Periodontitis is an independent risk indicator for atherosclerotic cardiovascular diseases among 60 174 participants in a large dental school in the Netherlands

Journal of Epidemiology and Community Health - Tập 71 Số 1 - Trang 37-42 - 2017
Nicky G. F. M. Beukers1, Geert J. M. G. van der Heijden2, Arjen J. van Wijk2, Bruno G. Loos3
1Department of Periodontology, Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam and VU University Amsterdam, Gustav Mahlerlaan 3004, Amsterdam 1081 LA, The Netherlands
2Department of Public Oral Health, Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam and VU University Amsterdam, Amsterdam, The Netherlands
3Department of Periodontology, Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam and VU University Amsterdam, Amsterdam, The Netherlands

Tóm tắt

BackgroundThe association between periodontitis and atherosclerotic cardiovascular diseases (ACVD) has been established in some modestly sized studies (<10 000). Rarely, however, periodontitis has been studied directly; often tooth loss or self-reported periodontitis has been used as a proxy measure for periodontitis. Our aim is to investigate the adjusted association between periodontitis and ACVD among all individuals registered in a large dental school in the Netherlands (Academic Centre for Dentistry Amsterdam (ACTA)).MethodsAnonymised data were extracted from the electronic health records for all registered patients aged >35 years (period 1998–2013). A participant was recorded as having periodontitis based on diagnostic and treatment codes. Any affirmative answer for cerebrovascular accidents, angina pectoris and/or myocardial infarction labelled a participant as having ACVD. Other risk factors for ACVD, notably age, sex, smoking, diabetes, hypertension, hypercholesterolaemia and social economic status, were also extracted. Logistic regression analyses were used to evaluate the adjusted associations between periodontitis and ACVD.Results60 174 individuals were identified; 4.7% of the periodontitis participants (455/9730) and 1.9% of the non-periodontitis participants (962/50 444) reported ACVD; periodontitis showed a significant association with ACVD (OR 2.52; 95% CI 2.3 to 2.8). After adjustment for the confounders, periodontitis remained independently associated with ACVD (OR 1.59; 95% CI 1.39 to 1.81). With subsequent stratification for age and sex, periodontitis remained independently associated with ACVD.ConclusionsThis cross-sectional analysis of a large cohort in the Netherlands of 60 174 participants shows the independent association of periodontitis with ACVD.

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Tài liệu tham khảo

10.1016/S0140-6736(05)67728-8

10.1111/j.1600-0757.2011.00415.x

10.1111/j.1600-051X.2008.01225.x

10.1177/0022034512457373

10.1902/jop.2015.140520

10.1016/j.amjcard.2009.05.002

10.1111/jcpe.12060

10.1016/S0140-6736(97)03079-1

10.1016/S0021-9150(98)00317-7

10.1161/01.CIR.0000113708.46466.C0

10.1902/annals.1998.3.1.151

10.1128/CMR.13.4.547-558.2000

10.1902/jop.2005.76.11-S.2106

10.1902/jop.2000.71.10.1554

10.1016/S0002-8703(99)70294-2

10.1161/CIRCULATIONAHA.105.579979

10.1371/journal.pgen.1000378

10.1007/s11606-008-0787-6

10.1111/jcpe.12062

10.1093/oxfordjournals.aje.a010203

10.1016/j.atherosclerosis.2011.07.091

10.1161/CIR.0b013e31825719f3

10.1007/s12471-013-0504-x

10.1161/01.CIR.103.22.2705

McGill, 2000, Origin of atherosclerosis in childhood and adolescence, Am J Clin Nutr, 72, 1307S, 10.1093/ajcn/72.5.1307s

10.1111/j.1600-0757.2005.00127.x

Hung, 2004, The association between tooth loss and coronary heart disease in men and women, J Public Health Dent, 64, 209, 10.1111/j.1752-7325.2004.tb02755.x

10.1016/j.atherosclerosis.2008.07.017

10.1016/j.tripleo.2007.09.032

10.1902/jop.2004.75.6.782

10.1177/154405910308201212

10.1034/j.1600-051X.2001.280807.x

10.1161/CIRCULATIONAHA.106.171016

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Journal of Epidemiology and Community Health

Tập 71 Số 1

37-42

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