Papilledema: A review of etiology, pathophysiology, diagnosis, and management

Survey of Ophthalmology - Tập 67 - Trang 1135-1159 - 2022
Jim Shenchu Xie1, Laura Donaldson2, Edward Margolin2,3
1Michael G. DeGroote School of Medicine, McMaster University, Hamilton, Ontario, Canada
2Faculty of Medicine, Department of Ophthalmology and Visual Sciences, University of Toronto, Toronto, Ontario, Canada
3Faculty of Medicine, Department of Medicine, Division of Neurology, University of Toronto, Toronto, Ontario, Canada

Tài liệu tham khảo

Abrams, 2020, Papilledema in chronic inflammatory demyelinating polyradiculoneuropathy (CIDP): a pediatric case and review of the literature, J Child Neurol, 35, 700, 10.1177/0883073820925302 Abubaker, 2011, Idiopathic intracranial hypertension: lumboperitoneal shunts versus ventriculoperitoneal shunts-case series and literature review, Br J Neurosurg, 25, 94, 10.3109/02688697.2010.544781 Abu-Serieh, 2007, Stereotactic ventriculoperitoneal shunting for refractory idiopathic intracranial hypertension, Neurosurgery, 60, 1039, 10.1227/01.NEU.0000255456.12978.31 Aghsaei Fard, 2019, Optic nerve head and macular optical coherence tomography measurements in papilledema compared with pseudopapilledema, J Neuroophthalmol, 39, 28, 10.1097/WNO.0000000000000641 Ahmed, 2013, Venous hypertension as the cause of intracranial hypertension in patients with transverse sinus dural arteriovenous fistula, J Neuroophthalmol, 33, 102, 10.1097/WNO.0b013e318250575b Ahn, 2019, Accuracy of machine learning for differentiation between optic neuropathies and pseudopapilledema, BMC Ophthalmol, 19, 178, 10.1186/s12886-019-1184-0 Alghamdi, 2016, Neuro-ophthalmological manifestations of Behcet's disease, Acta Ophthalmologica, 94, 10.1111/j.1755-3768.2016.0695 Al-Jahdali, 2010, Massive hemoptysis and deep venous thrombosis presenting in a woman with Hughes-Stovin syndrome: a case report, J Med Case Rep, 4, 109, 10.1186/1752-1947-4-109 Allen, 1993, The clinical and radiological evaluation of primary brain tumors in children, Part I: clinical evaluation, J Natl Med Assoc, 85, 445 Andrews, 2014, Idiopathic intracranial hypertension and obesity, Horm Res Paediatr, 81, 217, 10.1159/000357730 Armstrong, 2014, Acquired thrombophilia, J Pharm Pract, 27, 234, 10.1177/0897190014530424 Armstrong-Javors, 2019, HaNDL Syndrome: case report and literature review, J Child Neurol, 34, 161, 10.1177/0883073818811546 Ashkenazi, 1998, Paraganglioma of the filum terminale: case report and literature review, J Spinal Disord, 11, 540, 10.1097/00002517-199812000-00016 Atta, 1988, Imaging of the optic nerve with standardised echography, Eye, 2, 358, 10.1038/eye.1988.66 Bartek, 2013, Intracranial hemorrhage due to intracranial hypertension caused by the superior vena cava syndrome, J Clin Neurosci, 20, 1040, 10.1016/j.jocn.2012.10.012 Bassi, 2014, Optical coherence tomography in papilledema and pseudopapilledema with and without optic nerve head drusen, Indian J Ophthalmol, 62, 1146, 10.4103/0301-4738.149136 Battal, 2011, Cerebrospinal fluid flow imaging by using phase-contrast MR technique, Br J Radiol, 84, 758, 10.1259/bjr/66206791 Beaumont, 1948, A case of reversible papilloedema due to heart failure, Br Med J, 1, 50, 10.1136/bmj.1.4540.50-a Bhosale, 2017, Accuracy of crescent sign on ocular ultrasound in diagnosing papilledema, World J Methodol, 7, 108, 10.5662/wjm.v7.i3.108 Bidot, 2015, Asymmetric papilledema in idiopathic intracranial hypertension, J Neuroophthalmol, 35, 31, 10.1097/WNO.0000000000000205 Bidot, 2015, Brain imaging in idiopathic intracranial hypertension, J Neuroophthalmol, 35, 400, 10.1097/WNO.0000000000000303 Biousse, 2012, Update on the pathophysiology and management of idiopathic intracranial hypertension, J Neurol Neurosurg Psychiatry, 83, 488, 10.1136/jnnp-2011-302029 Biousse, 2020, Optic disc classification by deep learning versus expert neuro-ophthalmologists, Ann Neurol, 88, 785, 10.1002/ana.25839 Biousse, 2003, Anemia and papilledema, Am J Ophthalmol, 135, 437, 10.1016/S0002-9394(02)02062-7 Boddu, 2018, Contrast enhanced magnetic resonance venography in the follow-up evaluation of idiopathic intracranial hypertension patients with cerebral venous sinus stenting, Clin Imaging, 50, 330, 10.1016/j.clinimag.2018.04.016 Bordley, 1909, Observations in experimentally induced choked disc, Bull Johns Hopkins Hosp, 20, 95 Brazis, 1998, Elevated intracranial pressure and pseudotumor cerebri, Curr Opin Ophthalmol, 9, 27, 10.1097/00055735-199812000-00005 Brune, 2021, Complications of ventriculoperitoneal shunt for idiopathic intracranial hypertension: a single-institution study of 32 patients, J Neuroophthalmol, 41, 224, 10.1097/WNO.0000000000000922 Buonanno, 1980, Neuroradiologic aspects of cerebral disseminated intravascular coagulation, AJNR Am J Neuroradiol, 1, 245 Burman, 2019, Comparing invasive with MRI-derived intracranial pressure measurements in healthy elderly and brain trauma cases: a pilot study, J Magn Reson Imaging, 50, 975, 10.1002/jmri.26695 Bynke, 2004, Ventriculoperitoneal shunting for idiopathic intracranial hypertension, Neurology, 63, 1314, 10.1212/01.WNL.0000140699.43019.48 Carter, 1989, Pseudodrusen of the optic disc. Papilledema simulating buried drusen of the optic nerve head, J Clin Neuroophthalmol, 9, 273 Chamberlain, 2018, Mechanisms of visual loss from orbital cellulitis, 23 Chandana, 2008, Primary brain tumors in adults, Am Fam Physician, 77, 1423 Chen, 2018, Optic disc edema in glial fibrillary acidic protein autoantibody–positive meningoencephalitis, J Neuroophthalmol, 38, 276, 10.1097/WNO.0000000000000593 Chen, 2018, Papilloedema and autoimmune retinopathy from systemic lupus erythematosus, Neuro-Ophthalmology, 42, 117, 10.1080/01658107.2017.1355395 Chen, 2019, Int Ophthalmol Clin, 59, 3, 10.1097/IIO.0000000000000274 Chen, 2014, Epidemiology and risk factors for idiopathic intracranial hypertension, Int Ophthalmol Clin, 54, 1, 10.1097/IIO.0b013e3182aabf11 Chong, 2007, Optic disc edema, cystoid macular edema, and elevated vascular endothelial growth factor in a patient with POEMS syndrome, J Neuroophthalmol, 27, 180, 10.1097/WNO.0b013e31814b2845 Clarke, 1955, Ophthalmological complications of multiple myelomatosis, Br J Ophthalmol, 39, 233, 10.1136/bjo.39.4.233 Cleaver, 2021, A patient with papilloedema, Pract Neurol, 21, 249, 10.1136/practneurol-2020-002563 Cognard, 1998, Dural arteriovenous fistulas as a cause of intracranial hypertension due to impairment of cranial venous outflow, J Neurol Neurosurg Psychiatry, 65, 308, 10.1136/jnnp.65.3.308 Conde-Díaz, 2017, Severe skull base osteomyelitis caused by Pseudomonas aeruginosa with successful outcome after prolonged outpatient therapy with continuous infusion of ceftazidime and oral ciprofloxacin: a case report, J Med Case Rep, 11, 48, 10.1186/s13256-017-1221-7 Corbett, 1988, Enlargement of the blind spot caused by papilledema, Am J Ophthalmol, 105, 261, 10.1016/0002-9394(88)90007-4 Corbett, 1988, Results of optic nerve sheath fenestration for pseudotumor cerebri. The lateral orbitotomy approach, Arch Ophthalmol, 106, 1391, 10.1001/archopht.1988.01060140555022 Delaidelli, 2017, Respiration: a new mechanism for CSF circulation?, J Neurosci, 37, 7076, 10.1523/JNEUROSCI.1155-17.2017 Derdeyn, 2017, Management of brain arteriovenous malformations: a scientific statement for healthcare professionals from the American Heart Association/American Stroke Association, Stroke., 48, e200, 10.1161/STR.0000000000000134 De Stefano, 2007, Incidence of the JAK2 V617F mutation among patients with splanchnic or cerebral venous thrombosis and without overt chronic myeloproliferative disorders, J Thromb Haemost, 5, 708, 10.1111/j.1538-7836.2007.02424.x Dhungana, 2010, Idiopathic intracranial hypertension, Acta Neurol Scand, 121, 71, 10.1111/j.1600-0404.2009.01172.x Donaldson, 1979, Cerebrospinal fluid hypersecretion in pseudotumor cerebri, Trans Am Neurol Assoc, 104, 196 Donaldson, 2021, Approach to patient with unilateral optic disc edema and normal visual function, J Neurol Sci, 424, 10.1016/j.jns.2021.117414 Donaldson, 2021, Rapid development of optic disc edema secondary to topical retinoid cream, Can J Neurol Sci, 10.1017/cjn.2021.11 van Egmond, 2012, A rare cause of facial nerve palsy in children: hyperostosis corticalis generalisata (Van Buchem disease): three new pediatric cases and a literature review, Eur J Paediatr Neurol, 16, 740, 10.1016/j.ejpn.2012.03.002 Eklund, 2007, Assessment of cerebrospinal fluid outflow resistance, Med Biol Eng Comput, 45, 719, 10.1007/s11517-007-0199-5 Esfahani, 2015, Quantitative magnetic resonance venography is correlated with intravenous pressures before and after venous sinus stenting: implications for treatment and monitoring, Neurosurgery, 77, 254, 10.1227/NEU.0000000000000771 Falanga, 2015, Cancer tissue procoagulant mechanisms and the hypercoagulable state of patients with cancer, Semin Thromb Hemost, 41, 756, 10.1055/s-0035-1564040 Fard, 2014, Quantification of peripapillary total retinal volume in pseudopapilledema and mild papilledema using spectral-domain optical coherence tomography, Am J Ophthalmol, 158, 136, 10.1016/j.ajo.2014.03.008 Fard, 2018, Optical coherence tomography angiography in optic disc swelling, Am J Ophthalmol, 191, 116, 10.1016/j.ajo.2018.04.017 Fard, 2019, Optical coherence tomography angiography in papilledema compared with pseudopapilledema, Invest Ophthalmol Vis Sci, 60, 168, 10.1167/iovs.18-25453 Ferro, 2004, Prognosis of cerebral vein and dural sinus thrombosis: results of the International Study on Cerebral Vein and Dural Sinus Thrombosis (ISCVT), Stroke, 35, 664, 10.1161/01.STR.0000117571.76197.26 Florisson, 2010, Papilledema in isolated single-suture craniosynostosis, J Craniofaci Surg, 21, 20, 10.1097/SCS.0b013e3181c3465e Flowers, 2020, Variability within optic nerve optical coherence tomography measurements distinguishes papilledema from pseudopapilledema, J Neuroophthalmol Francis, 2003, Benign intracranial hypertension in children following renal transplantation, Pediatr Nephrol, 18, 1265, 10.1007/s00467-003-1274-2 Friedman, 2002, Diagnostic criteria for idiopathic intracranial hypertension, Neurology, 59, 1492, 10.1212/01.WNL.0000029570.69134.1B Friedman, 2013, Revised diagnostic criteria for the pseudotumor cerebri syndrome in adults and children, Neurology, 81, 1159, 10.1212/WNL.0b013e3182a55f17 Frisén, 1982, Swelling of the optic nerve head: a staging scheme, J Neurol Neurosurg Psychiatry, 45, 13, 10.1136/jnnp.45.1.13 Gadhiya, 2020, A rare case of mollaret's meningitis complicated by chronic intractable migraine and papilledema: case report and review of literature, Cureus, 12, e7026 Gaston, 1991, Ophthalmic complications of spina bifida and hydrocephalus, Eye, 5, 279, 10.1038/eye.1991.44 Georgakis, 2018, Clinical, neuroimaging and histopathological features of gliomatosis cerebri: a systematic review based on synthesis of published individual patient data, J Neurooncol, 140, 467, 10.1007/s11060-018-2976-4 Ghosh, 2011, Lateral sinus thrombosis associated with mastoiditis and otitis media in children: a retrospective chart review and review of the literature, J Child Neurol, 26, 1000, 10.1177/0883073811401745 Gideon, 1994, Assessment of CSF dynamics and venous flow in the superior sagittal sinus by MRI in idiopathic intracranial hypertension: a preliminary study, Neuroradiology, 36, 350, 10.1007/BF00612116 Givre, 2008, Intracranial hypertension in a patient using topical adapalene, J Neuroophthalmol, 28, 156, 10.1097/WNO.0b013e318175c9da Göbel, 1997, Quantitative and objective follow-up of papilledema with the Heidelberg Retina Tomograph, Ophthalmologe, 94, 673, 10.1007/s003470050182 Green, 2018, Non-genetic and genetic risk factors for adult cerebral venous thrombosis, Thromb Res, 169, 15, 10.1016/j.thromres.2018.07.005 Grehn, 1981, Glaucomatouslike visual field defects in chronic papilledema, Albrecht Von Graefes Arch Klin Exp Ophthalmol., 217, 99, 10.1007/BF00418984 2014, Baseline OCT measurements in the idiopathic intracranial hypertension treatment trial, part II: correlations and relationship to clinical features, Invest Ophthalmol Vis Sci., 55, 8173, 10.1167/iovs.14-14961 Guirgis, 2003, Intracranial hypertension secondary to all-trans retinoic acid treatment for leukemia: diagnosis and management, J AAPOS, 7, 432, 10.1016/j.jaapos.2003.08.005 Gu, 1995, Pattern of axonal loss in longstanding papilledema due to idiopathic intracranial hypertension, Curr Eye Res, 14, 173, 10.3109/02713689509033512 Hady-Cohen, 2019, Familial intracranial hypertension in 2 brothers with pten mutation: expansion of the phenotypic spectrum, J Child Neurol, 34, 506, 10.1177/0883073819842970 Handattu, 2020, Unilateral lateral rectus palsy - an unusual presentation of pineal epidermoid cyst, Pan Afr Med, 36, 252 Harati, 2018, Disease and treatment-related sequelae in patients with complex jugulotympanic paraganglioma, J Clin Med, 7, 51, 10.3390/jcm7030051 Hattenhauer, 1997, Incidence of nonarteritic anterior ischemic optic neuropathy, Am J Ophthalmol, 123, 103, 10.1016/S0002-9394(14)70999-7 Hayreh, 1977, Optic disc edema in raised intracranial pressure. I. Evolution and resolution, Arch Ophthalmol, 95, 1237, 10.1001/archopht.1977.04450070135013 Hayreh, 1977, Optic disc edema in raised intracranial pressure, V. Pathogenesis. Arch Ophthalmol., 95, 1553, 10.1001/archopht.1977.04450090075006 Hayreh, 2016, Pathogenesis of optic disc edema in raised intracranial pressure, Prog Retin Eye Res, 50, 108, 10.1016/j.preteyeres.2015.10.001 Hayreh, 1976, Pathogenesis of optic disc oedema in raised intracranial pressure, Trans Ophthalmol Soc UK, 96, 404 Hayreh, 2001, The blood supply of the optic nerve head and the evaluation of it — myth and reality, Prog Retin Eye Res, 20, 563, 10.1016/S1350-9462(01)00004-0 Hickman, 2013, Neuro-ophthalmological complications of chronic inflammatory demyelinating polyradiculoneuropathy, Neuroophthalmology, 37, 146, 10.3109/01658107.2013.809459 Holl, 2018, Cystic degeneration of craniofacial fibrous dysplasia, World Neurosurg, 120, 159, 10.1016/j.wneu.2018.08.175 Hood, 2018, Efficacy of a deep learning system for detecting glaucomatous optic neuropathy based on color fundus photographs, Ophthalmology, 125, 1207, 10.1016/j.ophtha.2018.04.020 Hopper, 1987, The interventricular extension of choroid plexus papillomas, AJNR Am J Neuroradiol, 8, 469 Hornby, 2018, Metabolic concepts in idiopathic intracranial hypertension and their potential for therapeutic intervention, J Neuroophthalmol, 38, 522, 10.1097/WNO.0000000000000684 Horsburgh, 2013, Is higher choroid plexus “load” an aetiologic factor in idiopathic intracranial hypertension? A clinico-imaging morphometric correlative study, Cephalalgia, 33, 20, 10.1177/0333102412465202 Huang, 2014, Ventriculoperitoneal shunt as a treatment of visual loss in idiopathic intracranial hypertension, J Neuroophthalmol, 34, 223, 10.1097/WNO.0000000000000106 Imai, 2005, A case of POEMS syndrome with cystoid macular edema, Am J Ophthalmol, 139, 563, 10.1016/j.ajo.2004.09.016 Jiramongkolchai, 2017, Temporary lumbar drain as treatment for pediatric fulminant idiopathic intracranial hypertension, J Neuroophthalmol, 37, 126, 10.1097/WNO.0000000000000457 Jivraj, 2020, Utility of spectral-domain optical coherence tomography in differentiating papilledema from pseudopapilledema: a prospective longitudinal study, J Neuroophthalmol Johnston, 2004, Evidence of connections between cerebrospinal fluid and nasal lymphatic vessels in humans, non-human primates and other mammalian species, Cerebrospinal Fluid Res, 1, 2, 10.1186/1743-8454-1-2 Jooma, 1984, Intracranial neoplasms during the first year of life: analysis of one hundred consecutive cases, Neurosurgery, 14, 31, 10.1227/00006123-198401000-00008 Kabanovski, 2021, Dural venous sinus stenting in the treatment of idiopathic intracranial hypertension: a systematic review and critique of literature, Surv Ophthalmol Kalyvas, 2021, A systematic review of surgical treatments of idiopathic intracranial hypertension (IIH), Neurosurg Rev, 44, 773, 10.1007/s10143-020-01288-1 Kalyvas, 2017, Efficacy, complications and cost of surgical interventions for idiopathic intracranial hypertension: a systematic review of the literature, Acta Neurochir, 159, 33, 10.1007/s00701-016-3010-2 Kandasamy, 2011, Electromagnetic stereotactic ventriculoperitoneal csf shunting for idiopathic intracranial hypertension: a successful step forward?, World Neurosurg, 75, 155, 10.1016/j.wneu.2010.10.025 Kardon, 2014, Optical coherence tomography in papilledema, J Neuroophthalmol, 34, S10, 10.1097/WNO.0000000000000162 Katz, 2003, The pathogenesis and treatment of optic disc swelling in neurosarcoidosis: a unique therapeutic response to infliximab, Arch Neurol, 60, 426, 10.1001/archneur.60.3.426 Killer, 2013, Production and circulation of cerebrospinal fluid with respect to the subarachnoid space of the optic nerve, J Glaucoma, 22, S8, 10.1097/IJG.0b013e318293498b Killer, 2007, Cerebrospinal fluid dynamics between the intracranial and the subarachnoid space of the optic nerve. Is it always bidirectional?, Brain, 130, 514, 10.1093/brain/awl324 Killer, 2003, Architecture of arachnoid trabeculae, pillars, and septa in the subarachnoid space of the human optic nerve: anatomy and clinical considerations, Br J Ophthalmol, 87, 777, 10.1136/bjo.87.6.777 Killer, 1999, Lymphatic capillaries in the meninges of the human optic nerve, J Neuroophthalmol, 19, 222, 10.1097/00041327-199912000-00002 Killer, 2014, Compartmentalized cerebrospinal fluid, Int Ophthalmol Clin, 54, 95, 10.1097/IIO.0000000000000010 King, 1995, Tress BM. Cerebral venography and manometry in idiopathic intracranial hypertension, Neurology, 45, 2224, 10.1212/WNL.45.12.2224 King, 2002, Tress BM. Manometry combined with cervical puncture in idiopathic intracranial hypertension, Neurology, 58, 26, 10.1212/WNL.58.1.26 Kisilevsky, 2020, Papilledema and extensive dural sinus thrombosis due to jak2 mutation, J Neuroophthalmol Klein, 2013, Hyperandrogenism is associated with earlier age of onset of idiopathic intracranial hypertension in women, Curr Eye Res, 38, 972, 10.3109/02713683.2013.799214 Knapp, 1987, Multiple myeloma and its ocular manifestations, Surv Ophthalmol, 31, 343, 10.1016/0039-6257(87)90119-6 Kohli, 2021, Role of ocular ultrasonography to distinguish papilledema from pseudopapilledema, J Neuroophthalmol, 41, 206, 10.1097/WNO.0000000000000984 Komro, 2020, Cerebral venous sinus thrombosis in adults with prothrombotic conditions: a systematic review and a case from our institution, Cureus, 12, e7654 Kumar, 2015, Cerebral proliferative angiopathy with papilledema, Clin Neurol Neurosurg, 139, 12, 10.1016/j.clineuro.2015.08.032 Lam, 2016, A case of POEMS and chronic papilledema with preserved optic nerve function, Can J Ophthalmol, 51, e8, 10.1016/j.jcjo.2015.08.015 Lee, 2012, Papilledema: are we any nearer to a consensus on pathogenesis and treatment?, Curr Neurol Neurosci Rep, 12, 334, 10.1007/s11910-012-0257-8 Lee, 2017, Papilledema in children with hydrocephalus: incidence and associated factors, J Neurosurg Pediatr, 19, 627, 10.3171/2017.2.PEDS16561 Lepore, 2002, False and non-localizing signs in neuro-ophthalmology, Curr Opin Ophthalmol, 13, 371, 10.1097/00055735-200212000-00005 Lertakyamanee, 2015, Papilledema and vision loss caused by jugular paragangliomas, J Neuroophthalmol, 35, 364, 10.1097/WNO.0000000000000281 Li, 2021, Development and evaluation of a deep learning model for the detection of multiple fundus diseases based on colour fundus photography, Br J Ophthalmol Liu, 1993, Measurement and relationship of subarachnoid pressure of the optic nerve to intracranial pressures in fresh cadavers, Am J Ophthalmol, 116, 548, 10.1016/S0002-9394(14)73195-2 Liugan, 2017, Reduced free communication of the subarachnoid space within the optic canal in the human, Am J Ophthalmol, 179, 25, 10.1016/j.ajo.2017.04.012 Liu, 2020, Current concepts of cerebrospinal fluid dynamics and the translaminar cribrosa pressure gradient: a paradigm of optic disk disease, Surv Ophthalmol, 65, 48, 10.1016/j.survophthal.2019.08.005 Liu, 2021, Detection of optic disc abnormalities in color fundus photographs using deep learning, J Neuroophthalmol, 41, 368, 10.1097/WNO.0000000000001358 Loomba, 2012, Headache and papilledema in an adult with cyanotic congenital heart disease: the importance of fundoscopic evaluation rather than phlebotomy, Congenit Heart Dis, 7, E14, 10.1111/j.1747-0803.2011.00586.x Mader, 2017, Persistent asymmetric optic disc swelling after long-duration space flight: implications for pathogenesis, J Neuroophthalmol, 37, 133, 10.1097/WNO.0000000000000467 Mader, 2011, Optic disc edema, globe flattening, choroidal folds, and hyperopic shifts observed in astronauts after long-duration space flight, Ophthalmology, 118, 2058, 10.1016/j.ophtha.2011.06.021 Maher, 2001, Refractory idiopathic intracranial hypertension treated with stereotactically planned ventriculoperitoneal shunt placement, Neurosurg Focus, 10, E1, 10.3171/foc.2001.10.2.2 Malmqvist, 2018, The Optic Disc Drusen Studies Consortium recommendations for diagnosis of optic disc drusen using optical coherence tomography, J Neuroophthalmol, 38, 299, 10.1097/WNO.0000000000000585 Maloca, 2000, Bilateral papilledema from a massive intracranial epidermoid cyst, Am J Ophthalmol, 130, 254, 10.1016/S0002-9394(00)00502-X Manschot, 1954, Subarachnoid hemorrhage; intraocular symptoms and their pathogenesis, Am J Ophthalmol, 38, 501, 10.1016/0002-9394(54)90700-X Margolin, 2019, The swollen optic nerve: an approach to diagnosis and management, Pract Neurol, 19, 302, 10.1136/practneurol-2018-002057 Markey, 2016, Understanding idiopathic intracranial hypertension: mechanisms, management, and future directions, Lancet Neurol, 15, 78, 10.1016/S1474-4422(15)00298-7 Martinelli, 2014, Cerebral vein thrombosis in patients with Philadelphia-negative myeloproliferative neoplasms: an European Leukemia Net study, Am J Hematol, 89, E200, 10.1002/ajh.23809 Marzban, 2016, Hydrocephalus and papilledema in spinal cord tumors: a report of two cases, Surg J (NY), 2, e51, 10.1055/s-0036-1584584 McLeod, 1980, Role of axoplasmic transport in the pathophysiology of ischaemic disc swelling, Br J Ophthalmol, 64, 247, 10.1136/bjo.64.4.247 Mehrpour, 2015, Optic nerve sonography in the diagnostic evaluation of pseudopapilledema and raised intracranial pressure: a cross-sectional study, Neurol Res Int, 2015, 10.1155/2015/146059 Menger, 2014, A comparison of lumboperitoneal and ventriculoperitoneal shunting for idiopathic intracranial hypertension: an analysis of economic impact and complications using the Nationwide Inpatient Sample, Neurosurg Focus, 37, E4, 10.3171/2014.8.FOCUS14436 Micieli, 2016, Development of dural arteriovenous fistulas after cerebral venous sinus thrombosis, J Neuroophthalmol, 36, 53, 10.1097/WNO.0000000000000288 Mikkilineni, 2019, Visual field mean deviation at diagnosis of idiopathic intracranial hypertension predicts visual outcome, J Neuroophthalmol, 39, 186, 10.1097/WNO.0000000000000709 Milea, 2020, Artificial intelligence to detect papilledema from ocular fundus photographs, N Engl J Med, 382, 1687, 10.1056/NEJMoa1917130 Miller, 2015, Papilledema, 240 Minckler, 1977, Axoplasmic transport in ocular hypotony and papilledema in the monkey, Arch Ophthalmol, 95, 1430, 10.1001/archopht.1977.04450080140018 Mollanji, 2002, Blocking cerebrospinal fluid absorption through the cribriform plate increases resting intracranial pressure, Am J Physiol Regul Integr Comp Physiol, 282, R1593, 10.1152/ajpregu.00695.2001 Mollan, 2016, Evolving evidence in adult idiopathic intracranial hypertension: pathophysiology and management, J Neurol Neurosurg Psychiatry, 87, 982, 10.1136/jnnp-2015-311302 Mollan, 2018, Idiopathic intracranial hypertension: consensus guidelines on management, J Neurol Neurosurg Psychiatry, 89, 1088, 10.1136/jnnp-2017-317440 Morgan, 1995, The influence of cerebrospinal fluid pressure on the lamina cribrosa tissue pressure gradient, Invest Ophthalmol Vis Sci, 36, 1163 Moss, 2021, Should lumbar puncture be required to diagnose every patient with idiopathic intracranial hypertension?, J Neuroophthalmol, 41, 379, 10.1097/WNO.0000000000001373 Mulholland, 1998, Use of scanning laser ophthalmoscopy to monitor papilloedema in idiopathic intracranial hypertension, Br J Ophthalmol, 82, 1301, 10.1136/bjo.82.11.1301 Noetzel, 1986, Pseudotumor cerebri associated with obstructive nephropathy, Pediatr Neurol, 2, 238, 10.1016/0887-8994(86)90055-X Wall, 2014, Effect of acetazolamide on visual function in patients with idiopathic intracranial hypertension and mild visual loss: the idiopathic intracranial hypertension treatment trial, JAMA, 311, 1641, 10.1001/jama.2014.3312 Ochoa, 1972, Anatomical changes in peripheral nerves compressed by a pneumatic tourniquet, J Anat, 113, 433 Olfat, 2004, Pattern of neuropsychiatric manifestations and outcome in juvenile systemic lupus erythematosus, Clin Rheumatol, 23, 395, 10.1007/s10067-004-0898-3 Omuro, 2013, Glioblastoma and other malignant gliomas: a clinical review, JAMA, 310, 1842, 10.1001/jama.2013.280319 Orefice, 1995, Benign intracranial hypertension: a non-thrombotic complication of the primary antiphospholipid syndrome?, Lupus, 4, 324, 10.1177/096120339500400417 Özgönül, 2015, Abducens palsy due to cerebral venous sinus thrombosis in a patient with heart failure, Türk Oftalmoloji Dergisi, 45, 179, 10.4274/tjo.94468 Pencalet, 1998, Papillomas and carcinomas of the choroid plexus in children, J Neurosurg, 88, 521, 10.3171/jns.1998.88.3.0521 Petrohelos, 1951, The ocular findings of intracranial tumor; a study of 358 cases, Am J Ophthalmol, 34, 1387, 10.1016/0002-9394(51)90478-3 Price, 2001, Arachnoid cyst of the craniocervical junction: case report, Neurosurgery, 49, 212 Radius, 1980, Optic nerve fast axonal transport abnormalities in primates: occurrence after short posterior ciliary artery occlusion, Arch Ophthalmol, 98, 2018, 10.1001/archopht.1980.01020040870017 Ramesh, 2017, Vertex epidural hematoma: an analysis of a large series, Asian J Neurosurg, 12, 167, 10.4103/1793-5482.145555 Raper, 2018, Effect of body mass index on venous sinus pressures in idiopathic intracranial hypertension patients before and after endovascular stenting, Neurosurgery, 82, 555, 10.1093/neuros/nyx186 Reid, 1980, Pathogenesis of papilloedema and raised intracranial pressure in Guillain-Barré syndrome, Br Med J, 281, 1393, 10.1136/bmj.281.6252.1393 Riggeal, 2013, Clinical course of idiopathic intracranial hypertension with transverse sinus stenosis, Neurology, 80, 289, 10.1212/WNL.0b013e31827debd6 Rigi, 2015, Papilledema: epidemiology, etiology, and clinical management, Eye Brain, 7, 47 Rios-Montenegro, 1973, Intracranial pressure and ocular hemodynamics, Arch Ophthalmol, 89, 52, 10.1001/archopht.1973.01000040054013 Roberts, 2017, Effects of spaceflight on astronaut brain structure as indicated on MRI, N Engl J Med, 377, 1746, 10.1056/NEJMoa1705129 Rodriguez Torres, 2021, Correlation between optic disc peripapillary capillary network and papilledema grading in patients with idiopathic intracranial hypertension: a study of optical coherence tomography angiography, J Neuroophthalmol, 41, 48, 10.1097/WNO.0000000000000877 Rudich, 2015, Antiphospholipid antibody syndrome: raised intracranial pressure without cerebral venous sinus thrombosis, J Neuroophthalmol, 35, 396, 10.1097/WNO.0000000000000277 Saba, 2021, Automatic detection of papilledema through fundus retinal images using deep learning, Microsc Res Tech, 84, 912 Saber, 2018, Stent survival and stent-adjacent stenosis rates following venous sinus stenting for idiopathic intracranial hypertension: a systematic review and meta-analysis, Interv Neurol, 7, 490, 10.1159/000490578 Sadun, 1984, Lessell S. Transient visual obscurations with elevated optic discs, Ann Neurol, 16, 489, 10.1002/ana.410160410 Safaee, 2013, Choroid plexus papillomas: advances in molecular biology and understanding of tumorigenesis, Neuro Oncol, 15, 255, 10.1093/neuonc/nos289 Salgarello, 2001, Correlation of optic nerve head tomography with visual field sensitivity in papilledema, Invest Ophthalmol Vis Sci, 42, 1487 Salpietro, 2012, Idiopathic intracranial hypertension: a unifying neuroendocrine hypothesis through the adrenal-brain axis, Neuro Endocrinol Lett, 33, 569 Sanders, 1997, Papilloedema: ‘The pendulum of progress, Eye, 11, 267, 10.1038/eye.1997.63 Santos, 2017, The choroid plexus as a sex hormone target: Functional implications, Front Neuroendocrinol, 44, 103, 10.1016/j.yfrne.2016.12.002 Satti, 2015, Meta-analysis of csf diversion procedures and dural venous sinus stenting in the setting of medically refractory idiopathic intracranial hypertension, AJNR Am J Neuroradiol, 36, 1899, 10.3174/ajnr.A4377 Satti, 2017, Dural venous sinus stenting for medically and surgically refractory idiopathic intracranial hypertension, Interv Neuroradiol, 23, 186, 10.1177/1591019916680110 Schiffman, 2006, Evaluation and treatment of papilledema in pregnancy, Compr Ophthalmol Update, 7, 187 Schirmer, 2007, Mechanisms of visual loss in papilledema, Neurosurg Focus, 23, E5, 10.3171/FOC-07/11/E5 Schutta, 1971, Fine structure observations on experimental papilledema in the rhesus monkey, J Neurol Sci, 12, 1, 10.1016/0022-510X(71)90248-6 Shakeri, 2008, A review of hydrocephalus, Neurosurg Q, 18, 216, 10.1097/WNQ.0b013e31817328c9 Sibony, 2021, Optical coherence tomography neuro-toolbox for the diagnosis and management of papilledema, optic disc edema, and pseudopapilledema, J Neuroophthalmol, 41, 77, 10.1097/WNO.0000000000001078 Silvis, 2016, Risk factors for cerebral venous thrombosis, Semin Thromb Hemost, 42, 622, 10.1055/s-0036-1584132 Simonin, 2019, Correlation between papilledema and intracranial hypertension in crouzon syndrome: a case report and review of the literature, Pediatr Neurosurg, 54, 223, 10.1159/000500767 Sugerman, 1995, Effects of surgically induced weight loss on idiopathic intracranial hypertension in morbid obesity, Neurology, 45, 1655, 10.1212/WNL.45.9.1655 Suh, 2019, Papilledema from gain-of-function mutations in the STAT3 gene, Ophthalmic Genet, 40, 165, 10.1080/13816810.2019.1592202 Tacconi, 1996, Choroid plexus papillomas: consideration of a surgical series of 33 cases, Acta Neurochir, 138, 802, 10.1007/BF01411257 Takkar, 2018, Clinical and neuro-ophthalmologic predictors of visual outcome in idiopathic intracranial hypertension, Neuro-Ophthalmology, 42, 201, 10.1080/01658107.2017.1400570 Tanaka, 1988, Papilledema and spinal cord tumors, Surg Neurol, 29, 462, 10.1016/0090-3019(88)90141-3 Tan, 2020, Drug-induced intracranial hypertension: a systematic review and critical assessment of drug-induced causes, Am J Clin Derm, 21, 163, 10.1007/s40257-019-00485-z Tata, 2019, Idiopathic intracranial hypertension: are there predictors for visual outcome or recurrences?, Clin Neurol Neurosurg, 183, 10.1016/j.clineuro.2019.105378 Taylor, 1965, Demonstration of axonal flow by the movement of tritium-labeled protein in mature optic nerve fibers, Proc Natl Acad Sci USA., 54, 1521, 10.1073/pnas.54.6.1521 Tefferi, 2019, Polycythemia vera and essential thrombocythemia: 2019 update on diagnosis, risk-stratification and management, Am J Hematol, 94, 133, 10.1002/ajh.25303 Teleb, 2015, Stenting and angioplasty for idiopathic intracranial hypertension: a case series with clinical, angiographic, ophthalmological, complication, and pressure reporting, J Neuroimaging, 25, 72, 10.1111/jon.12072 Thomas, 2019, Multisuture craniosynostosis and papilledema in pycnodysostosis: a paradox?, J Craniofac Surg, 30, 110, 10.1097/SCS.0000000000004870 Thurtell, 2013, Idiopathic intracranial hypertension (pseudotumor cerebri): recognition, treatment, and ongoing management, Curr Treat Options Neurol, 15, 1, 10.1007/s11940-012-0207-4 Ting, 2017, Development and validation of a deep learning system for diabetic retinopathy and related eye diseases using retinal images from multiethnic populations with diabetes, JAMA, 318, 2211, 10.1001/jama.2017.18152 Toscano, 1991, Cerebrospinal fluid estrone in pseudotumor cerebri: a change in cerebral steroid hormone metabolism?, J Endocrinol Invest, 14, 81, 10.1007/BF03350271 Trobe, 2011, Papilledema: the vexing issues, J Neuroophthalmol, 31, 175, 10.1097/WNO.0b013e31821a8b0b Tso, 1977, Optic disc edema in raised intracranial pressure. III. A pathologic study of experimental papilledema, Arch Ophthalmol, 95, 1448, 10.1001/archopht.1977.04450080158022 Tso, 1977, Optic disc edema in raised intracranial pressure. IV. Axoplasmic transport in experimental papilledema, Arch Ophthalmol, 95, 1458, 10.1001/archopht.1977.04450080168023 Van Stavern, 2007, Optic disc edema, Semin Neurol, 27, 233, 10.1055/s-2007-979684 Vargiami, 2008, Hemolytic anemia presenting with idiopathic intracranial hypertension, Pediatr Neurol, 38, 53, 10.1016/j.pediatrneurol.2007.08.012 Vasseneix, 2021, Accuracy of a deep learning system for classification of papilledema severity on ocular fundus photographs, Neurology, 97, e369, 10.1212/WNL.0000000000012226 Vazhayil, 2018, Surgical management of colloid cysts in children: experience at a tertiary care center, Childs Nerv Syst, 34, 1215, 10.1007/s00381-018-3760-7 Vosoughi, 2021, Can lumbar puncture be safely deferred in patients with mild presumed idiopathic intracranial hypertension?, J Neuroophthalmol Wall, 1991, Idiopathic intracranial hypertension: a prospective study of 50 patients, Brain, 114, 155 Wall, 1987, Visual loss in pseudotumor cerebri: incidence and defects related to visual field strategy, Arch Neurol, 44, 170, 10.1001/archneur.1987.00520140040015 Wall, 2014, The idiopathic intracranial hypertension treatment trial: clinical profile at baseline, JAMA Neurol, 71, 693, 10.1001/jamaneurol.2014.133 Wall, 1995, Using motion perimetry to detect visual field defects in patients with idiopathic intracranial hypertension: a comparison with conventional automated perimetry, Neurology, 45, 1169, 10.1212/WNL.45.6.1169 Wall, 1998, Asymmetric papilledema in idiopathic intracranial hypertension: prospective interocular comparison of sensory visual function, Invest Ophthalmol Vis Sci, 39, 134 Walsh, 1969, Papilledema, 567 Wang, 2019, Headache and intracranial hypertension in Guillain-Barré syndrome: a case report and literature review, Int J Neurosci, 129, 1179, 10.1080/00207454.2019.1645139 Wasserman, 2007, Minocycline protects the blood–brain barrier and reduces edema following intracerebral hemorrhage in the rat, Exp Neurol, 207, 227, 10.1016/j.expneurol.2007.06.025 Weiss, 1948, Experiments on the mechanism of nerve growth, J Exp Zool, 107, 315, 10.1002/jez.1401070302 Westhout, 2008, Obstructive hydrocephalus and progressive psychosis: rare presentations of neurosarcoidosis, Surg Neurol, 69, 288, 10.1016/j.surneu.2007.01.068 Wiaux, 2007, Unusual cause of bilateral optic disc swelling: POEMS syndrome, Klin Monbl Augenheilkd, 224, 334, 10.1055/s-2007-962850 Wilson, 2016, Monro-Kellie 2.0: The dynamic vascular and venous pathophysiological components of intracranial pressure, J Cereb Blood Flow Metab, 36, 1338, 10.1177/0271678X16648711 Wirtschafter, 1975, Optic nerve axoplasm and papilledema, Surv Ophthalmol, 20, 157, 10.1016/0039-6257(75)90001-6 Duke-Elder, 1971, XII, 32 Wostyn, 2018, The first histologic evidence of a paravascular pathway within the optic nerve, Invest Ophthalmol Vis Sci, 59, 1717, 10.1167/iovs.17-23119 Xue, 2009, Intracranial hypertension syndrome in systemic lupus erythematosus: clinical analysis and review of the literature, J Huazhong Univ Sci Technolog Med Sci, 29, 107, 10.1007/s11596-009-0123-3 Yen, 1978, Camurati-Engelmann disease (progressive hereditary craniodiaphyseal dysplasia), J Neurosurg, 48, 138, 10.3171/jns.1978.48.1.0138 Yetimler, 2021, Serum glial fibrillary acidic protein (GFAP)-antibody in idiopathic intracranial hypertension, Int J Neurosci, 131, 775, 10.1080/00207454.2020.1758084 Zaki, 2013, Vitamin D deficiency rickets presenting as pseudotumor cerebri, JNRP, 04, 464, 10.4103/0976-3147.120210 Zhao, 2018, Increased intracranial pressure in Guillain–Barré syndrome, Medicine, 97, e11584, 10.1097/MD.0000000000011584 Zhou, 2021, Increased intracranial pressure without hydrocephalus associated with spinal cord tumor, J Neuroophthalmol, 41, 13, 10.1097/WNO.0000000000001026 Zunz, 2011, Gliomatosis cerebri presenting as idiopathic intracranial hypertension in a child, J Neuroophthalmol, 31, 339, 10.1097/WNO.0b013e31821a6d22