Parkinson's Disease and Related α‐Synucleinopathies Are Brain Amyloidoses

Annals of the New York Academy of Sciences - Tập 991 Số 1 - Trang 107-110 - 2003
John Q. Trojanowski1, VIRGINIA M.‐Y. LEE1
1Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, and the Institute on Aging, the University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA

Tóm tắt

Abstract: A paradigm shift in understanding Parkinson's disease (PD) and related disorders is emerging from studies showing that alpha‐synuclein (AS) gene mutations cause familial PD; AS is abnormally nitrated, phosphorylated, and ubiquitinated; AS forms neuronal and glial inclusions; AS fibrillizes in vitro; and AS transgenic animals develop neurodegeneration with AS amyloid inclusions. Thus, PD and related synucleinopathies are brain amyloidoses that may share similar mechanisms and targets for drug discovery.

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Tài liệu tham khảo

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Annals of the New York Academy of Sciences

Tập 991 Số 1

107-110

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