Tín hiệu ubiquitin do parkin trung gian trong sự hình thành aggresome và autophagy

Gregersen, 2006, Protein misfolding disorders: pathogenesis and intervention, J. Inherit. Metab. Dis., 29, 456, 10.1007/s10545-006-0301-4

Whatley, 2008, The ubiquitin–proteasome system in spongiform degenerative disorders, Biochim. Biophys. Acta, 1782, 700, 10.1016/j.bbadis.2008.08.006

Olzmann, 2008, Aggresome formation and neurodegenerative diseases: therapeutic implications, Curr. Med. Chem., 15, 47, 10.2174/092986708783330692

Kopito, 2000, Aggresomes, inclusion bodies and protein aggregation, Trends Cell Biol., 10, 524, 10.1016/S0962-8924(00)01852-3

Xie, 2007, Autophagosome formation: core machinery and adaptations, Nat. Cell Biol., 9, 1102, 10.1038/ncb1007-1102

Levine, 2008, Autophagy in the pathogenesis of disease, Cell, 132, 27, 10.1016/j.cell.2007.12.018

Iwata, 2005, Increased susceptibility of cytoplasmic over nuclear polyglutamine aggregates to autophagic degradation, Proc. Natl. Acad. Sci. U.S.A., 102, 13135, 10.1073/pnas.0505801102

Ravikumar, 2002, Aggregate-prone proteins with polyglutamine and polyalanine expansions are degraded by autophagy, Hum. Mol. Genet., 11, 1107, 10.1093/hmg/11.9.1107

Ravikumar, 2004, Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease, Nat. Genet., 36, 585, 10.1038/ng1362

Iwata, 2005, HDAC6 and microtubules are required for autophagic degradation of aggregated Huntingtin, J. Biol. Chem., 280, 40282, 10.1074/jbc.M508786200

Shibata, 2006, Regulation of intracellular accumulation of mutant Huntingtin by Beclin 1, J. Biol. Chem., 281, 14474, 10.1074/jbc.M600364200

Kitada, 1998, Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism, Nature, 392, 605, 10.1038/33416

Hattori, 2004, Pathogenetic mechanisms of parkin in Parkinson's disease, Lancet, 364, 722, 10.1016/S0140-6736(04)16901-8

Moore, 2006, Parkin: a multifaceted ubiquitin ligase, Biochem. Soc. Trans., 34, 749, 10.1042/BST0340749

Tan, 2007, Pathogenic mutations in Parkinson disease, Hum. Mutat., 28, 641, 10.1002/humu.20507

Goldberg, 2003, Parkin-deficient mice exhibit nigrostriatal deficits but not loss of dopaminergic neurons, J. Biol. Chem., 278, 43628, 10.1074/jbc.M308947200

Fallon, 2006, A regulated interaction with the UIM protein Eps15 implicates parkin in EGF receptor trafficking and PI(3)K–Akt signalling, Nat. Cell Biol., 8, 834, 10.1038/ncb1441

Henn, 2007, Parkin mediates neuroprotection through activation of IκB kinase/nuclear factor-κB signaling, J. Neurosci., 27, 1868, 10.1523/JNEUROSCI.5537-06.2007

Clark, 2006, Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin, Nature, 441, 1162, 10.1038/nature04779

Narendra, 2008, Parkin is recruited selectively to impaired mitochondria and promotes their autophagy, J. Cell Biol., 183, 795, 10.1083/jcb.200809125

Olzmann, 2007, Parkin-mediated K63-linked polyubiquitination targets misfolded DJ-1 to aggresomes via binding to HDAC6, J. Cell Biol., 178, 1025, 10.1083/jcb.200611128

Bonifati, 2003, Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism, Science, 299, 256, 10.1126/science.1077209

Olzmann, 2004, Familial Parkinson's disease-associated L166P mutation disrupts DJ-1 protein folding and function, J. Biol. Chem., 279, 8506, 10.1074/jbc.M311017200

Huai, 2003, Crystal structure of DJ-1/RS and implication on familial Parkinson's disease, FEBS Lett., 549, 171, 10.1016/S0014-5793(03)00764-6

Kawaguchi, 2003, The deacetylase HDAC6 regulates aggresome formation and cell viability in response to misfolded protein stress, Cell, 115, 727, 10.1016/S0092-8674(03)00939-5

Olzmann, 2008, Parkin-mediated K63-linked polyubiquitination: a signal for targeting misfolded proteins to the aggresome-autophagy pathway, Autophagy, 4, 85, 10.4161/auto.5172

Tan, 2008, Lysine 63-linked ubiquitination promotes the formation and autophagic clearance of protein inclusions associated with neurodegenerative diseases, Hum. Mol. Genet., 17, 431, 10.1093/hmg/ddm320

Bjørkøy, 2005, p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on Huntingtin-induced cell death, J. Cell Biol., 171, 603, 10.1083/jcb.200507002

Pankiv, 2007, p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy, J. Biol. Chem., 282, 24131, 10.1074/jbc.M702824200

Seibenhener, 2004, Sequestosome 1/p62 is a polyubiquitin chain binding protein involved in ubiquitin proteasome degradation, Mol. Cell. Biol., 24, 8055, 10.1128/MCB.24.18.8055-8068.2004

Wooten, 2008, Essential role of sequestosome 1/p62 in regulating accumulation of Lys63-ubiquitinated proteins, J. Biol. Chem., 283, 6783, 10.1074/jbc.M709496200

Komatsu, 2007, Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice, Cell, 131, 1149, 10.1016/j.cell.2007.10.035

Rapoport, 1985, Proteolysis of mitochondria in reticulocytes during maturation is ubiquitin-dependent and is accompanied by a high rate of ATP hydrolysis, FEBS Lett., 180, 249, 10.1016/0014-5793(85)81080-2

Sutovsky, 1999, Ubiquitin tag for sperm mitochondria, Nature, 402, 371, 10.1038/46466

Martinez-Vicente, 2007, Autophagy and neurodegeneration: when the cleaning crew goes on strike, Lancet Neurol., 6, 352, 10.1016/S1474-4422(07)70076-5

Nixon, 2006, Autophagy in neurodegenerative disease: friend, foe or turncoat?, Trends Neurosci., 29, 528, 10.1016/j.tins.2006.07.003

Bennett, 2007, Global changes to the ubiquitin system in Huntington's disease, Nature, 448, 704, 10.1038/nature06022

Laurin, 2002, Recurrent mutation of the gene encoding sequestosome 1 (SQSTM1/p62) in Paget disease of bone, Am. J. Hum. Genet., 70, 1582, 10.1086/340731

Ramesh Babu, 2008, Genetic inactivation of p62 leads to accumulation of hyperphosphorylated tau and neurodegeneration, J. Neurochem., 106, 107, 10.1111/j.1471-4159.2008.05340.x

Johnston, 2002, Cytoplasmic dynein/dynactin mediates the assembly of aggresomes, Cell Motil. Cytoskeleton, 53, 26, 10.1002/cm.10057

Ravikumar, 2005, Dynein mutations impair autophagic clearance of aggregate-prone proteins, Nat. Genet., 37, 771, 10.1038/ng1591

Puls, 2003, Mutant dynactin in motor neuron disease, Nat. Genet., 33, 455, 10.1038/ng1123

Hafezparast, 2003, Mutations in dynein link motor neuron degeneration to defects in retrograde transport, Science, 300, 808, 10.1126/science.1083129

LaMonte, 2002, Disruption of dynein/dynactin inhibits axonal transport in motor neurons causing late-onset progressive degeneration, Neuron, 34, 715, 10.1016/S0896-6273(02)00696-7

Skibinski, 2005, Mutations in the endosomal ESCRTIII-complex subunit CHMP2B in frontotemporal dementia, Nat. Genet., 37, 806, 10.1038/ng1609

Parkinson, 2006, ALS phenotypes with mutations in CHMP2B (charged multivesicular body protein 2B), Neurology, 67, 1074, 10.1212/01.wnl.0000231510.89311.8b

Filimonenko, 2007, Functional multivesicular bodies are required for autophagic clearance of protein aggregates associated with neurodegenerative disease, J. Cell Biol., 179, 485, 10.1083/jcb.200702115

Lee, 2007, ESCRT-III dysfunction causes autophagosome accumulation and neurodegeneration, Curr. Biol., 17, 1561, 10.1016/j.cub.2007.07.029

Pandey, 2007, HDAC6 rescues neurodegeneration and provides an essential link between autophagy and the UPS, Nature, 447, 859, 10.1038/nature05853

Berger, 2006, Rapamycin alleviates toxicity of different aggregate-prone proteins, Hum. Mol. Genet., 15, 433, 10.1093/hmg/ddi458