Perfusion CT and acute stroke imaging: Foundations, applications, and literature review

Journal of Neuroradiology - Tập 42 Số 1 - Trang 21-29 - 2015
Joseph Donahue1, Max Wintermark2,1
1Division of Neuroradiology, University of Virginia, Charlottesville, VA, United States
2Department of Radiology, Division of Neuroradiology, Stanford University, 300, Pasteur Drive, Room S047, Stanford, CA 94305-5105, United States

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Go, 2014, Heart disease and stroke statistics-2014 update: a report from the American Heart Association, Circulation, 129, pe28, 10.1161/01.cir.0000441139.02102.80

Shetty, 2005, CT perfusion in acute stroke, Neuroimaging Clin N Am, 15, 481, 10.1016/j.nic.2005.08.004

Konstas, 2009, Theoretic basis and technical implementations of CT perfusion in acute ischemic stroke, part 2: technical implementations, AJNR Am J Neuroradiol, 30, 885, 10.3174/ajnr.A1492

Wintermark, 2008, Acute stroke imaging research roadmap, Stroke, 39, 1621, 10.1161/STROKEAHA.107.512319

Hom, 2011, Blood-brain barrier permeability assessed by perfusion CT predicts symptomatic hemorrhagic transformation and malignant edema in acute ischemic stroke, AJNR Am J Neuroradiol, 32, 41, 10.3174/ajnr.A2244

Konstas, 2011, CT perfusion imaging in acute stroke, Neuroimaging Clin N Am, 21, 215, 10.1016/j.nic.2011.01.008

Roberts, 2001, Multisection dynamic CT perfusion for acute cerebral ischemia: the “toggling-table” technique, AJNR Am J Neuroradiol, 22, 1077

Wintermark, 2004, Dynamic perfusion CT: optimizing the temporal resolution and contrast volume for calculation of perfusion CT parameters in stroke patients, AJNR Am J Neuroradiol, 25, 720

Abels, 2011, CT perfusion in acute ischemic stroke: a comparison of 2-second and 1-second temporal resolution, AJNR Am J Neuroradiol, 32, 1632, 10.3174/ajnr.A2576

Kamena, 2007, Dynamic perfusion CT: optimizing the temporal resolution for the calculation of perfusion CT parameters in stroke patients, Eur J Radiol, 64, 111, 10.1016/j.ejrad.2007.02.025

Thierfelder, 2013, Whole-brain CT perfusion: reliability and reproducibility of volumetric perfusion deficit assessment in patients with acute ischemic stroke, Neuroradiology, 55, 827, 10.1007/s00234-013-1179-0

Smith, 2007, Radiation dose-reduction strategies for neuroradiology CT protocols, AJNR Am J Neuroradiol, 28, 1628, 10.3174/ajnr.A0814

Eastwood, 2003, Perfusion CT with iodinated contrast material, AJR Am J Roentgenol, 180, 3, 10.2214/ajr.180.1.1800003

Mnyusiwalla, 2009, Radiation dose from multidetector row CT imaging for acute stroke, Neuroradiology, 51, 635, 10.1007/s00234-009-0543-6

Diekmann, 2010, Dose exposure of patients undergoing comprehensive stroke imaging by multidetector-row CT: comparison of 320-detector row and 64-detector row CT scanners, AJNR Am J Neuroradiol, 31, 1003, 10.3174/ajnr.A1971

Nabavi, 1999, CT assessment of cerebral perfusion: experimental validation and initial clinical experience, Radiology, 213, 141, 10.1148/radiology.213.1.r99oc03141

Saba, 2014, Multi-modal CT scanning in the evaluation of cerebrovascular disease patients, Cardiovasc Diagn Ther, 4, 245

Sabarudin, 2014, Radiation dose associated with cerebral ct angiography and ct perfusion: an experimental phantom study, Radiat Prot Dosimetry, 162, 316, 10.1093/rpd/nct280

Corcuera-Solano, 2014, Whole-brain adaptive 70-kVp perfusion imaging with variable and extended sampling improves quality and consistency while reducing dose, AJNR Am J Neuroradiol, 35, 2045, 10.3174/ajnr.A4043

Tong, 2014, CTA-enhanced perfusion CT: an original method to perform ultra-low-dose CTA-enhanced perfusion CT, Neuroradiology, 56, 955, 10.1007/s00234-014-1416-1

Fang, 2013, Towards robust deconvolution of low-dose perfusion CT: sparse perfusion deconvolution using online dictionary learning, Med Image Anal, 17, 417, 10.1016/j.media.2013.02.005

Ma, 2012, Iterative image reconstruction for cerebral perfusion CT using a pre-contrast scan induced edge-preserving prior, Phys Med Biol, 57, 7519, 10.1088/0031-9155/57/22/7519

Konstas, 2009, Theoretic basis and technical implementations of CT perfusion in acute ischemic stroke, part 1: theoretic basis, AJNR Am J Neuroradiol, 30, 662, 10.3174/ajnr.A1487

Leiva-Salinas, 2011, Responses to the 10 most frequently asked questions about perfusion CT, AJR Am J Roentgenol, 196, 53, 10.2214/AJR.10.5705

Miles, 1991, Measurement of tissue perfusion by dynamic computed tomography, Br J Radiol, 64, 409, 10.1259/0007-1285-64-761-409

Klotz, 1999, Perfusion measurements of the brain: using dynamic CT for the quantitative assessment of cerebral ischemia in acute stroke, Eur J Radiol, 30, 170, 10.1016/S0720-048X(99)00009-1

Leiva-Salinas, 2012, The alphabet soup of perfusion CT and MR imaging: terminology revisited and clarified in five questions, Neuroradiology, 54, 907, 10.1007/s00234-012-1028-6

Ferreira, 2010, Arterial input function placement for accurate CT perfusion map construction in acute stroke, AJR Am J Roentgenol, 194, 1330, 10.2214/AJR.09.2845

Shin, 2014, Does the location of the arterial input function affect quantitative CTP in patients with vasospasm?, AJNR Am J Neuroradiol, 35, 49, 10.3174/ajnr.A3655

Bivard, 2013, Perfusion CT in acute stroke: a comprehensive analysis of infarct and penumbra, Radiology, 267, 543, 10.1148/radiol.12120971

Abels, 2010, Perfusion CT in acute ischemic stroke: a qualitative and quantitative comparison of deconvolution and maximum slope approach, AJNR Am J Neuroradiol, 31, 1690, 10.3174/ajnr.A2151

Abels, 2012, Acute stroke: a comparison of different CT perfusion algorithms and validation of ischaemic lesions by follow-up imaging, Eur Radiol, 22, 2559, 10.1007/s00330-012-2529-8

Soares, 2009, Automated versus manual post-processing of perfusion-CT data in patients with acute cerebral ischemia: influence on interobserver variability, Neuroradiology, 51, 445, 10.1007/s00234-009-0516-9

Sanelli, 2004, The effect of varying user-selected input parameters on quantitative values in CT perfusion maps, Acad Radiol, 11, 1085, 10.1016/j.acra.2004.07.002

Bisdas, 2007, Effect of the arterial input function on the measured perfusion values and infarct volumetric in acute cerebral ischemia evaluated by perfusion computed tomography, Invest Radiol, 42, 147, 10.1097/01.rli.0000252486.79800.a7

Wintermark, 2008, The anterior cerebral artery is an appropriate arterial input function for perfusion-CT processing in patients with acute stroke, Neuroradiology, 50, 227, 10.1007/s00234-007-0336-8

Riordan, 2013, CT brain perfusion protocol to eliminate the need for selecting a venous output function, AJNR Am J Neuroradiol, 34, 1353, 10.3174/ajnr.A3397

Wintermark, 2013, Imaging recommendations for acute stroke and transient ischemic attack patients: a joint statement by the American Society of Neuroradiology, the American College of Radiology, and the Society of NeuroInterventional Surgery, AJNR Am J Neuroradiol, 34, E117, 10.3174/ajnr.A3690

Sims, 2005, The evolving role of acute stroke imaging in intravenous thrombolytic therapy: patient selection and outcomes assessment, Neuroimaging Clin N Am, 15, 421, 10.1016/j.nic.2005.06.001

Tong, 2014, The role of imaging in acute ischemic stroke, Neurosurg Focus, 36, 10.3171/2013.10.FOCUS13396

Lev, 2013, Perfusion imaging of acute stroke: its role in current and future clinical practice, Radiology, 266, 22, 10.1148/radiol.12121355

Donahue, 2014, Assessment of collateral flow in patients with cerebrovascular disorders, J Neuroradiol, 41, 234, 10.1016/j.neurad.2013.11.002

McVerry, 2014, Derivation and evaluation of thresholds for core and tissue at risk of infarction using CT perfusion, J Neuroimaging, 24, 562, 10.1111/jon.12134

Kamalian, 2011, CT cerebral blood flow maps optimally correlate with admission diffusion-weighted imaging in acute stroke but thresholds vary by postprocessing platform, Stroke, 42, 1923, 10.1161/STROKEAHA.110.610618

Schaefer, 2006, First-pass quantitative CT perfusion identifies thresholds for salvageable penumbra in acute stroke patients treated with intra-arterial therapy, AJNR Am J Neuroradiol, 27, 20

Wintermark, 2006, Perfusion-CT assessment of infarct core and penumbra: receiver operating characteristic curve analysis in 130 patients suspected of acute hemispheric stroke, Stroke, 37, 979, 10.1161/01.STR.0000209238.61459.39

Wintermark, 2002, Prognostic accuracy of cerebral blood flow measurement by perfusion computed tomography, at the time of emergency room admission, in acute stroke patients, Ann Neurol, 51, 417, 10.1002/ana.10136

Bivard, 2011, Defining the extent of irreversible brain ischemia using perfusion computed tomography, Cerebrovasc Dis, 31, 238, 10.1159/000321897

Nighoghossian, 2003, Baseline magnetic resonance imaging parameters and stroke outcome in patients treated by intravenous tissue plasminogen activator, Stroke, 34, 458, 10.1161/01.STR.0000053850.64877.AF

von Kummer, 2003, Early major ischemic changes on computed tomography should preclude use of tissue plasminogen activator, Stroke, 34, 820, 10.1161/01.STR.0000059430.55671.56

Barber, 2000, Validity and reliability of a quantitative computed tomography score in predicting outcome of hyperacute stroke before thrombolytic therapy. ASPECTS Study Group. Alberta Stroke Programme Early CT Score, Lancet, 355, 1670, 10.1016/S0140-6736(00)02237-6

Lev, 2001, Utility of perfusion-weighted CT imaging in acute middle cerebral artery stroke treated with intra-arterial thrombolysis: prediction of final infarct volume and clinical outcome, Stroke, 32, 2021, 10.1161/hs0901.095680

Kruetzelmann, 2011, Pretreatment diffusion-weighted imaging lesion volume predicts favorable outcome after intravenous thrombolysis with tissue-type plasminogen activator in acute ischemic stroke, Stroke, 42, 1251, 10.1161/STROKEAHA.110.600148

Souza, 2012, Malignant CTA collateral profile is highly specific for large admission DWI infarct core and poor outcome in acute stroke, AJNR Am J Neuroradiol, 33, 1331, 10.3174/ajnr.A2985

Yoo, 2012, Infarct volume is a pivotal biomarker after intra-arterial stroke therapy, Stroke, 43, 1323, 10.1161/STROKEAHA.111.639401

Albers, 2006, Magnetic resonance imaging profiles predict clinical response to early reperfusion: the diffusion and perfusion imaging evaluation for understanding stroke evolution (DEFUSE) study, Ann Neurol, 60, 508, 10.1002/ana.20976

Davis, 2008, Effects of alteplase beyond 3h after stroke in the Echoplanar Imaging Thrombolytic Evaluation Trial (EPITHET): a placebo-controlled randomised trial, Lancet Neurol, 7, 299, 10.1016/S1474-4422(08)70044-9

Janjua, 2008, Impact of arterial reocclusion and distal fragmentation during thrombolysis among patients with acute ischemic stroke, AJNR Am J Neuroradiol, 29, 253, 10.3174/ajnr.A0825

Ames, 1968, Cerebral ischemia. II. The no-reflow phenomenon, Am J Pathol, 52, 437

del Zoppo, 2008, Virchow's triad: the vascular basis of cerebral injury, Rev Neurol Dis, 5, S12

Soares, 2010, Reperfusion is a more accurate predictor of follow-up infarct volume than recanalization: a proof of concept using CT in acute ischemic stroke patients, Stroke, 41, pe34, 10.1161/STROKEAHA.109.568766

De Silva, 2009, Assessing reperfusion and recanalization as markers of clinical outcomes after intravenous thrombolysis in the echoplanar imaging thrombolytic evaluation trial (EPITHET), Stroke, 40, 2872, 10.1161/STROKEAHA.108.543595

Zhu, 2013, Prediction of recanalization trumps prediction of tissue fate: the penumbra: a dual-edged sword, Stroke, 44, 1014, 10.1161/STROKEAHA.111.000229

Broderick, 2013, Endovascular therapy after intravenous t-PA versus t-PA alone for stroke, N Engl J Med, 368, 893, 10.1056/NEJMoa1214300

Kidwell, 2013, A trial of imaging selection and endovascular treatment for ischemic stroke, N Engl J Med, 368, 914, 10.1056/NEJMoa1212793

Parsons, 2012, A randomized trial of tenecteplase versus alteplase for acute ischemic stroke, N Engl J Med, 366, 1099, 10.1056/NEJMoa1109842

Lemmens, 2013, Comparison of the response to endovascular reperfusion in relation to site of arterial occlusion, Neurology, 81, 614, 10.1212/WNL.0b013e3182a08f07

Hacke, 2009, Intravenous desmoteplase in patients with acute ischaemic stroke selected by MRI perfusion-diffusion weighted imaging or perfusion CT (DIAS-2): a prospective, randomised, double-blind, placebo-controlled study, Lancet Neurol, 8, 141, 10.1016/S1474-4422(08)70267-9

Hill, 2014, Alberta Stroke Program early computed tomography score to select patients for endovascular treatment: Interventional Management of Stroke (IMS)-III Trial, Stroke, 45, 444, 10.1161/STROKEAHA.113.003580

Demchuk, 2014, Recanalization and Clinical Outcome of Occlusion Sites at Baseline CT Angiography in the Interventional Management of Stroke III Trial, Radiology, 273, 10.1148/radiol.14132649

Hacke, 1995, Intravenous thrombolysis with recombinant tissue plasminogen activator for acute hemispheric stroke. The European Cooperative Acute Stroke Study (ECASS), Jama, 274, 1017, 10.1001/jama.1995.03530130023023

von Kummer, 1994, Sensitivity and prognostic value of early CT in occlusion of the middle cerebral artery trunk, AJNR Am J Neuroradiol, 15, 9

Larrue, 2001, Risk factors for severe hemorrhagic transformation in ischemic stroke patients treated with recombinant tissue plasminogen activator: a secondary analysis of the European-Australasian Acute Stroke Study (ECASS II), Stroke, 32, 438, 10.1161/01.STR.32.2.438

Wahlgren, 2008, Multivariable analysis of outcome predictors and adjustment of main outcome results to baseline data profile in randomized controlled trials: Safe Implementation of Thrombolysis in Stroke-MOnitoring STudy (SITS-MOST), Stroke, 39, 3316, 10.1161/STROKEAHA.107.510768

Kidwell, 2008, Imaging of intracranial haemorrhage, Lancet Neurol, 7, 256, 10.1016/S1474-4422(08)70041-3

Huisman, 2005, Intracranial hemorrhage: ultrasound, CT and MRI findings, Eur Radiol, 15, 434, 10.1007/s00330-004-2615-7

Rha, 2007, The impact of recanalization on ischemic stroke outcome: a meta-analysis, Stroke, 38, 967, 10.1161/01.STR.0000258112.14918.24

Ciccone, 2013, Endovascular treatment for acute ischemic stroke, N Engl J Med, 368, 904, 10.1056/NEJMoa1213701

Saqqur, 2007, Site of arterial occlusion identified by transcranial Doppler predicts the response to intravenous thrombolysis for stroke, Stroke, 38, 948, 10.1161/01.STR.0000257304.21967.ba

Sims, 2005, Arterial occlusion revealed by CT angiography predicts NIH stroke score and acute outcomes after IV tPA treatment, AJNR Am J Neuroradiol, 26, 246

Nguyen-Huynh, 2008, How accurate is CT angiography in evaluating intracranial atherosclerotic disease?, Stroke, 39, 1184, 10.1161/STROKEAHA.107.502906

Hirai, 2002, Prospective evaluation of suspected stenoocclusive disease of the intracranial artery: combined MR angiography and CT angiography compared with digital subtraction angiography, AJNR Am J Neuroradiol, 23, 93

Knauth, 1997, Potential of CT angiography in acute ischemic stroke, AJNR Am J Neuroradiol, 18, 1001

Pulli, 2012, Acute ischemic stroke: infarct core estimation on CT angiography source images depends on CT angiography protocol, Radiology, 262, 593, 10.1148/radiol.11110896

Liebeskind, 2003, Collateral circulation, Stroke, 34, 2279, 10.1161/01.STR.0000086465.41263.06

Zhu, 2013, Computed tomography workup of patients suspected of acute ischemic stroke: perfusion computed tomography adds value compared with clinical evaluation, noncontrast computed tomography, and computed tomography angiogram in terms of predicting outcome, Stroke, 44, 1049, 10.1161/STROKEAHA.111.674705

McVerry, 2012, Systematic review of methods for assessing leptomeningeal collateral flow, AJNR Am J Neuroradiol, 33, 576, 10.3174/ajnr.A2794

Bang, 2008, Impact of collateral flow on tissue fate in acute ischaemic stroke, J Neurol Neurosurg Psychiatry, 79, 625, 10.1136/jnnp.2007.132100

Miteff, 2009, The independent predictive utility of computed tomography angiographic collateral status in acute ischaemic stroke, Brain, 132, 2231, 10.1093/brain/awp155

Kucinski, 2003, Collateral circulation is an independent radiological predictor of outcome after thrombolysis in acute ischaemic stroke, Neuroradiology, 45, 11, 10.1007/s00234-002-0881-0

Cao, 2014, Relative Filling time delay based on CT perfusion source imaging: a simple method to predict outcome in acute ischemic stroke, AJNR Am J Neuroradiol, 35, 1683, 10.3174/ajnr.A3931

Schellinger, 2013, Favorable vascular profile is an independent predictor of outcome: a post hoc analysis of the safety and efficacy of NeuroFlo Technology in Ischemic Stroke trial, Stroke, 44, 1606, 10.1161/STROKEAHA.111.000709

Liebeskind, 2011, Collaterals dramatically alter stroke risk in intracranial atherosclerosis, Ann Neurol, 69, 963, 10.1002/ana.22354

Bang, 2011, Collateral flow predicts response to endovascular therapy for acute ischemic stroke, Stroke, 42, 693, 10.1161/STROKEAHA.110.595256

Keedy, 2012, Contrast delay on perfusion CT as a predictor of new, incident infarct: a retrospective cohort study, Stroke, 43, 1295, 10.1161/STROKEAHA.111.639229

Lin, 2007, Measuring elevated microvascular permeability and predicting hemorrhagic transformation in acute ischemic stroke using first-pass dynamic perfusion CT imaging, AJNR Am J Neuroradiol, 28, 1292, 10.3174/ajnr.A0539

Aviv, 2009, Hemorrhagic transformation of ischemic stroke: prediction with CT perfusion, Radiology, 250, 867, 10.1148/radiol.2503080257

Nguyen, 2013, Measurement of blood-brain barrier permeability in acute ischemic stroke using standard first-pass perfusion CT data, Neuroimage Clin, 2, 658, 10.1016/j.nicl.2013.04.004