Pancreatic cancer-associated inflammation drives dynamic regulation of p35 and Ebi3

Vignali, 2012, IL-12 family cytokines: immunological playmakers, Nat. Immunol., 13, 722, 10.1038/ni.2366 Shen, 2014, IL-35-producing B cells are critical regulators of immunity during autoimmune and infectious diseases, Nature, 507, 366, 10.1038/nature12979 Dambuza, 2017, IL-12p35 induces expansion of IL-10 and IL-35-expressing regulatory B cells and ameliorates autoimmune disease, Nat. Commun., 8, 10.1038/s41467-017-00838-4 Wang, 2014, Interleukin-35 induces regulatory B cells that suppress autoimmune disease, Nat. Med., 20, 633, 10.1038/nm.3554 Sun, 2015, Interleukin 35 may contribute to the loss of immunological self-tolerance in patients with primary immune thrombocytopenia, Br. J. Haematol., 169, 278, 10.1111/bjh.13292 Pylayeva-Gupta, 2016, IL35-producing B cells promote the development of pancreatic neoplasia, Cancer Discov., 6, 247, 10.1158/2159-8290.CD-15-0843 Mirlekar, 2018, IL35 hinders endogenous antitumor T-cell immunity and responsiveness to immunotherapy in pancreatic cancer, Cancer Immunol. Res., 6, 1014, 10.1158/2326-6066.CIR-17-0710 Pylayeva-Gupta, 2016, Molecular pathways: Interleukin-35 in autoimmunity and cancer, Clin. Cancer Res., 22, 4973, 10.1158/1078-0432.CCR-16-0743 Turnis, 2016, Interleukin-35 limits anti-tumor immunity, Immunity, 44, 316, 10.1016/j.immuni.2016.01.013 Lee, 2018, Macrophage-secreted interleukin-35 regulates cancer cell plasticity to facilitate metastatic colonization, Nat. Commun., 9, 10.1038/s41467-018-06268-0 Collison, 2007, The inhibitory cytokine IL-35 contributes to regulatory T-cell function, Nature, 450, 566, 10.1038/nature06306 Collison, 2010, IL-35-mediated induction of a potent regulatory T cell population, Nat. Immunol., 11, 1093, 10.1038/ni.1952 Chehboun, 2017, Epstein-Barr virus-induced gene 3 (EBI3) can mediate IL-6 trans -signaling, J. Biol. Chem., 292, 6644, 10.1074/jbc.M116.762021 Bayne, 2012, Tumor-derived granulocyte-macrophage colony-stimulating factor regulates myeloid inflammation and T cell immunity in pancreatic cancer, Cancer Cell, 21, 822, 10.1016/j.ccr.2012.04.025 Schweighoffer, 2017, TLR4 signals in B lymphocytes are transduced via the B cell antigen receptor and SYK, J. Exp. Med., 214, 1269, 10.1084/jem.20161117 Haxhinasto, 2004, Synergistic B cell activation by CD40 and the B cell antigen receptor: role of B lymphocyte antigen receptor-mediated kinase activation and tumor necrosis factor receptor-associated factor regulation, J. Biol. Chem., 279, 2575, 10.1074/jbc.M310628200 Mizuno, 2005, B cell receptor (BCR) cross-talk: CD40 engagement enhances BCR-induced ERK activation, J Immunol., 174, 3369, 10.4049/jimmunol.174.6.3369 Elgueta, 2009, Molecular mechanism and function of CD40/CD40L engagement in the immune system, Immunol. Rev., 229, 152, 10.1111/j.1600-065X.2009.00782.x Yanaba, 2009, The development and function of regulatory B cells expressing IL-10 (B10 cells) requires antigen receptor diversity and TLR signals, J. Immunol., 182, 7459, 10.4049/jimmunol.0900270 Pone, 2012, BCR-signalling synergizes with TLR-signalling for induction of AID and immunoglobulin class-switching through the non-canonical NF-kappaB pathway, Nat. Commun., 3, 767, 10.1038/ncomms1769 Suthers, 2017, TLR7/TLR9- and B cell receptor-signaling crosstalk: promotion of potentially dangerous B cells, Front. Immunol., 8, 775, 10.3389/fimmu.2017.00775 Kuraoka, 2017, BCR and endosomal TLR signals synergize to increase AID expression and establish central B cell tolerance, Cell Reports, 18, 1627, 10.1016/j.celrep.2017.01.050 Nicholl, 2014, IL-35 promotes pancreas cancer growth through enhancement of proliferation and inhibition of apoptosis: Evidence for a role as an autocrine growth factor, Cytokine, 70, 126, 10.1016/j.cyto.2014.06.020 Huang, 2017, Tumour-derived Interleukin 35 promotes pancreatic ductal adenocarcinoma cell extravasation and metastasis by inducing ICAM1 expression, Nat. Commun., 8 Huang, 2018, Interleukin 35 expression correlates with microvessel density in pancreatic ductal adenocarcinoma, recruits monocytes, and promotes growth and angiogenesis of xenograft tumors in mice, Gastroenterology, 154, 675, 10.1053/j.gastro.2017.09.039