Panax notoginseng saponins induce apoptosis in retinoblastoma Y79 cells via the PI3K/AKT signalling pathway

Experimental Eye Research - Tập 216 - Trang 108954 - 2022
Jingchen Liu1,2, Chunli Zhang3, Baoyun Jia2,4, Kaiye Dong4, Mingjun Li2,5, Dong Qiu2, Lei Li2,4, Bing Xu2,6, Shuguang Sun2,7, Cairui Li2,4
1Department of Ophthalmology, Jiangxi Provincial Hospital of Integrated Traditional Chinese and Western Medicine, The Fourth Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine, Nanchang, China
2College of Clinical Medicine, Dali University, Dali, China
3Department of Ophthalmology, General Hospital of Southern Theatre Command, Guangzhou, China
4Department of Ophthalmology, The First Affiliated Hospital of Dali University, Dali, China
5Department of Ophthalmology, Weifang Hospital of Traditional Chinese Medicine, Weifang, China
6Department of Ophthalmology, Chongqing University Fuling Hospital, Chongqing, China
7Department of Endocrinology, The First Affiliated Hospital of Dali University, Dali, China

Tài liệu tham khảo

Ancona-Lezama, 2020, Modern treatment of retinoblastoma: a 2020 review, Indian J. Ophthalmol., 68, 2356, 10.4103/ijo.IJO_721_20 Andrs, 2015, Phosphatidylinositol 3-Kinase (PI3K) and phosphatidylinositol 3-kinase-related kinase (PIKK) inhibitors: importance of the morpholine ring, J. Med. Chem., 58, 41, 10.1021/jm501026z Baig, 2016, Potential of apoptotic pathway-targeted cancer therapeutic research: where do we stand?, Cell Death Dis., 7, e2058, 10.1038/cddis.2015.275 Bowman, 2021, International travel to obtain medical treatment for primary retinoblastoma: a global cohort study, Int. J. Cancer, 148, 1858, 10.1002/ijc.33350 Chen, 2020, Panax notoginseng saponins prevent colitis-associated colorectal cancer development: the role of gut microbiota, Chin. J. Nat. Med., 18, 500 Chen, 2020, The anticancer effects of 7-Methoxyheptaphylline against the human retinoblastoma cells are facilitated via S-phase cell cycle arrest, mitochondrial apoptosis and inhibition of Wnt/β-catenin signalling pathway, J. Buon, 25, 421 Chen, 2019, Panax notoginseng saponins protect cardiac myocytes against endoplasmic reticulum stress and associated apoptosis through mediation of intracellular calcium homeostasis, Front. Pharmacol., 10, 1013, 10.3389/fphar.2019.01013 Cohen, 2009, PI3K/Akt pathway mutations in retinoblastoma, Invest. Ophthalmol. Vis. Sci., 50, 5054, 10.1167/iovs.09-3617 Elmenier, 2019, Phosphatidylinositol 3 kinase (PI3K) inhibitors as new weapon to combat cancer, Eur. J. Med. Chem., 183, 10.1016/j.ejmech.2019.111718 Fox, 2016, Targeting cell death signalling in cancer: minimising ‘Collateral damage’, Br. J. Cancer, 115, 5, 10.1038/bjc.2016.111 Fruman, 2010, Regulatory subunits of class IA PI3K, Curr. Top. Microbiol. Immunol., 346, 225 Fulda, 2014, Synthetic lethality by co-targeting mitochondrial apoptosis and PI3K/Akt/mTOR signaling, Mitochondrion, 19, 85, 10.1016/j.mito.2014.04.011 Huang, 2015, Lactate promotes resistance to glucose starvation via upregulation of Bcl-2 mediated by mTOR activation, Oncol. Rep., 33, 875, 10.3892/or.2014.3655 Jhanwar-Uniyal, 2017, Discrete signaling mechanisms of mTORC1 and mTORC2: connected yet apart in cellular and molecular aspects, Adv. Biol. Regul., 64, 39, 10.1016/j.jbior.2016.12.001 Kaewkhaw, 2020, Retinoblastoma: etiology, modeling, and treatment, Cancers, 12, 2304, 10.3390/cancers12082304 Li, 2018, Post-marketing safety surveillance and re-evaluation of Xueshuantong injection, BMC Compl. Alternative Med., 18, 277, 10.1186/s12906-018-2329-z Li, 2018, Curcumin inhibits proliferation, migration, invasion and promotes apoptosis of retinoblastoma cell lines through modulation of miR-99a and JAK/STAT pathway, BMC Cancer, 18, 1230, 10.1186/s12885-018-5130-y Liang, 2021, Effect of micronization on Panax notoginseng: in vitro dissolution and in vivo bioavailability evaluations, Evid. base Compl. Alternative Med., 2021 Ma, 2018, FOXO family in regulating cancer and metabolism, Semin. Cancer Biol., 50, 32, 10.1016/j.semcancer.2018.01.018 Manning, 2017, AKT/PKB signaling: navigating the network, Cell, 169, 381, 10.1016/j.cell.2017.04.001 Marchetti, 2018, Melanoma metabolism contributes to the cellular responses to MAPK/ERK pathway inhibitors, Biochim. Biophys. Acta Gen. Subj., 1862, 999, 10.1016/j.bbagen.2018.01.018 Morgan, 2009, Targeted therapy for advanced prostate cancer: inhibition of the PI3K/Akt/mTOR pathway, Curr. Cancer Drug Targets, 9, 237, 10.2174/156800909787580999 Ozoren, 2002, Defining characteristics of Types I and II apoptotic cells in response to TRAIL, Neoplasia, 4, 551, 10.1038/sj.neo.7900270 Pistritto, 2016, Apoptosis as anticancer mechanism: function and dysfunction of its modulators and targeted therapeutic strategies, Aging (Albany NY), 8, 603, 10.18632/aging.100934 Plati, 2011, Apoptotic cell signaling in cancer progression and therapy, Integr. Biol. (Camb), 3, 279, 10.1039/c0ib00144a Qu, 2020, Panax notoginseng saponins and their applications in nervous system disorders: a narrative review, Ann. Transl. Med., 8, 1525, 10.21037/atm-20-6909 Ratna, 2020, Heritable retinoblastoma and risk of developing second primary cancer, JAMA Netw. Open, 3, 10.1001/jamanetworkopen.2020.22569 Salmena, 2008, Tenets of PTEN tumor suppression, Cell, 133, 403, 10.1016/j.cell.2008.04.013 Sun, 2021, Fufang Xueshuantong alleviates diabetic retinopathy by activating the PPAR signalling pathway and complement and coagulation cascades, J. Ethnopharmacol., 265, 10.1016/j.jep.2020.113324 Thapa, 2019, Phosphoinositide spatially free AKT/PKB activation to all membrane compartments, Adv. Biol. Regul., 72, 1, 10.1016/j.jbior.2019.04.002 Tia, 2018, Role of Forkhead Box O (FOXO) transcription factor in aging and diseases, Gene, 648, 97, 10.1016/j.gene.2018.01.051 Uzayisenga, 2014, Anti-diabetic potential of Panax notoginseng saponins (PNS): a review, Phytother Res., 28, 510, 10.1002/ptr.5026 Wang, 2016, Traditional uses, botany, phytochemistry, pharmacology and toxicology of Panax notoginseng (Burk.) F.H. Chen: a review, J. Ethnopharmacol., 188, 234, 10.1016/j.jep.2016.05.005 Wang, 2017, Pioglitazone inhibits growth of human retinoblastoma cells via regulation of NF-κB inflammation signals, J. Recept. Signal Transduct. Res., 37, 94, 10.3109/10799893.2016.1171341 Wang, 2016, Ginsenoside Rd attenuates breast cancer metastasis implicating derepressing microRNA-18a-regulated Smad2 expression, Sci. Rep., 6, 33709, 10.1038/srep33709 Won, 2020, The flavonol isoquercitrin promotes mitochondrial-dependent apoptosis in SK-Mel-2 melanoma cell via the PI3K/AKT/mTOR pathway, Nutrients, 12, 3683, 10.3390/nu12123683 Xie, 2017, Retinoblastoma cells activate the AKT pathway and are vulnerable to the PI3K/mTOR inhibitor NVP-BEZ235, Oncotarget, 8, 38084, 10.18632/oncotarget.16970 Yadav, 2018, FoxO transcription factors in cancer metabolism, Semin. Cancer Biol., 50, 65, 10.1016/j.semcancer.2018.01.004 Yan, 2020, RRS1 promotes retinoblastoma cell proliferation and invasion via activating the AKT/mTOR signaling pathway, BioMed Res. Int., 10.1155/2020/2420437 Yang, 2016, Panax notoginseng saponins attenuate lung cancer growth in part through modulating the level of Met/miR-222 axis, J. Ethnopharmacol., 193, 255, 10.1016/j.jep.2016.08.040 Yang, 2017, Panax Notoginseng Saponins attenuates sevofluraneinduced nerve cell injury by modulating AKT signaling pathway, Mol. Med. Rep., 16, 7829, 10.3892/mmr.2017.7519 Yao, 2020, Rapamycin inhibits proliferation and apoptosis of retinoblastoma cells through PI3K/AKT signaling pathway, Oncol. Lett., 19, 2950 Yao, 2020, Panax notoginseng saponins promote cell death and chemosensitivity in pancreatic cancer through the apoptosis and autophagy pathways, Anti Cancer Agents Med. Chem., 21, 1680, 10.2174/1871520620999201110191459 Zhang, 2020, Panax notoginseng saponins prevent senescence and inhibit apoptosis by regulating the PI3KAKTmTOR pathway in osteoarthritic chondrocytes, Int. J. Mol. Med., 45, 1225 Zheng, 2020, Sinomenine can inhibit the growth and invasion ability of retinoblastoma cell through regulating PI3K/AKT signaling pathway, Biol. Pharm. Bull., 43, 1551, 10.1248/bpb.b20-00387 Zhong, 2019, Panax notoginseng saponins promote liver regeneration through activation of the PI3K/AKT/mTOR cell proliferation pathway and upregulation of the AKT/Bad cell survival pathway in mice, BMC Compl. Alternative Med., 19, 122, 10.1186/s12906-019-2536-2 Zhu, 2018, Polyphyllin I induces cell cycle arrest and cell apoptosis in human retinoblastoma Y-79 cells through targeting p53, Anti Cancer Agents Med. Chem., 18, 875, 10.2174/1871520618666180108095148