Patient-derived models of brain metastases recapitulate human disseminated disease

Cell Reports Medicine - Tập 3 - Trang 100623 - 2022
Claudia C. Faria1,2, Rita Cascão1, Carlos Custódia1, Eunice Paisana1, Tânia Carvalho1, Pedro Pereira3, Rafael Roque3, José Pimentel3, José Miguéns2, Isidro Cortes-Ciriano4, João T. Barata1
1Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal
2Department of Neurosurgery, Hospital de Santa Maria, Centro Hospitalar Universitário Lisboa Norte (CHULN), Lisboa, Portugal
3Laboratory of Neuropathology, Neurology Department, Hospital de Santa Maria, Centro Hospitalar Universitário Lisboa Norte (CHULN), Lisboa, Portugal
4European Molecular Biology Laboratory, European Bioinformatics Institute, Hinxton, Cambridge CB10 1SD, UK

Tài liệu tham khảo

Gavrilovic, 2005, Brain metastases: epidemiology and pathophysiology, J. Neurooncol., 75, 5, 10.1007/s11060-004-8093-6 Achrol, 2019, Brain metastases, Nat. Rev. Dis. Primers, 5, 5, 10.1038/s41572-018-0055-y Taillibert, 2018, Leptomeningeal metastasis, Handb. Clin. Neurol., 149, 169, 10.1016/B978-0-12-811161-1.00013-X Leal, 2011, Leptomeningeal metastasis: challenges in diagnosis and treatment, Curr. Cancer Ther. Rev., 7, 319, 10.2174/157339411797642597 Soffietti, 2020, Management of brain metastases according to molecular subtypes, Nat. Rev. Neurol., 16, 557, 10.1038/s41582-020-0391-x Lin, 2004, CNS metastases in breast cancer, J. Clin. Oncol., 22, 3608, 10.1200/JCO.2004.01.175 Lin, 2015, Treatment of brain metastases, J. Clin. Oncol., 33, 3475, 10.1200/JCO.2015.60.9503 Groves, 2010, New strategies in the management of leptomeningeal metastases, Arch. Neurol., 67, 305, 10.1001/archneurol.2010.18 Lockman, 2010, Heterogeneous blood-tumor barrier permeability determines drug efficacy in experimental brain metastases of breast cancer, Clin. Cancer Res., 16, 5664, 10.1158/1078-0432.CCR-10-1564 Heerboth, 2015, EMT and tumor metastasis, Clin. Transl. Med., 4, 6, 10.1186/s40169-015-0048-3 Venur, 2020, Advances in management of brain and leptomeningeal metastases, Curr. Neurol. Neurosci. Rep., 20, 26, 10.1007/s11910-020-01039-1 Bos, 2009, Genes that mediate breast cancer metastasis to the brain, Nature, 459, 1005, 10.1038/nature08021 Brastianos, 2015, Genomic characterization of brain metastases reveals branched evolution and potential therapeutic targets, Cancer Discov., 5, 1164, 10.1158/2159-8290.CD-15-0369 Valiente, 2014, Serpins promote cancer cell survival and vascular co-option in brain metastasis, Cell, 156, 1002, 10.1016/j.cell.2014.01.040 Tentler, 2012, Patient-derived tumour xenografts as models for oncology drug development, Nat. Rev. Clin. Oncol., 9, 338, 10.1038/nrclinonc.2012.61 Rosfjord, 2014, Advances in patient-derived tumor xenografts: from target identification to predicting clinical response rates in oncology, Biochem. Pharmacol., 91, 135, 10.1016/j.bcp.2014.06.008 Hidalgo, 2014, Patient-derived xenograft models: an emerging platform for translational cancer research, Cancer Discov., 4, 998, 10.1158/2159-8290.CD-14-0001 Masmudi-Martin, 2021, Brain metastasis models: what should we aim to achieve better treatments?, Adv. Drug Deliv. Rev., 169, 79, 10.1016/j.addr.2020.12.002 Lai, 2017, Current status and perspectives of patient-derived xenograft models in cancer research, J. Hematol. Oncol., 10, 106, 10.1186/s13045-017-0470-7 Siolas, 2013, Patient-derived tumor xenografts: transforming clinical samples into mouse models, Cancer Res., 73, 5315, 10.1158/0008-5472.CAN-13-1069 Bruna, 2016, A biobank of breast cancer explants with preserved intra-tumor heterogeneity to screen anticancer compounds, Cell, 167, 260, 10.1016/j.cell.2016.08.041 Rubio-Viqueira, 2006, An in vivo platform for translational drug development in pancreatic cancer, Clin. Cancer Res., 12, 4652, 10.1158/1078-0432.CCR-06-0113 Charafe-Jauffret, 2013, ALDH1-positive cancer stem cells predict engraftment of primary breast tumors and are governed by a common stem cell program, Cancer Res., 73, 7290, 10.1158/0008-5472.CAN-12-4704 Li, 2013, Endocrine-therapy-resistant ESR1 variants revealed by genomic characterization of breast-cancer-derived xenografts, Cell Rep., 4, 1116, 10.1016/j.celrep.2013.08.022 Lee, 2015, Patient-derived xenografts from non-small cell lung cancer brain metastases are valuable translational platforms for the development of personalized targeted therapy, Clin. Cancer Res., 21, 1172, 10.1158/1078-0432.CCR-14-1589 Dong, 2010, Patient-derived first generation xenografts of non-small cell lung cancers: promising tools for predicting drug responses for personalized chemotherapy, Clin. Cancer Res., 16, 1442, 10.1158/1078-0432.CCR-09-2878 Metildi, 2014, Fluorescently labeled chimeric anti-CEA antibody improves detection and resection of human colon cancer in a patient-derived orthotopic xenograft (PDOX) nude mouse model, J. Surg. Oncol., 109, 451, 10.1002/jso.23507 Nicolle, 2017, Pancreatic adenocarcinoma therapeutic targets revealed by tumor-stroma cross-talk analyses in patient-derived xenografts, Cell Rep., 21, 2458, 10.1016/j.celrep.2017.11.003 Krepler, 2017, A comprehensive patient-derived xenograft collection representing the heterogeneity of melanoma, Cell Rep., 21, 1953, 10.1016/j.celrep.2017.10.021 Ricci, 2014, Patient-derived ovarian tumor xenografts recapitulate human clinicopathology and genetic alterations, Cancer Res., 74, 6980, 10.1158/0008-5472.CAN-14-0274 Contreras-Zarate, 2017, Development of novel patient-derived xenografts from breast cancer brain metastases, Front. Oncol., 7, 252, 10.3389/fonc.2017.00252 Ni, 2016, Combination inhibition of PI3K and mTORC1 yields durable remissions in mice bearing orthotopic patient-derived xenografts of HER2-positive breast cancer brain metastases, Nat. Med., 22, 723, 10.1038/nm.4120 Tew, 2020, Patient-derived xenografts of central nervous system metastasis reveal expansion of aggressive minor clones, Neuro Oncol., 22, 70, 10.1093/neuonc/noz137 Schwartz, 2016, Incipient melanoma brain metastases instigate astrogliosis and neuroinflammation, Cancer Res., 76, 4359, 10.1158/0008-5472.CAN-16-0485 Miarka, 2021, Animal models of brain metastasis, Neurooncol. Adv., 3, v144 Blazquez, 2018, PI3K: a master regulator of brain metastasis-promoting macrophages/microglia, Glia, 66, 2438, 10.1002/glia.23485 LoRusso, 2016, Inhibition of the PI3K/AKT/mTOR pathway in solid tumors, J. Clin. Oncol., 34, 3803, 10.1200/JCO.2014.59.0018 Hu, 2020, Multi-cancer analysis of clonality and the timing of systemic spread in paired primary tumors and metastases, Nat. Genet., 52, 701, 10.1038/s41588-020-0628-z McFadden, 2014, Genetic and clonal dissection of murine small cell lung carcinoma progression by genome sequencing, Cell, 156, 1298, 10.1016/j.cell.2014.02.031 Cleary, 2014, Tumour cell heterogeneity maintained by cooperating subclones in Wnt-driven mammary cancers, Nature, 508, 113, 10.1038/nature13187 Sanborn, 2015, Phylogenetic analyses of melanoma reveal complex patterns of metastatic dissemination, Proc. Natl. Acad. Sci. U S A, 112, 10995, 10.1073/pnas.1508074112 Marjanovic, 2020, Emergence of a high-plasticity cell state during lung cancer evolution, Cancer Cell, 38, 229, 10.1016/j.ccell.2020.06.012 Gundem, 2015, The evolutionary history of lethal metastatic prostate cancer, Nature, 520, 353, 10.1038/nature14347 Dankner, 2021, Invasive growth associated with cold-inducible RNA-binding protein expression drives recurrence of surgically resected brain metastases, Neuro Oncol., 23, 1470, 10.1093/neuonc/noab002 Dobin, 2013, STAR: ultrafast universal RNA-seq aligner, Bioinformatics, 29, 15, 10.1093/bioinformatics/bts635 Anders, 2015, HTSeq--a Python framework to work with high-throughput sequencing data, Bioinformatics, 31, 166, 10.1093/bioinformatics/btu638 Love, 2014, Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2, Genome Biol., 15, 550, 10.1186/s13059-014-0550-8