Peri-operative DDAVP Use Leading to Severe Hyponatremia after Total Shoulder Replacement in a Patient with von Willebrand’s Disease

Agerso H, Seiding Larsen L, Riis A, Lovgren U, Karlsson MO, Senderovitz T. Pharmacokinetics and renal excretion of desmopressin after intravenous administration to healthy subjects and renally impaired patients. Br J Clin Pharmacol. 2004; 58(4): 352-358. Berntorp E, Peake I, Budde U, et al. Von willebrand’s disease: A report from a meeting in the aland islands. Haemophilia. 2012; 18(Suppl 6): 1-13. Castaman G, Federici AB, Rodeghiero F, Mannucci PM. Von willebrand’s disease in the year 2003: Towards the complete identification of gene defects for correct diagnosis and treatment. Haematologica. 2003; 88(1): 94-108. Favaloro EJ, Bodo I, Israels SJ, Brown SA. Von willebrand disease and platelet disorders. Haemophilia. 2014; 20(Suppl 4): 59-64. Rodenburg EM, Hoorn EJ, Ruiter R, et al. Thiazide-associated hyponatremia: A population-based study. Am J Kidney Dis. 2013; 62(1): 67-72. Sharma R, Stein D. Hyponatremia after desmopressin (DDAVP) use in pediatric patients with bleeding disorders undergoing surgeries. J Pediatr Hematol Oncol. 2014; 36(6): e371-5. Stone ME, Mazzeffi M, Derham J, Korshin A. Current management of von willebrand disease and von willebrand syndrome. Curr Opin Anaesthesiol. 2014; 27(3): 353-358. Verrua E, Mantovani G, Ferrante E, et al. Severe water intoxication secondary to the concomitant intake of non-steroidal anti-inflammatory drugs and desmopressin: A case report and review of the literature. Hormones (Athens). 2013; 12(1): 135-141.