Peripheral site of action of levodropropizine in experimentally-induced cough: Role of sensory neuropeptides

Freedman, 1990, Mechanism of ventilation, 114 Widdicombe, 1977, Respiratory reflex and defense, 593 Corrao, 1979, Chronic cough as the sole presenting manifestation of bronchial asthma, N Engl J Med, 300, 633, 10.1056/NEJM197903223001201 Eddy, 1969, Codeine and its alternates for pain and cough relief. 3. The antitussive action of codeine-mechanisms, methodology and evaluation, Bull WHO, 40, 425 Salem, 1964, Antitussive drugs with special reference to a new theory for the initiation of the cough reflex and the influence of bronchodilators, Am J Med Sci, 247, 585, 10.1097/00000441-196405000-00009 Atwen, 1978, Presynaptic localisation of opiate receptors in the vagal and accessory optic system: an autoradiographic study, Neuropharmacology, 17, 65, 10.1016/0028-3908(78)90175-2 Young, 1980, Opioid receptors undergo axonal flow, Science, 210, 76, 10.1126/science.6158097 Adcock, 1991, Peripheral opioid receptors and the cough reflex, Respir Med, 85, 43, 10.1016/S0954-6111(06)80253-2 Adcock, 1988, Effects of codeine, morphine and a novel opioid pentapeptide BW443C, on cough, nociception and ventilation in the unanaesthetized guinea-pig, Br J Pharmacol, 93, 93, 10.1111/j.1476-5381.1988.tb11409.x Choudry, 1990, Effect of 443C81 on the respiratory responses to capsaicin in humans, Eur J Pharm, 183, 1095, 10.1016/0014-2999(90)92961-H Melillo, 1988, General pharmacology of the new antitussive levodropropizine, Arzneim Forsch/Drug Res, 38, 1144 Malandrino, 1988, Antitussive properties of levodropropizine, Arzneim Forsch/Drug Res, 38, 1141 Allegra, 1988, Clinical trials with the new antitussive levodropropizine in adult bronchitic patients, Arzneim Forsch/Drug Res, 38, 1163 Forsberg, 1986, Cough induced by stimulation of capsaicin-sensitive sensory neurons in conscious guinea-pigs, Acta Physiol Scand, 128, 319, 10.1111/j.1748-1716.1986.tb07981.x Kohrogi, 1988, Neutral endopeptidase inhibitors potentiate substance P- and capsaicin-induced cough in awake guinea pigs, J Clin Invest, 82, 2063, 10.1172/JCI113827 Kohrogi, 1989, Recombinant human enkephalinase (neutral endopeptidase) prevents cough induced by tachykinins in awake guinea pigs, J Clin Invest, 84, 781, 10.1172/JCI114236 Karlsson, 1988, Afferent neural pathways in cough and reflex bronchoconstriction, J Appl Physiol, 65, 1007, 10.1152/jappl.1988.65.3.1007 Cavanagh, 1976, Antitussive properties of butorphanol, Arch Int Pharmacodyn, 220, 258 Gamse, 1981, Immunoreactive substance P in sympathetic ganglia: distribution and sensitivity towards capsaicin, Neuroscience, 6, 437, 10.1016/0306-4522(81)90136-6 Del Monte, 1990, Ganglion-blocking agents enhance neurally mediated bronchoconstriction in the guinea-pig: possible role of sensory neuropeptides, Eur J Pharmacol, 180, 239, 10.1016/0014-2999(90)90307-R Friedman, 1937, The use of ranks to avoid the assumption of normality implicit in the analysis of variance, J Am Stat Assoc, 32, 675, 10.2307/2279372 Zaratin, 1988, Gas chromatographic-mass spectrometric determination of levodropropizine plasma levels in healthy volunteers, Arzneim Forsch/Drug Res, 38, 1156 Bossi, 1988, Antitussive activity and respiratory system effects of levodropropizine in man, Arzneim Forsch/Drug Res, 38, 1159 Daffonchio, 1991, The antitussive drug levodropropizine prevents airway hyperreactivity induced by exposure to cigarette smoke in guinea-pig, Eur Respir J, 4, 228s Daffonchio, 1990, Airways hyperreactivity induced by active cigarette smoke exposure in guinea pig: possible role of sensory neuropeptides, Pulmon Pharmacol, 3, 1, 10.1016/0952-0600(90)90048-N