Performance of BNP and NT-proBNP for diagnosis of heart failure in primary care patients: a systematic review

Ronald A. Booth1, Stephen A. Hill2, Andrew Don-Wauchope2, Pasqualina Santaguida3, Mark Oremus3, Robert S. McKelvie4, Cynthia Balion2, Judy Brown3, Usman Ali3, Amy Bustamam3, Nazmul Sohel3, Parminder Raina3
1Department of Pathology and Laboratory Medicine, University of Ottawa, Ottawa, Canada
2Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Canada
3Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Canada
4Department of Medicine, McMaster University, Hamilton, Canada

Tóm tắt

Từ khóa


Tài liệu tham khảo

(1992) Effect of enalapril on mortality and the development of heart failure in asymptomatic patients with reduced left ventricular ejection fractions. The SOLVD Investigattors. N Engl J Med 327:685–691. doi: 10.1056/NEJM199209033271003

Balion C, Santaguida PL, Hill S, Worster A, McQueen M, Oremus M, McKelvie R, Booker L, Fagbemi J, Reichert S, Raina P (2006) Testing for BNP and NT-proBNP in the diagnosis and prognosis of heart failure. AHRQ, Rockville. AHRQ Publication No. 06-E014

Jessup M, Abraham WT, Casey DE, Feldman AM, Francis GS, Ganiats TG et al (2009) 2009 focused update: ACCF/AHA Guidelines for the diagnosis and management of heart failure in adults: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines: developed in collaboration with the International Society for Heart and Lung Transplantation. Circ Cardiovasc Qual Outcomes 119:1977–2016. doi: 10.1161/CIRCULATIONAHA.109.192064

McKelvie RS, Moe GW, Ezekowitz JA, Heckman GA, Costigan J, Ducharme A et al (2013) The 2012 Canadian Cardiovascular Society heart failure management guidelines update: focus on acute and chronic heart failure. Can J Cardiol 29:168–181. doi: 10.1016/j.cjca.2012.10.007

Scottish Intercollegiate Guidelines Network (SIGN) (2007) Management of chronic heart failure. 95. http://www.sign.ac.uk/guidelines/fulltext/95/index.html

National Clinical Guideline Centre (2010) Chronic heart failure: management of chronic heart failure in adults in primary and secondary care. National Institute for Health and Clinical Excellence, Manchester. NICE Clinical Guideline 108. http://www.nice.org.uk/nicemedia/live/13099/50517/50517.pdf

American Academy of Family Physicians (2011) Primary care. American Academy of Family Physicians, Leawood. http://www.aafp.org/online/en/home/policy/policies/p/primarycare.html#Parsys0002

Hanley JA, McNeil BJ (1982) The meaning and use of the area under a receiver operating characteristic (ROC) curve. Radiology 143:29–36

Chu H, Cole SR (2006) Bivariate meta-analysis of sensitivity and specificity with sparse data: a generalized linear mixed model approach. J Clin Epidemiol 59:1331–1332. doi: 10.1016/j.jclinepi.2006.06.011

(2014) Methods guide for effectiveness and comparative effectiveness reviews. Agency for Healthcare Research and Quality, Rockville. AHRQ Publication No. 10(14)-EHC063-EF. http://www.effectivehealthcare.ahrq.gov/search-for-guides-reviews-and-reports/?pageaction=displayproduct&mp=1&productID=318

(2012) Methods guide for medical test reviews. Agency for Healthcare Research and Quality (AHRQ), Rockville. AHRQ Publication No. 12-EHC017. http://effectivehealthcare.ahrq.gov/index.cfm/search-for-guides-reviews-and-reports/?pageaction=displayproduct&productid=558

Aspromonte N, Feola M, Scardovi AB, Coletta C, D’Eri A, Giovinazzo P et al (2006) Early diagnosis of congestive heart failure: clinical utility of B-type natriuretic peptide testing associated with Doppler echocardiography. J Cardiovasc Med (Hagerstown) 7:406–413. doi: 10.2459/01.JCM.0000228690.40452.d3

Arques S, Roux E, Sbragia P, Ambrosi P, Taieb L, Pieri B et al (2005) Accuracy of tissue Doppler echocardiography in the emergency diagnosis of decompensated heart failure with preserved left ventricular systolic function: comparison with B-type natriuretic peptide measurement. Echocardiography 22:657–664. doi: 10.1111/j.1540-8175.2005.40076.x

Jeyaseelan S, Goudie BM, Pringle SD, Donnan PT, Sullivan FM, Struthers AD (2007) A critical re-appraisal of different ways of selecting ambulatory patients with suspected heart failure for echocardiography. Eur J Heart Fail 9:55–61. doi: 10.1016/j.ejheart.2006.04.003

Mak G, Ryder M, Murphy NF, O’Loughlin C, McCaffrey D, Ledwidge M et al (2008) Diagnosis of new onset heart failure in the community: the importance of a shared-care approach and judicious use of BNP. Ir J Med Sci 177:197–203. doi: 10.1007/s11845-008-0186-3

Macabasco-O’Connell A, Meymandi S, Bryg R (2010) B-type natriuretic peptide (BNP) is useful in detecting asymptomatic left ventricular dysfunction in low-income, uninsured patients. Biol Res Nurs 11:280–287. doi: 10.1177/1099800409339625

Barrios V, Llisterri JL, Escobar C, Alfaro P, Colado F, Ridocci F et al (2011) Clinical applicability of B-type natriuretic peptide in patients with suspected heart failure in primary care in Spain: the PANAMA study. Expert Rev Cardiovasc Ther 9:579–585. doi: 10.1586/erc.11.28

Murtagh G, Dawkins IR, O’Connell R, Badabhagni M, Patel A, Tallon E et al (2012) Screening to prevent heart failure (STOP-HF): expanding the focus beyond asymptomatic left ventricular systolic dysfunction. Eur J Heart Fail 14:480–486. doi: 10.1093/eurjhf/hfs030

Fuat A, Murphy JJ, Hungin AP, Curry J, Mehrzad AA, Hetherington A et al (2006) The diagnostic accuracy and utility of a B-type natriuretic peptide test in a community population of patients with suspected heart failure. Br J Gen Pract 56:327–333

Zaphiriou A, Robb S, Murray-Thomas T, Mendez G, Fox K, McDonagh T et al (2005) The diagnostic accuracy of plasma BNP and NTproBNP in patients referred from primary care with suspected heart failure: results of the UK natriuretic peptide study. Eur J Heart Fail 7:537–541. doi: 10.1016/j.ejheart.2005.01.022

Park HJ, Baek SH, Jang SW, Kim DB, Shin DI, Shin WS et al (2010) Direct comparison of B-type natriuretic peptide and N-terminal pro-BNP for assessment of cardiac function in a large population of symptomatic patients. Int J Cardiol 140:336–343. doi: 10.1016/j.ijcard.2008.11.107

Christenson RH, Azzazy HM, Duh SH, Maynard S, Seliger SL, deFilippi CR (2010) Impact of increased body mass index on accuracy of B-type natriuretic peptide (BNP) and N-terminal proBNP for diagnosis of decompensated heart failure and prediction of all-cause mortality. Clin Chem 56:633–641. doi: 10.1373/clinchem.2009.129742

Kelder JC, Cramer MJ, Verweij WM, Grobbee DE, Hoes AW (2011) Clinical utility of three B-type natriuretic peptide assays for the initial diagnostic assessment of new slow-onset heart failure. J Card Fail 17:729–734. doi: 10.1016/j.cardfail.2011.04.013

Goode KM, Clark AL, Bristow JA, Sykes KB, Cleland JG (2007) Screening for left ventricular systolic dysfunction in high-risk patients in primary-care: a cost–benefit analysis. Eur J Heart Fail 9:1186–1195. doi: 10.1016/j.ejheart.2007.10.003

Goode KM, Clark AL, Cleland JG (2008) Ruling out heart failure in primary-care: the cost-benefit of pre-screening using NT-proBNP and QRS width. Int J Cardiol 130:426–437. doi: 10.1016/j.ijcard.2007.08.131

Gustafsson F, Badskjaer J, Hansen FS, Poulsen AH, Hildebrandt P (2003) Value of N-terminal proBNP in the diagnosis of left ventricular systolic dysfunction in primary care patients referred for echocardiography. Heart Drug 3:141–146. doi: 10.1159/000073839

Gustafsson F, Steensgaard-Hansen F, Badskjaer J, Poulsen AH, Corell P, Hildebrandt P (2005) Diagnostic and prognostic performance of N-terminal ProBNP in primary care patients with suspected heart failure. J Card Fail 11:S15–S20. doi: 10.1016/j.cardfail.2005.04.022

Hobbs FD, Davis RC, Roalfe AK, Hare R, Davies MK (2004) Reliability of N-terminal proBNP assay in diagnosis of left ventricular systolic dysfunction within representative and high risk populations. Heart 90:866–870. doi: 10.1136/hrt.2003.014258

Kelder JC, Cramer MJ, van Wijngaarden J, van Tooren R, Mosterd A, Moons KG et al (2011) The diagnostic value of physical examination and additional testing in primary care patients with suspected heart failure. Circ Heart Fail 124:2865–2873. doi: 10.1161/CIRCULATIONAHA.111.019216

Koschack J, Scherer M, Luers C, Kochen MM, Wetzel D, Kleta S et al (2008) Natriuretic peptide vs. clinical information for diagnosis of left ventricular systolic dysfunction in primary care. BMC Fam Pract 9:14. doi: 10.1186/1471-2296-9-14

Lim TK, Dwivedi G, Hayat S, Collinson PO, Senior R (2007) Cost effectiveness of the B type natriuretic peptide, electrocardiography, and portable echocardiography for the assessment of patients from the community with suspected heart failure. Echocardiography 24:228–236. doi: 10.1111/j.1540-8175.2007.00398.x

Mikkelsen KV, Bie P, Moller JE, Videbaek L, Villadsen HD, Haghfelt T (2006) Neurohormonal activation and diagnostic value of cardiac peptides in patients with suspected mild heart failure. Int J Cardiol 110:324–333. doi: 10.1016/j.ijcard.2005.08.003

Nielsen LS, Svanegaard J, Klitgaard NA, Egeblad H (2004) N-terminal pro-brain natriuretic peptide for discriminating between cardiac and non-cardiac dyspnoea. Eur J Heart Fail 6:63–70. doi: 10.1016/j.ejheart.2003.10.003

Olofsson M, Boman K (2010) Usefulness of natriuretic peptides in primary health care: an exploratory study in elderly patients. Scand J Prim Health Care 28:29–35. doi: 10.3109/02813430903345074

Shelton RJ, Clark AL, Goode K, Rigby AS, Cleland JG (2006) The diagnostic utility of N-terminal pro-B-type natriuretic peptide for the detection of major structural heart disease in patients with atrial fibrillation. Eur Heart J 27:2353–2361. doi: 10.1093/eurheartj/ehl233

Sivakumar R, Wellsted D, Parker K, Lynch M, Ghosh P, Khan SA (2006) Utility of N terminal pro brain natriuretic peptide in elderly patients. Postgrad Med J 82:220–223. doi: 10.1136/pgmj.2005.037051

Stahrenberg R, Edelmann F, Mende M, Kockskämper A, Düngen HD, Lüers C et al (2010) The novel biomarker growth differentiation factor 15 in heart failure with normal ejection fraction. Eur J Heart Fail 12:1309–1316. doi: 10.1093/eurjhf/hfq151

Valle R, Aspromonte N, Barro S, Canali C, Carbonieri E, Ceci V et al (2005) The NT-proBNP assay identifies very elderly nursing home residents suffering from pre-clinical heart failure. Eur J Heart Fail 7:542–551. doi: 10.1016/j.ejheart.2004.07.005

Mant J, Doust J, Roalfe A, Barton P, Cowie M, Glasziou P et al (2009) Systematic review and individual patient data meta-analysis of diagnosis of heart failure, with modelling of implications of different diagnostic strategies in primary care. Health Technol Assess 13:1–207. doi: 10.3310/hta13320

Hildebrandt P, Collinson PO, Doughty RN, Fuat A, Gaze DC, Gustafsson F et al (2010) Age-dependent values of N-terminal pro-B-type natriuretic peptide are superior to a single cut-point for ruling out suspected systolic dysfunction in primary care. Eur Heart J 31:1881–1889. doi: 10.1093/eurheartj/ehq163

Hall C (2005) NT-ProBNP: the mechanism behind the marker. J Card Fail 11:S81–S83. doi: 10.1016/j.cardfail.2005.04.019

Charles CJ, Espiner EA, Richards AM (1993) Cardiovascular actions of ANF: contributions of renal, neurohumoral, and hemodynamic factors in sheep. Am J Physiol 264:R533–R538

Bursi F, Weston SA, Redfield MM, Jacobsen SJ, Pakhomov S, Nkomo VT et al (2006) Systolic and diastolic heart failure in the community. JAMA 296:2209–2216. doi: 10.1001/jama.296.18.2209

Mastandrea P (2008) Some heterogeneity factors affecting the B-type natriuretic peptides outcome: a meta-analysis. Clin Chem Lab Med 46:1687–1695. doi: 10.1515/CCLM.2008.348

Choi S, Park D, Lee S, Hong Y, Kim S, Lee J (2007) Cut-off values of B-type natriuretic peptide for the diagnosis of congestive heart failure in patients with dyspnoea visiting emergency departments: a study on Korean patients visiting emergency departments. Emerg Med J 24:343–347. doi: 10.1136/emj.2006.041368

Oh J, Kang SM, Hong N, Choi JW, Lee SH, Park S et al (2009) Relation between red cell distribution width with echocardiographic parameters in patients with acute heart failure. J Card Fail 15:517–522. doi: 10.1016/j.cardfail.2009.01.002