Thứ bậc sinh đẻ và nguy cơ gãy xương hông ở phụ nữ sau mãn kinh

Springer Science and Business Media LLC - Tập 22 - Trang 1765-1771 - 2010
M. Kauppi1, M. Heliövaara2, O. Impivaara1, P. Knekt2, A. Jula1
1Division of Welfare and Health Promotion, National Institute for Health and Welfare, Turku, Finland
2Division of Welfare and Health Policies, National Institute for Health and Welfare, Helsinki, Finland

Tóm tắt

Nguy cơ gãy xương hông được đánh giá theo thứ bậc sinh đẻ ở phụ nữ sau mãn kinh. So với phụ nữ không sinh đẻ, nguy cơ gãy xương thấp hơn ở những phụ nữ có ba lần sinh trở lên. Thứ bậc sinh đẻ được đánh giá để dự đoán nguy cơ gãy xương hông trong dài hạn ở phụ nữ sau mãn kinh. Nghiên cứu được tiến hành trên 2,028 phụ nữ sau mãn kinh từ 45 tuổi trở lên, không có tiền sử gãy xương hông. Từ năm 1978 đến 1980, tất cả họ đã tham gia một khảo sát sức khỏe toàn diện dựa trên mẫu dân số đại diện quốc gia. Các trường hợp gãy xương hông mới phát sinh được xác định từ Sổ đăng ký Xuất viện Quốc gia trong thời gian theo dõi kéo dài lên đến 17 năm. Nguy cơ gãy xương hông thấp hơn ở phụ nữ có sinh con so với phụ nữ không sinh đẻ. Mô hình điều chỉnh theo độ tuổi cho thấy có mối liên hệ nghịch đáng kể giữa thứ bậc sinh đẻ với nguy cơ gãy xương hông như một biến liên tục [RR = 0.74; khoảng tin cậy 95% (CI), 0.61–0.90] cho mỗi gia tăng một độ lệch chuẩn (2.4 lần sinh). Sau khi điều chỉnh theo độ tuổi, tuổi mãn kinh, trình độ học vấn, chỉ số khối cơ thể, tình trạng vitamin D, mức tiêu thụ rượu, tiền sử hút thuốc, hoạt động thể chất trong thời gian rảnh, và sức khỏe tự đánh giá, nguy cơ tương đối là 0.50 (95% CI, 0.32–0.79) cho phụ nữ có ba lần sinh trở lên và 0.85 (95% CI, 0.55–1.32) cho phụ nữ có một đến hai lần sinh so với phụ nữ không sinh đẻ. Thứ bậc sinh đẻ, đặc biệt là ba lần sinh trở lên, dự đoán nguy cơ gãy xương hông giảm trong dài hạn.

Từ khóa

#gãy xương hông #phụ nữ sau mãn kinh #thứ bậc sinh đẻ

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