Pelargonidin activates the AhR and induces CYP1A1 in primary human hepatocytes and human cancer cell lines HepG2 and LS174T

Toxicology Letters - Tập 218 - Trang 253-259 - 2013
Alzbeta Kamenickova1, Eva Anzenbacherova2, Petr Pavek3, Anatoly A. Soshilov4, Michael S. Denison4, Pavel Anzenbacher5, Zdenek Dvorak1
1Department of Cell Biology and Genetics, Faculty of Science, Palacky University, Slechtitelu 11, 783 71 Olomouc, Czech Republic
2Institute of Medical Chemistry and Biochemistry, Faculty of Medicine and Dentistry, Palacky University, Hnevotinska 3, 775 15 Olomouc, Czech Republic
3Department of Pharmacology and Toxicology, Charles University in Prague, Faculty of Pharmacy in Hradec Kralove, Heyrovskeho 1203, Hradec Kralove 50005, Czech Republic
4Department of Environmental Toxicology, University of California, Meyer Hall, One Shields Avenue, Davis,CA 95616-8588, USA
5Institute of Pharmacology, Faculty of Medicine and Dentistry, Palacky University, Hnevotinska 3, 775 15 Olomouc, Czech Republic

Tài liệu tham khảo

Abel, 2010, An introduction to the molecular basics of aryl hydrocarbon receptor biology, Biological Chemistry, 391, 1235, 10.1515/bc.2010.128 Amakura, 2008, Influence of food polyphenols on aryl hydrocarbon receptor-signaling pathway estimated by in vitro bioassay, Phytochemistry, 69, 3117, 10.1016/j.phytochem.2007.07.022 Anzenbacher, 2001, Cytochromes P450 and metabolism of xenobiotics, Cellular and Molecular Life Sciences: CMLS, 58, 737, 10.1007/PL00000897 Denison, 2003, Activation of the aryl hydrocarbon receptor by structurally diverse exogenous and endogenous chemicals, Annual Review of Pharmacology and Toxicology, 43, 309, 10.1146/annurev.pharmtox.43.100901.135828 Denison, 2002, Analysis of the AhR receptor signal transduction pathway Donato, 1993, A microassay for measuring cytochrome P450IA1 and P450IIB1 activities in intact human and rat hepatocytes cultured on 96-well plates, Analytical Biochemistry, 213, 29, 10.1006/abio.1993.1381 Dvorak, 2008, JNK inhibitor SP600125 is a partial agonist of human aryl hydrocarbon receptor and induces CYP1A1 and CYP1A2 genes in primary human hepatocytes, Biochemical Pharmacology, 75, 580, 10.1016/j.bcp.2007.09.013 Frank, 2005, Pharmacokinetics of anthocyanidin-3-glycosides following consumption of Hibiscus sabdariffa L. extract, Journal of Clinical Pharmacology, 45, 203, 10.1177/0091270004270561 Hodek, 2002, Flavonoids-potent and versatile biologically active compounds interacting with cytochromes P450, Chemico-Biological Interactions, 139, 1, 10.1016/S0009-2797(01)00285-X Kamenickova, 2012, Effects of flavored mineral waters on AhR-CYP1A1 signaling pathway in primary human hepatocytes and in human hepatic and intestinal cancer cells, Food and Chemical Toxicology: An International Journal Published for the British Industrial Biological Research Association, 50, 1933, 10.1016/j.fct.2012.03.073 Kamenickova, 2012, Effects of ready to drink teas on AhR- and PXR-mediated expression of cytochromes P450 CYP1A1 and CYP3A4 in human cancer cell lines and primary human hepatocytes, Food Chemistry, 131, 1201, 10.1016/j.foodchem.2011.09.104 Keppler, 2005, Metabolism of anthocyanins and their phenolic degradation products by the intestinal microflora, Bioorganic and Medicinal Chemistry, 13, 5195, 10.1016/j.bmc.2005.05.003 Kong, 2003, Analysis and biological activities of anthocyanins, Phytochemistry, 64, 923, 10.1016/S0031-9422(03)00438-2 Korashy, 2011, The p38 MAPK inhibitor SB203580 induces cytochrome P450 1A1 gene expression in murine and human hepatoma cell lines through ligand-dependent aryl hydrocarbon receptor activation, Chemical Research in Toxicology, 24, 1540, 10.1021/tx200141p Leclercq, 1996, Fast determination of low-level cytochrome P-450 1A1 activity by high-performance liquid chromatography with fluorescence or visible absorbance detection, Journal of Chromatography B, Biomedical Applications, 681, 227, 10.1016/0378-4347(95)00543-9 McGhie, 2007, The bioavailability and absorption of anthocyanins: towards a better understanding, Molecular Nutrition & Food Research, 51, 702, 10.1002/mnfr.200700092 Monostory, 2009, Hormonal regulation of CYP1A expression, Drug Metabolism Reviews, 41, 547, 10.1080/03602530903112284 Mullen, 2008, Bioavailability of pelargonidin-3-O-glucoside and its metabolites in humans following the ingestion of strawberries with and without cream, Journal of Agricultural and Food Chemistry, 56, 713, 10.1021/jf072000p Novotna, 2011, Novel stably transfected gene reporter human hepatoma cell line for assessment of aryl hydrocarbon receptor transcriptional activity: construction and characterization, Environmental Science & Technology, 45, 10133, 10.1021/es2029334 Pavek, 2007, Examination of glucocorticoid receptor alpha-mediated transcriptional regulation of P-glycoprotein, CYP3A4, and CYP2C9 genes in placental trophoblast cell lines, Placenta, 28, 1004, 10.1016/j.placenta.2007.05.001 Pavek, 2008, Xenobiotic-induced transcriptional regulation of xenobiotic metabolizing enzymes of the cytochrome P450 superfamily in human extrahepatic tissues, Current Drug Metabolism, 9, 129, 10.2174/138920008783571774 Stejskalova, 2011, Endogenous and exogenous ligands of aryl hydrocarbon receptor: current state of art, Current Drug Metabolism, 12, 198, 10.2174/138920011795016818 Welch, 2008, Recent advances in anthocyanin analysis and characterization, Current Analytical Chemistry, 4, 75, 10.2174/157341108784587795 Zhang, 2005, Human tumor cell growth inhibition by nontoxic anthocyanidins, the pigments in fruits and vegetables, Life sciences, 76, 1465, 10.1016/j.lfs.2004.08.025