Paradoxical response to sedative/hypnotics in patients with Self-injurious behavior and stereotypy
Tóm tắt
Paradoxical response to sedative medication has been reported previously among patients with Self-injurious (SIB) and Stereotypic (ST) Behavior (Barron and Sandman, 1983, 1985). The prevalence of this marker was examined in 648 consecutive developmentally delayed patients tested in the EEG laboratory. Several analyses compared response to sedative/hypnotics, assessment of the EEG, and behavioral profiles from the most recent annual comprehensive behavioral/medical evaluation (CDER). The presence of SIB and ST were significantly related to paradoxical response. The EEG was not related to paradoxical response, but had fewer epileptic foci in frequent or severe SIB and/or ST.
Tài liệu tham khảo
Adamson, W. C., Nellis, B. P., Runge, C., Cleland, C., and Killian, E. (1958). Use of tranquilizers for mentally deficient patients.J. Dis. Child. 96: 154–164.
Barrett, R. P., Feinstein, C., and Hole W. T. (1989). Effects of Naloxone and Naltrexone on Self-Injury: A double blind, placebo-controlled analysis.Am. J. Ment Retard. 93: 644–651.
Barron, J. L., and Sandman, C. A. (1985). Paradoxical excitement to sedative-hypnotics in mentally retarded clients.Am. J. Ment. Def. 2: 124–129.
Barron, J. L., and Sandman, C. A. (1983). Relationship of sedative-hypnotic response to self-injurious behavior and stereotypy in mentally retarded clients.Am. J. Ment. Def. 88–2: 177–186.
Campbell, M., Adams P., Small, A. M., Tesch, L. M., and Currens, E. L. (1988). Naltrexone in infantile autism.Psychopharmacol. Bull. 24: 135–139.
Campbell, M. C., Overall, J. E., Small, A. M., Sokol, M. S., Spencer, E. K., Adams, P., Foltz, R. L., Monti, K. M., Perry, R., Nobler, M., and Roberts, E. (1989) Naltrexone in autistic children: An acute open dose range tolerance trial.J. Am. Acad. Child. Adol. Psychiatry 28: 200–206.
Cataldo, M. F., and Harris, J. (1982). The biological basis for self-injury in the mentally retarded.Anal. Intervent. Devel. Dis. 2: 21–39.
Deutsch, S. I. (1989). Rationale for the administration of opiate antagonists in treating infantile autism.Am. J. Ment. Retard. 631–635.
Gedye, A. (1989). Extreme self-injury attributed to frontal lobe seizures.Am. J. Ment. Retard. 94: 20–26.
Gillberg, C., Terenius, and Lonneholm, G. (1985). Endorphin activity in childhood psychosis.Arch. Gen. Psychiatry 42: 780–783.
Green, A H. (1967). Self-mutilation in schizophrenic children.Arch. Gen. Psychiatry 17: 234–244.
Herman, B. H., Hammock, M. K., Arthur-Smith, A., Egan, J., Chatoor, I., Werner A., and Zelnik, N. (1987). Naltrexone decreases self-injurious behavior.Ann. Neurol. 22: 550–552.
Langee, H. R. (1989) A retrospective study of mentally retarded patients with behavioral disorders who were treated with carbamazapine.Am. J. Ment. Retard. 93: 640–643.
Loovas, O. I., and Simmons, J. Q. (1969). Manipulation of self-destructive behavior in three retarded children.J. Appl. Behav. Anal. 2: 143–157.
Maisto, C. R., Baumeister, A. A., and Maisto, A. A. (1978). An analysis of the variables related to self-injurious behavior among institutionalized retarded persons.J. Ment. Def. Res. 22: 27–35.
Pirodsky, D. M., Gibbs, J. L., Hesse, R. A., Heish, M. C., Krause, R. B., and Rodriquez, W. H. (1985). Use of dexamethasone suppression test to detect depressive disorders of mentally retarded individuals.Am. Ment. Def. 90: 245–252.
Richardson, J. S., and Zaleski, W. A. (1983). Naloxone and self-mutilation.,Biol. Psychiatry 18: 99–101.
Romanczyk, R. G., and Goren, E. R. (1975). Severe self-injurious behavior: The problem of clinical control.J. Consult. Clink. Psychol. 43: 730–739.
Ross, D. L., Klykylo, W. M., and Hitzemann, R. (1986). Reduction of elevated CSF beta-endorphin by fenfluramine in infantile autism.Pediat. Neurol. 3: 83–86.
Ross, R. T. (1972). Behavior correlates of levels of intelligence.Am. J. Ment. Def. 76: 545–549.
Sandman, C. A., Barron, J. L., Crinella, F. M. and Donnelly, J. F. (1987). Influence of naloxone on brain and behavior of a self-injurious woman.Biol. Psychiatry 22: 99–906.
Sandman, C. A., Barron, J. L., and Colman, H. (1990). An orally administered opiate blocker, Naltrexone attenuates self-injurious behavior.Am. J. Ment. Retard. 95: 93–102.
Sandman, C. A., Barron, J. L., Chicz-DeMet, A., and DeMet, E. (990). Plasma, B-endorphin levels in patients with self-injurious behavior and stereotypy.Am. J. Ment. Retard. 7: 84–92.
Sandman, C. A., Datta, P., Barron, J. L., Hoehler, F., Williams, C., and Swanson, J. (1983). Naloxone attenuates self-abusive behavior in developmentally disabled clients.Appl. Res. Ment. Retard. 4: 5–11.
Sandyk R. (1985). Naloxone abolished self-injuring in a mentally retarded child.Ann. Neurol. 17: 520.
Schroeder, S. R., Schroeder, C. S., Smith, B., and Dalldorf, J. (1978). Prevalence of self-injurious behavior in a large state facility for the retarded. A three-year follow-up study.J. Aut. Child. Schiz. 8: 261.
Shodell, M., and Reiter H. (1968). Self-mutilative behavior in verbal and non-verbal schizophrenic children.Arch. Gen. Psychiatry 19: 453–455.
Smeets, P. M. (1971). Some characteristics of mental defectives displaying self-mutilative behaviors.Train. School Bull. 68: 131–135.
Weizman, R., Weizman, A., Tyano, S., Szekely, B. A., and Sarne, Y. H. (1984). Humoralendorphin blood levels in autistic, schizophrenic and healthy subjects.Psychopharmacology 82: 368–370.