Pathophysiology of Migraine

Goadsby, 2017, Pathophysiology of migraine- a disorder of sensory processing, Physiol Rev, 97, 553, 10.1152/physrev.00034.2015

Hoffmann, 2018, Diagnosis, pathophysiology, and management of cluster headache, Lancet Neurol, 17, 75, 10.1016/S1474-4422(17)30405-2

Lance, 2005

Olesen, 2005

2018, The international classification of headache disorders, 3rd edition, Cephalalgia, 38, 1, 10.1177/0333102417738202

Giffin, 2003, Premonitory symptoms in migraine: an electronic diary study, Neurology, 60, 935, 10.1212/01.WNL.0000052998.58526.A9

Karsan, 2018, Biological insights from the premonitory symptoms of migraine, Nat Rev Neurol, 14, 699, 10.1038/s41582-018-0098-4

Viana, 2017, Clinical features of migraine aura: Results from a prospective diary-aided study, Cephalalgia, 37, 979, 10.1177/0333102416657147

Gelfand, 2013, Cranial autonomic symptoms in pediatric migraine are the rule, not the exception, Neurology, 81, 431, 10.1212/WNL.0b013e31829d872a

Lai, 2009, Cranial autonomic symptoms in migraine: characteristics and comparison with cluster headache, J Neurol Neurosurg Psychiatry, 80, 1116, 10.1136/jnnp.2008.157743

Obermann, 2007, Prevalence of trigeminal autonomic symptoms in migraine: a population-based study, Cephalalgia, 27, 504, 10.1111/j.1468-2982.2007.01316.x

Tolner, 2015, From migraine genes to mechanisms, Pain, 156, S64, 10.1097/01.j.pain.0000460346.00213.16

Silberstein, 2002

Willis, 1682

Russell, 1997, Genetic epidemiology of migraine and cluster headache, Cephalalgia, 17, 683, 10.1046/j.1468-2982.1997.1706683.x

Ulrich, 1999, Evidence of a genetic factor in migraine with aura: a population based Danish twin study, Ann Neurol, 45, 242, 10.1002/1531-8249(199902)45:2<242::AID-ANA15>3.0.CO;2-1

Mochi, 1993, Testing models for genetic determination in migraine, Cephalalgia, 13, 389, 10.1046/j.1468-2982.1993.1306389.x

Lalouel, 1981, Complex segregation analysis with pointers, Hum Hered, 31, 312, 10.1159/000153231

Russell, 1995, Investigation of the inheritance of migraine by complex segregation analysis, Hum Genet, 96, 726, 10.1007/BF00210307

Scher, 2006, Migraine and MTHFR C677T genotype in a population-based sample, Ann Neurol, 59, 372, 10.1002/ana.20755

Joutel, 1996, Notch3 mutations in CADASIL, a hereditary adult-onset condition causing stroke and dementia, Nature, 383, 707, 10.1038/383707a0

Richards, 2007, C-terminal truncations in human 3'-5' DNA exonuclease TREX1 cause autosomal dominant retinal vasculopathy with cerebral leukodystrophy, Nat Genet, 39, 1068, 10.1038/ng2082

Diener, 2007, Patent foramen ovale and migraine, Curr Pain Headache Rep, 11, 236, 10.1007/s11916-007-0196-2

Kurth, 2007, Migraine and ischaemic vascular events, Cephalalgia, 27, 965, 10.1111/j.1468-2982.2007.01405.x

Joutel, 1994, Genetic heterogeneity of familial hemiplegic migraine, Am J Hum Genet, 55, 1166

Ophoff, 1994, Genetic heterogeneity of familial hemiplegic migraine, Genomics, 22, 21, 10.1006/geno.1994.1340

Ducros, 2001, The clinical spectrum of familial hemiplegic migraine associated with mutations in a neuronal calcium channel, N Engl J Med, 345, 17, 10.1056/NEJM200107053450103

Joutel, 1993, A gene for familial hemiplegic migraine maps to chromosome 19, Nat Genet, 5, 40, 10.1038/ng0993-40

Haan, 1994, Familial hemiplegic migraine in The Netherlands, Clin Neurol Neurosurg, 96, 244, 10.1016/0303-8467(94)90076-0

Teh, 1995, Familial cerebellar periodic ataxia without myokymia maps to a 19-cM region on 19p13, Am J Hum Genet, 56, 1443

Terwindt, 1996, Familial hemiplegic migraine: a clinical comparison of families linked and unlinked to chromosome 19, Cephalalgia, 16, 153, 10.1046/j.1468-2982.1996.1603153.x

Ophoff, 1996, Familial hemiplegic migraine and episodic ataxia type-2 are caused by mutations in the Ca2+ channel gene CACNL1A4, Cell, 87, 543, 10.1016/S0092-8674(00)81373-2

Ertel, 2000, Nomenclature of voltage-gated calcium channels, Neuron, 25, 533, 10.1016/S0896-6273(00)81057-0

Marconi, 2003, Familial hemiplegic migraine type 2 is linked to 0.9Mb region on chromosome 1q23, Ann Neurol, 53, 376, 10.1002/ana.10464

De Fusco, 2003, Haploinsufficiency of ATP1A2 encoding the Na+/K+ pump a2 subunit associated with familial hemiplegic migraine type 2, Nat Genet, 33, 192, 10.1038/ng1081

Vanmolkot, 2003, Novel mutations in the Na+,K+-ATPase pump gene ATP1A2 associated with Familial Hemiplegic Migraine and Benign Familial Infantile Convulsions, Ann Neurol, 54, 360, 10.1002/ana.10674

Jurkat-Rott, 2004, Variability of familial hemiplegic migraine with novel A1A2 Na+/K+-ATPase variants, Neurology, 62, 1857, 10.1212/01.WNL.0000127310.11526.FD

Swoboda, 2004, Alternating hemiplegia of childhood or familial hemiplegic migraine?: A novel ATP1A2 mutation, Ann Neurol, 55, 884, 10.1002/ana.20134

Dichgans, 2005, Mutation in the neuronal voltage-gated sodium channel SCN1A causes familial hemiplegic migraine, Lancet, 366, 371, 10.1016/S0140-6736(05)66786-4

Goadsby, 2005, Another migraine gene - further opportunities to understand an important disorder, The Lancet, 366, 345, 10.1016/S0140-6736(05)66787-6

van den Maagdenberg, 2004, A Cacna1a knock-in migraine mouse model with increased susceptibility to cortical spreading depression, Neuron, 41, 701, 10.1016/S0896-6273(04)00085-6

Goadsby, 2004, Migraine aura: a knock-in mouse with a knock-out message, Neuron, 41, 679, 10.1016/S0896-6273(04)00112-6

Rasmussen, 1992, Migraine with aura and migraine without aura: an epidemiological study, Cephalalgia, 12, 221, 10.1046/j.1468-2982.1992.1204221.x

Olesen, 1990, Timing and topography of cerebral blood flow, aura, and headache during migraine attacks, Ann Neurol, 28, 791, 10.1002/ana.410280610

Cutrer, 1998, Perfusion-weighted imaging defects during spontaneous migrainous aura, Ann Neurol, 43, 25, 10.1002/ana.410430108

Leao, 1944, Pial circulation and spreading activity in the cerebral cortex, J Neurophysiol, 7, 391, 10.1152/jn.1944.7.6.391

Leao, 1944, Spreading depression of activity in cerebral cortex, J Neurophysiol, 7, 359, 10.1152/jn.1944.7.6.359

Lauritzen, 1994, Pathophysiology of the migraine aura. The spreading depression theory, Brain, 117, 199, 10.1093/brain/117.1.199

Lashley, 1941, Patterns of cerebral integration indicated by the scotomas of migraine, AMA Arch Neurol Psychiatry, 46, 331, 10.1001/archneurpsyc.1941.02280200137007

Hansen, 2013, Distinctive anatomical and physiological features of migraine aura revealed by 18 years of recording, Brain, 136, 3589, 10.1093/brain/awt309

Olesen, 1981, Focal hyperemia followed by spreading oligemia and impaired activation of rCBF in classic migraine, Ann Neurol, 9, 344, 10.1002/ana.410090406

Sakai, 1979, Abnormal cerebrovascular reactivity in patients with migraine and cluster headache, Headache, 19, 257, 10.1111/j.1526-4610.1979.hed1905257.x

Lauritzen, 1983, Regulation of regional cerebral blood flow during and between migraine attacks, Ann Neurol, 14, 569, 10.1002/ana.410140512

Harer, 1991, Cerebrovascular CO2 reactivity in migraine: assessment by transcranial Doppler ultrasound, J Neurol, 238, 23

Kaube, 1994, Anti-migraine compounds fail to modulate the propagation of cortical spreading depression in the cat, Eur Neurol, 34, 30, 10.1159/000117004

Lambert, 1999, Effect of cortical spreading depression on activity of trigeminovascular sensory neurons, Cephalalgia, 19, 631, 10.1046/j.1468-2982.1999.019007631.x

Kaube, 1999, Vasodilator agents and supracollicular transection fail to inhibit cortical spreading depression in the cat, Cephalalgia, 19, 592, 10.1046/j.1468-2982.1999.019006592.x

Brennan, 2007, Reduced threshold for cortical spreading depression in female mice, Ann Neurol, 61, 603, 10.1002/ana.21138

Hadjikhani, 2001, Mechanisms of migraine aura revealed by functional MRI in human visual cortex, Proc Natl Acad Sci U S A, 98, 4687, 10.1073/pnas.071582498

Moskowitz, 2004, Deciphering migraine mechanisms: clues from familial hemiplegic migraine genotypes, Ann Neurol, 55, 276, 10.1002/ana.20035

Goadsby, 2001, Migraine, aura and cortical spreading depression: why are we still talking about it?, Ann Neurol, 49, 4, 10.1002/1531-8249(200101)49:1<4::AID-ANA3>3.0.CO;2-W

Goadsby, 2009, Randomized double blind, placebo-controlled proof-of-concept study of the cortical spreading depression inhibiting agent tonabersat in migraine prophylaxis, Cephalalgia, 29, 742, 10.1111/j.1468-2982.2008.01804.x

Hauge, 2009, Effects of tonabersat on migraine with aura: a randomised, double-blind, placebo-controlled crossover study, Lancet Neurol, 8, 718, 10.1016/S1474-4422(09)70135-8

Read, 1999, SB-220453, a potential novel antimigraine compound, inhibits nitric oxide release following induction of cortical spreading depression in the anaesthetized cat, Cephalalgia, 20, 92, 10.1046/j.1468-2982.2000.00022.x

Smith, 2000, Repetitive cortical spreading depression in a gyrencephalic feline brain: inhibition by the novel benzoylamino-benzopyran SB-220453, Cephalalgia, 20, 546, 10.1046/j.1468-2982.2000.00092.x

MaassenVanDenBrink, 2000, The potential anti-migraine compound SB-220453 does not contract human isolated blood vessels or myocardium; a comparison with sumatriptan, Cephalalgia, 20, 538, 10.1046/j.1468-2982.2000.00078.x

Parsons, 2001, Tonabersat (SB-220453) a novel benzopyran with anticonvulsant properties attenuates trigeminal nerve-induced neurovascular reflexes, Br J Pharmacol, 132, 1549, 10.1038/sj.bjp.0703932

Diener, 2004, Topiramate in migraine prophylaxis--results from a placebo-controlled trial with propranolol as an active control, J Neurol, 251, 943

Brandes, 2004, Topiramate for migraine prevention: a randomized controlled trial, JAMA, 291, 965, 10.1001/jama.291.8.965

Silberstein, 2004, Topiramate in migraine prevention: results of a large controlled trial, Arch Neurol, 61, 490, 10.1001/archneur.61.4.490

Akerman, 2005, Topiramate inhibits cortical spreading depression in rat and cat: impact in migraine aura, Neuroreport, 16, 1383, 10.1097/01.wnr.0000175250.33159.a9

Ayata, 2006, Suppression of cortical spreading depression in migraine prophylaxis, Ann Neurol, 59, 652, 10.1002/ana.20778

Tvedskov, 2004, A double-blind study of SB-220453 (Tonerbasat) in the glyceryltrinitrate (GTN) model of migraine, Cephalalgia, 24, 875, 10.1111/j.1468-2982.2004.00762.x

Tvedskov, 2004, The effect of propranolol on glyceryltrinitrate-induced headache and arterial response, Cephalalgia, 24, 1076, 10.1111/j.1468-2982.2004.00796.x

Tvedskov, 2004, The prophylactic effect of valproate on glyceryltrinitrate induced migraine, Cephalalgia, 24, 576, 10.1111/j.1468-2982.2003.00720.x

Storer, 2004, Topiramate inhibits trigeminovascular neurons in the cat, Cephalalgia, 24, 1049, 10.1111/j.1468-2982.2004.00767.x

Storer, 2005, Topiramate has a locus of action outside of the trigeminocervical complex, Cephalalgia, 25, 934

Akerman, 2008, Mechanically-induced cortical spreading depression associated regional cerebral blood flow changes are blocked by Na+ ion channel blockade, Brain Res, 1229, 27, 10.1016/j.brainres.2008.07.014

Kaube, 2000, Aura in some patients with familial hemiplegic migraine can be stopped by intranasal ketamine, Neurology, 55, 139, 10.1212/WNL.55.1.139

May, 1998, Hypothalamic activation in cluster headache attacks, The Lancet, 352, 275, 10.1016/S0140-6736(98)02470-2

May, 1999, Intra-cranial vessels in trigeminal transmitted pain: a PET Study, Neuroimage, 9, 453, 10.1006/nimg.1999.0427

Matharu, 2006, Posterior hypothalamic activation in paroxysmal hemicrania, Ann Neurol, 59, 535, 10.1002/ana.20763

Matharu, 2004, Posterior hypothalamic and brainstem activation in hemicrania continua, Headache, 44, 747, 10.1111/j.1526-4610.2004.04141.x

Maniyar, 2014, Brain activations in the premonitory phase of nitroglycerin triggered migraine attacks, Brain, 137, 232, 10.1093/brain/awt320

Schulte, 2016, The migraine generator revisited: continuous scanning of the migraine cycle over 30 days and three spontaneous attacks, Brain, 139, 1987, 10.1093/brain/aww097

Sprenger, 2012, Midbrain activation in the premonitory phase of migraine: a H215O-positron emission tomography study, Headache, 52, 863

Denuelle, 2007, Hypothalamic activation in spontaneous migraine attacks, Headache, 47, 1418, 10.1111/j.1526-4610.2007.00776.x

Malick, 1998, Cells of origin of the trigeminohypothalamic tract in the rat, J Comp Neurol, 400, 125, 10.1002/(SICI)1096-9861(19981012)400:1<125::AID-CNE9>3.0.CO;2-B

Malick, 2000, Trigeminohypothalamic and reticulohypothalamic tract neurons in the upper cervical spinal cord and caudal medulla of the rat, J Neurophysiol, 84, 2078, 10.1152/jn.2000.84.4.2078

Robert, 2013, Paraventricular hypothalamic regulation of trigeminovascular mechanisms involved in headaches, J Neurosci, 33, 8827, 10.1523/JNEUROSCI.0439-13.2013

Settle, 2000, The hypothalamus, Neonatal Netw, 19, 9, 10.1891/0730-0832.19.6.9

Graebner, 2015, Understanding how discrete populations of hypothalamic neurons orchestrate complicated behavioral states, Front Syst Neurosci, 9, 111, 10.3389/fnsys.2015.00111

Schulte, 2017, Hypothalamus as a mediator of chronic migraine: Evidence from high-resolution fMRI, Neurology, 88, 2011, 10.1212/WNL.0000000000003963

Benjamin, 2004, Hypothalamic activation after stimulation of the superior sagittal sinus in the cat: a Fos study, Neurobiol Dis, 16, 500, 10.1016/j.nbd.2004.03.015

Malick, 2001, A neurohistochemical blueprint for pain-induced loss of appetite, Proc Natl Acad Sci U S A, 98, 9930, 10.1073/pnas.171616898

Peyron, 1998, Neurons containing hypocretin (orexin) project to multiple neuronal systems, J Neurosci, 18, 9996, 10.1523/JNEUROSCI.18-23-09996.1998

Bartsch, 2004, Differential modulation of nociceptive dural input to [hypocretin] Orexin A and B receptor activation in the posterior hypothalamic area, Pain, 109, 367, 10.1016/j.pain.2004.02.005

Lipton, 2014, Reduction in percieved stress as a migraine trigger: testing the "let-down headache" hypothesis, Neurology, 82, 1395, 10.1212/WNL.0000000000000332

Waterson, 2015, Neuronal regulation of energy homeostasis: beyond the hypothalamus and feeding, Cell Metab, 22, 962, 10.1016/j.cmet.2015.09.026

Buijs, 2017, Synchrony between suprachiasmatic nucleus-driven signals and the light/dark cycle is essential for liver homeostasis, Hepatology, 65, 2110, 10.1002/hep.29124

Parker, 2012, Hypothalamic neuropeptides and the regulation of appetite, Neuropharmacology, 63, 18, 10.1016/j.neuropharm.2012.02.004

Holland, 2014, Headache and sleep: shared pathophysiological mechanisms, Cephalalgia, 34, 725, 10.1177/0333102414541687

Holland, 2009, Cluster headache, hypothalamus, and orexin, Curr Pain Headache Rep, 13, 147, 10.1007/s11916-009-0025-x

Thorn, 1970, Antidiuretic hormone synthesis, release, and action under normal and pathological circumstances, Adv Metab Disord, 4, 39, 10.1016/B978-0-12-027304-1.50008-9

Brennan, 2013, Casein kinase id mutations in familial migraine and advanced sleep phase, Sci Transl Med, 5, 183ra56, 10.1126/scitranslmed.3005784

Holland PR, Goadsby PJ. Orexin and primary headache disorders. In: Lawrence AJ, de Lecea L, editors. Behavioural neuroscience of orexin/hypocretin. Current topics in behavioral neurosciences. New York: Springer, in press.

van Oosterhout, 2018, Chronotypes and circadian timing in migraine, Cephalalgia, 38, 617, 10.1177/0333102417698953

Hastings, 2018, Generation of circadian rhythms in the suprachiasmatic nucleus, Nat Rev Neurosci, 19, 453, 10.1038/s41583-018-0026-z

Martins-Oliveira, 2017, Neuroendocrine signaling modulates specific neural networks relevant to migraine, Neurobiol Dis, 101, 16, 10.1016/j.nbd.2017.01.005

Akerman, 2011, Diencephalic and brainstem mechanisms in migraine, Nat Rev Neurosci, 12, 570, 10.1038/nrn3057

Penfield, 1940, Dural headache and innervation of the dura mater, AMA Arch Neurol Psychiatry, 44, 43, 10.1001/archneurpsyc.1940.02280070051003

Ray, 1940, Experimental studies on headache. Pain sensitive structures of the head and their significance in headache, Arch Surg, 41, 813, 10.1001/archsurg.1940.01210040002001

McNaughton, 1977, Innervation of intracranial structures: a reappraisal, 279

Edvinsson, 1988, Nerve supply and receptor mechanisms in intra- and extracerebral blood vessels, 127

Uddman, 1985, Innervation of the feline cerebral vasculature by nerve fibers containing calcitonin gene-related peptide: trigeminal origin and co-existence with substance P, Neurosci Lett, 62, 131, 10.1016/0304-3940(85)90296-4

Uddman, 1993, Localization of pituitary adenylate cylase activating peptide (PACAP) in cerebral vessels. Colocalization with VIP, effects in cerebral blood vessels in vitro and in situ and on cerebral blood flow, J Cereb Blood Flow Metab, 13, S633

Uddman, 1989, Neuropeptides in the cerebral circulation, Cerebrovasc Brain Metab Rev, 1, 230

O'Connor, 1988, Enrichment of a vasoactive neuropeptide (calcitonin gene related peptide) in trigeminal sensory projection to the intracranial arteries, J Neurosci, 8, 2468, 10.1523/JNEUROSCI.08-07-02468.1988

Millan, 2002, Descending control of pain, Prog Neurobiol, 66, 355, 10.1016/S0301-0082(02)00009-6

Burstein, 1998, Chemical stimulation of the intracranial dura induces enhanced responses to facial stimulation in brain stem trigeminal neurons, J Neurophysiol, 79, 964, 10.1152/jn.1998.79.2.964

Liu, 2008, Central projections of the sensory innervation of the rat middle meningeal artery, Brain Res, 1208, 103, 10.1016/j.brainres.2008.02.078

Liu, 2004, Central projections of sensory innervation of the rat superior sagittal sinus, Neuroscience, 129, 431, 10.1016/j.neuroscience.2004.07.045

Holland, 2006, Modulation of nociceptive dural input to the trigeminal nucleus caudalis via activation of the orexin 1 receptor in the rat, Eur J Neurosci, 24, 2825, 10.1111/j.1460-9568.2006.05168.x

Rodriguez, 2017, A craniofacial-specific monosynaptic circuit enables heightened affective pain, Nat Neurosci, 20, 1734, 10.1038/s41593-017-0012-1

Cechetto, 1985, Spinal and trigeminal dorsal horn projections to the parabrachial nucleus in the rat, J Comp Neurol, 240, 153, 10.1002/cne.902400205

Dallel, 2004, Organization of parabrachial projections from the spinal trigeminal nucleus oralis: an anterograde tracing study in the rat, J Comp Neurol, 470, 181, 10.1002/cne.11043

Panneton, 2014, Direct reticular projections of trigeminal sensory fibers immunoreactive to CGRP: potential monosynaptic somatoautonomic projections, Front Neurosci, 8, 136, 10.3389/fnins.2014.00136

Zhang, 2018, VGLUT1 or VGLUT2 mRNA-positive neurons in spinal trigeminal nucleus provide collateral projections to both the thalamus and the parabrachial nucleus in rats, Mol Brain, 11, 22, 10.1186/s13041-018-0362-y

Carter, 2013, Genetic identification of a neural circuit that suppresses appetite, Nature, 503, 111, 10.1038/nature12596

Carter, 2015, Parabrachial calcitonin gene-related peptide neurons mediate conditioned taste aversion, J Neurosci, 35, 4582, 10.1523/JNEUROSCI.3729-14.2015

Li, 2019, Mouse parabrachial neurons signal a relationship between bitter taste and nociceptive stimuli, J Neurosci, 39, 1631

Ivanusic, 2011, 5-HT(1D) receptor immunoreactivity in the sphenopalatine ganglion: implications for the efficacy of triptans in the treatment of autonomic signs associated with cluster headache, Headache, 51, 392, 10.1111/j.1526-4610.2011.01843.x

Csati, 2012, Calcitonin gene-related peptide and its receptor components in the human sphenopalatine ganglion -- interaction with the sensory system, Brain Res, 1435, 29, 10.1016/j.brainres.2011.11.058

May, 1999, The trigeminovascular system in humans: pathophysiological implications for primary headache syndromes of the neural influences on the cerebral circulation, J Cereb Blood Flow Metab, 19, 115, 10.1097/00004647-199902000-00001

Takeuchi, 1991, Direct amygdaloid projections to the superior salivatory nucleus: a light and electron microscopic study in the cat, Brain Res Bull, 27, 85, 10.1016/0361-9230(91)90285-R

Akerman, 2009, Oxygen inhibits neuronal activation in the trigeminocervical complex after stimulation of trigeminal autonomic reflex, but not via direct dural activation of trigeminal afferents, Headache, 49, 1131, 10.1111/j.1526-4610.2009.01501.x

Akerman, 2012, A translational in vivo model of trigeminal autonomic cephalalgias: therapeutic characterization, Brain, 135, 3664, 10.1093/brain/aws249

Guo, 2018, Cranial parasympathetic activation induces autonomic symptoms but no cluster headache attacks, Cephalalgia, 38, 1418, 10.1177/0333102417738250

Burstein, 1987, Direct somatosensory projections from the spinal cord to the hypothalamus and telencephalon, J Neurosci, 7, 4159, 10.1523/JNEUROSCI.07-12-04159.1987

Burstein, 1990, Cells of origin of the spinohypothalamic tract in the rat, J Comp Neurol, 291, 329, 10.1002/cne.902910302

Liu, 2009, Brainstem and thalamic projections from a craniovascular sensory nervous centre in the rostral cervical spinal dorsal horn of rats, Cephalalgia, 29, 935, 10.1111/j.1468-2982.2008.01829.x

Matsushita, 1982, The cells of origin of the trigeminothalamic, trigeminospinal and trigeminocerebellar projections in the cat, Neuroscience, 7, 1439, 10.1016/0306-4522(82)90256-1

Shigenaga, 1983, The cells of origin of cat trigeminothalamic projections: especially in the caudal medulla, Brain Res, 277, 201, 10.1016/0006-8993(83)90928-9

Veinante, 2000, Thalamic projections from the whisker-sensitive regions of the spinal trigeminal complex in the rat, J Comp Neurol, 420, 233, 10.1002/(SICI)1096-9861(20000501)420:2<233::AID-CNE6>3.0.CO;2-T

Williams, 1994, Differential foci and synaptic organization of the principal and spinal trigeminal projections to the thalamus in the rat, Eur J Neurosci, 6, 429, 10.1111/j.1460-9568.1994.tb00286.x

Zagami, 1990, Stimulation of cranial vessels excites nociceptive neurones in several thalamic nuclei of the cat, Exp Brain Res, 81, 552, 10.1007/BF02423504

Zagami, 1991, Craniovascular application of capsaicin activates nociceptive thalamic neurons in the cat, Neurosci Lett, 121, 187, 10.1016/0304-3940(91)90681-I

Burstein, 2010, Thalamic sensitization transforms localized pain into widespread allodynia, Ann Neurol, 68, 81, 10.1002/ana.21994

Tyll, 2011, Thalamic influences on multisensory integration, Commun Integr Biol, 4, 378, 10.4161/cib.15222

Noseda, 2010, A neural mechanism for exacerbation of headache by light, Nat Neurosci, 13, 239, 10.1038/nn.2475

Bieler, 2018, Multisensory integration in rodent tactile but not visual thalamus, Sci Rep, 8, 15684, 10.1038/s41598-018-33815-y

Schwedt, 2013, Multisensory integration in migraine, Curr Opin Neurol, 26, 248, 10.1097/WCO.0b013e328360edb1

Porreca, 2002, Chronic pain and medullary descending facilitation, Trends Neurosci, 25, 319, 10.1016/S0166-2236(02)02157-4

Weiller, 1995, Brain stem activation in spontaneous human migraine attacks, Nat Med, 1, 658, 10.1038/nm0795-658

Afridi, 2005, A PET study in spontaneous migraine, Arch Neurol, 62, 1270, 10.1001/archneur.62.8.1270

Afridi, 2005, A PET study exploring the laterality of brainstem activation in migraine using glyceryl trinitrate, Brain, 128, 932, 10.1093/brain/awh416

Bahra, 2001, Brainstem activation specific to migraine headache, Lancet, 357, 1016, 10.1016/S0140-6736(00)04250-1

Dominguez, 2019, Iron deposition in periaqueductal gray matter as a potential biomarker for chronic migraine, Neurology, 92, e1076, 10.1212/WNL.0000000000007047

Welch, 2001, Periaqueductal grey matter dysfunction in migraine: cause or the burden of illness?, Headache, 41, 629, 10.1046/j.1526-4610.2001.041007629.x

Dahlberg, 2018, Responsivity of periaqueductal gray connectivity is related to headache frequency in episodic migraine, Front Neurol, 9, 61, 10.3389/fneur.2018.00061

Chong, 2017, Migraine classification using magnetic resonance imaging resting-state functional connectivity data, Cephalalgia, 37, 828, 10.1177/0333102416652091

Hoskin, 2001, Fos expression in the midbrain periaqueductal grey after trigeminovascular stimulation, J Anat, 198, 29

Keay, 1998, Vascular head pain selectively activates ventrolateral periaqueductal gray in the cat, Neurosci Lett, 245, 58, 10.1016/S0304-3940(98)00168-2

Oliveras, 1974, Inhibition of the jaw opening reflex by electrical stimulation of the periacqueductal gray matter in the awake, unrestrained cat, Brain Res, 72, 328, 10.1016/0006-8993(74)90875-0

Knight, 2001, The periaqueductal gray matter modulates trigeminovascular input: a role in migraine?, Neuroscience, 106, 793, 10.1016/S0306-4522(01)00303-7

Knight, 2003, Trigeminal antinociception induced by bicuculline in the periaqueductal grey (PAG) is not affected by PAG P/Q-type calcium channel blockade in rat, Neurosci Lett, 336, 113, 10.1016/S0304-3940(02)01250-8

Knight, 2002, P/Q-type calcium-channel blockade in the periaqueductal gray facilitates trigeminal nociception: a functional genetic link for migraine?, J Neurosci, 22, RC213, 10.1523/JNEUROSCI.22-05-j0002.2002

Pozo-Rosich, 2015, Periaqueductal gray calcitonin gene-related peptide modulates trigeminovascular neurons, Cephalalgia, 35, 1298, 10.1177/0333102415576723

Bartsch, 2004, Activation of 5-HT1B/1D receptors in the periaqueductal grey inhibits meningeal nociception, Ann Neurol, 56, 371, 10.1002/ana.20193

Marciszewski, 2018, Changes in brainstem pain modulation circuitry function over the migraine cycle, J Neurosci, 38, 10479, 10.1523/JNEUROSCI.1088-18.2018

Basbaum, 1978, Endogenous pain control mechanisms: review and hypothesis, Ann Neurol, 4, 451, 10.1002/ana.410040511

Edelmayer, 2009, Medullary pain facilitating neurons mediate allodynia in headache-related pain, Ann Neurol, 65, 184, 10.1002/ana.21537

Schwarz, 2015, Organization of the locus coeruleus-norepinephrine system, Curr Biol, 25, R1051, 10.1016/j.cub.2015.09.039

Reyes, 2005, Hypothalamic projections to locus coeruleus neurons in rat brain, Eur J Neurosci, 22, 93, 10.1111/j.1460-9568.2005.04197.x

Arima, 2019, Lateral parabrachial neurons innervate orexin neurons projecting to brainstem arousal areas in the rat, Sci Rep, 9, 2830, 10.1038/s41598-019-39063-y

Soya, 2017, Orexin modulates behavioral fear expression through the locus coeruleus, Nat Commun, 8, 1606, 10.1038/s41467-017-01782-z

Vila-Pueyo, 2019, Divergent influences of the locus coeruleus on migraine pathophysiology, Pain, 160, 385, 10.1097/j.pain.0000000000001421

Hickey, 2014, Optoactivation of locus ceruleus neurons evokes bidirectional changes in thermal nociception in rats, J Neurosci, 34, 4148, 10.1523/JNEUROSCI.4835-13.2014

Drummond, 2012, A possible role of the locus coeruleus in complex regional pain syndrome, Front Integr Neurosci, 6, 104, 10.3389/fnint.2012.00104

Charles, 2018, The migraine aura, Continuum (Minneap Minn), 24, 1009

Chan, 2010, Therapeutic antibodies for autoimmunity and inflammation, Nat Rev Immunol, 10, 301, 10.1038/nri2761

Brennan, 2009, Sleep and headache, Semin Neurol, 29, 406, 10.1055/s-0029-1237113

Zhang, 2011, Activation of central trigeminovascular neurons by cortical spreading depression, Ann Neurol, 69, 855, 10.1002/ana.22329

Kramer, 2016, Cortical spreading depolarization: pathophysiology, implications, and future directions, J Clin Neurosci, 24, 22, 10.1016/j.jocn.2015.08.004

Enger, 2015, Dynamics of ionic shifts in cortical spreading depression, Cereb Cortex, 25, 4469, 10.1093/cercor/bhv054

Melo-Carrillo, 2017, Selective inhibition of trigeminovascular neurons by fremanezumab: a humanized monoclonal Anti-CGRP antibody, J Neurosci, 37, 7149, 10.1523/JNEUROSCI.0576-17.2017

Hansen, 2010, Calcitonin gene-related peptide triggers migraine-like attacks in patients with migraine with aura, Cephalalgia, 30, 1179, 10.1177/0333102410368444

Hansen, 2011, Calcitonin gene-related peptide does not cause migraine attacks in patients with familial hemiplegic migraine, Headache, 51, 544, 10.1111/j.1526-4610.2011.01861.x

Filiz, 2019, CGRP receptor antagonist MK-8825 attenuates cortical spreading depression induced pain behavior, Cephalalgia, 39, 354, 10.1177/0333102417735845

Tozzi, 2012, Critical role of calcitonin gene-related peptide receptors in cortical spreading depression, Proc Natl Acad Sci U S A, 109, 18985, 10.1073/pnas.1215435109

Costa, 2013, Cortical spreading depression as a target for anti-migraine agents, J Headache Pain, 14, 62, 10.1186/1129-2377-14-62

Karatas, 2013, Spreading depression triggers headache by activating neuronal Panx1 channels, Science, 339, 1092, 10.1126/science.1231897

Ashina, 2017, Human models of migraine - short-term pain for long-term gain, Nat Rev Neurol, 13, 713, 10.1038/nrneurol.2017.137

Afridi, 2004, Glyceryl trinitrate triggers premonitory symptoms in migraineurs, Pain, 110, 675, 10.1016/j.pain.2004.05.007

Akerman, 2019, Nitroglycerin triggers triptan-responsive cranial allodynia and trigeminal neuronal hypersensitivity, Brain, 142, 103, 10.1093/brain/awy313

Demartini, 2019, Nitroglycerin as a comparative experimental model of migraine pain: from animal to human and back, Prog Neurobiol, 177, 15, 10.1016/j.pneurobio.2019.02.002

Bates, 2010, Sumatriptan alleviates nitroglycerin-induced mechanical and thermal allodynia in mice, Cephalalgia, 30, 170, 10.1111/j.1468-2982.2009.01864.x

Farkas, 2016, Utility of different outcome measures for the nitroglycerin model of migraine in mice, J Pharmacol Toxicol Methods, 77, 33, 10.1016/j.vascn.2015.09.006

Eller-Smith, 2018, Potential mechanisms underlying centralized pain and emerging therapeutic interventions, Front Cell Neurosci, 12, 35, 10.3389/fncel.2018.00035

Marone, 2018, TRPA1/NOX in the soma of trigeminal ganglion neurons mediates migraine-related pain of glyceryl trinitrate in mice, Brain, 141, 2312, 10.1093/brain/awy177

Abad, 2018, Dynamic sodium imaging at ultra-high field reveals progression in a preclinical migraine model, Pain, 159, 2058, 10.1097/j.pain.0000000000001307

Mason, 2017, Induction of migraine-like photophobic behavior in mice by both peripheral and central CGRP mechanisms, J Neurosci, 37, 204, 10.1523/JNEUROSCI.2967-16.2016

Wattiez, 2019, CGRP in animal models of migraine, Handb Exp Pharmacol, 1

Christensen, 2018, Migraine induction with calcitonin gene-related peptide in patients from erenumab trials, J Headache Pain, 19, 105, 10.1186/s10194-018-0927-2