Paradigm shift in safety assessment using new approach methods: The EU-ToxRisk strategy

Current Opinion in Toxicology - Tập 15 - Trang 33-39 - 2019
R. Graepel1, B. Ter Braak1, S.E. Escher2, C. Fisher3, I. Gardner3, H. Kamp4, D. Kroese5, M. Leist6, M.J. Moné1, M. Pastor7, B. van de Water1
1Division of Drug Discovery and Safety, Leiden Academic Centre for Drug Research, Leiden University, Einsteinweg 55, 2333 CC, Leiden, The Netherlands
2Fraunhofer Institute of Toxicology and Experimental Medicine (ITEM), Hannover, Germany
3Simcyp (A Certara Company), Sheffield, UK
4BASF SE, Experimental Toxicology and Ecology, Ludwigshafen am Rhein, Germany
5TNO (Department of Risk Analysis of Products in Development), Zeist, The Netherlands
6Fachbereich Biologie, University of Konstanz, Universitätsstrasse 1, 78457, Konstanz, Germany
7Research Programme on Biomedical Informatics (GRIB), Institut Hospital del Mar d'Investigacions Mèdiques (IMIM), Department of Experimental and Health Sciences, Universitat Pompeu Fabra, Barcelona, Spain

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