Penicopeptide A (PPA) from the deep-sea-derived fungus promotes osteoblast-mediated bone formation and alleviates ovariectomy-induced bone loss by activating the AKT/GSK-3β/β-catenin signaling pathway

Pharmacological Research - Tập 197 - Trang 106968 - 2023
Chun-Lan Xie1,2, Yu-Ting Yue1,3, Jing-Ping Xu1, Na Li1, Ting Lin4, Guang-Rong Ji3, Xian-Wen Yang2, Ren Xu1,5
1Fujian Provincial Key Laboratory of Organ and Tissue Regeneration, School of Medicine, Xiamen University, Xiamen 361102, China
2Key Laboratory of Marine Genetic Resources, Third Institute of Oceanography, Ministry of Natural Resources, Xiamen 361005, China
3Department of Orthopedics Surgery, Xiang’an Hospital of Xiamen University, School of Medicine, Xiamen University, 361102, Xiamen,China
4Fujian Provincial Key Laboratory of Innovative Drug Target Research, School of Pharmaceutical Sciences, Xiamen University, Xiamen, 361102, China.
5The First Affiliated Hospital of Xiamen University-ICMRS Collaborating Center for Skeletal Stem Cells, State Key Laboratory of Cellular Stress Biology, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen 361102, China

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