Perpetuating the double helix: molecular machines at eukaryotic DNA replication origins

BioEssays - Tập 25 Số 12 - Trang 1158-1167 - 2003
Juan Méndez1, Bruce Stillman1
1Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724

Tóm tắt

AbstractThe hardest part of replicating a genome is the beginning. The first step of DNA replication (called “initiation”) mobilizes a large number of specialized proteins (“initiators”) that recognize specific sequences or structural motifs in the DNA, unwind the double helix, protect the exposed ssDNA, and recruit the enzymatic activities required for DNA synthesis, such as helicases, primases and polymerases. All of these components are orderly assembled before the first nucleotide can be incorporated. On the occasion of the 50th anniversary of the discovery of the DNA structure, we review our current knowledge of the molecular mechanisms that control initiation of DNA replication in eukaryotic cells, with particular emphasis on the recent identification of novel initiator proteins. We speculate how these initiators assemble molecular machines capable of performing specific biochemical tasks, such as loading a ring‐shaped helicase onto the DNA double helix. BioEssays 25:1158–1167, 2003. © 2003 Wiley Periodicals, Inc.

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BioEssays

Tập 25 Số 12

1158-1167

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