Parkinson's disease: one biochemical pathway to fit all genes?

Jenner, 1998, Understanding cell death in Parkinson's disease, Ann. Neurol., 44, S72, 10.1002/ana.410440712 Dunnett, 1999, Prospects for new restorative and neuroprotective treatments in Parkinson's disease, Nature, 399, A32, 10.1038/19899 Piccini, 1997, Dopaminergic function in familial Parkinson's disease: a clinical and 18F-dopa positron emission tomography study, Ann. Neurol., 41, 222, 10.1002/ana.410410213 Piccini, 1999, The role of inheritance in sporadic Parkinson's disease: evidence from a longitudinal study of dopaminergic function in twins, Ann. Neurol., 45, 577, 10.1002/1531-8249(199905)45:5<577::AID-ANA5>3.0.CO;2-O Burn, 1992, Parkinson's disease in twins studied with 18F-dopa and positron emission tomography, Neurology, 42, 1894, 10.1212/WNL.42.10.1894 Sveinbjornsdottir, 2000, Familial aggregation of Parkinson's disease in Iceland, New Engl. J. Med., 343, 1765, 10.1056/NEJM200012143432404 Maher, 2002, Epidemiologic study of 203 sibling pairs with Parkinson's disease: the GenePD study, Neurology, 58, 79, 10.1212/WNL.58.1.79 Polymeropoulos, 1997, Mutation in the α-synuclein gene identified in families with Parkinson's disease, Science, 276, 2045, 10.1126/science.276.5321.2045 Krüger, 1998, Ala30Pro mutation in the gene encoding α-synuclein in Parkinson's disease, Nat. Genet., 18, 106, 10.1038/ng0298-106 Kitada, 1998, Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism, Nature, 392, 605, 10.1038/33416 Lücking, 2000, Association between early-onset Parkinson's disease and mutations in the Parkin gene, New Engl. J. Med., 342, 1560, 10.1056/NEJM200005253422103 Leroy, 1998, The ubiquitin pathway in Parkinson's disease, Nature, 395, 451, 10.1038/26652 Maraganore, 1999, Case-control study of the ubiquitin carboxy-terminal hydrolase L1 gene in Parkinson's disease, Neurology, 53, 1858, 10.1212/WNL.53.8.1858 Gasser, 1998, A susceptibility locus for Parkinson's disease maps to chromosome 2p13, Nat. Genet., 18, 262, 10.1038/ng0398-262 Farrer, 1999, A chromosome 4p haplotype segregating with Parkinson's disease and postural tremor, Hum. Mol. Genet., 8, 81, 10.1093/hmg/8.1.81 Valente, 2001, Localization of a novel locus for autosomal recessive early-onset parkinsonism, PARK6, on human chromosome 1p35–p36, Am. J. Hum. Genet., 68, 895, 10.1086/319522 van Duijn, 2001, Park7, a novel locus for autosomal recessive early-onset parkinsonism, on chromosome 1p36, Am. J. Hum. Genet., 69, 629, 10.1086/322996 Hicks, 2001, A susceptibility gene for late-onset idiopathic Parkinson's disease successfully mapped, Am. J. Hum. Genet., 69, 200 Funayama, 2002, A new locus for Parkinson's disease (PARK8) maps to chromosome 12p11.2–q13.1, Ann. Neurol., 51, 296, 10.1002/ana.10113 DeStefano, 2001, Genome-wide scan for Parkinson's disease: the GenePD study, Neurology, 57, 1124, 10.1212/WNL.57.6.1124 Martin, 2001, Association of single-nucleotide polymorphisms of the tau gene with late-onset Parkinson disease, J. Am. Med. Assoc., 286, 2245, 10.1001/jama.286.18.2245 Scott, 2001, Complete genomic screen in Parkinson disease: evidence for multiple genes, J. Am. Med. Assoc., 286, 2239, 10.1001/jama.286.18.2239 Farrer, 2001, α-Synuclein gene haplotypes are associated with Parkinson's disease, Hum. Mol. Genet., 10, 1847, 10.1093/hmg/10.17.1847 Krüger, 1999, Increased susceptibility to sporadic Parkinson's disease by a certain combined α-synuclein/apolipoprotein E genotype, Ann. Neurol., 45, 611, 10.1002/1531-8249(199905)45:5<611::AID-ANA9>3.0.CO;2-X McNaught, 2001, Failure of the ubiquitin–proteasome system in Parkinson's disease, Nat. Rev. Neurosci., 2, 589, 10.1038/35086067 Chung, 2001, The role of the ubiquitin–proteasomal pathway in Parkinson's disease and other neurodegenerative disorders, Trends Neurosci., 24, S7, 10.1016/S0166-2236(00)01998-6 Ancolio, 2000, α-Synuclein and the Parkinson's disease-related mutant Ala53Thr-α-synuclein do not undergo proteasomal degradation in HEK293 and neuronal cells, Neurosci. Lett., 285, 79, 10.1016/S0304-3940(00)01049-1 Bennett, 1999, Degradation of α-synuclein by proteasome, J. Biol. Chem., 274, 33855, 10.1074/jbc.274.48.33855 McLean, 2001, α-Synuclein-enhanced green fluorescent protein fusion proteins form proteasome sensitive inclusions in primary neurons, Neuroscience, 104, 901, 10.1016/S0306-4522(01)00113-0 Rideaut, 2001, Proteasomal inhibition leads to formation of ubiquitin/α-synuclein-immunoreactive inclusions in PC12 cells, J. Neurochem., 78, 899, 10.1046/j.1471-4159.2001.00474.x Tanaka, 2001, Inducible expression of mutant α-synuclein decreases proteasome activity and increases sensitivity to mitochondria-dependent apoptosis, Hum. Mol. Genet., 10, 919, 10.1093/hmg/10.9.919 Lee, 2001, Effect of the overexpression of wild-type or mutant α-synuclein on cell susceptibility to insult, J. Neurochem., 76, 998, 10.1046/j.1471-4159.2001.00149.x Stefanis, 2001, Expression of A53T mutant but not wild-type α-synuclein in PC12 cells induces alterations of the ubiquitin-dependent degradation system, loss of dopamine release, and autophagic cell death, J. Neurosci., 21, 9549, 10.1523/JNEUROSCI.21-24-09549.2001 Bennett, 1999, Degradation of α-synuclein by proteasome, J. Biol. Chem., 274, 33855, 10.1074/jbc.274.48.33855 Ghee, 2000, Rat α-synuclein interacts with Tat binding protein 1, a component of the 26S proteasomal complex, J. Neurochem., 75, 2221, 10.1046/j.1471-4159.2000.0752221.x McNaught, 2001, Proteasomal function is impaired in substantia nigra in Parkinson's disease, Neurosci. Lett., 297, 191, 10.1016/S0304-3940(00)01701-8 Spillantini, 1997, α-Synuclein in Lewy bodies, Nature, 388, 839, 10.1038/42166 Spillantini, 1998, α-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with lewy bodies, Proc. Natl. Acad. Sci. U. S. A., 95, 6469, 10.1073/pnas.95.11.6469 Irizarry, 1998, Nigral and cortical Lewy bodies and dystrophic nigral neurites in Parkinson's disease and cortical Lewy body disease contain α-synuclein immunoreactivity, J. Neuropathol. Exp. Neurol., 57, 334, 10.1097/00005072-199804000-00005 Mezey, 1998, α-Synuclein in neurodegenerative disorders: murderer or accomplice?, Nat. Med., 4, 755, 10.1038/nm0798-755 Touchman, 2001, Human and mouse α-synuclein genes: comparative genomic sequence analysis and identification of a novel gene regulatory element, Genome Res., 11, 78, 10.1101/gr.165801 Chiba-Falek, 2001, Effect of allelic variation at the NACP-Rep1 repeat upstream of the α-synuclein gene (SNCA) on transcription in a cell culture luceferase reporter system, Hum. Mol. Genet., 10, 3101, 10.1093/hmg/10.26.3101 Farrer, 2001, Lewy bodies and parkinsonism in families with parkin mutations, Ann. Neurol., 50, 293, 10.1002/ana.1132 Hershko, 1992, The ubiquitin system for protein degradation, Annu. Rev. Biochem., 61, 761, 10.1146/annurev.bi.61.070192.003553 Saigoh, 1999, Intragenic deletion in the gene encoding ubiquitin carboxy-terminal hydrolase in gad mice, Nat. Genet., 23, 47, 10.1038/12647 Satoh, 2001, A polymorphic variation of serine to tyrosine at codon 18 in the ubiquitin C-terminal hydrolase-L1 gene is associated with a reduced risk of sporadic Parkinson's disease in a Japanese population, J. Neurol. Sci., 189, 113, 10.1016/S0022-510X(01)00555-X Wintermeyer, 2000, Mutation analysis and association studies of the UCHL1 gene in German Parkinson's disease patients, NeuroReport, 11, 2079, 10.1097/00001756-200007140-00004 Zhang, 2000, Association between a polymorphism of ubiquitin carboxy-terminal hydrolase L1 (UCH-L1) gene and sporadic Parkinson's disease, Parkinsonism Relat. Disord., 6, 195, 10.1016/S1353-8020(00)00015-8 Levecque, 2001, No genetic association of the ubiquitin carboxy-terminal hydrolase-L1 gene S18Y polymorphism with familial Parkinson's disease, J. Neural Transm., 108, 979, 10.1007/s007020170017 Savettieri, 2001, Lack of association between ubiquitin carboxy-terminal hydrolase L1 gene polymorphism and PD, Neurology, 57, 560, 10.1212/WNL.57.3.560 Zhang, 2000, Parkin functions as an E2-dependent ubiquitin-protein ligase and promotes the degradation of the synaptic vesicle-associated protein, CDCrel-1, Proc. Natl. Acad. Sci. U. S. A., 97, 11354, 10.1073/pnas.240347797 Shimura, 2000, Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase, Nat. Genet., 25, 302, 10.1038/77060 Peng, 2002, The septin CDCrel-1 is dispensable for normal development and neurotransmitter release, Mol. Cell. Biol., 22, 378, 10.1128/MCB.22.1.378-387.2002 Engelender, 1999, Synphilin-1 associates with α-synuclein and promotes the formation of cytosolic inclusions, Nat. Genet., 22, 110, 10.1038/8820 Shimura, 2001, Ubiquitination of a new form of α-synuclein by parkin from human brain: implications for Parkinson's disease, Science, 293, 263, 10.1126/science.1060627 Imai, 2001, An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of Parkin, Cell, 105, 891, 10.1016/S0092-8674(01)00407-X Conway, 2001, Kinetic stability of the α-synuclein protofibril by a dopamine-α-synuclein adduct, Science, 294, 1346, 10.1126/science.1063522 Chung, 2001, Parkin ubiquitinates the α-synuclein-interacting protein, synphilin-1: implications for Lewy-body formation in Parkinson disease, Nat. Med., 7, 1144, 10.1038/nm1001-1144 Kawamata, 2001, Interaction of α-synuclein and synphilin-1: effect of Parkinson's disease-associated mutations, J. Neurochem., 77, 929, 10.1046/j.1471-4159.2001.00301.x Wakabayashi, 2000, Synphilin-1 is present in Lewy bodies in Parkinson's disease, Ann. Neurol., 47, 521, 10.1002/1531-8249(200004)47:4<521::AID-ANA18>3.0.CO;2-B Heutink, 2000, Untangling tau-related dementia, Hum. Mol. Genet., 9, 979, 10.1093/hmg/9.6.979 Valente, 2002, Park6-linked parkinsonism occurs in several european families, Ann. Neurol., 51, 14, 10.1002/ana.10053 Klein, 2000, Parkin deletions in a family with adult-onset, tremor-dominant parkinsonism: expanding the phenotype, Ann. Neurol., 48, 65, 10.1002/1531-8249(200007)48:1<65::AID-ANA10>3.0.CO;2-L