Passenger Lymphocyte Syndrome; a Review of the Diagnosis, Treatment, and Proposed Detection Protocol

Foell, 2017, Successful management of passenger lymphocyte syndrome in an ABO-compatible, nonidentical isolated bowel transplant: a case report and review of the literature, Transfusion, 57, 1396, 10.1111/trf.14086

Starzl, 1964, Experimental and clinical homotransplantation of the liver, Ann N Y Acad Sci, 120, 739, 10.1111/j.1749-6632.1965.tb30698.x

Marchioro, 1964, Splenic homotransplantation, Ann N Y Acad Sci, 120, 626, 10.1111/j.1749-6632.1965.tb30689.x

H. Beck MG, Oberman HA. Unexpected serologic findings following lung homotransplant., 24th Annual meeting of the American Association of Blood Banks, Chicago 1971; 98.

H.G. Klein, and David J. Anstee. Hemolytic transfusion reactions, Mollison’s blood transfusion in clinical medicine. 12th ed. (pp. 486), John Wiley and Sons, Inc., 2014.

Stevens, 1981, Emergence of red blood cell agglutinins following renal transplantation in a patient with systemic lupus erythematosus, Transplantation, 32, 398, 10.1097/00007890-198111000-00012

Hedley, 2008, Alloimmune haemolysis in a renal transplant recipient receiving sirolimus, NDT Plus, 1, 164

Peck, 2015, Passenger lymphocyte syndrome: a forgotten cause of postliver transplant jaundice and anemia, Exp Clin Transplant, 13, 200

de Bruijn, 2017, Passenger lymphocyte syndrome (PLS): a single-center retrospective analysis of minor ABO-incompatible liver transplants, J Clin Transl Hepatol, 5, 9, 10.14218/JCTH.2016.00072

Romero, 2015, Passenger lymphocyte syndrome in liver transplant recipients: a description of 12 cases, Blood Transfus, 13, 423

G. Ramsey. Red cell antibodies arising from solid organ transplants, Transfusion 1991; 31:76–86.

Berger, 2012, Immunologic challenges in small bowel transplantation, Am J Transplant, 12, S2, 10.1111/j.1600-6143.2012.04332.x

A.P. Marton, J.M.; Keshavjee, S.; Singer, L.; Hawes, J.; Cserti-Gazdewich, C. Passenger lymphocyte syndrome following solid organ transplantation: graft source, incidence, specificity, duration, and severity of hemolysis, Blood 2013; 122 37.

Adams, 2010, Self-limited hemolysis due to anti-D passenger lymphocyte syndrome in allogeneic hematopoietic stem cell transplantation, Bone Marrow Transplant, 45, 772, 10.1038/bmt.2009.202

Zaimoku, 2013, IgM anti-recipient ABO antibodies predict acute graft-versus-host disease following allogeneic hematopoietic stem cell transplantation, Int J Hematol, 98, 96, 10.1007/s12185-013-1360-6

Watz, 2014, Analysis of donor and recipient ABO incompatibility and antibody-associated complications after allogeneic stem cell transplantation with reduced-intensity conditioning, Biol Blood Marrow Transplant, 20, 264, 10.1016/j.bbmt.2013.11.011

Nadarajah, 2013, Literature review of passenger lymphocyte syndrome following renal transplantation and two case reports, Am J Transplant, 13, 1594, 10.1111/ajt.12219

Brunetta, 2017, Passenger lymphocyte syndrome in liver transplantation, Rev Bras Hematol Hemoter, 39, 364, 10.1016/j.bjhh.2017.07.006

Woolfson, 2019, Passenger lymphocyte syndrome after pediatric liver transplantation, J Pediatr Gastroenterol Nutr, 69, 95, 10.1097/MPG.0000000000002337

Brunetta, 2020, Prospective evaluation of immune haemolysis in liver transplantation, Vox Sang, 115, 72, 10.1111/vox.12865

Sandler, 2017, Nonhemolytic passenger lymphocyte syndrome, Transfusion, 57, 2942, 10.1111/trf.14383

Gniadek, 2017, A rare, potentially life-threatening presentation of passenger lymphocyte syndrome, Transfusion, 57, 1262, 10.1111/trf.14055

Monfort, 2015, Simultaneous passenger lymphocyte syndrome and multiple alloimmunization against donor's blood group antigens after liver transplantation, Vox Sang, 109, 86, 10.1111/vox.12253

Tong, 2017

Tong, 2016, Optimal conditions for the performance of a monocyte monolayer assay, Transfusion, 56, 2680, 10.1111/trf.13766

Achkar, 2011, Hemolytic anemia after kidney transplantation: a prospective analysis, Transfusion, 51, 2495, 10.1111/j.1537-2995.2011.03192.x

Hurtarte-Sandoval, 2015, Passenger lymphocyte syndrome after simultaneous pancreas-kidney transplantation: a case report of an unusual cause of alloimmune hemolytic anemia, Transplant Proc, 47, 2667, 10.1016/j.transproceed.2015.08.042

Karanth, 2014, Immune hemolysis resulting from passenger lymphocyte syndrome derived anti-rh (D) reactivity after kidney transplantation: a case report and literature review, Transplantation, 97, e54, 10.1097/TP.0000000000000100

ElAnsary, 2015, Passenger lymphocyte syndrome in ABO and rhesus D minor mismatched liver and kidney transplantation: a prospective analysis, Hum Immunol, 76, 447, 10.1016/j.humimm.2015.03.006

C.M. Cserti-Gazdewich, T.K. Waddell, L.G. Singer, C. Chaparro, J.M. Pendergrast, J. Hawes, N. denHollander, K. Tinckam, S. Keshavjee. Passenger lymphocyte syndrome with or without immune hemolytic anemia in all Rh-positive recipients of lungs from rhesus alloimmunized donors: three new cases and a review of the literature, Transfus Med Rev 2009; 23:134–145.

Aujayeb, 2014, The passenger lymphocyte syndrome—experience from a cardiothoracic transplant unit, Transfus Med, 24, 423, 10.1111/tme.12158

Hoffman, 2009, Immune hemolytic anemia—selected topics, Hematology Am Soc Hematol Educ Program, 80, 10.1182/asheducation-2009.1.80

Petz, 2005, Immune hemolysis associated with transplantation, Semin Hematol, 42, 145, 10.1053/j.seminhematol.2005.05.017

Smith, 2010, Hematologic disorders after solid organ transplantation, Hematology Am Soc of Hematol Educ Program, 2010, 281, 10.1182/asheducation-2010.1.281

Makuria, 2009, Nonhemolytic passenger lymphocyte syndrome: donor-derived anti-M in an M+ recipient of a multiorgan transplant, Immunohematology, 25, 20, 10.21307/immunohematology-2019-226

Davis, 2011, Severe haemolysis due to passenger lymphocyte syndrome after an ABO mismatched bowel transplant—a case report, Transfus Med, 21, 65, 10.1111/j.1365-3148.2010.01045.x

Smith, 2015, OPTN/SRTR 2013 annual data report: intestine, Am J Transplant, 15, 1, 10.1111/ajt.13198

Seltsam, 2001, Donor-derived alloantibodies and passenger lymphocyte syndrome in two of four patients who received different organs from the same donor, Transfusion, 41, 365, 10.1046/j.1537-2995.2001.41030365.x

Koepsell, 2013, Passenger lymphocyte syndrome: use of archived donor organ biopsy obtained at the time of transplantation for diagnosis, Am J Transplant, 13, 2227, 10.1111/ajt.12343

Shortt, 2008, A 'dangerous' group O donor: severe hemolysis in all recipients of organs from a donor with multiple red cell alloantibodies, Am J Transplant, 8, 711, 10.1111/j.1600-6143.2007.02113.x

Hows, 1986, Donor-derived red blood cell antibodies and immune hemolysis after allogeneic bone marrow transplantation, Blood, 67, 177, 10.1182/blood.V67.1.177.177

Cunnion, 2017, Discriminating the hemolytic risk of blood type A plasmas using the complement hemolysis using human erythrocytes (CHUHE) assay, Transfusion, 57, 517, 10.1111/trf.13948

Dean, 2018

Dubey, 2014, A case of passenger lymphocyte syndrome following minor ABO incompatible renal transplantation, Asian J Transfus Sci, 8, 56, 10.4103/0973-6247.126694

Arthur, 2017, Antigen density dictates immune responsiveness following red blood cell transfusion, J Immunol, 198, 2671, 10.4049/jimmunol.1601736

Mener, 2018, Complement component 3 negatively regulates antibody response by modulation of red blood cell antigen, Front Immunol, 9, 676, 10.3389/fimmu.2018.00676

Mener, 2018, Complement serves as a switch between CD4+ T cell-independent and -dependent RBC antibody responses, JCI Insight, 3, 10.1172/jci.insight.121631

Arthur, 2019, Examining the role of complement in predicting, preventing, and treating hemolytic transfusion reactions, Transfus Med Rev, 33, 217, 10.1016/j.tmrv.2019.09.006

Saba, 1997, Anti-D in a D-positive renal transplant patient, Transfusion, 37, 321, 10.1046/j.1537-2995.1997.37397240216.x

Kummrow, 2019, Transfer of donor anti-HLA antibody expression to multiple transplant recipients: a potential variant of the passenger lymphocyte syndrome?, Am J Transplant, 19, 1577, 10.1111/ajt.15262

Maxfield, 2015, Transfer of HLA-specific allosensitization from a highly sensitized deceased organ donor to the recipients of each kidney, Am J Transplant, 15, 2501, 10.1111/ajt.13300

Koshizuka, 2019, Detection of engraftment of donor-derived antibody producing cells in a lung transplant recipient by anti-cytomegalovirus IgG avidity test, Transpl Immunol, 53, 34, 10.1016/j.trim.2018.12.003

Smibert, 2018, J Heart Lung Transpl, 37, S77, 10.1016/j.healun.2018.01.175

Arthur, 2016, CD8+ T cells mediate antibody-independent platelet clearance in mice, Blood, 127, 1823, 10.1182/blood-2015-10-673426

Hill, 2018, Autoimmune hemolytic anemia, Hematology Am Soc Hematol Educ Program, 2018, 382, 10.1182/asheducation-2018.1.382

Flegel, 2015, Pathogenesis and mechanisms of antibody-mediated hemolysis, Transfusion, 55, S47, 10.1111/trf.13147

Chonat, 2019, Challenges in preventing and treating hemolytic complications associated with red blood cell transfusion, Transfus Clin Biol, 26, 130, 10.1016/j.tracli.2019.03.002

Chonat, 2018, Contribution of alternative complement pathway to delayed hemolytic transfusion reaction in sickle cell disease, Haematologica, 103, e483, 10.3324/haematol.2018.194670

Chou, 2020, American Society of Hematology 2020 guidelines for sickle cell disease: transfusion support, Blood Adv, 4, 327, 10.1182/bloodadvances.2019001143

Itri, 2013, Hepatic transplantation: postoperative complications, Abdom Imaging, 38, 1300, 10.1007/s00261-013-0002-z

Stowell, 2019, Biologic roles of the ABH and Lewis histo-blood group antigens part I: infection and immunity, Vox Sang, 114, 426, 10.1111/vox.12786

Stowell, 2019, Biologic roles of the ABH and Lewis histo-blood group antigens part II: thrombosis, cardiovascular disease and metabolism, Vox Sang, 114, 535, 10.1111/vox.12786

P. Matzinger. The danger model: a renewed sense of self, Science (New York, N.Y.) 2002; 296:301–305.

Zimring, 2016, Cellular immune responses in red blood cell alloimmunization, Hematology Am Soc Hematol Educ Program, 2016, 452, 10.1182/asheducation-2016.1.452

Chinnakotla, 2007, Acute graft-versus-host disease after liver transplantation: role of withdrawal of immunosuppression in therapeutic management, Liver Transpl, 13, 157, 10.1002/lt.20982

A. Salama. Treatment options for primary autoimmune hemolytic anemia: a short comprehensive review, Transfus Med Hemother 2015; 42:294–301.

Sarwal, 2016, Fingerprints of transplant tolerance suggest opportunities for immunosuppression minimization, Clin Biochem, 49, 404, 10.1016/j.clinbiochem.2016.01.007

Holt, 2017, Overview of immunosuppressive therapy in solid organ transplantation, Anesthesiol Clin, 35, 365, 10.1016/j.anclin.2017.04.001

Padmanabhan, 2019, Guidelines on the use of therapeutic apheresis in clinical practice—evidence-based approach from the Writing Committee of the American Society for Apheresis: the eighth special issue, J Clinical Apher, 34, 171, 10.1002/jca.21705

Emory Transplant Center: liver transplant program. Retrieved March 14, from https://www.emoryhealthcare.org/centers-programs/liver-transplant-program/index.html.

Yang, 2019, AABB issues recommendations to decrease group O blood overuse: association encourages blood banks and hospitals to work together to optimize group O blood use, AABB Communications June, 27

Turino-Luque, 2012, Early detection of biliary complications and graft rejection in a non-RH Identitical liver transplant recipient from a non-heart-beating donor: a case report, Transplant Proc, 44, 2124, 10.1016/j.transproceed.2012.07.075

Sachan, 2018, Passenger lymphocyte syndrome following minor ABO mismatch liver transplantation, Indian J Hematol Blood Transfus, 34, 783, 10.1007/s12288-018-0971-8

Jung, 2018, Transient loss of A1 phenotype in a patient with passenger lymphocyte syndrome after ABO minor incompatible liver transplantation: the first case report, Transfus Apher Sci, 57, 759, 10.1016/j.transci.2018.09.014

Ainsworth, 2009, Severe hemolytic anemia post-renal transplantation produced by donor anti-D passenger lymphocytes: case report and literature review, Transfusion Med Rev, 23, 155, 10.1016/j.tmrv.2008.12.005

Kato, 2009, Acute graft-versus-host-disease in kidney transplantation: case report and review of literature, Transplant Proc, 41, 3949, 10.1016/j.transproceed.2009.05.030

Pascual-Perez, 2013, Passenger lymphocyte syndrome: an uncommon form of anaemia in renal transplantation, Nefrologia, 33, 615

Sengupta, 2015, Passenger lymphocyte syndrome in a renal transplant recipient, J Assoc Physicians India, 63, 86

Nishide, 2019, Passenger lymphocyte syndrome in the ABO-incompatible kidney transplant recipient receiving rituximab, Exp Clinical Transplant, 17, 558, 10.6002/ect.2016.0261

Low, 2012, Passenger lymphocyte syndrome after lung transplant, Blood, 120, 4122, 10.1182/blood-2012-06-438614

Horlait, 2013, Passenger lymphocyte syndrome mimicking hemolytic uremic syndrome after lung transplantation, J Heart Lung Transplant, 32, 271, 10.1016/j.healun.2012.11.020