Periodontal disease, tooth loss and dementia: Is there a link? A systematic review

Gerodontology - Tập 34 Số 2 - Trang 151-163 - 2017
Pallavi Tonsekar1, Shuying Jiang2, Gang Yue1
1Department of Periodontics, Rutgers School of Dental Medicine, Newark, NJ, USA
2Institutional Assessment and Quality Improvement, Rutgers School of Dental Medicine, Newark, NJ, USA

Tóm tắt

BackgroundIt has been suggested that dementia is caused by neuronal damage due to chronic inflammation from peripheral sources such as the oral cavity in periodontal disease.ObjectiveThe aim of our review was to assess the risk of dementia or cognitive impairment associated with chronic periodontitis and multiple tooth loss.Materials and methodsAn extensive search of electronic databases of articles on the relation between periodontitis, tooth loss and dementia published on or before April 2016 was conducted. Experimental and human studies that provided a description consistent with multiple tooth loss, chronic periodontal disease and cognitive impairment obtained by validated methods were selected. The data extracted from the articles included study design, country of origin, sample size, methods used to assess periodontitis and cognition, average age at the baseline and number of years of follow‐up. The Newcastle‐Ottawa scale was used to assess the quality of human studies.ResultsThe literature search yielded 756 articles which were independently screened, and 16 articles were included in the review. Four human studies reported an association of subsequent dementia with multiple tooth loss. One human study reported that chronic periodontal disease was associated with dementia. Eight experimental studies demonstrated an association between cognitive impairment and tooth loss.ConclusionThe literature on chronic periodontitis and multiple tooth loss as risk factors to dementia remains inconclusive. More randomised clinical trials on the association between periodontitis and dementia with uniform criteria for evaluation and diagnosis of periodontitis are warranted.

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Tài liệu tham khảo

10.1586/14737175.7.4.407

World Health Organization:Dementiaathttp://www.who.int/mediacentre/factsheets/fs362/en/. Accessed June 2 2016.

Alz.org.Alzheimer's diseaseathttp://www.alz.org/alzheimers_disease.asp. Accessed July 3 2016.

10.1159/000109998

Chu CH, 2015, Oral health status of elderly Chinese with dementia in Hong Kong, Oral Health Prev Dent, 13, 51

10.1007/s11910-013-0384-x

Small GW, 1997, Diagnosis and treatment of Alzheimer disease and related disorders. Consensus statement of the American Association, and the American Geriatrics Society, JAMA, 278, 1363, 10.1001/jama.1997.03550160083043

10.1155/2015/620143

10.1053/scnp.2003.50003

10.1016/S0197-4580(01)00289-5

10.1159/000017115

10.1016/S0197-4580(00)00124-X

10.1042/CS20060043

10.1016/j.bbi.2006.12.004

10.1016/S1566-0702(00)00220-4

10.1016/j.jalz.2007.08.004

10.1002/ana.10265

10.1111/j.1600-0404.1997.tb00275.x

10.1186/s13195-015-0117-2

10.1111/ggi.12425

10.1902/jop.2008.080173

10.1902/jop.2008.080183

10.1111/j.1600-0757.1994.tb00020.x

10.1111/j.1600-051X.1979.tb01935.x

10.1155/2015/137357

10.14219/jada.archive.2007.0046

10.1186/1744-859X-12-20

10.1371/journal.pone.0136271

Coenen M, 2015, Psychosocial difficulties from the perspective of persons with neuropsychiatric disorders, Disabil Rehabil, 18, 1

10.1016/j.pharep.2014.09.004

10.1016/j.ijsu.2010.02.007

10.1046/j.1365-2532.1999.00222.x

WellsGA SheaB O'ConnellD et al.The Newcastle‐Ottawa Scale (NOS) for assessing the quality of non randomized studies in meta‐analyses.http://www.ohri.ca/programs/clinical_epidemiology/oxford.htm. Accessed 6 October 2015.

10.1016/S0929-6646(09)60402-2

10.1111/j.1532-5415.2010.02788.x

10.1111/j.1600-0528.2011.00650.x

10.1111/cdoe.12128

10.1177/0022034509357881

10.1111/jgs.13194

10.1002/gps.1750

10.1016/j.jpor.2009.06.003

10.1016/S0166-4328(97)86078-0

10.1016/S0166-4328(99)00145-X

10.1016/S0006-8993(99)01255-X

10.1016/j.bbr.2013.06.015

10.1016/S0166-4328(01)00268-6

10.1016/S0531-5565(00)00216-3

10.1002/hipo.20440

10.1001/jama.1997.03550160069041

Cicciù M, 2013, Relationship between oral health and its impact on the quality life of Alzheimer's disease patients: a supportive care trial, Int J Clin Exp Med, 6, 766

10.1177/1533317514549650

10.1093/ajcn.82.3.627

10.1111/j.1532-5415.2006.01020.x

10.14219/jada.archive.2011.0192

10.1192/apt.7.1.24

10.1016/S1474-4422(11)70072-2

10.1016/j.neubiorev.2010.06.002

10.1111/j.1365-2842.2010.02079.x

10.1111/j.1600-0501.2005.01171.x

10.1177/154405910708600110

10.1111/j.1532-5415.2012.04154.x

10.1016/j.jalz.2006.01.002

Stevens RG, 1991, A study of the reasons for tooth extraction in a Canadian population sample, Can Dent Assoc, 57, 501

Coxhead LJ, 1960, Reasons for extractions in general practice, N Z Dent J, 56, 182

10.3109/00016356709104024

10.1902/jop.2007.060264

10.1016/S0197-4580(00)00241-4

10.1212/WNL.48.3.626

10.1097/00001756-199307000-00002

10.1097/00001756-199307000-00002

10.1046/j.0902-0055.2001.00100.x

10.3233/JAD-121918

10.1161/01.ATV.0000078603.90302.4A

10.1111/j.1532-5415.2008.01847.x

10.1161/hc0902.104353

10.1378/chest.06-2179

10.1002/ana.21073

10.1074/jbc.271.31.18295

10.1016/j.bbrc.2012.08.020

10.5402/2012/917167

10.1017/S0140525X00062713

10.1016/0306-4522(89)90424-7

10.2186/prp.5.37

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Gerodontology

Tập 34 Số 2

151-163

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