Perspectives and advances in probiotics and the gut microbiome in companion animals

Springer Science and Business Media LLC - Tập 64 Số 2 - Trang 197-217 - 2022
Daniel Junpyo Lee1, Tae Wook Goh1, Min-Geun Kang1, Hye‐Jin Choi1, So Young Yeo1, Jungwoo Yang2, Chul‐Sung Huh3,4, Yoo Yong Kim1, Younghoon Kim1
1Department of Agricultural Biotechnology and Research Institute of Agriculture and Life Science, Seoul National University, Seoul, 08826, Korea
2Ildong Bioscience, Pyeongtaek 17957, Korea
3Graduate School of International Agricultural Technology, Seoul National University, Pyeongchang 25354, Korea
4Research Institute of Eco-Friendly Livestock Science, Institute of Green-Bio Science and Technology, Seoul National University, Pyeongchang 25354, Korea

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Krebs, 1992, Konrad zacharias lorenz, 7 November 1903 - 27 February 1989, Biogr Mem Fell R Soc, 38, 209, 10.1098/rsbm.1992.0011

Hwang, 2021, Companion animal in Korea report

Mosteller, 2008, Animal-companion extremes and underlying consumer themes, J Bus Res., 61, 512, 10.1016/j.jbusres.2007.07.004

Do, 2021, Nutrient digestibility and fecal characteristics, microbiota, and metabolites in dogs fed human-grade foods, J Anim Sci., 99, 10.1093/jas/skab028

Redfern, 2017, Role of the gastrointestinal microbiota in small animal health and disease, Vet Rec., 181, 370, 10.1136/vr.103826

MacDonald, 1984, Nutrition of the domestic cat, a mammalian carnivore, Annu Rev Nutr., 4, 521, 10.1146/annurev.nu.04.070184.002513

Clauss, 2010, Carnivorous mammals: nutrient digestibility and energy evaluation, Zoo Biol., 29, 687, 10.1002/zoo.20302

Deng, 2015, Gut microbiota of humans, dogs and cats: current knowledge and future opportunities and challenges, Br J Nutr., 113, S6, 10.1017/S0007114514002943

Morelli, 2012, FAO/WHO guidelines on probiotics: 10 years later, J Clin Gastroenterol., 46, S1, 10.1097/MCG.0b013e318269fdd5

Hill, 2014, The International Scientific Association for Probiotics and Prebiotics consensus statement on the scope and appropriate use of the term probiotic, Nat Rev Gastroenterol Hepatol., 11, 506, 10.1038/nrgastro.2014.66

Sarowska, 2013, The therapeutic effect of probiotic bacteria on gastrointestinal diseases, Adv Clin Exp Med., 22, 759

Case, 2010, Canine and feline nutrition: a resource for companion animal professionals, 3rd ed

Coelho, 2018, Similarity of the dog and human gut microbiomes in gene content and response to diet, Microbiome, 6, 72, 10.1186/s40168-018-0450-3

Xu, 2019, Oral administration of compound probiotics improved canine feed intake, weight gain, immunity and intestinal microbiota, Front Immunol., 10, 666, 10.3389/fimmu.2019.00666

Culligan, 2009, Probiotics and gastrointestinal disease: successes, problems and future prospects, Gut Pathog., 1, 19, 10.1186/1757-4749-1-19

Suchodolski, 2011, Companion animals symposium: microbes and gastrointestinal health of dogs and cats, J Anim Sci., 89, 1520, 10.2527/jas.2010-3377

Mondo, 2019, Role of gut microbiota in dog and cat’s health and diseases, Open Vet J., 9, 253, 10.4314/ovj.v9i3.10

Unterer, 2021, Acute hemorrhagic diarrhea syndrome in dogs, Vet Clin Small Anim Pract., 51, 79, 10.1016/j.cvsm.2020.09.007

Jergens, 2012, Inflammatory bowel disease in veterinary medicine, Front Biosci (Elite Ed)., 4, 1404, 10.2741/e470

Huang, 2020, The canine gastrointestinal microbiota: early studies and research frontiers, Gut Microbes., 11, 635, 10.1080/19490976.2019.1704142

Grześkowiak, 2015, Microbiota and probiotics in canine and feline welfare, Anaerobe., 34, 14, 10.1016/j.anaerobe.2015.04.002

Kelley, 2009, Clinical benefits of probiotic canine-derived Bifidobacterium animalis strain AHC7 in dogs with acute idiopathic diarrhea, Vet Ther., 10, 121

Fernández, 2019, Characterization of Lactobacillus rhamnosus MP01 and Lactobacillus plantarum MP02 and assessment of their potential for the prevention of gastrointestinal infections in an experimental canine model, Front Microbiol., 10, 1117, 10.3389/fmicb.2019.01117

Delucchi, 2017, Effect of the probiotic Lactobacillus murinus LbP2 on clinical parameters of dogs with distemper-associated diarrhea, Can J Vet Res., 81, 118

Kumar, 2017, Comparative assessment of canine-origin Lactobacillus johnsonii CPN23 and dairy-origin Lactobacillus acidophillus NCDC 15 for nutrient digestibility, faecal fermentative metabolites and selected gut health indices in dogs, J Nutr Sci., 6, 10.1017/jns.2017.35

Strompfová, 2017, Health benefits observed after probiotic Lactobacillus fermentum CCM 7421 application in dogs, Appl Microbiol Biotechnol., 101, 6309, 10.1007/s00253-017-8425-z

Strompfová, 2006, Application of potential probiotic Lactobacillus fermentum AD1 strain in healthy dogs, Anaerobe, 12, 75, 10.1016/j.anaerobe.2005.12.001

Strompfová, 2014, Effect of Bifidobacterium animalis B/12 administration in healthy dogs, Anaerobe., 28, 37, 10.1016/j.anaerobe.2014.05.001

Kumar, 2016, Species-specific probiotic Lactobacillus johnsonii CPN23 supplementation modulates blood biochemical profile and erythrocytic antioxidant indices in Labrador dogs, Indian J Anim Sci., 86, 918

Strompfová, 2019, Oral administration of bacteriocin-producing and non-producing strains of Enterococcus faecium in dogs, Appl Microbiol Biotechnol., 103, 4953, 10.1007/s00253-019-09847-3

Marelli, 2020, Effects of probiotic Lactobacillus acidophilus D2/CSL (CECT 4529) on the nutritional and health status of boxer dogs, Vet Rec., 187, 10.1136/vr.105434

Fenimore, 2017, Evaluation of metronidazole with and without Enterococcus faecium SF68 in shelter dogs with diarrhea, Top Companion Anim Med., 32, 100, 10.1053/j.tcam.2017.11.001

Lucena, 2019, Effect of probiotic Enterococcus faecium SF68 on liver function in healthy dogs, J Vet Intern Med., 33, 2628, 10.1111/jvim.15625

Masuoka, 2017, Transition of the intestinal microbiota of dogs with age, Biosci Microbiota Food Health, 36, 27, 10.12938/bmfh.BMFH-2016-021

Mitsuoka, 2014, Establishment of intestinal bacteriology, Biosci Microbiota Food Health, 33, 99, 10.12938/bmfh.33.99

Armstrong, 1996, Changes in body composition and energy balance with aging, Vet Clin Nutr., 3, 83

Ritchie, 2008, Assessment of microbial diversity along the feline intestinal tract using 16S rRNA gene analysis, FEMS Microbiol Ecol., 66, 590, 10.1111/j.1574-6941.2008.00609.x

Suchodolski, 2011, Intestinal microbiota of dogs and cats: a bigger world than we thought, Vet Clin North Am Small Anim Pract., 41, 261, 10.1016/j.cvsm.2010.12.006

Honneffer, 2014, Microbiota alterations in acute and chronic gastrointestinal inflammation of cats and dogs, World J Gastroenterol., 20, 16489, 10.3748/wjg.v20.i44.16489

Willard, 1999, Feline inflammatory bowel disease: a review, J Feline Med Surg., 1, 155, 10.1016/S1098-612X(99)90204-8

Marshall-Jones, 2006, Effects of Lactobacillus acidophilus DSM13241 as a probiotic in healthy adult cats, Am J Vet Res., 67, 1005, 10.2460/ajvr.67.6.1005

Watson, 2019, Influence of the intestinal microbiota on disease susceptibility in kittens with experimentally-induced carriage of atypical enteropathogenic Escherichia coli, Vet Microbiol., 231, 197, 10.1016/j.vetmic.2019.03.020

Veir, 2007, Effect of supplementation with Enterococcus faecium (SF68) on immune functions in cats, Vet Ther Res Appl Vet Med., 8, 229

Fusi, 2019, Effects of Lactobacillus acidophilus D2/CSL (CECT 4529) supplementation on healthy cat performance, Vet Rec Open, 6, 10.1136/vetreco-2019-000368

Bybee, 2011, Effect of the probiotic Enterococcus faecium SF68 on presence of diarrhea in cats and dogs housed in an animal shelter, J Vet Intern Med., 25, 856, 10.1111/j.1939-1676.2011.0738.x

Torres-Henderson, 2017, Effect of Enterococcus faecium strain SF68 on gastrointestinal signs and fecal microbiome in cats administered amoxicillin-clavulanate, Top Companion Anim Med., 32, 104, 10.1053/j.tcam.2017.11.002

Lappin, 2009, Pilot study to evaluate the effect of oral supplementation of Enterococcus faecium SF68 on cats with latent feline herpesvirus 1, J Feline Med Surg., 11, 650, 10.1016/j.jfms.2008.12.006

Hart, 2012, Open-label trial of a multi-strain synbiotic in cats with chronic diarrhea, J Feline Med Surg., 14, 240, 10.1177/1098612X11434386

Segovia, 2018, Communication of the results of the treatment with probiotics in two cats with chronic gingivostomatitis, Open J Vet Med., 8, 9, 10.4236/ojvm.2018.82002

Sofyan, 2019, Management of feline idiopathic cystitis (FIC) using probiotic combination treatment, Indian Vet J., 96, 20

Masuoka, 2017, Transition of the intestinal microbiota of cats with age, PLOS ONE, 12, 10.1371/journal.pone.0181739

Suchodolski, 2004, Application of molecular fingerprinting for qualitative assessment of small-intestinal bacterial diversity in dogs, J Clin Microbiol., 42, 4702, 10.1128/JCM.42.10.4702-4708.2004

Suchodolski, 2005, Assessment of the qualitative variation in bacterial microflora among compartments of the intestinal tract of dogs by use of a molecular fingerprinting technique, Am J Vet Res., 66, 1556, 10.2460/ajvr.2005.66.1556

Ritchie, 2010, Characterization of fecal microbiota in cats using universal 16S rRNA gene and group-specific primers for Lactobacillus and Bifidobacterium spp, Vet Microbiol., 144, 140, 10.1016/j.vetmic.2009.12.045

Pilla, 2021, The gut microbiome of dogs and cats, and the influence of diet, Vet Clin North Am Small Anim Pract., 51, 605, 10.1016/j.cvsm.2021.01.002

Altveş, 2020, Interaction of the microbiota with the human body in health and diseases, Biosci Microbiota Food Health, 39, 23, 10.12938/bmfh.19-023

Peterson, 2020, B vitamins and their role in immune regulation and cancer, Nutrients, 12, 3380, 10.3390/nu12113380

Vermeer, 2012, Vitamin K: the effect on health beyond coagulation – an overview, Food Nutr Res., 56, 5329, 10.3402/fnr.v56i0.5329

Kather, 2020, Review of cobalamin status and disorders of cobalamin metabolism in dogs, J Vet Intern Med., 34, 13, 10.1111/jvim.15638

Weiss, 2011, Schalm’s veterinary hematology

Xu, 2019, Metagenomic analysis revealed beneficial effects of probiotics in improving the composition and function of the gut microbiota in dogs with diarrhoea, Food Funct., 10, 2618, 10.1039/C9FO00087A

Swanson, 2011, Phylogenetic and gene-centric metagenomics of the canine intestinal microbiome reveals similarities with humans and mice, ISME J., 5, 639, 10.1038/ismej.2010.162

Nash, 2017, Early microbes modify immune system development and metabolic homeostasis-the “restaurant” hypothesis revisited, Front Endocrinol., 8, 349, 10.3389/fendo.2017.00349

Kamada, 2013, Role of the gut microbiota in the development and function of lymphoid cells, J Immunol., 190, 1389, 10.4049/jimmunol.1203100

Tomkovich, 2016, Microbiota and host immune responses: a love–hate relationship, Immunology, 147, 1, 10.1111/imm.12538

Tizard, 2018, The microbiota regulates immunity and immunologic diseases in dogs and cats, Vet Clin North Am Small Anim Pract., 48, 307, 10.1016/j.cvsm.2017.10.008

Zilber-Rosenberg, 2008, Role of microorganisms in the evolution of animals and plants: the hologenome theory of evolution, FEMS Microbiol Rev., 32, 723, 10.1111/j.1574-6976.2008.00123.x

Qin, 2008, What is human inflammatory bowel disease (IBD) more like: Johne’s disease in cattle or IBD in dogs and cats?, Inflamm Bowel Dis., 14, 138, 10.1002/ibd.20240

Minamoto, 2012, Feline gastrointestinal microbiota, Anim Health Res Rev., 13, 64, 10.1017/S1466252312000060

Suchodolski, 2008, Analysis of bacterial diversity in the canine duodenum, jejunum, ileum, and colon by comparative 16S rRNA gene analysis, FEMS Microbiol Ecol., 66, 567, 10.1111/j.1574-6941.2008.00521.x

Inness, 2007, Molecular characterisation of the gut microflora of healthy and inflammatory bowel disease cats using fluorescence in situ hybridisation with special reference to Desulfovibrio spp, J Anim Physiol Anim Nutr., 91, 48, 10.1111/j.1439-0396.2006.00640.x

Werner, 2021, Diagnostic value of fecal cultures in dogs with chronic diarrhea, J Vet Intern Med., 35, 199, 10.1111/jvim.15982

Mentula, 2005, Comparison between cultured small-intestinal and fecal microbiotas in beagle dogs, Appl Environ Microbiol., 71, 4169, 10.1128/AEM.71.8.4169-4175.2005

German, 2003, Comparison of direct and indirect tests for small intestinal bacterial overgrowth and antibiotic-responsive diarrhea in dogs, J Vet Intern Med., 17, 33, 10.1111/j.1939-1676.2003.tb01321.x

Benno, 1992, Impact of the advances in age on the gastrointestinal microflora of beagle dogs, J Vet Med Sci., 54, 703, 10.1292/jvms.54.703

Buddington, 2003, Postnatal changes in bacterial populations in the gastrointestinal tract of dogs, Am J Vet Res., 64, 646, 10.2460/ajvr.2003.64.646

Greetham, 2002, Bacteriology of the Labrador dog gut: a cultural and genotypic approach, J Appl Microbiol., 93, 640, 10.1046/j.1365-2672.2002.01724.x

Leser, 2002, Culture-independent analysis of gut bacteria: the pig gastrointestinal tract microbiota revisited, Appl Environ Microbiol., 68, 673, 10.1128/AEM.68.2.673-690.2002

Holland, 2013, Anaerobic bacteria

Lagier, 2018, Culturing the human microbiota and culturomics, Nat Rev Microbiol., 16, 540, 10.1038/s41579-018-0041-0

Pereira, 2020, An effective culturomics approach to study the gut microbiota of mammals, Res Microbiol., 171, 290, 10.1016/j.resmic.2020.09.001

Hayashi, 2002, Phylogenetic analysis of the human gut microbiota using 16S rDNA clone libraries and strictly anaerobic culture-based methods, Microbiol Immunol., 46, 535, 10.1111/j.1348-0421.2002.tb02731.x

Lan, 2002, Phylogenetic analysis of cecal microbiota in chicken by the use of 16S rDNA clone libraries, Microbiol Immunol., 46, 371, 10.1111/j.1348-0421.2002.tb02709.x

Suchodolski, 2009, The effect of the macrolide antibiotic tylosin on microbial diversity in the canine small intestine as demonstrated by massive parallel 16S rRNA gene sequencing, BMC Microbiol., 9, 210, 10.1186/1471-2180-9-210

Garcia-Mazcorro, 2011, Effect of a multi-species synbiotic formulation on fecal bacterial microbiota of healthy cats and dogs as evaluated by pyrosequencing, FEMS Microbiol Ecol., 78, 542, 10.1111/j.1574-6941.2011.01185.x

Hand, 2013, Pyrosequencing the canine faecal microbiota: breadth and depth of biodiversity, PLOS ONE, 8, 10.1371/journal.pone.0053115

Rodrigues Hoffmann, 2014, The skin microbiome in healthy and allergic dogs, PLOS ONE, 9, 10.1371/journal.pone.0083197

Sturgeon, 2013, Metagenomic analysis of the canine oral cavity as revealed by high-throughput pyrosequencing of the 16S rRNA gene, Vet Microbiol., 162, 891, 10.1016/j.vetmic.2012.11.018

Sturgeon, 2014, Characterization of the oral microbiota of healthy cats using next-generation sequencing, Vet J., 201, 223, 10.1016/j.tvjl.2014.01.024

Dorn, 2017, Bacterial microbiome in the nose of healthy cats and in cats with nasal disease, PLOS ONE, 12, 10.1371/journal.pone.0180299

Hutchins, 2014, Vaginal microbiota of spayed dogs with or without recurrent urinary tract infections, J Vet Intern Med., 28, 300, 10.1111/jvim.12299

Pilla, 2020, The role of the canine gut microbiome and metabolome in health and gastrointestinal disease, Front Vet Sci., 6, 498, 10.3389/fvets.2019.00498

Bermingham, 2018, The fecal microbiota in the domestic cat (Felis catus) is influenced by interactions between age and diet; a five year longitudinal study, Front Microbiol., 9, 1231, 10.3389/fmicb.2018.01231

Hasan, 2019, Factors affecting the composition of the gut microbiota, and its modulation, PeerJ., 7, 10.7717/peerj.7502

Reddy, 2019, Impact of breed on the fecal microbiome of dogs under the same dietary condition, J Microbiol Biotechnol., 29, 1947, 10.4014/jmb.1906.06048

Older, 2019, The feline cutaneous and oral microbiota are influenced by breed and environment, PLOS ONE, 14, 10.1371/journal.pone.0220463

Du, 2021, Effects of cat ownership on the gut microbiota of owners, PLOS ONE, 16, 10.1371/journal.pone.0253133

Bermingham, 2013, Dietary format alters fecal bacterial populations in the domestic cat (Felis catus), MicrobiologyOpen, 2, 173, 10.1002/mbo3.60

Scarsella, 2020, Learning machine approach reveals microbial signatures of diet and sex in dog, PLOS ONE, 15, 10.1371/journal.pone.0237874

Kim, 2020, Sex differences in gut microbiota, World J Men’s Health, 38, 48, 10.5534/wjmh.190009

Serpell, 2014, Dog breeds and their behavior, Domestic dog cognition and behavior: the scientific study of Canis familiaris, 31, 10.1007/978-3-642-53994-7_2

Kathrani, 2011, Canine breeds at high risk of developing inflammatory bowel disease in the south-eastern UK, Vet Rec., 169, 635, 10.1136/vr.d5380

You, 2021, Comparison of gut microbiota of 96 healthy dogs by individual traits: breed, age, and body condition score, Animals, 11, 2432, 10.3390/ani11082432

Lehtimäki, 2020, Simultaneous allergic traits in dogs and their owners are associated with living environment, lifestyle and microbial exposures, Sci Rep., 10, 21954, 10.1038/s41598-020-79055-x

Kil, 2011, Companion animals symposium: role of microbes in canine and feline health, J Anim Sci., 89, 1498, 10.2527/jas.2010-3498

Karen, 1999, Small intestinal bacterial overgrowth, Vet Clin North Am Small Anim Pract., 29, 523, 10.1016/S0195-5616(99)50033-8

Xenoulis, 2008, Molecular-phylogenetic characterization of microbial communities imbalances in the small intestine of dogs with inflammatory bowel disease, FEMS Microbiol Ecol., 66, 579, 10.1111/j.1574-6941.2008.00556.x

Tang, 2012, Dominance of Lactobacillus acidophilus in the facultative jejunal Lactobacillus microbiota of fistulated beagles, Appl Environ Microbiol., 78, 7156, 10.1128/AEM.01975-12

Handl, 2011, Massive parallel 16S rRNA gene pyrosequencing reveals highly diverse fecal bacterial and fungal communities in healthy dogs and cats, FEMS Microbiol Ecol., 76, 301, 10.1111/j.1574-6941.2011.01058.x

Kim, 2007, Biological and genetic classification of canine intestinal lactic acid bacteria and bifidobacteria, Microbiol Immunol., 51, 919, 10.1111/j.1348-0421.2007.tb03983.x

Beasley, 2006, Lactic acid bacteria isolated from canine faeces, J Appl Microbiol., 101, 131, 10.1111/j.1365-2672.2006.02884.x

Silva, 2013, In vitro assessment of functional properties of lactic acid bacteria isolated from faecal microbiota of healthy dogs for potential use as probiotics, Benef Microbes., 4, 267, 10.3920/BM2012.0048

Bunešová, 2012, Bifidobacterium animalis subsp. lactis strains isolated from dog faeces, Vet Microbiol., 160, 501, 10.1016/j.vetmic.2012.06.005

Araujo, 2010, Helicobacter species detection and histopathological changes in stray cats from Niterói, Brazil, J Feline Med Surg., 12, 509, 10.1016/j.jfms.2010.01.008

Johnston, 2001, Comparison of the bacterial flora of the duodenum in healthy cats and cats with signs of gastrointestinal tract disease, J Am Vet Med Assoc., 218, 48, 10.2460/javma.2001.218.48

Tun, 2012, Gene-centric metagenomics analysis of feline intestinal microbiome using 454 junior pyrosequencing, J Microbiol Methods, 88, 369, 10.1016/j.mimet.2012.01.001

Alessandri, 2020, Deciphering the bifidobacterial populations within the canine and feline gut microbiota, Appl Environ Microbiol., 86, e02875, 10.1128/AEM.02875-19

Buommino, 2016, Correlation between genetic variability and virulence factors in clinical strains of Malassezia pachydermatis of animal origin, New Microbiol., 39, 216

Jacobi, 2011, Treating critically ill patients with probiotics: beneficial or dangerous?, Gut Pathog., 3, 2, 10.1186/1757-4749-3-2

Kochan, 2011, Lactobacillus rhamnosus administration causes sepsis in a cardiosurgical patient—is the time right to revise probiotic safety guidelines?, Clin Microbiol Infect., 17, 1589, 10.1111/j.1469-0691.2011.03614.x

Sanders, 2010, Safety assessment of probiotics for human use, Gut Microbes., 1, 164, 10.4161/gmic.1.3.12127

EFSA [European Food Safety Authority], 2005, Opinion of the Scientific Committee on a request from EFSA related to a generic approach to the safety assessment by EFSA of microorganisms used in food/feed and the production of food/feed additives, EFSA J., 226, 1

European Commission On a generic approach to the safety assessment of microorganisms used in feed/food and feed/food production. A working paper open for comment [Internet] 2003 [cited 2021 Nov 4]. Available at https://ec.europa.eu/food/sites/food/files/safety/docs/animal-feed_additives_rules_scan-old_report_out178.pdf

Hempel, 2011, Safety of probiotics used to reduce risk and prevent or treat disease, Evid Rep Technol Assess, 1

Baffoni, 2018, Probiotics and prebiotics for the health of companion animals, Probiotics and prebiotics in animal health and food safety, 175, 10.1007/978-3-319-71950-4_7

Schmitz, 2021, Value of probiotics in canine and feline gastroenterology, Vet Clin North Am Small Anim Pract., 51, 171, 10.1016/j.cvsm.2020.09.011

FEEDAP [EFSA Panel on Additives, Products or Substances used in Animal Feed], 2012, Guidance on the safety assessment of Enterococcus faecium in animal nutrition, EFSA J., 10, 2682, 10.2903/j.efsa.2012.2682

Rinkinen, 2003, Interaction between probiotic lactic acid bacteria and canine enteric pathogens: a risk factor for intestinal Enterococcus faecium colonization?, Vet Microbiol., 92, 111, 10.1016/S0378-1135(02)00356-5

EFSA [European Food Safety Authority, 2004, Opinion of the scientific panel on additives and products or substances used in animal feed (FEEDAP) on the efficacy and safety of the coccidiostat Koffogran, EFSA J., 2, 16, 10.2903/j.efsa.2004.16

FEEDAP [EPSA Panel on Additives], Products or Substances used in Animal Feed], 2013, Scientific opinion on the safety and efficacy of Cylactin® (Enterococcus faecium) as a feed additive for cats and dogs, EFSA J., 11, 3098

Holzapfel, 2018, Enterococcus faecium SF68 as a model for efficacy and safety evaluation of pharmaceutical probiotics, Benef Microbes., 9, 375, 10.3920/BM2017.0148

Dogi, 2006, Importance of the host specificity in the selection of probiotic bacteria, J Dairy Res., 73, 357, 10.1017/S0022029906001993

Park, 2018, Role of the gut microbiota in health and disease, Probiotics and prebiotics in animal health and food safety, 35, 10.1007/978-3-319-71950-4_2

Yeo, 2016, Development of putative probiotics as feed additives: validation in a porcine-specific gastrointestinal tract model, Appl Microbiol Biotechnol., 100, 10043, 10.1007/s00253-016-7812-1

Weese, 2002, Preliminary evaluation of Lactobacillus rhamnosus strain GG, a potential probiotic in dogs, Can Vet J., 43, 771

Strompfová, 2004, Lactobacilli and enterococci — potential probiotics for dogs, Folia Microbiol., 49, 203, 10.1007/BF02931403

Kainulainen, 2015, The canine isolate Lactobacillus acidophilus LAB20 adheres to intestinal epithelium and attenuates LPS-induced IL-8 secretion of enterocytes in vitro, BMC Microbiol., 15, 4, 10.1186/s12866-014-0337-9

Cunningham, 2021, Shaping the future of probiotics and prebiotics, Trends Microbiol., 29, 667, 10.1016/j.tim.2021.01.003

Weese, 2003, Bacteriological evaluation of dog and cat diets that claim to contain probiotics, Can Vet J., 44, 212

Weese, 2011, Assessment of commercial probiotic bacterial contents and label accuracy, Can Vet J., 52, 43

Metras, 2020, Assessment of commercial companion animal kefir products for label accuracy of microbial composition and quantity, J Anim Sci., 98, 10.1093/jas/skaa301

Mora, 2019, Development of omics-based protocols for the microbiological characterization of multi-strain formulations marketed as probiotics: the case of VSL#3, Microb Biotechnol., 12, 1371, 10.1111/1751-7915.13476