Renu Virmani1, Allen Burke, Frank D. Kolodgie, Andrew Farb
1Department of Cardiovascular Pathology, Armed Forces Institute of Pathology, 6825, 16th Street NW, Washington, DC 20306-6000, USA. [email protected]
Tóm tắt
Thin cap atheroma is the precursor of plaque rupture, which accounts for a majority of coronary thrombi. The morphologic features of thin cap atheromas that predict rupture are unknown, but we know from studies of ruptured plaques that large necrotic cores, fibrous cap <65 microns and numerous macrophages within the cap likely indicate instability. There is some evidence that a speckled pattern of calcification is associated with vulnerability to rupture. There are usually multiple thin cap atheroma in the hearts of patients dying with acute plaque rupture, as well as multiple fibroatheromas with intraplaque hemorrhage. Targeted therapy for the purpose of stabilizing coronary lesions that are prone to rupture is a major future goal of the interventionist. (J Interven Cardiol 2003;16:267–272)
Từ khóa
Tài liệu tham khảo
10.1161/01.ATV.20.5.1262
10.1056/NEJM199705013361802
10.1016/0002-9149(90)90395-H
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