Patient Barriers to and Enablers of Deprescribing: a Systematic Review

Springer Science and Business Media LLC - Tập 30 Số 10 - Trang 793-807 - 2013
Emily Reeve1,2, Josephine To3, Ivanka Hendrix4, Sepehr Shakib1, Michael S. Roberts2,5, Michael Wiese2
1Department of Clinical Pharmacology, Royal Adelaide Hospital, Adelaide, Australia
2Sansom Institute, University of South Australia, Adelaide, Australia
3School of Pharmacy and Medical Sciences, University of South Australia, Adelaide, Australia
4Pharmacy Department, Repatriation General Hospital, Daw Park, Australia
5Therapeutics Research Centre, School of Medicine, University of Queensland, Brisbane, Australia

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Guaraldo L, Cano FG, Damasceno GS, Rozenfeld S. Inappropriate medication use among the elderly: a systematic review of administrative databases. BMC Geriatrics. 2011;11:79.

Elliott R. Problems with medication use in the elderly: an Australian perspective. J Pharm Pract Res. 2006;36:58–66.

Steinman MA, Landefeld CS, Rosenthal GE, Berthenthal D, Sen S, Kaboli PJ. Polypharmacy and prescribing quality in older people. J Am Geriatr Soc. 2006;54:1516–23.

Fialova D, Topinkova E, Gambassi G, Finne-Soveri H, Jonsson PV, Carpenter I, et al. Potentially inappropriate medication use among elderly home care patients in Europe. JAMA. 2005;293:1348–58.

Dedhiya SD, Hancock E, Craig BA, Doebbeling CC, Thomas J. Incident use and outcomes associated with potentially inappropriate medication use in older adults. Am J Geriatr Pharmacother. 2010;8:562–70.

Chrischilles EA, VanGilder R, Wright K, Kelly M, Wallace RB. Inappropriate medication use as a risk factor for self reported adverse drug effects in older adults. J Am Geriatr Soc. 2009;57:1000–6.

Holmes H. Rational prescribing for patients with a reduced life expectancy. Clin Pharmacol Ther. 2008;85:103–7.

Dimitrow MS, Airaksinen MSA, Kivelä SL, Lyles A, Leikola SNS. Comparison of prescribing criteria to evaluate the appropriateness of drug treatment in individuals aged 65 and older: a systematic review. J Am Geriatr Soc. 2011;59:1521–30.

Gnjidic D, Le Couteur DG, Kouladjian L, Hilmer SN. Deprescribing trials: methods to reduce polypharmacy and the impact on prescribing and clinical outcomes. Clin Geriatr Med. 2012;28:237–53.

Kaur S, Mitchell G, Vitetta L, Roberts MS. Interventions that can reduce inappropriate prescribing in the elderly: a systematic review. Drugs Aging. 2009;26:1013–28.

Woodward M. Deprescribing: achieving better health outcomes for older people through reducing medications. J Pharm Pract Res. 2003;33:323–8.

Le Couteur DG, Banks E, Gnjidic D, McLachlan A. Deprescribing. Aust Prescr. 2011;34:182–5.

Iyer S, Naganathan V, McLachlan AJ, Le Couteur DG. Medication withdrawal trials in people aged 65 years and older: a systematic review. Drugs Aging. 2008;25:1021–31.

Hering-Hanit R, Yavetz A, Dagan Y. Effect of withdrawal of misused medication on sleep disturbances in migraine sufferers with chronic daily headache. Headache. 2000;40:809–12.

Alexander GC, Sayla MA, Holmes HM, Sachs GA. Prioritizing and stopping prescription medicines. Can Med Assoc J. 2006;174:1083–4.

Bain KT, Holmes HM, Beers MH, Maio V, Handler SM, Pauker SG. Discontinuing medications: a novel approach for revising the prescribing stage of the medication-use process. J Am Geriatr Soc. 2008;56:1946–52.

Ostini R, Hegney D, Jackson C, Tett SE. Knowing how to stop: ceasing prescribing when the medicine is no longer required. J Manage Care Pharm. 2012;18:68.

Scott I, Gray L, Martin J, Mitchell C. Minimizing inappropriate medications in older populations: a 10-step conceptual framework. Am J Med. 2012;125:529–37.

Ostini R, Hegney D, Jackson C, Williamson M, Mackson JM, Gurman K, et al. Systematic review of interventions to improve prescribing. Ann Pharmacother. 2009;43:502–13.

Reeve E, Wiese MD, Hendrix I, Roberts M, Shakib S. Patient attitudes, beliefs and experiences of polypharmacy and willingness of deprescribing. J Am Geriatr Soc. 2013 (accepted).

Beer C, Loh Pk, Peng YG, Potter K, Millar A. A pilot randomized controlled trial of deprescribing. Ther Adv Drug Saf. 2011;2:37–43.

Williams M, Pulliam C, Hunter R, Johnson T, Owens J, Kincaid J, et al. The short-term effect of interdisciplinary medication review on function and cost in ambulatory elderly people. J Am Geriatr Soc. 2004;52:93–8.

van Duijn HJ, Belo JN, Blom JW, Velberg ID, Assendelft WJ. Revised guidelines for cardiovascular risk management time to stop medication? A practice-based intervention study. Br J Gen Pract. 2011;61:e347–52.

Gnjidic D, Le Couteur DG, Abernethy DR, Hilmer SN. A pilot randomized clinical trial utilizing the drug burden index to reduce exposure to anticholinergic and sedative medications in older people. Ann Pharmacother. 2010;44:1725–32.

Fried TR, McGraw S, Agostini JV, Tinetti ME. Views of older persons with multiple morbidities on competing outcomes and clinical decision-making. J Am Geriatr Soc. 2008;56:1839–44.

TRIP. Trip database. 2012. http://www.tripdatabase.com (Accessed 1 July 2013).

The Joanna Briggs Institute. Systematic review registered trials. University of Adelaide. 2013. http://www.joannabriggs.edu.au (Accessed 1 July 2013).

Dixon-Woods M, Bonas S, Booth A, Jones DR, Miller T, Sutton AJ, et al. How can systematic reviews incorporate qualitative research? A critical perspective. Qual Res. 2006;6:27–44.

Popay J, Roberts H, Sowden A, Petticrew M, Arai L, Rodgers M et al. Guidance on the conduct of narrative synthesis in systematic reviews. Lancaster: Institute of Health Research, ESRC Methods Programme; 2006.

Dixon-Woods M, Fitzpatrick R, Roberts K. Including qualitative research in systematic reviews: opportunities and problems. J Eval Clin Pract. 2001;7:125–33.

Tong A, Sainsbury P, Craig J. Consolidated criteria for reporting qualitative research (COREQ): a 32-item checklist for interviews and focus groups. Int J Qual Health Care. 2007;19:349–57.

Straand J, Sandvik H. Stopping long-term drug therapy in general practice. How well do physicians and patients agree? Fam Pract. 2001;18:597–601.

Barter G, Cormack M. The long-term use of benzodiazepines: patients’ views, accounts and experiences. Fam Pract. 1996;13:491–7.

Cook JM, Biyanova T, Masci C, Coyne JC. Older patient perspectives on long-term anxiolytic benzodiazepine use and discontinuation: a qualitative study. J Gen Intern Med. 2007;22:1094–100.

Iliffe S, Curran HV, Collins R, Kee SC, Fletcher S, Woods B. Attitudes to long-term use of benzodiazepine hypnotics by older people in general practice: findings from interviews with service users and providers. Aging Ment Health. 2004;8:242–8.

King MB, Gabe J, Williams P, Rodrigo EK. Long term use of benzodiazepines: the views of patients. Br J Gen Pract. 1990;40:194–6.

Parr JM, Kavanagh DJ, Young RM, McCafferty K. Views of general practitioners and benzodiazepine users on benzodiazepines: a qualitative analysis. Soc Sci Med. 2006;62:1237–49.

Roe D, Goldblatt H, Baloush-Klienman V, Swarbrick M, Davidson L. Why and how people decide to stop taking prescribed psychiatric medication: exploring the subjective process of choice. Psychiatr Rehabil J. 2009;33:38–46.

Moses T. Adolescents’ commitment to continuing psychotropic medication: a preliminary investigation of considerations, contradictions, and correlates. Child Psychiatry Hum Dev. 2011;42:93–117.

Haslam C, Brown S, Atkinson S, Haslam R. Patients’ experiences of medication for anxiety and depression: effects on working life. Fam Pract. 2004;21:204–12.

Leydon GM, Rodgers L, Kendrick T. A qualitative study of patient views on discontinuing long-term selective serotonin reuptake inhibitors. Fam Pract. 2007;24:570–5.

Verbeek-Heida P, Mathot E. Better safe than sorry—why patients prefer to stop using selective serotonin reuptake inhibitor (SSRI) antidepressants but are afraid to do so: results of a qualitative study. Chronic Illn. 2006;2:133–42.

Post SG, Stuckey JC, Whitehouse PJ, Ollerton S, Durkin C, Robbins D, et al. A focus group on cognition-enhancing medications in Alzheimer disease: disparities between professionals and consumers. Alzheimer Dis Assoc Disord. 2001;15:80–8.

Gold ML, Sorences JL, McCanlies N, Trier M, Dlugosch G. Tapering from methadone maintenance: Attitudes of clients and staff. J Subst Abuse Treat. 1988;5:37–44.

Kilinç S, Campbell C. The experience of discontinuing antiepileptic drug treatment: An exploratory investigation. Seizure. 2008;17:505–13.

Bertero C, Johansson G. Compliance with hormone replacement therapy among Swedish women. Int Nurs Rev. 2001;48:224–32.

Castelo-Branco C, Ferrer J, Palacios S, Cornago S, Peralta S. Spanish post-menopausal women’s viewpoints on hormone therapy. Maturitas. 2007;56:420–8.

Horner E, Fleming J, Studd J. A study of women on long-term hormone replacement therapy and their attitude to suggested cessation. Climacteric. 2006;9:459–63.

Boath EH, Blenkinsopp A. The rise and rise of proton pump inhibitor drugs: patients’ perspectives. Soc Sci Med. 1997;45:1571–9.

Grime J, Pollock K, Blenkinsopp A. Proton pump inhibitors: perspectives of patients and their GPs. Br J Gen Pract. 2001;51:703.

Berger BA, Hudmon KS, Liang H. Predicting treatment discontinuation among patients with multiple sclerosis: application of the transtheoretical model of change. J Am Pharm Assoc. 2004;44:445–54.

Benson J, Britten N. Patients’ decisions about whether or not to take antihypertensive drugs: qualitative study. BMJ. 2002;325:873.

O’Connor M, Gallagher P, O’Mahony D. Inappropriate prescribing: criteria, detection and prevention. Drugs Aging. 2012;29:437.

Reeve E, Shakib S, Hendrix I, Roberts MS, Wiese MD. Development and validation of the patients’ attitudes towards deprescribing (PATD) questionnaire. Int J Clin Pharm. 2013;35:51–6.

Dolovich L, Nair K, Sellors C, Lohfeld L, Lee A, Levine M. Do patients’ expectations influence their use of medications? Qualitative study. Can Fam Physician. 2008;54:384–93.

Morecroft C, Cantrill J, Tully MP. Patients’ evaluation of the appropriateness of their hypertension management—a qualitative study. Res Social Adm Pharm. 2006;2:186–211.

Krol N, Wensing M, Haaijer-Ruskamp F, Muris JW, Numans ME, Schattenberg G, et al. Patient-directed strategy to reduce prescribing for patients with dyspepsia in general practice: a randomized trial. Aliment Pharmacol Ther. 2004;19:917–22.

Haddad P. Do antidepressants have any potential to cause addiction? J Psychopharmacol. 1999;13:300–7.

Charach A, Skyba A, Cook L, Antle BJ. Using stimulant medication for children with ADHD: What do parents say? A brief report. J Can Acad Child Adolesc Psychiatry. 2006;15:75–83.

Graves T, Hanlon JT, Schmader KE, Landsman PB, Samsa GP, Pieper CF, et al. Adverse events after discontinuing medications in elderly outpatients. Arch Intern Med. 1997;157:2205–10.

Inadomi JM, Jamal R, Murata GH, Hoffman RM, Lavezo LA, Vigil JM, et al. Step-down management of gastroesophageal reflux disease. Gastroenterology. 2001;121:1095–100.

Raghunath A, Hungin A, Cornford C, Featherstone V. Use of proton pump inhibitors: an exploration of the attitudes, knowledge and perceptions of general practitioners. Digestion. 2005;72:212–8.

Bashir K, King M, Ashworth M. Controlled evaluation of brief intervention by general practitioners to reduce chronic use of benzodiazepines. Br J Gen Pract. 1994;44:408–12.

Espeland MA, Whelton PK, Kostis JB, Bahnson JL, Ettinger WH, Cutler JA, et al. Predictors and mediators of successful long-term withdrawal from antihypertensive medications. Arch Fam Med. 1999;8:228–36.

Hesse BW, Nelson DE, Kreps GL, Croyle RT, Arora NK, Rimer BK, et al. Trust and sources of health information: the impact of the Internet and its implications for health care providers: findings from the first Health Information National Trends Survey. Arch Intern Med. 2005;165:2618.

Zermansky AG. Who controls repeats? Br J Gen Pract. 1996;46:643.

Schuling J, Gebben H, Veehof LJG, Haaijer-Ruskamp FM. Deprescribing medication in very elderly patients with multimorbidity: the view of Dutch GPs. A qualitative study. BMC Fam Pract. 2012;13:56.

Mays N, Pope C. Assessing quality in qualitative research. BMJ. 2000;320:50–2.

Meeks TW, Culberson JW, Horton MS. Medications in long-term care: when less is more. Clin Geriatr Med. 2011;27:171–91.

Hardy JE, Hilmer SN. Deprescribing in the last year of life. J Pharm Pract Res. 2011.

Naunton M, Peterson GM, Bleasel MD. Overuse of proton pump inhibitors. J Clin Pharm Ther. 2000;25:333–40.

Poses RM, Isen AM. Qualitative research in medicine and health care. J Gen Intern Med. 1998;13:32–8.