Periodic acid-Schiff granules in the brain of aged mice: From amyloid aggregates to degenerative structures containing neo-epitopes

Akiyama, 1986, Periodic acid-Schiff (PAS)-positive: granular structures increase in the brain of senescence accelerated mouse (SAM), Acta Neuropathol., 72, 124, 10.1007/BF00685973 Avrameas, 2013, Natural autoantibodies in the physiology and pathophysiology of the immune system, J. Autoimmun., 41, 46, 10.1016/j.jaut.2013.01.006 Binder, 2003, Pneumococcal vaccination decreases atherosclerotic lesion formation: molecular mimicry between Streptococcus pneumoniae and oxidized LDL, Nat. Med., 9, 736, 10.1038/nm876 Brändlein, 2003, Natural IgM antibodies and immunosurveillance mechanisms against epithelial cancer cells in humans, Cancer Res., 63, 7995 Cana, 2015, Characterization of periodic acid-Schiff-positive granular deposits in the hippocampus of SJL/J mice, Toxicol. Pathol., 43, 737, 10.1177/0192623314564254 Cavanagh, 1999, Corpora-amylacea and the family of polyglucosan diseases, Brain Res. Rev., 29, 265, 10.1016/S0165-0173(99)00003-X Corsetti, 2008, Identification of a caspase-derived N-terminal tau fragment in cellular and animal Alzheimer’s disease models, Mol. Cell Neurosci., 38, 381, 10.1016/j.mcn.2008.03.011 Del Valle, 2010, Early amyloid accumulation in the hippocampus of SAMP8 mice, J. Alzheimers Dis., 19, 1303, 10.3233/JAD-2010-1321 Del Valle, 2011, Cerebral amyloid angiopathy: blood-brain barrier disruption and amyloid accumulation in SAMP8 mice, Neurodegener. Dis., 8, 421, 10.1159/000324757 Doehner, 2010, Co-localization of Reelin and proteolytic AbetaPP fragments in hippocampal plaques in aged wild-type mice, J. Alzheimers Dis., 19, 1339, 10.3233/JAD-2010-1333 Doehner, 2012, Extrusion of misfolded and aggregated proteins—a protective strategy of aging neurons?, Eur. J. Neurosci., 35, 1938, 10.1111/j.1460-9568.2012.08154.x Ganesh, 2002, Targeted disruption of the Epm2a gene causes formation of Lafora inclusion bodies neurodegeneration, ataxia, myoclonus epilepsy and impaired behavioral response in mice, Hum. Mol. Genet., 11, 1251, 10.1093/hmg/11.11.1251 Goldin, 2006, Advanced glycation end products: sparking the development of diabetic vascular injury, Circulation, 114, 597, 10.1161/CIRCULATIONAHA.106.621854 Gudi, 2014, Glial response during cuprizone-induced de- and remyelination in the CNS: lessons learned, Front. Cell. Neurosci., 8, 73, 10.3389/fncel.2014.00073 Harman, 2006, Free radical theory of aging: an update: increasing the functional life span, Ann. N. Y. Acad. Sci., 1067, 10, 10.1196/annals.1354.003 Ingram, 1994, Motor and memory performance of SAMP8, R1 and C57BL/6 mice: assessing the relationship to PAS positive granules in the brain, 73 Irino, 1994, Ultrastructural study of PAS-positive granular structures (PGS) in brains of SAMP8, 371 Jenner, 2012, Mitochondria, monoamine oxidase B and Parkinson’s disease, Basal Ganglia, 2, S3, 10.1016/j.baga.2012.06.006 Jucker, 1992, Age-associated inclusions in normal and transgenic mouse brain, Science, 255, 1445, 10.1126/science.1542796 Jucker, 1994, Age-related fibrillar deposits in brains of C57BL/6 mice: a review of localization staining characteristics incidence of fibrillar deposits with aging, Mol. Neurobiol., 9, 125, 10.1007/BF02816112 Jucker, 1994, Age-related deposition of glia-associated fibrillar material in brains of C57BL/6 mice, Neuroscience, 60, 875, 10.1016/0306-4522(94)90269-0 Kern, 2011, Neural stem cells reduce hippocampal tau and reelin accumulation in aged Ts65Dn down syndrome mice, Cell Transplant., 20, 371, 10.3727/096368910X528085 Knuesel, 2009, Age-related accumulation of reelin in amyloid-like deposits, Neurobiol. Aging, 30, 697, 10.1016/j.neurobiolaging.2007.08.011 Kocherhans, 2010, Reduced reelin expression accelerates amyloid-beta plaque formation and tau pathology in transgenic Alzheimer’s disease mice, J. Neurosci., 30, 9228, 10.1523/JNEUROSCI.0418-10.2010 Krass, 2003, Genetic loci contributing to age-related hippocampal lesions in mice, Neurobiol. Dis., 13, 102, 10.1016/S0969-9961(03)00034-2 Kuo, 1996, Similarities in the age-related hippocampal deposition of periodic acid-schiff-positive granules in the senescence-accelerated mouse P8 and C57BL/6 mouse strains, Neuroscience, 74, 733, 10.1016/0306-4522(96)00169-8 Lamar, 1976, Alterations in the hippocampus of aged mice, Acta Neuropathol., 36, 387, 10.1007/BF00699644 López-Otín, 2013, The hallmarks of aging, Cell, 153, 1194, 10.1016/j.cell.2013.05.039 Madhusudan, 2009, Accumulation of reelin-positive plaques is accompanied by a decline in basal forebrain projection neurons during normal aging, Eur. J. Neurosci., 30, 1064, 10.1111/j.1460-9568.2009.06884.x Mandybur, 1989, Cerebral aging: a quantitative study of gliosis in old nude mice, Acta Neuropathol., 77, 507, 10.1007/BF00687252 Manich, 2011, Characterization of amyloid-β granules in the hippocampus of SAMP8 mice, J. Alzheimers Dis., 25, 535, 10.3233/JAD-2011-101713 Manich, 2014, Clustered granules present in the hippocampus of aged mice result from a degenerative process affecting astrocytes and their surrounding neuropil, Age, 36, 9690, 10.1007/s11357-014-9690-8 Manich, 2014, Presence of a neo-epitope and absence of amyloid beta and tau protein in degenerative hippocampal granules of aged mice, Age, 36, 151, 10.1007/s11357-013-9560-9 Manich, 2015, Neo-epitopes emerging in the neurodegenerative hippocampal granules of aged mice can be recognized by natural IgM auto-antibodies, Immun. Ageing, 10.1186/s12979-015-0050-z Mitsuno, 1999, Immunohistochemical: conventional and immunoelectron microscopical characteristics of periodic acid-Schiff-positive granules in the mouse brain, Acta Neuropathol., 98, 31, 10.1007/s004010051048 Nakamura, 1995, Monoamine oxidase-B-positive granular structures in the hippocampus of aged senescence-accelerated mouse (SAMP8), Acta Neuropathol., 90, 626, 10.1007/BF00318576 Oddo, 2003, Triple-transgenic model of Alzheimer’s disease with plaques and tangles: intracellular abeta and synaptic dysfunction, Neuron, 39, 409, 10.1016/S0896-6273(03)00434-3 Ouyang, 2007, Selective dysfunction of hippocampal CA1 astrocytes contributes to delayed neuronal damage after transient forebrain ischemia, J. Neurosci., 27, 4253, 10.1523/JNEUROSCI.0211-07.2007 Perluigi, 2014, Redox proteomics and the dynamic molecular landscape of the aging brain, Ageing Res. Rev., 13, 75, 10.1016/j.arr.2013.12.005 Porquet, 2013, Dietary resveratrol prevents Alzheimer’s markers and increases life span in SAMP8, Age, 35, 1851, 10.1007/s11357-012-9489-4 Rachubinski, 2012, Modulating cognitive deficits and tau accumulation in a mouse model of aging down syndrome through neonatal implantation of neural progenitor cells, Exp. Gerontol., 47, 723, 10.1016/j.exger.2012.06.013 Robertson, 1998, Age-related congophilic inclusions in the brains of apolipoprotein E-deficient mice, Neuroscience, 82, 171, 10.1016/S0306-4522(97)00284-4 Robertson, 2000, Comparison of astrocytic and myocytic metabolic dysregulation in apolipoprotein E deficient and human apolipoprotein E transgenic mice, Neuroscience, 98, 353, 10.1016/S0306-4522(00)00126-3 Schmidt, 1994, Cellular receptors for advanced glycation end products implications for induction of oxidant stress and cellular dysfunction in the pathogenesis of vascular lesions, Arterioscler. Thromb., 14, 1521, 10.1161/01.ATV.14.10.1521 Shih, 1999, Monoamine oxidase: from genes to behavior, Annu. Rev. Neurosci., 22, 197, 10.1146/annurev.neuro.22.1.197 Sinadinos, 2014, Neuronal glycogen synthesis contributes to physiological aging, Aging Cell, 13, 935, 10.1111/acel.12254 Singh, 2001, Advanced glycation end-products: a review, Diabetologia, 44, 129, 10.1007/s001250051591 Soontornniyomkij, 2012, Increased hippocampal accumulation of autophagosomes predicts short-term recognition memory impairment in aged mice, Age, 34, 305, 10.1007/s11357-011-9234-4 Spicer, 1961, The use of various cationic reagents in histochemical differentiation of mucopolysaccharides, Am. J. Clin. Pathol., 36, 393, 10.1093/ajcp/36.5.393 Spicer, 1992, Diversity of cell glycoconjugates shown histochemically: a perspective, J. Histochem. Cytochem., 40, 1, 10.1177/40.1.1370305 Takemura, 1993, Beta/A4 proteinlike immunoreactive granular structures in the brain of senescence-accelerated mouse, Am. J. Pathol., 142, 1887 Valles-Ortega, 2011, Neurodegeneration and functional impairments associated with glycogen synthase accumulation in a mouse model of Lafora disease, EMBO Mol. Med., 3, 667, 10.1002/emmm.201100174 Veurink, 2003, Reduction of inclusion body pathology in ApoE-deficient mice fed a combination of antioxidants, Free Radic. Biol. Med., 34, 1070, 10.1016/S0891-5849(03)00042-X Vollmers, 2006, Natural IgM antibodies: the orphaned molecules in immune surveillance, Adv. Drug Deliv. Rev., 58, 755, 10.1016/j.addr.2005.08.007 Wang, 2007, Genome-wide transcriptome profiling of region-specific vulnerability to oxidative stress in the hippocampus, Genomics, 90, 201, 10.1016/j.ygeno.2007.03.007 Wang, 2009, Genomic and biochemical approaches in the discovery of mechanisms for selective neuronal vulnerability to oxidative stress, BMC Neurosci., 10, 12, 10.1186/1471-2202-10-12 Wang, 2010, Selective neuronal vulnerability to oxidative stress in the brain, Front Aging Neurosci., 2, 12 Wilde, 1997, Differential vulnerability of the CA1 and CA3 subfields of the hippocampus to superoxide and hydroxyl radicals in vitro, J. Neurochem., 69, 883, 10.1046/j.1471-4159.1997.69020883.x Wirak, 1991, Deposits of amyloid beta protein in the central nervous system of transgenic mice, Science, 253, 323, 10.1126/science.1857970 Ye, 2004, The occurrence of vacuolation, and periodic acid-Schiff (PAS)-positive granules and plaques in the brains of C57BL/6 AKR, senescence-prone (SAMP8) and senescence-resistant (SAMR1) mice infected with various scrapie strains, Brain Res., 995, 158, 10.1016/j.brainres.2003.09.071 Yeoman, 2012, Insights into CNS ageing from animal models of senescence, Nat. Rev. Neurosci., 13, 435, 10.1038/nrn3230