell, 117, 211, 10.1016/S0092-8674(04)00298-3 Dijkers, 2000, Expression of the pro-apoptotic Bcl-2 family member Bim is regulated by the forkhead transcription factor FKHR-L1, Curr Biol, 10, 1201, 10.1016/S0960-9822(00)00728-4 Nemoto, 2002, Redox regulation of forkhead proteins through a p66shc-dependent signaling pathway, Science, 295, 2450, 10.1126/science.1069004 Wilhelm, 2016, FOXO1 couples metabolic activity and growth state in the vascular endothelium, Nature, 529, 216, 10.1038/nature16498 Sun, 2015, Hydrogen sulfide upregulates KATP channel expression in vascular smooth muscle cells of spontaneously hypertensive rats, J Mol Med (Berl), 93, 439, 10.1007/s00109-014-1227-1 Majumder, 2019, Hydrogen sulphide mitigates homocysteine-induced apoptosis and matrix remodelling in mesangial cells through Akt/FOXO1 signalling cascade, Cell Signal, 61, 66, 10.1016/j.cellsig.2019.05.003 Savai, 2014, Pro-proliferative and inflammatory signaling converge on FoxO1 transcription factor in pulmonary hypertension, Nat Med, 20, 1289, 10.1038/nm.3695 Siqueira, 2011, FOXO1 modulates osteoblast differentiation, Bone, 48, 1043, 10.1016/j.bone.2011.01.019 Zhang, 2018, The increased endogenous sulfur dioxide acts as a compensatory mechanism for the downregulated endogenous hydrogen sulfide pathway in the endothelial cell inflammation, Front Immunol, 9, 882, 10.3389/fimmu.2018.00882 Du, 2014, Hydrogen sulfide suppresses oxidized low-density lipoprotein (ox-LDL)-stimulated monocyte chemoattractant protein 1 generation from macrophages via the nuclear factor κB (NF-κB) pathway, J Biol Chem, 289, 9741, 10.1074/jbc.M113.517995 Saline, 2019, Lau R, Gunnarsson A, Jacso T, et al, AMPK and AKT protein kinases hierarchically phosphorylate the N-terminus of the FOXO1 transcription factor, modulating interactions with 14–3-3 proteins, J Biol Chem, 294, 13106, 10.1074/jbc.RA119.008649 Elsey, 2010, Regulation of cardiovascular cell function by hydrogen sulfide (H(2)S), Cell Biochem Funct, 28, 95, 10.1002/cbf.1618 Sun, 2016, Exogenous H2S modulates mitochondrial fusion-fission to inhibit vascular smooth muscle cell proliferation in a hyperglycemic state, Cell Biosci, 6, 36, 10.1186/s13578-016-0102-x Wu, 2019, H2S attenuates endoplasmic reticulum stress in hypoxia-induced pulmonary artery hypertension, Biosci Rep, 39, 10.1042/BSR20190304 Jeong, 2016, Long noncoding RNA linc00598 regulates CCND2 transcription and modulates the G1 checkpoint, Sci Rep, 6, 32172, 10.1038/srep32172 Chang, 2013, Liver X receptor α inhibits osteosarcoma cell proliferation through up-regulation of FoxO1, Cell Physiol Biochem, 32, 180, 10.1159/000350134 Link, 2019, Introduction to FOXO biology, Methods Mol Biol, 1890, 1, 10.1007/978-1-4939-8900-3_1 Ye, 2018, Exogenous hydrogen sulfide attenuates the development of diabetic cardiomyopathy via the FoxO1pathway, J Cell Physiol, 233, 9786, 10.1002/jcp.26946 Zhang, 2002, Phosphorylation of serine 256 suppresses transactivation by FKHR (FOXO1) by multiple mechanisms: direct and indirect effects on nuclear/cytoplasmic shuttling and DNA binding, J Biol Chem, 277, 45276, 10.1074/jbc.M208063200 Zhang, 2019, Endogenous hydrogen sulfide sulfhydrates IKKβ at cysteine 179 to control pulmonary artery endothelial cell inflammation, Clin Sci (Lond), 133, 2045, 10.1042/CS20190514 Xie, 2014, Sulfhydration of p66Shc at cysteine59 mediates the antioxidant effect of hydrogen sulfide, Antioxid Redox Signal, 21, 2531, 10.1089/ars.2013.5604 Wu, 2018, Amelioration of mitochondrial dysfunction in heart failure through S-sulfhydration of Ca2+/calmodulin-dependent protein kinase II, Redox Biol, 19, 250, 10.1016/j.redox.2018.08.008 Kim, 2010, Regulation of FOXO1 by TAK1-Nemo-like kinase pathway, J Biol Chem, 285, 8122, 10.1074/jbc.M110.101824 Biggs, 1999, Protein kinase B/Akt-mediated phosphorylation promotes nuclear exclusion of the winged helix transcription factor FKHR1, Proc Natl Acad Sci U S A, 96, 7421, 10.1073/pnas.96.13.7421 Gerst, 2015, Anita M Hennige, Protein kinase Cδ regulates nuclear export of FOXO1 through phosphorylation of the chaperone 14–3-3ζ, Diabetologia, 58, 2819, 10.1007/s00125-015-3744-z