Persistent Organic Pollutants and Type 2 Diabetes: A Critical Review of Review Articles

Taylor, 2013, Evaluation of the association between persistent organic pollutants (POPs) and diabetes in epidemiological studies: a national toxicology program workshop review, Environ Health Perspect., 121, 774, 10.1289/ehp.1205502

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Magliano, 2014, Persistent organic pollutants and diabetes: a review of the epidemiological evidence, Diabetes Metab., 40, 1, 10.1016/j.diabet.2013.09.006

Ngwa, 2015, Persistent organic pollutants as risk factors for type 2 diabetes, Diabetol Metab Syndr., 7, 41, 10.1186/s13098-015-0031-6

Jaacks, 2015, Association of persistent organic pollutants and non-persistent pesticides with diabetes and diabetes-related health outcomes in Asia: a systematic review, Environ Int., 76, 57, 10.1016/j.envint.2014.12.001

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Lee, 2006, A strong dose-response relation between serum concentrations of persistent organic pollutants and diabetes: results from the National Health and Examination Survey 1999–2002, Diabetes Care, 29, 1638, 10.2337/dc06-0543

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Imamura, 2013, Risk factors for type 2 diabetes mellitus preceded by beta-cell dysfunction, insulin resistance, or both in older adults: the cardiovascular health study, Am J Epidemiol., 177, 1418, 10.1093/aje/kws440

McCarthy, 2010, Genomics, type 2 diabetes, and obesity, N Engl J Med., 363, 2339, 10.1056/NEJMra0906948

Ma, 2013, Type 2 diabetes in East Asians: similarities and differences with populations in Europe and the United States, Ann N Y Acad Sci., 1281, 64, 10.1111/nyas.12098

Fabricio, 2016, Environmental contaminants and pancreatic beta-cells, J Clin Res Pediatr Endocrinol., 8, 257, 10.4274/jcrpe.2812

Ruzzin, 2010, Persistent organic pollutant exposure leads to insulin resistance syndrome, Environ Health Perspect., 118, 465, 10.1289/ehp.0901321

Ibrahim, 2011, Chronic consumption of farmed salmon containing persistent organic pollutants causes insulin resistance and obesity in mice, PLoS ONE, 6, e25170, 10.1371/journal.pone.0025170

Jensen, 2014, Polychlorinated biphenyl exposure and glucose metabolism in 9-year-old Danish children, J Clin Endocrinol Metab., 99, E2643, 10.1210/jc.2014-1683

Jorgensen, 2008, A cross-sectional study of the association between persistent organic pollutants and glucose intolerance among Greenland Inuit, Diabetologia, 51, 1416, 10.1007/s00125-008-1066-0

Park, 2016, Serum Levels of Persistent organic pollutants and insulin secretion among children Age 7–9 Years: A Prospective Cohort Study, Environ Health Perspect., 124, 1924, 10.1289/EHP147

Lee, 2017, Low-dose persistent organic pollutants impair insulin secretory function of pancreatic beta-cells: human and in vitro evidence, Diabetes, 66, 2669, 10.2337/db17-0188

Morimoto, 2013, Impact of impaired insulin secretion and insulin resistance on the incidence of type 2 diabetes mellitus in a Japanese population: the Saku study, Diabetologia, 56, 1671, 10.1007/s00125-013-2932-y

Yoon, 2006, Epidemic obesity and type 2 diabetes in Asia, Lancet, 368, 1681, 10.1016/S0140-6736(06)69703-1

Chang, 2003, Aging and insulin secretion, Am J Physiol Endocrinol Metab., 284, E7, 10.1152/ajpendo.00366.2002

Hue, 2007, Plasma concentration of organochlorine compounds is associated with age and not obesity, Chemosphere, 67, 1463, 10.1016/j.chemosphere.2006.10.033

Tanabe, 2010, Dioxins and organohalogen contaminants in the Asia-Pacific region, Ecotoxicology, 19, 463, 10.1007/s10646-009-0445-8

Tilg, 2006, Adipocytokines: mediators linking adipose tissue, inflammation and immunity, Nat Rev Immunol., 6, 772, 10.1038/nri1937

Shulman, 2014, Ectopic fat in insulin resistance, dyslipidemia, and cardiometabolic disease, N Engl J Med, 371, 2237, 10.1056/NEJMc1412427

La Merrill, 2013, Toxicological function of adipose tissue: focus on persistent organic pollutants, Environ Health Perspect., 121, 162, 10.1289/ehp.1205485

Arsenescu, 2008, Polychlorinated biphenyl-77 induces adipocyte differentiation and proinflammatory adipokines and promotes obesity and atherosclerosis, Environ Health Perspect., 116, 761, 10.1289/ehp.10554

May, 2018, In vitro cocktail effects of PCB-DL (PCB118) and Bulky PCB (PCB153) with BaP on Adipogenesis and on expression of genes involved in the establishment of a pro-inflammatory state, Int J Mol Sci., 19, E841, 10.3390/ijms19030841

Pestana, 2017, Adipose tissue dysfunction as a central mechanism leading to dysmetabolic obesity triggered by chronic exposure to p,p'-DDE, Sci Rep., 7, 2738, 10.1038/s41598-017-02885-9

Cinti, 2005, Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humans, J Lipid Res., 46, 2347, 10.1194/jlr.M500294-JLR200

Rosen, 2006, Adipocytes as regulators of energy balance and glucose homeostasis, Nature, 444, 847, 10.1038/nature05483

de Ferranti, 2008, The perfect storm: obesity, adipocyte dysfunction, and metabolic consequences, Clin Chem., 54, 945, 10.1373/clinchem.2007.100156

Morigny, 2016, Adipocyte lipolysis and insulin resistance, Biochimie, 125, 259, 10.1016/j.biochi.2015.10.024

Louis, 2014, PCB-153 shows different dynamics of mobilisation from differentiated rat adipocytes during lipolysis in comparison with PCB-28 and PCB-118, PLoS ONE, 9, e106495, 10.1371/journal.pone.0106495

Jandacek, 2005, Effects of yo-yo diet, caloric restriction, and olestra on tissue distribution of hexachlorobenzene, Am J Physiol Gastrointest Liver Physiol., 288, G292, 10.1152/ajpgi.00285.2004

Ahotupa, 1983, Adipose tissue content as a modifier of the tissue distribution, biological effects, and excretion of a hexachlorobiphenyl in C57BL/6J and DBA/JBOMf mice, Mol Pharmacol., 24, 464

Antonopoulos, 2016, From the BMI paradox to the obesity paradox: the obesity-mortality association in coronary heart disease, Obes Rev., 17, 989, 10.1111/obr.12440

Hainer, 2013, Obesity paradox does exist, Diabetes Care, 36, S276, 10.2337/dcS13-2023

Hong, 2012, The association between obesity and mortality in the elderly differs by serum concentrations of persistent organic pollutants: a possible explanation for the obesity paradox, Int J Obes., 36, 1170, 10.1038/ijo.2011.187

Imbeault, 2002, Weight loss-induced rise in plasma pollutant is associated with reduced skeletal muscle oxidative capacity, Am J Physiol Endocrinol Metab., 282, E574, 10.1152/ajpendo.00394.2001

Jansen, 2017, Increased blood levels of persistent organic pollutants (POP) in obese individuals after weight loss-A review, J Toxicol Environ Health B Crit Rev., 20, 22, 10.1080/10937404.2016.1246391

Lim, 2011, Inverse associations between long-term weight change and serum concentrations of persistent organic pollutants, Int J Obes., 35, 744, 10.1038/ijo.2010.188

Pelletier, 2002, Associations between weight loss-induced changes in plasma organochlorine concentrations, serum T3 concentration, and resting metabolic rate, Toxicol Sci., 67, 46, 10.1093/toxsci/67.1.46

Tremblay, 2004, Thermogenesis and weight loss in obese individuals: a primary association with organochlorine pollution, Int J Obes Relat Metab Disord., 28, 936, 10.1038/sj.ijo.0802527

Look, 2013, Cardiovascular effects of intensive lifestyle intervention in type 2 diabetes, N Engl J Med., 369, 145, 10.1056/NEJMoa1212914

Lee, 2017, Persistent organic pollutants in adipose tissue should be considered in obesity research, Obes Rev., 18, 129, 10.1111/obr.12481

Kim, 2017, Evolutionarily adapted hormesis-inducing stressors can be a practical solution to mitigate harmful effects of chronic exposure to low dose chemical mixtures, Environ Pollut., 233, 725, 10.1016/j.envpol.2017.10.124

McLachlan, 2012, Drug metabolism in older people–a key consideration in achieving optimal outcomes with medicines, J Gerontol A Biol Sci Med Sci., 67, 175, 10.1093/gerona/glr118

Lee, 2018, Neurotoxic chemicals in adipose tissue: A role in puzzling findings on obesity and dementia, Neurology, 90, 176, 10.1212/WNL.0000000000004851

Chamorro-Garcia, 2014, Transgenerational effects of obesogens and the obesity epidemic, Curr Opin Pharmacol., 19, 153, 10.1016/j.coph.2014.10.010

Janesick, 2014, Transgenerational inheritance of prenatal obesogen exposure, Mol Cell Endocrinol., 398, 31, 10.1016/j.mce.2014.09.002

Heindel, 2015, Endocrine disruptors and obesity, Nat Rev Endocrinol., 11, 653, 10.1038/nrendo.2015.163

Thayer, 2012, Role of environmental chemicals in diabetes and obesity: a National Toxicology Program workshop review, Environ Health Perspect., 120, 779, 10.1289/ehp.1104597

Kloting, 2010, Insulin-sensitive obesity, Am J Physiol Endocrinol Metab., 299, E506, 10.1152/ajpendo.00586.2009

Cano-Sancho, 2017, Association between Exposure to p,p'-DDT and Its Metabolite p,p'-DDE with Obesity: integrated systematic review and meta-analysis, Environ Health Perspect., 125, 096002, 10.1289/EHP527

Alexander, 1998, Aryl-hydrocarbon receptor is an inhibitory regulator of lipid synthesis and of commitment to adipogenesis, J Cell Sci., 111, 3311, 10.1242/jcs.111.22.3311

Bowe, 2018, The 2016 global and national burden of diabetes mellitus attributable to PM2·5 air pollution, Lancet Planet Health, 2, e301, 10.1016/S2542-5196(18)30140-2

Lanphear, 2017, Low-level toxicity of chemicals: no acceptable levels?, PLoS Biol., 15, e2003066, 10.1371/journal.pbio.2003066

Lanphear, 2018, Low-level lead exposure and mortality in US adults: a population-based cohort study, Lancet Public Health, 3, e177, 10.1016/S2468-2667(18)30025-2

Banner, 2014, Low blood lead level effects on intelligence: can a dose-response curve be determined from the epidemiological data?, Clin Toxicol., 52, 113, 10.3109/15563650.2013.876544

Bowers, 2006, What is the meaning of non-linear dose-response relationships between blood lead concentrations and IQ?, Neurotoxicology, 27, 520, 10.1016/j.neuro.2006.02.001

Vandenberg, 2012, Hormones and endocrine-disrupting chemicals: low-dose effects and nonmonotonic dose responses, Endocr Rev., 33, 378, 10.1210/er.2011-1050

Calabrese, 2017, How does hormesis impact biology, toxicology, and medicine?, NPJ Aging Mech Dis., 3, 13, 10.1038/s41514–017-0013-z

Lee, 2015, Hormesis and public health: can glutathione depletion and mitochondrial dysfunction due to very low-dose chronic exposure to persistent organic pollutants be mitigated?, J Epidemiol Community Health, 69, 294, 10.1136/jech-2014-203861

Kortenkamp, 2014, Low dose mixture effects of endocrine disrupters and their implications for regulatory thresholds in chemical risk assessment, Curr Opin Pharmacol., 19, 105, 10.1016/j.coph.2014.08.006

Carnevali, 2017, Dietary administration of EDC mixtures: a focus on fish lipid metabolism, Aquat Toxicol., 185, 95, 10.1016/j.aquatox.2017.02.007

Hu, 2014, Antagonistic effects of a mixture of low-dose nonylphenol and di-n-butyl phthalate (monobutyl phthalate) on the Sertoli cells and serum reproductive hormones in prepubertal male rats in vitro and in vivo, PLoS ONE, 9, e93425, 10.1371/journal.pone.0093425

Ribeiro, 2017, EDCs mixtures: a stealthy hazard for human health?, Toxics, 5, 5, 10.3390/toxics5010005

Sarria, 2011, The unpredictable effects of mixtures of androgenic and estrogenic chemicals on fish early life, Environ Int., 37, 418, 10.1016/j.envint.2010.11.004

Meyer, 2013, Mitochondria as a target of environmental toxicants, Toxicol Sci., 134, 1, 10.1093/toxsci/kft102

Lim, 2009, Chronic exposure to the herbicide, atrazine, causes mitochondrial dysfunction and insulin resistance, PLoS ONE, 4, e5186, 10.1371/journal.pone.0005186

Liu, 2017, Organochloride pesticides impaired mitochondrial function in hepatocytes and aggravated disorders of fatty acid metabolism, Sci Rep., 7, 46339, 10.1038/srep46339

Mailloux, 2014, Exposure to a northern contaminant mixture (NCM) alters hepatic energy and lipid metabolism exacerbating hepatic steatosis in obese JCR rats, PLoS ONE, 9, e106832, 10.1371/journal.pone.0106832

Byczkowski, 1976, The mode of action of p,p' = DDT on mammalian mitochondria, Toxicology, 6, 309, 10.1016/0300-483X(76)90034-2

Miller, 2013, Steroid hormone synthesis in mitochondria, Mol Cell Endocrinol., 379, 62, 10.1016/j.mce.2013.04.014

Chan, 2006, Mitochondria: dynamic organelles in disease, aging, and development, Cell, 125, 1241, 10.1016/j.cell.2006.06.010

Sano, 2008, Activation of mitochondrial biogenesis by hormesis, Circ Res., 103, 1191, 10.1161/CIRCRESAHA.108.189092

Yun, 2014, Mitohormesis, Cell Metab., 19, 757, 10.1016/j.cmet.2014.01.011

Merry, 2016, Mitohormesis in exercise training, Free Radic Biol Med., 98, 123, 10.1016/j.freeradbiomed.2015.11.032

Ristow, 2010, How increased oxidative stress promotes longevity and metabolic health: the concept of mitochondrial hormesis (mitohormesis), Exp Gerontol., 45, 410, 10.1016/j.exger.2010.03.014

Grabacka, 2014, Phytochemical modulators of mitochondria: the search for chemopreventive agents and supportive therapeutics, Pharmaceuticals, 7, 913, 10.3390/ph7090913

Lee, 2015, Methodological issues in human studies of endocrine disrupting chemicals, Rev Endocr Metab Disord., 16, 289, 10.1007/s11154-016-9340-9