Paradigm Shift in the Management of Milk and Egg Allergy: Baked Milk and Egg Diet

Beyer, 2001, Effects of cooking methods on peanut allergenicity, J Allergy Clin Immunol, 107, 1077, 10.1067/mai.2001.115480

Carnes, 2007, The use of raw or boiled crustacean extracts for the diagnosis of seafood allergic individuals, Ann Allergy Asthma Immunol, 98, 349, 10.1016/S1081-1206(10)60881-2

Barlow, 1986, Continuous and discontinuous protein antigenic determinants, Nature, 322, 747, 10.1038/322747a0

Thomas, 2007, Evaluating the effect of food processing on the potential human allergenicity of novel proteins: international workshop report, Food Chem Toxicol, 45, 1116, 10.1016/j.fct.2006.12.016

Besler, 2001, Stability of food allergens and allergenicity of processed foods, J Chromatogr, 756, 207, 10.1016/S0378-4347(01)00110-4

Van Regenmortel, 2009, What is a B-cell epitope?, Methods Mol Biol, 524, 3, 10.1007/978-1-59745-450-6_1

Jarvinen, 2002, B-cell epitopes as a screening instrument for persistent cow’s milk allergy, J Allergy Clin Immunol, 110, 293, 10.1067/mai.2002.126080

Jarvinen, 2007, Specificity of IgE antibodies to sequential epitopes of hen’s egg ovomucoid as a marker for persistence of egg allergy, Allergy, 62, 758, 10.1111/j.1398-9995.2007.01332.x

Chatchatee, 2001, Identification of IgE- and IgG-binding epitopes on alpha(s1)-casein: differences in patients with persistent and transient cow’s milk allergy, J Allergy Clin Immunol, 107, 379, 10.1067/mai.2001.112372

Chatchatee, 2001, Identification of IgE and IgG binding epitopes on beta- and kappa-casein in cow’s milk allergic patients, Clin Exp Allergy, 31, 1256, 10.1046/j.1365-2222.2001.01167.x

Vila, 2001, Role of conformational and linear epitopes in the achievement of tolerance in cow’s milk allergy, Clin Exp Allergy, 31, 1599, 10.1046/j.1365-2222.2001.01218.x

Cooke, 1997, Allergenic properties of ovomucoid in man, J Immunol, 159, 2026, 10.4049/jimmunol.159.4.2026

Wang, 2010, Correlation of IgE/IgG4 milk epitopes and affinity of milk-specific IgE antibodies with different phenotypes of clinical milk allergy, J Allergy Clin Immunol, 125, 695, 10.1016/j.jaci.2009.12.017

Kocho, 1966, Nihon Shonika Gakkai Zasshi, 70, 606

Farrell, 2004, Nomenclature of the proteins of cows’ milk—sixth revision, J Dairy Sci, 87, 1641, 10.3168/jds.S0022-0302(04)73319-6

Lewis, 2000

Roth-Walter, 2008, Pasteurization of milk proteins promotes allergic sensitization by enhancing uptake through Peyer’s patches, Allergy, 63, 882, 10.1111/j.1398-9995.2008.01673.x

Poulsen, 1987, Effect of homogenization and pasteurization on the allergenicity of bovine milk analysed by a murine anaphylactic shock model, Clin Allergy, 17, 449, 10.1111/j.1365-2222.1987.tb02039.x

Poulsen, 1990, Comparison of intestinal anaphylactic reactions in sensitized mice challenged with untreated bovine milk and homogenized bovine milk, Allergy, 45, 321, 10.1111/j.1398-9995.1990.tb00506.x

Nielsen, 1989, Reagin production in mice: effect of subcutaneous and oral sensitization with untreated bovine milk and homogenized bovine milk, In Vivo, 3, 271

Docena, 1996, Identification of casein as the major allergenic and antigenic protein of cow’s milk, Allergy, 51, 412, 10.1111/j.1398-9995.1996.tb04639.x

Shek, 2005, Humoral and cellular responses to cow milk proteins in patients with milk-induced IgE-mediated and non-IgE-mediated disorders, Allergy, 60, 912, 10.1111/j.1398-9995.2005.00705.x

Host, 1988, Allergic reactions to raw, pasteurized, and homogenized/pasteurized cow milk: a comparison. A double-blind placebo-controlled study in milk allergic children, Allergy, 43, 113, 10.1111/j.1398-9995.1988.tb00404.x

Kilshaw, 1982, Effects of heat treatment of cow’s milk and whey on the nutritional quality and antigenic properties, Arch Dis Child, 57, 842, 10.1136/adc.57.11.842

Anderson, 1979, Anaphylactic sensitivity of guinea-pigs drinking different preparations of cows’ milk and infant formulae, Clin Exp Immunol, 35, 454

McLaughlan, 1981, Effect of heat on the anaphylactic-sensitising capacity of cows’ milk, goats’ milk, and various infant formulae fed to guinea-pigs, Arch Dis Child, 56, 165, 10.1136/adc.56.3.165

Heppell, 1984, Reduction in the antigenicity of whey proteins by heat treatment: a possible strategy for producing a hypoallergenic infant milk formula, Br J Nutr, 51, 29, 10.1079/BJN19840006

Werfel, 1997, Clinical reactivity to beef in children allergic to cow’s milk, J Allergy Clin Immunol, 99, 293, 10.1016/S0091-6749(97)70045-9

Fiocchi, 1998, Heat treatment modifies the allergenicity of beef and bovine serum albumin, Allergy, 53, 798, 10.1111/j.1398-9995.1998.tb03977.x

Gjesing, 1986, Allergen-specific IgE antibodies against antigenic components in cow milk and milk substitutes, Allergy, 41, 51, 10.1111/j.1398-9995.1986.tb00275.x

Boye, 1996, Effects of physicochemical factors on the secondary structure of beta-lactoglobulin, J Dairy Res, 63, 97

Chen, 2005, Beta-lactoglobulin is a thermal marker in processed milk as studied by electrophoresis and circular dichroic spectra, J Dairy Sci, 88, 1618, 10.3168/jds.S0022-0302(05)72833-2

Garcia-Hernandez, 1998, Spectroscopic and thermodynamic evidence for a complex denaturation mechanism of bovine beta-lactoglobulin A, Biochem Mol Biol Int, 45, 761

Iametti, 1996, Modifications occur at different structural levels during the heat denaturation of beta-lactoglobulin, Eur J Biochem, 237, 106, 10.1111/j.1432-1033.1996.0106n.x

Sava, 2005, The kinetics of heat-induced structural changes of beta-lactoglobulin, J Dairy Sci, 88, 1646, 10.3168/jds.S0022-0302(05)72836-8

Ehn, 2005, Modification of IgE binding to beta-lactoglobulin by fermentation and proteolysis of cow’s milk, J Agric Food Chem, 53, 3743, 10.1021/jf048121w

Ehn, 2004, Modification of IgE binding during heat processing of the cow’s milk allergen beta-lactoglobulin, J Agric Food Chem, 52, 1398, 10.1021/jf0304371

Jarvinen, 2001, IgE and IgG binding epitopes on alpha-lactalbumin and beta-lactoglobulin in cow’s milk allergy, Int Arch Allergy Immunol, 126, 111, 10.1159/000049501

Kaminogawa, 1989, Monoclonal antibodies as probes for monitoring the denaturation process of bovine beta-lactoglobulin, Biochim Biophys Acta, 998, 50, 10.1016/0167-4838(89)90117-9

Negroni, 1998, Two-site enzyme immunometric assays for determination of native and denatured beta-lactoglobulin, J Immunol Methods, 220, 25, 10.1016/S0022-1759(98)00150-1

Nowak-Wegrzyn, 2008, Tolerance to extensively heated milk in children with cow’s milk allergy, J Allergy Clin Immunol, 122, 342, 10.1016/j.jaci.2008.05.043

Jost, 1991, Reduction of whey protein allergenicity by processing, Adv Exp Med Biol, 289, 309, 10.1007/978-1-4899-2626-5_23

Hildebrandt, 2008, In vitro determination of the allergenic potential of technologically altered hen’s egg, J Agric Food Chem, 56, 1727, 10.1021/jf0725981

Jurado-Palomo, 2010, Oral challenge with pasteurized egg white from Gallus domesticus, Int Arch Allergy Immunol, 151, 331, 10.1159/000250441

Eigenmann, 2000, Anaphylactic reactions to raw eggs after negative challenges with cooked eggs, J Allergy Clin Immunol, 105, 587, 10.1067/mai.2000.104255

Peng, 1998, Heat denaturation of egg-white proteins abrogates the induction of oral tolerance of specific Th2 immune responses in mice, Scand J Immunol, 48, 491, 10.1046/j.1365-3083.1998.00432.x

Anet, 1985, Allergens in the white and yolk of hen’s egg. A study of IgE binding by egg proteins, Int Arch Allergy Appl Immunol, 77, 364, 10.1159/000233846

Mine, 2002, Comparative studies on antigenicity and allergenicity of native and denatured egg white proteins, J Agric Food Chem, 50, 2679, 10.1021/jf0112264

Bernhisel-Broadbent, 1994, Allergenicity and antigenicity of chicken egg ovomucoid (Gal d III) compared with ovalbumin (Gal d I) in children with egg allergy and in mice, J Allergy Clin Immunol, 93, 1047, 10.1016/S0091-6749(94)70054-0

Mine, 2001, The allergenicity of ovomucoid and its elimination from hen’s egg white, J Sci Food Agric, 81, 1540, 10.1002/jsfa.974

Honma, 1994, Specificities of IgE, IgG and IgA antibodies to ovalbumin. Comparison of binding activities to denatured ovalbumin or ovalbumin fragments of IgE antibodies with those of IgG or IgA antibodies, Int Arch Allergy Immunol, 103, 28, 10.1159/000236602

Elsayed, 1986, Antigenic and allergenic determinants of ovalbumin. I. Peptide mapping, cleavage at the methionyl peptide bonds and enzymic hydrolysis of native and carboxymethyl OA, Int Arch Allergy Appl Immunol, 79, 101, 10.1159/000233952

Gu, 1996, Antigenicity of ovomucoid remaining in boiled shell eggs, J Food Sci, 51, 1448, 10.1111/j.1365-2621.1986.tb13831.x

Gu, 1989, Chemical deglycosylation of hen ovomucoid: protective effect of carbohydrate moiety on tryptic hydrolysis and heat denaturation, J Biochem, 106, 66, 10.1093/oxfordjournals.jbchem.a122821

Van der Plancken, 2004, Trypsin inhibition activity of heat-denatured ovomucoid: a kinetic study, Biotechnol Prog, 20, 82, 10.1021/bp034126m

Baker, 1962, Molecular genetics of avian proteins, I. The egg proteins of the domestic fowl, Br Poult Sci, 3, 161, 10.1080/00071666208415471

Lee, 2002, Allergenicity of hen’s egg ovomucoid gamma irradiated and heated under different pH conditions, J Food Prot, 65, 1196, 10.4315/0362-028X-65.7.1196

Yoshino, 2004, Peptic digestibility of raw and heat-coagulated hen’s egg white proteins at acidic pH range, Int J Food Sci Nutr, 55, 635, 10.1080/09637480412331350173

Joo, 2006, Assessment of allergenic activity of a heat-coagulated ovalbumin after in vivo digestion, Biosci Biotechnol Biochem, 70, 591, 10.1271/bbb.70.591

Martos, 2011, Mechanisms underlying differential food allergy response to heated egg, J Allergy Clin Immunol, 127, 990, 10.1016/j.jaci.2011.01.057

Kato, 1997, Decrease in ovomucoid antigenicity in the processes of breadmaking supplemented with egg white, Food Sci Technol Int Tokyo, 3, 362, 10.3136/fsti9596t9798.3.362

Kato, 2000, Ovomucoid rendered insoluble by heating with wheat gluten but not with milk casein, Biosci Biotechnol Biochem, 64, 198, 10.1271/bbb.64.198

Urisu, 1997, Allergenic activity of heated and ovomucoid-depleted egg white, J Allergy Clin Immunol, 100, 171, 10.1016/S0091-6749(97)70220-3

Des Roches, 2006, Tolerance to cooked egg in an egg allergic population, Allergy, 61, 900, 10.1111/j.1398-9995.2006.01134.x

Lemon-Mule, 2008, Immunologic changes in children with egg allergy ingesting extensively heated egg, J Allergy Clin Immunol, 122, 977, 10.1016/j.jaci.2008.09.007

Ando, 2008, Utility of ovomucoid-specific IgE concentrations in predicting symptomatic egg allergy, J Allergy Clin Immunol, 122, 583, 10.1016/j.jaci.2008.06.016

Fiocchi, 2010, World Allergy Organization (WAO) Diagnosis and Rationale for Action against Cow’s Milk Allergy (DRACMA) guidelines, Pediatr Allergy Immunol, 21, 1

Fiocchi, 2010, Diagnosis and Rationale for Action Against Cow’s Milk Allergy (DRACMA): a summary report, J Allergy Clin Immunol, 126, 1119, 10.1016/j.jaci.2010.10.011

Kim, 2011, Dietary baked milk accelerates the resolution of cow’s milk allergy in children, J Allergy Clin Immunol, 128, 125, 10.1016/j.jaci.2011.04.036

Shreffler, 2009, Association of allergen-specific regulatory T cells with the onset of clinical tolerance to milk protein, J Allergy Clin Immunol, 123, 43, 10.1016/j.jaci.2008.09.051

Konstantinou, 2008, Consumption of heat-treated egg by children allergic or sensitized to egg can affect the natural course of egg allergy: hypothesis-generating observations, J Allergy Clin Immunol, 122, 414, 10.1016/j.jaci.2008.05.032

Clark, 2011, A longitudinal study of resolution of allergy to well-cooked and uncooked egg, Clin Exp Allergy, 41, 706, 10.1111/j.1365-2222.2011.03697.x

McGuffey, 2005, Denaturation and aggregation of three alpha-lactalbumin preparations at neutral pH, J Agric Food Chem, 53, 3182, 10.1021/jf048863p

Wang, 2006, Quantitative assessment of thermal denaturation of bovine alpha-lactalbumin via low-intensity ultrasound, HPLC, and DSC, J Agric Food Chem, 54, 6501, 10.1021/jf060895k

Chung, 1995, Heat Denaturation and Emulsifying Properties of Egg Yolk Phosvitin, J Food Sci, 60, 906, 10.1111/j.1365-2621.1995.tb06258.x

Dixon, 1981, Electrophoretic and chromatographic changes in egg yolk proteins due to heat, J Food Sci, 46, 981, 10.1111/j.1365-2621.1981.tb02971.x

Quirce, 2001, Chicken serum albumin (Gal d 5∗) is a partially heat-labile inhalant and food allergen implicated in the bird-egg syndrome, Allergy, 56, 754, 10.1034/j.1398-9995.2001.056008754.x

Chang, 1970, Disc gel electrophoresis of protein in native and heat treatment albumen, yolk and centrifuged whole egg, J Food Sci, 35, 774, 10.1111/j.1365-2621.1970.tb01992.x

Le Denmat, 1999, Protein denaturation and emulsifying properties of plasma and granules of egg yolk as related to heat treatment, J Food Sci, 64, 194, 10.1111/j.1365-2621.1999.tb15863.x

Amo, 2010, Gal d 6 is the second allergen characterized from egg yolk, J Agric Food Chem, 58, 7453, 10.1021/jf101403h