Peptide Histidine Isoleucine and Vasoactive Intestinal Polypeptide Cause Relaxation of Opossum Internal Anal Sphincter via Two Distinct Receptors

Goyal, 1980, VIP as a possible neurotransmitter of non-cholinergic, non-adrenergic inhibitory neurons, Nature, 288, 378, 10.1038/288378a0 Rattan, 1986, The non-adrenergic, non-cholinergic innervation of the esophagus and the lower esophageal sphincter, Arch Int Pharmacodyn, 280, 62 Biancani, 1984, Vasoactive intestinal polypeptide. A neurotransmitter for lower esophageal sphincter relaxation, J Clin Invest, 73, 963, 10.1172/JCI111320 Makhlouf, 1987, Isolated smooth muscle cells of the gut, 555 Grider, 1985, Vasoactive intestinal peptide as a neural mediator of gastric relaxation, Am J Physiol, 248, G73 Angel, 1983, Vasoactive intestinal polypeptide. A putative neurotransmitter in the canine gastric muscularis mucosa, J Physiol (Lond), 341, 641, 10.1113/jphysiol.1983.sp014830 Grider, 1986, Colonic peristaltic reflex: identification of vasoactive intestinal peptide as a mediator of descending relaxation, Am J Physiol, 251, G40 Furness, 1981, Evidence for and significance of the projection of VIP neurons from the myenteric plexus to the tenia coli in the guinea pig, Gastroenterology, 80, 1557, 10.1016/0016-5085(81)90272-9 Schultzberg, 1980, Neuroscience, 5, 689, 10.1016/0306-4522(80)90166-9 Matsuzaki, 1980, Vasoactive intestinal peptide: a possible transmitter of nonadrenergic relaxation of guinea pig airways, Science, 210, 1252, 10.1126/science.6254154 Biancani, 1985, Vasoactive intestinal polypeptide: neurotransmitter for relaxation of the rabbit internal anal sphincter, Gastroenterology, 89, 867, 10.1016/0016-5085(85)90585-2 Nurko, 1988, Role of vasoactive intestinal polypeptide in the internal anal sphincter relaxation of the opossum, J Clin Invest, 81, 1146, 10.1172/JCI113429 Tatemoto, 1981, Isolation and characterization of the intestinal peptide porcine PHI (PHI-27), a new member of the glucagon secretin family, Proc Natl Acad Sci USA, 78, 6603, 10.1073/pnas.78.11.6603 Bataille, 1980, Porcine peptide having N-terminal histidine and C-terminal isoleucine amide (PHI), FEBS Lett, 114, 240, 10.1016/0014-5793(80)81124-0 Beinfeld, 1984, The distribution and chromatographic characterization of PHI (peptide histidine isoleucine amide)-27-like peptides in the rat and porcine brain, J Neurosci, 212, 51 Tatemoto, 1983, Isolation of a brain peptide identical to the intestinal PHI (peptide HI), FEBS Lett, 153, 248, 10.1016/0014-5793(83)80617-6 Christofides, 1984, Studies on the distribution of PHI in mammals, Peptides, 5, 261, 10.1016/0196-9781(84)90216-X Korchak, 1985, The subcellular distribution of PHI (peptide histidine isoleucine amide)-27-like peptides in rat brain and their release from rat cerebral cortical slices, J Neurochem, 44, 255, 10.1111/j.1471-4159.1985.tb07138.x Hökfelt, 1982, PHI, a VIP like peptide is present in the rat median eminence, Acta Physiol Scand, 116, 469, 10.1111/j.1748-1716.1982.tb07169.x Christofides, 1982, Distribution of PHI in the rat brain, Biomed Res, 3, 573, 10.2220/biomedres.3.573 Polak, 1984, Regulatory peptides—the distribution of two newly discovered peptides: PHI and NPY, Peptides (Suppl), 5, 79, 10.1016/0196-9781(84)90267-5 Christofides, 1983, Radio-immunoassay and intramural distribution of PHI-IR in the human intestine, Dig Dis Sci, 28, 507, 10.1007/BF01308152 Ekblad, 1985, Peptide containing nerve fibers in the stomach wall of rat and mouse, Gastroenterology, 89, 73, 10.1016/0016-5085(85)90747-4 Bishop, 1984, The distribution of PHI and VIP in porcine gut and their co-localization to a proportion of intrinsic ganglion cells, Peptides, 5, 255, 10.1016/0196-9781(84)90215-8 Yanaihara, 1983, Immunocytochemical demonstration of PHI and its co-existence with VIP in intestinal nerves of the rat and pig, Arch Histol Jpn, 46, 575, 10.1679/aohc.46.575 Ekblad, 1984, VIP and PHI coexist with an NPY-like peptide in intramural neurones of the small intestine, Regul Pept, 10, 47, 10.1016/0167-0115(84)90052-1 Bishop, 1983, Co-localization of VIP and PHI in the human gut, Regul Pept, 6, 287, 10.1016/0167-0115(83)90155-6 Yiangou, 1983, The presence of peptide histidine isoleucine in human, dog, guinea pig and rat pancreas, Diabetologia, 25, 125, 10.1007/BF00250901 Christofides, 1984, Distribution of PHI in the mammalian respiratory tract and some aspects of its pharmacology, Endocrinology, 115, 1958, 10.1210/endo-115-5-1958 Lundberg, 1984, Coexistence of peptide HI (PHI) and VIP in nerves regulating blood flow and bronchial smooth muscle tone in various mammals including man, Peptides, 5, 593, 10.1016/0196-9781(84)90090-1 Grunditz, 1986, Peptide histidine isoleucine amide stimulates thyroid hormone secretion and coexists with vasoactive intestinal polypeptide in intrathyroid nerve fibers from laryngeal ganglia, Endocrinology, 118, 783, 10.1210/endo-118-2-783 Lundberg, 1984, Corelease of vasoactive intestinal polypeptide and peptide histidine isoleucine in relation to atropine-resistant vasodilatation in cat submandibular salivary gland, Neurosci Lett, 52, 37, 10.1016/0304-3940(84)90347-1 Itoh, 1983, Human preprovasoactive intestinal polypeptide contains a novel PHI-27 like peptide, PHM-27, Nature, 304, 547, 10.1038/304547a0 Christofides, 1982, Are PHI and VIP co-synthesized in the same pro-hormone?, Lancet, ii, 1398, 10.1016/S0140-6736(82)91292-2 Holst, 1987, VIP and PHI in pig pancreas: coexistence, corelease and cooperative effects, Am J Physiol, 252, G182 Yasui, 1987, Corelease of PHI and VIP by vagal stimulation in the dog, Am J Physiol, 253, G13 Hoshino, 1984, Production of VIP and PHM (human PHI)-related peptides in human neuroblastoma cells, Peptides, 5, 155, 10.1016/0196-9781(84)90199-2 Bloom, 1983, Diarrhoea in VIPoma patients associated with co-secretion of a second active peptide (peptide histidine isoleucine) explained by a single coding gene, Lancet, ii, 1163, 10.1016/S0140-6736(83)91215-1 Ghiglione, 1982, Effect of the intestinal peptide PHI on rat intestinal fluid transport in the rat, Neuropeptides, 3, 79, 10.1016/0143-4179(82)90002-6 Anagnostides, 1983, Porcine histidine isoleucine (PHI) induces secretion in the pig small intestine, Dig Dis Sci, 28, 893, 10.1007/BF01317039 Laburthe, 1984, Interactions of PHM, PHI and 24-glutamine PHI with human VIP receptors from colonic epithelium: comparison with rat intestinal receptors, Life Sci, 36, 991, 10.1016/0024-3205(85)90396-0 Jensen, 1981, Action of a newly isolated intestinal peptide PHI on pancreatic acini, Am J Physiol, 4, G498 Szecowka, 1983, Effects of porcine intestinal heptacosapeptide PHI and vasoactive intestinal peptide (VIP) on insulin and glucagon secretion in rat, Endocrinology, 112, 1469, 10.1210/endo-112-4-1469 Lundberg, 1982, Vascular effects of the peptides PYY and PHI: comparison with APP and VIP, Eur J Pharmacol, 83, 143, 10.1016/0014-2999(82)90300-4 Samson, 1983, Prolactin-releasing activity of porcine intestinal peptide (PHI27), Peptides, 4, 817, 10.1016/0196-9781(83)90073-6 Kaji, 1985, Administration of antisera to vasoactive intestinal polypeptide and peptide histidine isoleucine attenuates ether-induced prolactin secretion in rats, Neuroendocrinology, 41, 529, 10.1159/000124231 Schusdziarra, 1986, Effect of vasoactive intestinal peptide, peptide histidine isoleucine and growth hormone releasing factor-40 on bombesin like immu noreactivity, somatostatin and gastrin release from the perfused rat stomach, Peptides, 7, 127, 10.1016/0196-9781(86)90072-0 Bardrum, 1986, Peptides PHI and VIP: comparison between vascular and non vascular smooth muscle effect in rabbit uterus, Am J Physiol, 251, E48 Blank, 1986, Effects of VIP and related peptides and Gila monster venom on genitourinary smooth muscle, Eur J Pharmacol, 132, 155, 10.1016/0014-2999(86)90600-X Fahrenkrug, 1987, Occurrence of VIP and peptide HM in human pancreas and their influence on pancreatic endocrine secretion in man, Regul Pept, 18, 51, 10.1016/0167-0115(87)90050-4 Kimura, 1987, Effects of preoptic injections of gastrin, cholecystokinin, secretin, vasoactive intestinal peptide and PHI on the secretion of luteiniz ing hormone and prolactin in ovariectomized estrogenprimed rats, Brain Res, 410, 312, 10.1016/0006-8993(87)90330-1 Rattan, 1987, Influence of the sacral nerves on the internal anal sphincter of the opossum, Am J Physiol, 253, G345 Culver, 1986, Genesis of anal canal pressures in the opossum, Am J Physiol, 251, G765 Pandol, 1986, Vasoactive intestinal peptide receptor antagonist [4Cl-D-Phe6, Leu17] VIP, Am J Physiol, 250, G553 Waelbroeck, 1985, Interaction of growth hormone-releasing factor (GRF) and 14 GRF analogs with vasoactive intestinal peptide (VIP) receptors of rat pancreas. Discovery of (N-Ac-Tyr1, D-Phe2)-GRF(1-29)-NH2 as a VIP antagonist, Endocrinology, 116, 2643, 10.1210/endo-116-6-2643 Snedecor, 1967 Biancani, 1986, (N-Ac-Tyr1, D-Phe2)-GRF(1-29)-NH2 and (D-Phe2)-VIP act as VIP antagonists and reduce neurally mediated lower esophageal sphincter (LES) relaxation in the cat (abstr.), Gastroenterology, 91, 1046, 10.1016/0016-5085(86)90747-X Pipkorn, 1984, The effect of VIP on guinea pig taenia coli requires the whole sequence, Peptides, 5, 267, 10.1016/0196-9781(84)90217-1 Yanaihara, 1986, PHI structural requirements for potentiation of glucose-induced insulin release, Peptides, 7, 83, 10.1016/0196-9781(86)90169-5