Perspectives in Multiphasic Osteochondral Tissue Engineering

Anatomical Record - Tập 297 Số 1 - Trang 26-35 - 2014
June Jeon1, Cédryck Vaquette1, Travis J. Klein1, Dietmar W. Hutmacher2,1
1Institute of Health and Biomedical Innovation, Queensland University of Technology, 60 Musk Ave., Kelvin Grove, Qld 4059, Australia
2George W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology, 315 Ferst Drive Atlanta, GA 30332, USA

Tóm tắt

ABSTRACTCritical‐sized osteochondral defects are clinically challenging, with limited treatment options available. By engineering osteochondral grafts using a patient's own cells and osteochondral scaffolds designed to facilitate cartilage and bone regeneration, osteochondral defects may be treated with less complications and better long‐term clinical outcomes. Scaffolds can influence the development and structure of the engineered tissue, and there is an increased awareness that osteochondral tissue engineering concepts need to take thein vivocomplexities into account in order to increase the likelihood of successful osteochondral tissue repair. The developing trend in osteochondral tissue engineering is the utilization of multiphasic scaffolds to recapitulate the multiphasic nature of the native tissue. Cartilage and bone have different structural, mechanical, and biochemical microenvironments. By designing osteochondral scaffolds with tissue‐specific architecture, it may be possible to enhance osteochondral repair within shorter timeframe. While there are promisingin vivooutcomes using multiphasic approaches, functional regeneration of osteochondral constructs still remains a challenge. In this review, we provide an overview ofin vivoosteochondral repair studies that have taken place in the past three years, and define areas which needs improvement in future studies. Anat Rec, 297:26–35, 2014. © 2013 Wiley Periodicals, Inc.

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Anatomical Record

Tập 297 Số 1

26-35

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